{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:02:36Z","timestamp":1790694156401,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Vicerrector\u00eda de Investigaci\u00f3n of Universidad de Costa Rica","award":["741-B7-108"],"award-info":[{"award-number":["741-B7-108"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jprot.2018.04.007","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T14:11:29Z","timestamp":1523542289000},"page":"104-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus"],"prefix":"10.1016","volume":"181","author":[{"given":"Andr\u00e9s","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauren","family":"Villalta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-6469","authenticated-orcid":false,"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e1ngela","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2018.04.007_bb0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ympev.2007.07.021","article-title":"The phylogeny of cobras inferred from mitochondrial DNA sequences: evolution of venom spitting and the phylogeography of the African spitting cobras (Serpentes: Elapidae: Naja nigricollis complex)","volume":"45","author":"W\u00fcster","year":"2007","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/21564574.1998.9649997","article-title":"Diel activity patterns in a captive colony of rinkhals, Hemachatus haemachatus","volume":"47","author":"Alexander","year":"1998","journal-title":"Afr. J. Herpetol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1432-1033.1976.tb10870.x","article-title":"Snake venom toxins. Purification, properties, and complete amino acid sequence of two toxins from Ringhals (Hemachatus haemachatus) venom","volume":"69","author":"Strydom","year":"1971","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0020","first-page":"362","article-title":"Snake bite in southern Africa: diagnosis and management","volume":"30","author":"Muller","year":"2012","journal-title":"Contin. Med. Edu."},{"key":"10.1016\/j.jprot.2018.04.007_bb0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/21564574.2011.632029","article-title":"Assimilation efficiency and gut passage time in an African elapid snake, Hemachatus haemachatus","volume":"61","author":"Alexander","year":"2012","journal-title":"Afr. J. Herpetol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0030","series-title":"Venomous Snakes of the World","author":"O'Shea","year":"2008"},{"key":"10.1016\/j.jprot.2018.04.007_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1469-7998.2006.00252.x","article-title":"Ecology of cobras from southern Africa","volume":"272","author":"Shine","year":"2007","journal-title":"J. Zool."},{"key":"10.1016\/j.jprot.2018.04.007_bb0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/toxins9030103","article-title":"How the cobra got its flesh-eating venom: cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting","volume":"9","author":"Panagides","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jprot.2018.04.007_bb0045","series-title":"WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins","author":"WHO","year":"2016"},{"key":"10.1016\/j.jprot.2018.04.007_bb0050","first-page":"48","article-title":"The identification and syndromic management of snakebite in South Africa","volume":"47","author":"Rs","year":"2005","journal-title":"Fam. Pract."},{"key":"10.1016\/j.jprot.2018.04.007_bb0055","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature04328","article-title":"Early evolution of the venom system in lizards and snakes","volume":"439","author":"Fry","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2018.04.007_bb0060","series-title":"South African Snake Venoms and Antivenoms","author":"Christensen","year":"1955"},{"key":"10.1016\/j.jprot.2018.04.007_bb0065","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0006-3002(59)90303-8","article-title":"Fractionation of venom from the ringhals cobra","volume":"34","author":"Bj\u00f6rk","year":"1959","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2018.04.007_bb0070","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3891\/acta.chem.scand.13-1256","article-title":"Fractionation of snake venom by the gel-filtration method","volume":"13","author":"Bj\u00f6rk","year":"1959","journal-title":"Acta Chem. Scand."},{"key":"10.1016\/j.jprot.2018.04.007_bb0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0020-711X(70)90077-7","article-title":"A comparative study of enzyme activities in snake venoms","volume":"1","author":"Mebs","year":"1970","journal-title":"Int. J. BioChemiPhysics"},{"key":"10.1016\/j.jprot.2018.04.007_bb0080","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1432-1033.1975.tb04025.x","article-title":"Hemachatus haemachatus (Ringhals) venom. Purification, some properties and amino-acid sequence of phospholipase A (fraction DE-I)","volume":"52","author":"Joubert","year":"1975","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1432-1033.1977.tb11403.x","article-title":"Snake venom toxins. The amino-acid sequences of three toxins (9B, 11 and 12A) from Hemachatus haemachatus (Ringhals) venom","volume":"74","author":"Joubert","year":"1977","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0090","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0041-0101(80)90073-2","article-title":"The complete primary structure of toxin CM-1b from Hemachatus haemachatus (Ringhals) snake venom","volume":"18","author":"Joubert","year":"1980","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0095","first-page":"191","article-title":"Complete primary structure of toxin CM-1C from Hemachatus haemachatus (Ringhals) venom","volume":"18","author":"Joubert","year":"1979","journal-title":"South Afr. J. Chem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/oxfordjournals.jbchem.a131100","article-title":"Snake venom proteinase inhibitors. III. Isolation of five polypeptide inhibitors from the venoms of Hemachatus haemachatus (Ringhal's corbra) and Naja nivea (Cape cobra) and the complete amino acid sequences of two of them","volume":"79","author":"Hokama","year":"1976","journal-title":"J. Biochem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0105","doi-asserted-by":"crossref","first-page":"42601","DOI":"10.1074\/jbc.M508987200","article-title":"Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity","volume":"280","author":"Banerjee","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep32036","article-title":"Exactin: a specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus","volume":"6","author":"Girish","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2018.04.007_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/srep25935","article-title":"Ringhalexin from Hemachatus haemachatus: a novel inhibitor of extrinsic tenase complex","volume":"6","author":"Barnwal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2018.04.007_bb0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jb\/mvn174","article-title":"Structural divergence of cysteine-rich secretory proteins in snake venoms","volume":"145","author":"Matsunaga","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0125","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40409-017-0117-8","article-title":"Strategies in \u201csnake venomics\u201d aiming at an integrative view of compositional, functional, and immunological characteristics of venoms","volume":"23","author":"Lomonte","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jprot.2018.04.007_bb0130","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/pr101040f","article-title":"Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the Pan-African EchiTAb-Plus-ICP antivenom by antivenomics and eutralization approaches","volume":"10","author":"Petras","year":"2011","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2018.04.007_bb0135","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2018.04.007_bb0140","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0145","series-title":"CIOMS International Guiding Principles for Biomedical Research Involving Animals","volume":"12","author":"CIOMS","year":"1985"},{"key":"10.1016\/j.jprot.2018.04.007_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0155","first-page":"949","article-title":"Development of simple standard assay procedures for the characterization of snake venoms","volume":"61","author":"Theakston","year":"1983","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jprot.2018.04.007_bb0160","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/jps.2600600940","article-title":"Probit analysis, 3rd ed","volume":"60","author":"Finney","year":"1971","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jprot.2018.04.007_bb0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxicon.2016.06.006","article-title":"Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: an experimental study in mice","volume":"119","author":"Rivel","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0170","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.toxicon.2017.10.005","article-title":"An improved technique for the assessment of venom-induced haemorrhage in a murine model","volume":"139","author":"Jenkins","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0175","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0041-0101(89)90096-2","article-title":"Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom","volume":"27","author":"Gen\u00e9","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0180","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0041-0101(96)00128-6","article-title":"Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties","volume":"35","author":"D\u00edaz-Oreiro","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0185","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1021\/pr8003826","article-title":"Snake venomics of the lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom","volume":"7","author":"Guti\u00e9rrez","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2018.04.007_bb0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0742-8413(86)90183-0","article-title":"Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper","volume":"84","author":"Guti\u00e9rrez","year":"1986","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.jprot.2018.04.007_bb0195","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1172\/JCI103259","article-title":"A relation between non-esterified fatty acids in plasma and the metabolism of glucose","volume":"35","author":"Dole","year":"1956","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2018.04.007_bb0200","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jprot.2014.06.016","article-title":"Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: an antivenomics and neutralization study","volume":"110","author":"Pla","year":"2014","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2018.04.007_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.vascn.2009.06.004","article-title":"A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma","volume":"61","author":"O'Leary","year":"2010","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.jprot.2018.04.007_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40409-017-0135-6","article-title":"It is time for top-down venomics","volume":"23","author":"Melani","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jprot.2018.04.007_bb0215","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00239-003-2461-2","article-title":"Molecular evolution and phylogeny of elapid snake venom three-finger toxins","volume":"57","author":"Fry","year":"2003","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0220","series-title":"Handb. Venoms Toxins Reptil","first-page":"287","article-title":"Snake venom three-finger toxins","author":"Hegde","year":"2009"},{"key":"10.1016\/j.jprot.2018.04.007_bb0225","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.toxicon.2010.07.010","article-title":"Structure, function and evolution of three-finger toxins: mini proteins with multiple targets","volume":"56","author":"Kini","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0230","first-page":"81","article-title":"Biological activities of various fractions isolated from venom of Hemachatus haemachates","volume":"208","author":"Cheymol","year":"1974","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.jprot.2018.04.007_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0048112","article-title":"Identification and structural characterization of a new three-finger toxin Hemachatoxin from Hemachatus haemachatus venom","volume":"7","author":"Girish","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2018.04.007_bb0240","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0041-0101(76)90002-7","article-title":"Postsynaptic blockade of neuromuscular transmission by toxin II from the venom of the South African ringhals cobra (Hemachatus haemachatus)","volume":"14","author":"Bengis","year":"1976","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0245","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.toxicon.2009.01.011","article-title":"Paraspecific