{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:21:20Z","timestamp":1777609280649,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["005-2014"],"award-info":[{"award-number":["005-2014"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jprot.2016.07.020","type":"journal-article","created":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T08:37:48Z","timestamp":1469349468000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy"],"prefix":"10.1016","volume":"148","author":[{"given":"Irene","family":"Izquierdo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Bel\u00e9n","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Guiti\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"P\u00e9rez-Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Campuzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alipio","family":"Mangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Toro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jprot.2016.07.020_bb0005","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur. Heart J."},{"issue":"9716","key":"10.1016\/j.jprot.2016.07.020_bb0010","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(09)62023-7","article-title":"Dilated cardiomyopathy","volume":"375","author":"Jefferies","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jprot.2016.07.020_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"McNally","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jprot.2016.07.020_bb0020","doi-asserted-by":"crossref","first-page":"e570","DOI":"10.1016\/j.ejmg.2011.07.005","article-title":"Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy","volume":"54","author":"Millat","year":"2011","journal-title":"Eur. J. Med. Genet."},{"issue":"14","key":"10.1016\/j.jprot.2016.07.020_bb0025","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1161\/CIRCULATIONAHA.109.192064","volume":"119","author":"Jessup","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jprot.2016.07.020_bb0030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2741\/4120","article-title":"Biomarker discovery by plasma proteomics in familial Brugada Syndrome","volume":"18","author":"Di Domenico","year":"2013","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"3","key":"10.1016\/j.jprot.2016.07.020_bb0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cardfail.2014.12.003","article-title":"A novel mutation in lamin a\/c causing familial dilated cardiomyopathy associated with sudden cardiac death","volume":"21","author":"P\u00e9rez-Serra","year":"2015","journal-title":"J. Card. Fail."},{"issue":"4","key":"10.1016\/j.jprot.2016.07.020_bb0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cardfail.2013.03.001","article-title":"Temporal relationship of conduction system disease and ventricular dysfunction in LMNA cardiomyopathy","volume":"19","author":"Brodt","year":"2013","journal-title":"J. Card. Fail."},{"issue":"15","key":"10.1016\/j.jprot.2016.07.020_bb0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jacc.2008.06.044","article-title":"Long-term outcome and risk stratification in dilated cardiolaminopathies","volume":"52","author":"Pasotti","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.jprot.2016.07.020_bb0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0735-1097(02)02954-6","article-title":"Natural history of dilated cardiomyopathy due to lamin A\/C gene mutations","volume":"41","author":"Taylor","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.jprot.2016.07.020_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00109-004-0589-1","article-title":"Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A\/C mutations portend a high risk of sudden death?","volume":"83","author":"Van Berlo","year":"2005","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.jprot.2016.07.020_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cjca.2015.06.034","article-title":"The rationale and timing of molecular genetic testing for dilated cardiomyopathy","author":"Morales","year":"2015","journal-title":"Canadian J. Cardiol."},{"issue":"3","key":"10.1016\/j.jprot.2016.07.020_bb0065","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/HCO.0b013e32835f0c79","article-title":"\u2018State-of-the-heart\u2019 of cardiac laminopathies","volume":"28","author":"Cattin","year":"2013","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.jprot.2016.07.020_bb0070","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trprot.2014.09.002","article-title":"Platelet proteomics in cardiovascular diseases","volume":"7","author":"V\u00e9lez","year":"2015","journal-title":"Transl. Proteomics"},{"issue":"3","key":"10.1016\/j.jprot.2016.07.020_bb0075","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"11","key":"10.1016\/j.jprot.2016.07.020_bb0080","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.hlc.2011.07.008","article-title":"Guidelines for the diagnosis and management of familial dilated cardiomyopathy","volume":"20","author":"Fatkin","year":"2011","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.jprot.2016.07.020_bb0085","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.93.25.14440","article-title":"Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels","volume":"93","author":"Shevchenko","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2016.07.020_bb0090","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.jprot.2016.07.020_bb0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"Bendtsen","year":"2004","journal-title":"Protein Eng. Des. Sel."