{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:39:26Z","timestamp":1792136366306,"version":"4.4.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia \u00e9 Innovaci\u00f3n","doi-asserted-by":"crossref","award":["BFU2010-17373"],"award-info":[{"award-number":["BFU2010-17373"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2013-42833-P"],"award-info":[{"award-number":["BFU2013-42833-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa CSIC i-LINK+","award":["i-LINK0950"],"award-info":[{"award-number":["i-LINK0950"]}]},{"DOI":"10.13039\/501100008441","name":"CYTED","doi-asserted-by":"crossref","award":["BIOTOX P211RT0412"],"award-info":[{"award-number":["BIOTOX P211RT0412"]}],"id":[{"id":"10.13039\/501100008441","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vicerrector\u00eda de Investigaci\u00f3n, UCR","award":["741-B2-652"],"award-info":[{"award-number":["741-B2-652"]}]},{"name":"FEES-CONARE"},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["Genoprot 560931\/2010-7"],"award-info":[{"award-number":["Genoprot 560931\/2010-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["Pensa-Rio E-26\/110.319\/2010"],"award-info":[{"award-number":["Pensa-Rio E-26\/110.319\/2010"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.jprot.2015.04.029","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T13:25:47Z","timestamp":1431177947000},"page":"73-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest"],"prefix":"10.1016","volume":"135","author":[{"given":"Larissa","family":"Gon\u00e7alves-Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinia","family":"Pla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libia","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Jeane B.","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0655","authenticated-orcid":false,"given":"Moema","family":"Leit\u00e3o-De-Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-1274","authenticated-orcid":false,"given":"Maria L\u00facia M.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Janisch","family":"Alvares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joari","family":"De Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-3758","authenticated-orcid":false,"given":"Jenifer","family":"Nowatzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"de Morais-Zani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Mitico","family":"Tanaka-Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russolina B.","family":"Zingali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Corr\u00eaa-Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-3122","authenticated-orcid":false,"given":"Juan J.","family":"Calvete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2015.04.029_bb0005","series-title":"The Venomous Reptiles of the Western Hemisphere","isbn-type":"print","author":"Campbell","year":"2004","ISBN":"https:\/\/id.crossref.org\/isbn\/0801441412"},{"key":"10.1016\/j.jprot.2015.04.029_bb0010","series-title":"Biology of the Pitvipers","first-page":"199","article-title":"Natural history of the jararaca pitviper, Bothrops jararaca, in Southeastern Brazil","author":"Sazima","year":"1992"},{"key":"10.1016\/j.jprot.2015.04.029_bb0015","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1111\/j.1365-294X.2006.03057.x","article-title":"Phylogeography of the Bothrops jararaca complex (Serpentes: Viperidae): past fragmentation and island colonization in the Brazilian Atlantic Forest","volume":"15","author":"Grazziotin","year":"2006","journal-title":"Mol Ecol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0020","series-title":"Biology of the Vipers","first-page":"1","article-title":"Ecological and phylogenetic correlates of feeding habits in Neotropical pitvipers of the genus Bothrops","author":"Martins","year":"2002"},{"key":"10.1016\/j.jprot.2015.04.029_bb0025","first-page":"43","article-title":"Bothropic accidents","volume":"52","author":"Cardoso","year":"1990","journal-title":"Mem Inst Butantan"},{"key":"10.1016\/j.jprot.2015.04.029_bb0030","first-page":"23491","article-title":"Normas de Produ\u00e7\u00e3o e Controle de Qualidade de Soros Antiof\u0131dicos","author":"Minist\u00e9rio da Sa\u00fade do Brasil","year":"1996"},{"key":"10.1016\/j.jprot.2015.04.029_bb0035","first-page":"1","article-title":"Manual de diagn\u00f3stico e tratamento de acidentes por animais pe\u00e7onhentos. COMED\/ASPLAN\/FNS","author":"Minist\u00e9rio da Sa\u00fade do Brasil\/FUNASA (Funda\u00e7\u00e3o Nacional de Sa\u00fade).","year":"1998","journal-title":"Bras\u00edlia"},{"key":"10.1016\/j.jprot.2015.04.029_bb0040","series-title":"The Venomous Reptiles of the Western Hemisphere","first-page":"709","article-title":"Snakebites in Central and South America: epidemiology, clinical features, and clinical management","author":"Warrell","year":"2004"},{"key":"10.1016\/j.jprot.2015.04.029_bb0045","series-title":"Toxicology and Pharmacology of Venoms From Poisonous Snakes","isbn-type":"print","author":"Brown","year":"1973","ISBN":"https:\/\/id.crossref.org\/isbn\/0398028087"},{"key":"10.1016\/j.jprot.2015.04.029_bb0050","series-title":"Venomous Animals and Their Venoms","first-page":"345","article-title":"Symptomatology, pathology and treatment of snake bites in South America","volume":"1971","author":"Rosenfeld","year":"1971"},{"key":"10.1016\/j.jprot.2015.04.029_bb0055","series-title":"Animais pe\u00e7onhentos no Brasil: biologia, cl\u00ednica e terap\u00eautica dos acidentes","isbn-type":"print","first-page":"81","article-title":"Acidente