{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:23:22Z","timestamp":1788805402991,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["31470238"],"award-info":[{"award-number":["31470238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["31670129"],"award-info":[{"award-number":["31670129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Agricultural and Forestry University Foundation","award":["XJQ201201"],"award-info":[{"award-number":["XJQ201201"]}]},{"name":"Fujian-Taiwan Joint Innovative Center for Germplasm Resources and Cultivation of Crop","award":["2015-75"],"award-info":[{"award-number":["2015-75"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jprot.2018.03.002","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T03:25:01Z","timestamp":1520306701000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Systematically integrated metabonomic-proteomic studies of Escherichia coli under ciprofloxacin stress"],"prefix":"10.1016","volume":"179","author":[{"given":"Wanxin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-0198","authenticated-orcid":false,"given":"Xiangmin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jprot.2018.03.002_bb0005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cell.2014.01.068","article-title":"Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin","volume":"157","author":"Slager","year":"2014","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jprot.2018.03.002_bb0010","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1111\/1462-2920.12775","article-title":"Differential transcriptional response to antibiotics by Pseudomonas putida DOT-T1E","volume":"17","author":"Molina-Santiago","year":"2015","journal-title":"Environ. Microbiol."},{"issue":"9","key":"10.1016\/j.jprot.2018.03.002_bb0015","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/jac\/dkw198","article-title":"Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets","volume":"71","author":"Moller","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jprot.2018.03.002_bb0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fmicb.2017.00069","article-title":"Outer membrane proteins form specific patterns in antibiotic-resistant Edwardsiella tarda","volume":"8","author":"Peng","year":"2017","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.jprot.2018.03.002_bb0025","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.fsi.2010.07.027","article-title":"Identification of vaccine candidates from differentially expressed outer membrane proteins of Vibrio alginolyticus in response to NaCl and iron limitation","volume":"29","author":"Xiong","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.jprot.2018.03.002_bb0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/jac\/45.6.789","article-title":"An evaluation of the potential of the multiple antibiotic resistance operon (mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms","volume":"45","author":"Maira-Litran","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"issue":"8","key":"10.1016\/j.jprot.2018.03.002_bb0035","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1128\/AAC.00242-10","article-title":"Adaptive resistance to the \"last hope\" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS","volume":"54","author":"Fernandez","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.jprot.2018.03.002_bb0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jac\/49.2.309","article-title":"Effects of quorum-sensing deficiency on Pseudomonas aeruginosa biofilm formation and antibiotic resistance","volume":"49","author":"Shih","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"issue":"9","key":"10.1016\/j.jprot.2018.03.002_bb0045","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1016\/j.jprot.2012.03.006","article-title":"Downregulation of Na(+)-NQR complex is essential for Vibrio alginolyticus in resistance to balofloxacin","volume":"75","author":"Li","year":"2012","journal-title":"J. Proteome"},{"issue":"13","key":"10.1016\/j.jprot.2018.03.002_bb0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jprot.2013.05.019","article-title":"Low abundance of respiratory nitrate reductase is essential for Escherichia coli in resistance to aminoglycoside and cephalosporin","volume":"87","author":"Ma","year":"2013","journal-title":"J. Proteome"},{"issue":"7","key":"10.1016\/j.jprot.2018.03.002_bb0055","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1128\/AAC.00433-15","article-title":"Contribution of stress responses to antibiotic tolerance in Pseudomonas aeruginosa biofilms","volume":"59","author":"Stewart","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.jprot.2018.03.002_bb0060","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1021\/acs.jproteome.5b01127","article-title":"Proteomics analysis reveals a potential antibiotic cocktail therapy strategy for Aeromonas hydrophila infection in biofilm","volume":"15","author":"Li","year":"2016","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.jprot.2018.03.002_bb0065","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2015.01.008","article-title":"Exogenous alanine and\/or glucose plus kanamycin kills antibiotic-resistant bacteria","volume":"21","author":"Peng","year":"2015","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.jprot.2018.03.002_bb0070","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/pr501285f","article-title":"Fructose restores susceptibility of multidrug-resistant Edwardsiella tarda to kanamycin","volume":"14","author":"Su","year":"2015","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.jprot.2018.03.002_bb0075","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.1714645115","article-title":"Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in vacteria","volume":"115","author":"Su","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jprot.2018.03.002_bb0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jprot.2016.09.006","article-title":"Quantitative proteomic analysis of Edwardsiella tarda in response to oxytetracycline stress in biofilm","volume":"150","author":"Sun","year":"2017","journal-title":"J. Proteome"},{"issue":"2","key":"10.1016\/j.jprot.2018.03.002_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016628","article-title":"Proteome analyses of cellular proteins in methicillin-resistant Staphylococcus aureus treated with rhodomyrtone, a novel antibiotic candidate","volume":"6","author":"Sianglum","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jprot.2018.03.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033599","article-title":"Quantitative proteome profiling of C. burnetii under tetracycline stress conditions","volume":"7","author":"Vranakis","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jprot.2018.03.002_bb0095","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1128\/AAC.47.3.948-955.2003","article-title":"Proteomic approach to understanding antibiotic action","volume":"47","author":"Bandow","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.jprot.2018.03.002_bb0100","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.6b00489","article-title":"Qualitative alterations of bacterial metabolome after exposure to metal nanoparticles with bactericidal properties: a comprehensive workflow based on (1)H NMR, UHPLC-HRMS, and metabolic databases","volume":"15","author":"Chatzimitakos","year":"2016","journal-title":"J. Proteome Res."