},{"issue":"Database issue","key":"10.1016\/j.jprot.2016.07.020_bb0100","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"Uniprot Consortium","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2016.07.020_bb0105","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2015.10.119","article-title":"Histological and proteomic profile of diabetic versus non-diabetic dilated cardiomyopathy","volume":"203","author":"Frustaci","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"10.1016\/j.jprot.2016.07.020_bb0110","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jprot.2011.11.036","article-title":"Inside human aortic stenosis: a proteomic analysis of plasma","volume":"75","author":"Gil-Dones","year":"2012","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2016.07.020_bb0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijcard.2015.05.148","article-title":"Prediction of development and maintenance of high albuminuria during chronic renin-angiotensin suppression by plasma proteomics","volume":"196","author":"Baldan-Martin","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"12","key":"10.1016\/j.jprot.2016.07.020_bb0120","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1073\/pnas.94.12.6438","article-title":"A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophy growth program","volume":"94","author":"Sack","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2016.07.020_bb0125","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","article-title":"MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure","volume":"116","author":"Thum","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jprot.2016.07.020_bb0130","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/01.CIR.92.9.2385","article-title":"Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs","volume":"92","author":"Calderone","year":"1995","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jprot.2016.07.020_bb0135","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1161\/01.CIR.96.12.4146","article-title":"A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes","volume":"96","author":"Hwang","year":"1997","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jprot.2016.07.020_bb0140","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.biocel.2008.02.020","article-title":"Molecular regulation of cardiac hypertrophy","volume":"40","author":"Barry","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.jprot.2016.07.020_bb0145","doi-asserted-by":"crossref","first-page":"e34653","DOI":"10.1371\/journal.pone.0034653","article-title":"Cardiomyocyte microvesicles contain DNA\/RNA and convey biological messages to target cells","volume":"7","author":"Waldenstr\u00f6m","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2016.07.020_bb0150","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.4049\/jimmunol.173.6.4130","article-title":"Platelet-derived thrombospondin-1 is necessary for the vitamin D binding protein (Gc-globulin) to function as a chemotactic cofactor for C5a","volume":"173","author":"Trujillo","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jprot.2016.07.020_bb0155","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00000542-200101000-00025","article-title":"Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of P-selectin glycoprotein ligand-1 with P-selectin","volume":"94","author":"Faraday","year":"2001","journal-title":"Anesthesiology"},{"issue":"Pt 2","key":"10.1016\/j.jprot.2016.07.020_bb0160","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1107\/S0907444902021455","article-title":"Actin-DBP: the perfect structural fit?","volume":"59","author":"Verboven","year":"2003","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jprot.2016.07.020_bb0165","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.4049\/jimmunol.157.11.5126","article-title":"Alpha(1)-antitrypsin inhibits the lethal response to TNF in mice","volume":"157","author":"Libert","year":"1996","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.jprot.2016.07.020_bb0170","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1111\/jcmm.12652","article-title":"New circulating biomarkers for predicting cardiovascular death in healthy population","volume":"19","author":"Melander","year":"2015","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.jprot.2016.07.020_bb0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11154-013-9275-3","article-title":"The physiological roles of apolipoprotein J\/clusterin in metabolic and cardiovascular diseases","volume":"15","author":"Park","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jprot.2016.07.020_bb0180","first-page":"177","article-title":"Co-deposition of clusterin with the complement membrane attack complex in myocardial infarction","volume":"80","author":"Vakeva","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.jprot.2016.07.020_bb0185","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/ATVBAHA.109.190058","article-title":"Protective role of clusterin\/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells","volume":"29","author":"Kim","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.jprot.2016.07.020_bb0190","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3858\/emm.2011.43.1.006","article-title":"Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt\/GSK-3\u03b2 signaling pathway","volume":"43","author":"Jun","year":"2011","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.jprot.2016.07.020_bb0195","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/0735-1097(95)00049-A","article-title":"The coagulation system is activated in idiopathic cardiomyopathy","volume":"25","author":"Yamamoto","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.jprot.2016.07.020_bb0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.mca.0000135596.54871.6f","article-title":"Activation of coagulation system in dilated cardiomyopathy: comparison of patients with and without left ventricular thrombus","volume":"15","author":"Riza Erbay","year":"2004","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.jprot.2016.07.020_bb0205","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1160\/TH03-11-0674","article-title":"Coagulation activation in young survivors of myocardial infarction (MI) \u2013 a population-based case-control study","volume":"92","author":"Brodin","year":"2004","journal-title":"Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.jprot.2016.07.020_bb0210","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1161\/01.ATV.0000249406.92992.0d","article-title":"Haemostatic factors and the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study","volume":"26","author":"Morange","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391916303293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391916303293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:34:26Z","timestamp":1692423266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391916303293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":42,"alternative-id":["S1874391916303293"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2016.07.020","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2016.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}