botr\u00f3pico","author":"Fran\u00e7a","year":"2003","ISBN":"https:\/\/id.crossref.org\/isbn\/8573781335"},{"key":"10.1016\/j.jprot.2015.04.029_bb0060","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2009.01.034","article-title":"Functional basis of a molecular adaptation: prey-specific toxic effects of venom from Sistrurus rattlesnakes","volume":"53","author":"Gibbs","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0065","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.toxicon.2012.02.013","article-title":"The structural and functional diversification of the Toxicofera reptile venom system","volume":"60","author":"Fry","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxicon.2013.03.020","article-title":"Snake venomics: from the inventory of toxins to biology","volume":"75","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0080","doi-asserted-by":"crossref","first-page":"20651","DOI":"10.1073\/pnas.1314702110","article-title":"The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system","volume":"110","author":"Vonk","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jprot.2015.04.029_bb0085","series-title":"Rattlesnakes of Arizona","article-title":"A role for genomics in rattlesnake research \u2014 current knowledge and future potential","author":"Schield","year":"2015"},{"key":"10.1016\/j.jprot.2015.04.029_bb0090","series-title":"Handbook of Toxinology: Venom Genomics and Proteomics","article-title":"Squamate reptile genomics and evolution","author":"Shaney","year":"2015"},{"key":"10.1016\/j.jprot.2015.04.029_bb0095","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.toxicon.2006.01.022","article-title":"Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid venom proteomes","volume":"47","author":"Fox","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0100","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.toxicon.2005.11.007","article-title":"Sex-based individual variation of snake venom proteome among eighteen Bothrops jararaca siblings","volume":"47","author":"Menezes","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0105","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/rcm.2931","article-title":"Mass spectrometric analysis of the individual variability of Bothrops jararaca venom peptide fraction. Evidence for sex-based variation among the bradykinin-potentiating peptides","volume":"21","author":"Pimenta","year":"2007","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.jprot.2015.04.029_bb0110","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/pr901027r","article-title":"Analysis of the ontogenetic variation in the venom proteome\/peptidome of Bothrops jararaca reveals different strategies to deal with prey","volume":"9","author":"Zelanis","year":"2010","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2015.04.029_bb0115","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1002\/pmic.201100287","article-title":"Bothrops jararaca venom proteome rearrangement upon neonate to adult transition","volume":"11","author":"Zelanis","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0120","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jprot.2011.09.017","article-title":"N-glycome profiling of Bothrops jararaca newborn and adult venoms","volume":"75","author":"Zelanis","year":"2012","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0125","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1074\/mcp.M112.019331","article-title":"Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes","volume":"11","author":"Tashima","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0130","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/pr4007393","article-title":"Individual variability in the venom proteome of juvenile Bothrops jararaca specimens","volume":"12","author":"Dias","year":"2013","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2015.04.029_bb0135","doi-asserted-by":"crossref","first-page":"e2442","DOI":"10.1371\/journal.pntd.0002442","article-title":"Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex","volume":"7","author":"Sousa","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jprot.2015.04.029_bb0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.toxicon.2006.07.008","article-title":"Bothrops jararaca venom gland transcriptome: analysis of the gene expression pattern","volume":"48","author":"Cidade","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0145","doi-asserted-by":"crossref","first-page":"e1554","DOI":"10.1371\/journal.pntd.0001554","article-title":"A transcriptomic view of the proteome variability of newborn and adult Bothrops jararaca snake venoms","volume":"6","author":"Zelanis","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jprot.2015.04.029_bb0150","first-page":"1369","article-title":"Variation g\u00e9ographique du venin de Bothrops atrox","volume":"204","author":"Vellard","year":"1937","journal-title":"C. R Acad Sci"},{"key":"10.1016\/j.jprot.2015.04.029_bb0155","first-page":"463","article-title":"Variation g\u00e9ographique du venin de Crotalus terrificus","volume":"130","author":"Vellard","year":"1939","journal-title":"C R Soc Biol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0160","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0041-0101(91)90116-9","article-title":"Snake venom variability: methods of study, results and interpretation","volume":"29","author":"Chippaux","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0165","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0041-0101(78)90065-X","article-title":"Mojave rattlesnake Crotalus scutulatus scutulatus venom: variation in toxicity with geographical