neutralization of the venom of African species of cobra by an equine antiserum against Naja melanoleuca: a comparative study","volume":"53","author":"Casasola","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0250","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxicon.2015.10.001","article-title":"Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms","volume":"108","author":"S\u00e1nchez","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0255","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2016.11.259","article-title":"Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa","volume":"125","author":"S\u00e1nchez","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0260","series-title":"Handb. Clin. Toxicol. Anim. Venoms Poisons","first-page":"433","article-title":"Clinical toxicology of snakebite in Africa and the Middle East\/Arabian Peninsula","author":"Warrell","year":"1995"},{"key":"10.1016\/j.jprot.2018.04.007_bb0265","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.toxicon.2010.02.023","article-title":"Venom ophthalmia caused by venoms of spitting elapid and other snakes: report of ten cases with review of epidemiology, clinical features, pathophysiology and management","volume":"56","author":"Chu","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0270","first-page":"31","article-title":"The ocular effects of sppiting cobras: I. The Ringhals cobra (Hemachatus haemachatus) venom induced corneal opacification syndrome","volume":"31","author":"Ismail","year":"1993","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0275","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0041-0101(93)90376-T","article-title":"Cardiotoxin 1 from cobra (Naja naja atra) venom causes necrosis of skeletal muscle in vivo","volume":"31","author":"Ownby","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0280","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1529\/biophysj.106.100164","article-title":"Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus","volume":"93","author":"Banerjee","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.jprot.2018.04.007_bb0285","series-title":"Excitement Ahead: Structure, Function and Mechanism of Snake Venom Phospholipase A2 Enzymes","first-page":"827","volume":"42","author":"Kini","year":"2003"},{"key":"10.1016\/j.jprot.2018.04.007_bb0290","series-title":"Handb. Venoms Toxins Reptil","article-title":"Kini, Snake venom phospholipase A2 enzymes","author":"Doley","year":"2009"},{"key":"10.1016\/j.jprot.2018.04.007_bb0295","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0005-2736(87)90401-9","article-title":"Different susceptibilities of platelet phospholipids to various phospholipases and modifications induced by thrombin. Possible evidence of rearrangement of lipid domains","volume":"899","author":"Wang","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2018.04.007_bb0300","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/0006-2952(80)90608-5","article-title":"Comparison of a relatively toxic phospholipase A2 from Naja nigricollis snake venom with that of a relatively non-toxic phospholipase A2 from Hemachatus haemachatus snake venom-I. Enzymatic activity on free and membrane bound substrates","volume":"29","author":"Condrea","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0305","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/0006-2952(80)90609-7","article-title":"Comparison of a relatively toxic phospholipase A2 from Naja nigricollis snake venom with that of a relatively non-toxic phospholipase A2 from Hemachatus haemachatus snake venom\u2014II: Pharmacological properties in relationship to enzymatic activity","volume":"29","author":"Fletcher","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0310","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0041-0101(80)90081-1","article-title":"Chemical modification of the histidine residue in phospholipase A2 from the Hemachatus haemachatus snake venom","volume":"18","author":"Yang","year":"1980","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2018.04.007_bb0315","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/toxins8040093","article-title":"Hemorrhage caused by snake venom metalloproteinases: a journey of discovery and understanding","volume":"8","author":"Guti\u00e9rrez","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.jprot.2018.04.007_bb0320","series-title":"Handbook of Venoms and Toxins of Reptiles","author":"Mackessy","year":"2010"},{"key":"10.1016\/j.jprot.2018.04.007_bb0325","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.molimm.2004.11.009","article-title":"Oxiagin from the Naja oxiana cobra venom is the first reprolysin inhibiting the classical pathway of complement","volume":"42","author":"Shoibonov","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jprot.2018.04.007_bb0330","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0037-1615236","article-title":"Purification and characterization of kaouthiagin, a von Willebrand factor-binding and -cleaving metalloproteinase from Naja kaouthia cobra venom","volume":"80","author":"Hamako","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jprot.2018.04.007_bb0335","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.biochi.2010.12.008","article-title":"Cloning and characterisation of novel cystatins from elapid snake venom glands","volume":"93","author":"Richards","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.jprot.2018.04.007_bb0340","doi-asserted-by":"crossref","first-page":"13137","DOI":"10.1074\/jbc.M414137200","article-title":"Ohanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice","volume":"280","author":"Yuh","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2018.04.007_bb0345","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/BJ20060302","article-title":"Anticoagulant proteins from snake venoms: structure, function and mechanism","volume":"397","author":"Kini","year":"2006","journal-title":"Biochem. J."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918301660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918301660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T09:18:40Z","timestamp":1553073520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391918301660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":69,"alternative-id":["S1874391918301660"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2018.04.007","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2018.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}