},{"issue":"11","key":"10.1016\/j.jprot.2018.03.002_bb0105","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1021\/acs.jproteome.5b00697","article-title":"Annotation of the Staphylococcus aureus metabolome using liquid chromatography coupled to high-resolution mass spectrometry and application to the study of methicillin resistance","volume":"14","author":"Aros-Calt","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2018.03.002_bb0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12866-016-0696-5","article-title":"Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics","volume":"16","author":"Hoerr","year":"2016","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.jprot.2018.03.002_bb0115","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1038\/srep10720","article-title":"Myo-inositol improves the host's ability to eliminate balofloxacin-resistant Escherichia coli","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jprot.2018.03.002_bb0120","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1038\/s41598-017-02996-3","article-title":"Integrated proteomic and metabolomic analysis reveals that rhodomyrtone reduces the capsule in Streptococcus pneumoniae","volume":"7","author":"Mitsuwan","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jprot.2018.03.002_bb0125","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1128\/AAC.44.5.1223-1228.2000","article-title":"Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar typhimurium","volume":"44","author":"Giraud","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.jprot.2018.03.002_bb0130","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/clinids\/10.3.516","article-title":"Ciprofloxacin: in vitro activity, mechanism of action, and resistance","volume":"10","author":"Sanders","year":"1988","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.jprot.2018.03.002_bb0135","doi-asserted-by":"crossref","first-page":"39413","DOI":"10.1038\/srep39413","article-title":"Proteomic analysis reveals that metabolic flows affect the susceptibility of Aeromonas hydrophila to antibiotics","volume":"6","author":"Yao","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jprot.2018.03.002_bb0140","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.bbapap.2015.01.007","article-title":"Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery","volume":"1854","author":"Lin","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jprot.2018.03.002_bb0145","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/pr501188g","article-title":"An integrated quantitative and targeted proteomics reveals fitness mechanisms of Aeromonas hydrophila under oxytetracycline stress","volume":"14","author":"Lin","year":"2015","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.jprot.2018.03.002_bb0150","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/acs.jproteome.6b00944","article-title":"Metabolic mechanism for l-Leucine-induced metabolome to eliminate Streptococcus iniae","volume":"16","author":"Du","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2018.03.002_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fimmu.2017.00207","article-title":"Exogenousl-valine promotes phagocytosis to kill multidrug-resistant bacterial pathogens","volume":"8","author":"Chen","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jprot.2018.03.002_bb0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"issue":"17","key":"10.1016\/j.jprot.2018.03.002_bb0165","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/bioinformatics\/btg321","article-title":"MetaGeneAlyse: analysis of integrated transcriptional and metabolite data","volume":"19","author":"Daub","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jprot.2018.03.002_bb0170","doi-asserted-by":"crossref","first-page":"W501","DOI":"10.1093\/nar\/gkx372","article-title":"Pathview web: user friendly pathway visualization and data integration","volume":"45","author":"Luo","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2018.03.002_bb0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fsi.2016.12.010","article-title":"Glucose enhances tilapia against Edwardsiella tarda infection through metabolome reprogramming","volume":"61","author":"Zeng","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.jprot.2018.03.002_bb0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","article-title":"Molecular basis of bacterial outer membrane permeability revisited","volume":"67","author":"Nikaido","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jprot.2018.03.002_bb0185","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jprot.2013.12.024","article-title":"Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli","volume":"98","author":"Lin","year":"2014","journal-title":"J. Proteome"},{"issue":"1","key":"10.1016\/j.jprot.2018.03.002_bb0190","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2174\/138955712798868977","article-title":"Tetracyclines: drugs with huge therapeutic potential","volume":"12","author":"Bahrami","year":"2012","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.jprot.2018.03.002_bb0195","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1039\/C3MB70522F","article-title":"Fluctuation of multiple metabolic pathways is required for Escherichia coli in response to chlortetracycline","volume":"10","author":"Lin","year":"2014","journal-title":"Mol. BioSyst."},{"issue":"3\u20134","key":"10.1016\/j.jprot.2018.03.002_bb0200","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/10409239109114072","article-title":"DNA gyrase: structure and function","volume":"26","author":"Reece","year":"1991","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"10","key":"10.1016\/j.jprot.2018.03.002_bb0205","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1021\/bi992302n","article-title":"Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement","volume":"39","author":"Anderson","year":"2000","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.jprot.2018.03.002_bb0210","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/AAC.35.1.20","article-title":"Effects of ciprofloxacin on plasmid DNA supercoiling of Escherichia coli topoisomerase I and gyrase mutants","volume":"35","author":"Aleixandre","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.jprot.2018.03.002_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004299","article-title":"Regulatory RNAs involved in bacterial antibiotic resistance","volume":"10","author":"Lalaouna","year":"2014","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.jprot.2018.03.002_bb0220","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00253-003-1243-5","article-title":"Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics","volume":"61","author":"Kim","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.jprot.2018.03.002_bb0225","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.celrep.2015.09.059","article-title":"Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage","volume":"13","author":"Belenky","year":"2015","journal-title":"Cell Rep."},{"issue":"27","key":"10.1016\/j.jprot.2018.03.002_bb0230","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1073\/pnas.1509743112","article-title":"Antibiotic efficacy is linked to bacterial cellular respiration","volume":"112","author":"Lobritz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jprot.2018.03.002_bb0235","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1073\/pnas.1218524110","article-title":"Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism","volume":"110","author":"Derewacz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918300952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918300952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T11:50:38Z","timestamp":1535025038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391918300952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":47,"alternative-id":["S1874391918300952"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2018.03.002","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematically integrated metabonomic-proteomic studies of Escherichia coli under ciprofloxacin stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2018.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}