origin","volume":"16","author":"Glenn","year":"1978","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0170","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.jprot.2012.02.035","article-title":"Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona","volume":"75","author":"Massey","year":"2012","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0175","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jprot.2011.01.003","article-title":"Snake population venomics and antivenomics of Bothrops atrox: paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management","volume":"74","author":"Calvete","year":"2011","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0180","first-page":"149","volume":"53","author":"Furtado","year":"1991","journal-title":"Mem Inst Butantan"},{"key":"10.1016\/j.jprot.2015.04.029_bb0185","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.3390\/toxins6123388","article-title":"Omics meets biology: application to the design and preclinical assessment of antivenoms","volume":"6","author":"Calvete","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.jprot.2015.04.029_bb0190","series-title":"Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins","author":"WHO","year":"2010"},{"key":"10.1016\/j.jprot.2015.04.029_bb0195","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.toxicon.2012.04.342","article-title":"Second generation snake antivenomics: comparing immunoaffinity and immunodepletion protocols","volume":"60","author":"Pla","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0200","series-title":"Handbook of Natural Toxins","first-page":"557","article-title":"Antivenins in Brazil: preparation","author":"Raw","year":"1991"},{"key":"10.1016\/j.jprot.2015.04.029_bb0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0041-0101(96)00077-3","article-title":"Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom","volume":"35","author":"Angulo","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0041-0101(94)90087-6","article-title":"Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production","volume":"32","author":"Rojas","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0215","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0041-0101(92)90534-C","article-title":"Gene expression in Echis carinatus (carpet viper) venom glands following milking","volume":"30","author":"Paine","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0220","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"Margulies","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2015.04.029_bb0225","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0230","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0235","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"10.1016\/j.jprot.2015.04.029_bb0240","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1471-2164-14-234","article-title":"Integrated \u201comics\u201d profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake Crotalus simus simus","volume":"14","author":"Durban","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jprot.2014.11.011","article-title":"Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil","volume":"114","author":"Jorge","year":"2015","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0250","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1586\/epr.11.61","article-title":"Proteomic tools against the neglected pathology of snake bite envenoming","volume":"8","author":"Calvete","year":"2011","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0255","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1586\/14789450.2014.900447","article-title":"Next-generation snake venomics: protein-locus resolution through venom proteome decomplexation","volume":"11","author":"Calvete","year":"2014","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0260","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0041-0101(85)90380-0","article-title":"Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom","volume":"23","author":"Guti\u00e9rrez","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0265","first-page":"949","article-title":"Development of simple standard procedures for the characterisation of snake venom","volume":"61","author":"Theakston","year":"1983","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jprot.2015.04.029_bb0270","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0041-0101(89)90096-2","article-title":"Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom","volume":"27","author":"Gen\u00e9","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0275","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0041-0101(96)00057-8","article-title":"An aqueous endpoint assay of snake venom phospholipase A2","volume":"34","author":"Holzer","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0280","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2004.09.031","article-title":"A novel P-I class metalloproteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom","volume":"324","author":"Wang","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jprot.2015.04.029_bb0285","series-title":"Immunochemistry in Practice","author":"Johnstone","year":"1987"},{"key":"10.1016\/j.jprot.2015.04.029_bb0290","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tree.2014.10.004","article-title":"Advances and limits of using population genetics to understand local adaptation","volume":"29","author":"Tiffin","year":"2014","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0295","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrg3522","article-title":"Ecological genomics of local adaptation","volume":"14","author":"Savolainen","year":"2013","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jprot.2015.04.029_bb0300","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tig.2010.05.003","article-title":"Evolution of the mutation rate","volume":"26","author":"Lynch","year":"2010","journal-title":"Trends Genet"},{"key":"10.1016\/j.jprot.2015.04.029_bb0305","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1073\/pnas.1405484111","article-title":"Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms","volume":"111","author":"Casewell","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jprot.2015.04.029_bb0310","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.129.3359.1361","article-title":"Geographical pattern of crotamine distribution in the same rattlesnake subspecies","volume":"129","author":"Schenberg","year":"1959","journal-title":"Science"},{"key":"10.1016\/j.jprot.2015.04.029_bb0315","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1096-4959(01)00422-5","article-title":"Mojave rattlesnakes (Crotalus scutulatus scutulatus) lacking the acidic subunit DNA sequence lack Mojave toxin in their venom","volume":"130","author":"Wooldridge","year":"2001","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxicon.2010.03.015","article-title":"Absence of phospholipase A2 in most Crotalus horridus venom due to translation blockage: comparison with Crotalus horridus atricaudatus venom","volume":"56","author":"Wang","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0325","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/pr800332p","article-title":"Snake venomics of the lancehead pitviper Bothrops asper. Geographic, individual and ontogenetic variations","volume":"7","author":"Alape-Gir\u00f3n","year":"2008","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2015.04.029_bb0330","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jprot.2012.09.003","article-title":"Snake venomics across genus Lachesis Ontogenetic changes in the venom composition of L. stenophrys and comparative proteomics of the venoms of adult L. melanocephala and L. acrochorda","volume":"77","author":"Madrigal","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0335","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.biochi.2006.10.006","article-title":"Purification, sequencing and structural analysis of two acidic phospholipases A2 from the venom of Bothrops insularis (jararaca ilhoa)","volume":"88","author":"Cogo","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2015.04.029_bb0340","doi-asserted-by":"crossref","first-page":"39836","DOI":"10.1074\/jbc.M106531200","article-title":"Molecular cloning and expression of a functional snake venom vascular endothelium growth factor (VEGF) from the Bothrops insularis pit viper. A new member of the VEGF family of proteins","volume":"276","author":"de Azevedo IL","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jprot.2015.04.029_bb0345","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1590\/0001-37652014119013","article-title":"Seasonal, daily activity, and habitat use by three sympatric pit vipers (Serpentes, Viperidae) from southern Brazil","volume":"86","author":"Rocha","year":"2014","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.jprot.2015.04.029_bb0350","first-page":"127","article-title":"mtDNA phylogeny of neotropical pitvipers of the genus Bothrops (Squamata: Serpentes: Viperidae)","volume":"8","author":"Salom\u00e3o","year":"1999","journal-title":"Kaupia"},{"key":"10.1016\/j.jprot.2015.04.029_bb0355","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1096-3642.2008.00495.x","article-title":"Morphological and molecular evidence for phylogeny and classification of South American pitvipers, genera Bothrops, Bothriopsis, and Bothrocophias (Serpentes: Viperidae)","volume":"156","author":"Fenwick","year":"2009","journal-title":"Zool J Linn Soc"},{"key":"10.1016\/j.jprot.2015.04.029_bb0360","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1463-6409.2011.00511.x","article-title":"Morphology, phylogeny and taxonomy of South American bothropoid pitvipers (Serpentes, Viperidae)","volume":"41","author":"Carrasco","year":"2012","journal-title":"Zool Scr"},{"key":"10.1016\/j.jprot.2015.04.029_bb0365","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.toxicon.2010.08.011","article-title":"Comparative analysis of newborn and adult Bothrops jararaca snake venoms","volume":"56","author":"Antunes","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0370","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.toxicon.2007.09.005","article-title":"Purification and functional characterization of bothrojaractivase, a prothrombin-activating metalloproteinase isolated from Bothrops jararaca snake venom","volume":"51","author":"Berger","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0375","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/bi00173a030","article-title":"Purification and characterization of bothrombin, a fibrinogen-clotting serine protease from the venom of Bothrops jararaca","volume":"33","author":"Nishida","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.jprot.2015.04.029_bb0380","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/abbi.1999.1230","article-title":"A novel phospholipase A2, BJ-PLA2, from the venom of the snake Bothrops jararaca: purification, primary structure analysis, and its characterization as a platelet aggregation-inhibiting factor","volume":"367","author":"Serrano","year":"1999","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jprot.2015.04.029_bb0385","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0041-0101(88)90244-9","article-title":"Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin","volume":"26","author":"Homsi-Brandeburgo","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0390","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0300-9084(00)01150-0","article-title":"Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu","volume":"82","author":"Andri\u00e3o-Escarso","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2015.04.029_bb0395","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.toxicon.2005.08.013","article-title":"Microvessel damage by B. jararacussu snake venom: pathogenesis and influence on muscle regeneration","volume":"46","author":"Neto","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0400","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1742-7843.2004.pto_950405.x","article-title":"The presynaptic activity of bothropstoxin-I, a myotoxin from Bothrops jararacussu snake venom","volume":"95","author":"Oshima-Franco","year":"2004","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0405","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1655\/0018-0831(2002)058[0303:ANISOP]2.0.CO;2","article-title":"A new insular species of pitviper from Brazil, with comments on evolutionary biology and conservation of the Bothrops jararaca group (Serpentes, Viperidae)","volume":"58","author":"Marques","year":"2002","journal-title":"Herpetologica"},{"key":"10.1016\/j.jprot.2015.04.029_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0952836904006247","article-title":"Morphological correlates of incipient arboreality and ornithophagy in island pitvipers, and the phylogenetic position of Bothrops insularis","volume":"266","author":"W\u00fcster","year":"2005","journal-title":"J Zool"},{"key":"10.1016\/j.jprot.2015.04.029_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01650529509360936","article-title":"A biological survey of the pitviper Bothrops insularis Amaral (Serpentes: Viperidae): an endemic and threatened offshore island snake of Southeastern Brazil","volume":"30","author":"Duarte","year":"1995","journal-title":"Stud Neotropical Fauna Environ"},{"key":"10.1016\/j.jprot.2015.04.029_bb0420","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/00222933.2011.654278","article-title":"The Golden Lancehead Bothrops insularis (Serpentes: Viperidae) relies on two seasonally plentiful bird species visiting its island habitat","volume":"46","author":"Marques","year":"2012","journal-title":"J Nat Hist"},{"key":"10.1016\/j.jprot.2015.04.029_bb0425","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/379537a0","article-title":"Diet and snake venom evolution","volume":"379","author":"Daltry","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2015.04.029_bb0430","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0041-0101(97)00174-8","article-title":"An unusual presynaptic action of Bothrops insularis snake venom mediated by phospholipase A2 fraction","volume":"36","author":"Cogo","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0435","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.toxicon.2008.10.002","article-title":"Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus","volume":"52","author":"Queiroz","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0440","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/1097-4598(200012)23:12<1832::AID-MUS6>3.0.CO;2-F","article-title":"Neutralizing capacity of commercial bothropic antivenom against Bothrops jararacussu venom and bothropstoxin-I","volume":"23","author":"Oshima-Franco","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jprot.2015.04.029_bb0445","first-page":"315","article-title":"Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in S\u00e3o Paulo Brazil","volume":"86","author":"Cardoso","year":"1993","journal-title":"Q J Med"},{"key":"10.1016\/j.jprot.2015.04.029_bb0450","series-title":"Snakes: The Evolution and Mystery in Nature","isbn-type":"print","author":"Greene","year":"1997","ISBN":"https:\/\/id.crossref.org\/isbn\/0520224876"},{"key":"10.1016\/j.jprot.2015.04.029_bb0455","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0169-5347(00)01853-X","article-title":"Snakes: a new \u2018model organism\u2019 in ecological research?","volume":"15","author":"Shine","year":"2000","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0460","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2307\/3544421","article-title":"Diversity and the coevolution of competitors, or the ghost of competition past","volume":"35","author":"Connell","year":"1980","journal-title":"Oikos"},{"key":"10.1016\/j.jprot.2015.04.029_bb0465","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/1365-2656.12121","article-title":"Snake co-occurrence patterns are best explained by habitat and hypothesized effects of interspecific interactions","volume":"83","author":"Steen","year":"2014","journal-title":"J Anim Ecol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0470","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2307\/1941410","article-title":"Habitat separation between sympatric snake populations","volume":"65","author":"Reinert","year":"1984","journal-title":"Ecology"},{"key":"10.1016\/j.jprot.2015.04.029_bb0475","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.2006.0030-1299.14064.x","article-title":"Resource partitioning and interspecific competition in snakes: the search for general geographical and guild patterns","volume":"114","author":"Luiselli","year":"2006","journal-title":"Oikos"},{"key":"10.1016\/j.jprot.2015.04.029_bb0480","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.es.16.110185.001413","article-title":"Predation, competition, and prey communities: a review of field experiments","volume":"16","author":"Sih","year":"1985","journal-title":"Annu Rev Ecol Syst"},{"key":"10.1016\/j.jprot.2015.04.029_bb0485","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1365-294X.2011.05426.x","article-title":"Proteomics in evolutionary ecology: linking the genotype with the phenotype","volume":"21","author":"Diz","year":"2012","journal-title":"Mol Ecol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0490","series-title":"Venomous Snakes: Ecology, Evolution and Snakebite","isbn-type":"print","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/oso\/9780198549864.003.0007","article-title":"DNA evolution of South American pitvipers of the genus Bothrops (Reptilia: Serpentes: Viperidae)","author":"Salom\u00e3o","year":"1996","ISBN":"https:\/\/id.crossref.org\/isbn\/9780198549864"},{"key":"10.1016\/j.jprot.2015.04.029_bb0495","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ympev.2011.11.004","article-title":"Demographic processes in the montane Atlantic rainforest: molecular and cytogenetic evidence from the endemic frog Proceratophrys boiei","volume":"62","author":"Amaro","year":"2012","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0500","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1126\/science.1166955","article-title":"Stability predicts genetic diversity in the Brazilian Atlantic forest hotspot","volume":"323","author":"Carnaval","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jprot.2015.04.029_bb0505","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tree.2006.11.004","article-title":"Cryptic species as a window on diversity and conservation","volume":"22","author":"Bickford","year":"2007","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0510","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1095-8312.2004.00354.x","article-title":"Maximising information in systematic revisions: a combined molecular and morphological analysis of a cryptic green pitviper complex (Trimeresurus stejnegeri)","volume":"82","author":"Malhotra","year":"2004","journal-title":"Biol J Linn Soc"},{"key":"10.1016\/j.jprot.2015.04.029_bb0515","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1095-8312.2006.00568.x","article-title":"Combining molecular, morphological and ecological data to infer species boundaries in a cryptic tropical pitviper","volume":"87","author":"Sanders","year":"2006","journal-title":"Biol J Linn Soc"},{"key":"10.1016\/j.jprot.2015.04.029_bb0520","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ympev.2011.02.010","article-title":"Phylogenetic structure and species boundaries in the mountain pitviper Ovophis monticola (Serpentes: Viperidae: Crotalinae) in Asia","volume":"59","author":"Malhotra","year":"2011","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0525","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1021\/pr8003826","article-title":"Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom","volume":"7","author":"Guti\u00e9rrez","year":"2008","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jprot.2015.04.029_bb0530","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jprot.2009.01.005","article-title":"Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: contributing to its taxonomy and snakebite management","volume":"72","author":"Calvete","year":"2009","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0535","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jprot.2014.02.021","article-title":"Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays","volume":"105","author":"Guti\u00e9rrez","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.jprot.2015.04.029_bb0540","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0041-0101(99)00236-6","article-title":"Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica","volume":"38","author":"Bogar\u00edn","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2015.04.029_bb0545","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ympev.2008.08.019","article-title":"A nesting of vipers: phylogeny and historical phylogeography of the Viperidae (Squamata: Serpentes)","volume":"49","author":"W\u00fcster","year":"2008","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0550","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ympev.2005.12.014","article-title":"Bayesian mixed models and the phylogeny of pitvipers (Viperidae: Serpentes)","volume":"39","author":"Castoe","year":"2006","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ympev.2013.10.003","article-title":"Phylogenetic relationships within Bothrops neuwiedi group (Serpentes, Squamata): geographically highly-structured lineages, evidence of introgressive hybridization and Neogene\/Quaternary diversification","volume":"71","author":"Machado","year":"2014","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.jprot.2015.04.029_bb0560","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0041-0101(00)00208-7","article-title":"Proteolytic action of Bothrops jararaca venom upon its own constituents","volume":"39","author":"Sousa","year":"2001","journal-title":"Toxicon"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391915002213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391915002213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T18:19:16Z","timestamp":1717870756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391915002213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":112,"alternative-id":["S1874391915002213"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2015.04.029","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2015.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}