{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:10:33Z","timestamp":1790777433873,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["140742\/2015-8"],"award-info":[{"award-number":["140742\/2015-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PDSE 19\/2016 - 88881.133246\/2016-01"],"award-info":[{"award-number":["PDSE 19\/2016 - 88881.133246\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["19752551\/13-3"],"award-info":[{"award-number":["19752551\/13-3"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jprot.2018.08.018","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T18:54:08Z","timestamp":1535741648000},"page":"147-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Differential secretome profiling of a swine tracheal cell line infected with mycoplasmas of the swine respiratory tract"],"prefix":"10.1016","volume":"192","author":[{"given":"Fernanda Munhoz dos Anjos","family":"Leal Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Prado","family":"Paludo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hercules","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-6040","authenticated-orcid":false,"given":"Henrique Bunselmeyer","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2018.08.018_bb0005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.vetmic.2016.07.023","article-title":"Cross reactivity among the swine mycoplasmas as identified by protein microarray","volume":"192","author":"Petersen","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-2164-14-175","article-title":"New insights on the biology of swine respiratory tract mycoplasmas from a comparative genome analysis","volume":"14","author":"Siqueira","year":"2013","journal-title":"BMC Genomics"},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110327","article-title":"Unravelling the transcriptome profile of the Swine respiratory tract mycoplasmas","volume":"9","author":"Siqueira","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0020","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2460\/ajvr.1990.51.03.344","article-title":"Effect of growth in cell cultures and strain on virulence of Mycoplasma hyopneumoniae for swine","volume":"51","author":"Zielinski","year":"1990","journal-title":"Am. J. Vet. Res."},{"issue":"16","key":"10.1016\/j.jprot.2018.08.018_bb0025","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1128\/JB.187.16.5568-5577.2005","article-title":"Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae","volume":"187","author":"Vasconcelos","year":"2005","journal-title":"J. Bacteriol."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0030","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/iai.63.3.1013-1019.1995","article-title":"Identification and characterization of a Mycoplasma hyopneumoniae adhesin","volume":"63","author":"Zhang","year":"1995","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.jprot.2018.08.018_bb0035","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/iai.62.5.1616-1622.1994","article-title":"Microtiter plate adherence assay and receptor analogs for Mycoplasma hyopneumoniae","volume":"62","author":"Zhang","year":"1994","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0040","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1021\/pr400903s","article-title":"P159 from Mycoplasma hyopneumoniae binds porcine cilia and heparin and is cleaved in a manner akin to ectodomain shedding","volume":"12","author":"Raymond","year":"2013","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/cmi.12377","article-title":"Proteolytic processing of the cilium adhesin MHJ_0194 (P123J) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules","volume":"17","author":"Raymond","year":"2014","journal-title":"Cell. Microbiol."},{"issue":"1","key":"10.1016\/j.jprot.2018.08.018_bb0050","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/IAI.74.1.481-487.2006","article-title":"Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin","volume":"74","author":"Jenkins","year":"2006","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.jprot.2018.08.018_bb0055","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1365-2958.2010.07345.x","article-title":"Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia","volume":"78","author":"Deutscher","year":"2010","journal-title":"Mol. Microbiol."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/cmi.12377","article-title":"Proteolytic processing of the cilium adhesin MHJ_0194 (P123J) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules","volume":"17","author":"Raymond","year":"2015","journal-title":"Cell. Microbiol."},{"issue":"9","key":"10.1016\/j.jprot.2018.08.018_bb0065","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2460\/ajvr.1992.53.09.1705","article-title":"Histochemical and morphologic changes of porcine airway epithelial cells in response to infection with Mycoplasma hyopneumoniae","volume":"53","author":"Debey","year":"1992","journal-title":"Am. J. Vet. Res."},{"issue":"5","key":"10.1016\/j.jprot.2018.08.018_bb0070","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1128\/IAI.70.5.2502-2506.2002","article-title":"Mycoplasma hyopneumoniae increases intracellular calcium release in porcine ciliated tracheal cells","volume":"70","author":"Park","year":"2002","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.jprot.2018.08.018_bb0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vetmic.2014.11.013","article-title":"Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro","volume":"175","author":"Bai","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.vetmic.2017.01.024","article-title":"Pro-apoptotic effect of a Mycoplasma hyopneumoniae putative type I signal peptidase on PK(15) swine cells","volume":"201","author":"Paes","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1477-5956-7-45","article-title":"Comparative proteomic analysis of pathogenic and non-pathogenic strains from the swine pathogen Mycoplasma hyopneumoniae","volume":"7","author":"Pinto","year":"2009","journal-title":"Proteome Sci."},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0090","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1128\/IAI.66.10.4762-4766.1998","article-title":"Identification of the cilium binding epitope of the Mycoplasma hyopneumoniae P97 adhesin","volume":"66","author":"Hsu","year":"1998","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0095","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/BF03547222","article-title":"Mycoplasm suipneumoniae and Mycoplasma flocculare in comparative pathogenicity studies","volume":"15","author":"Friis","year":"1974","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.jprot.2018.08.018_bb0100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.vetmic.2016.05.008","article-title":"Mycoplasma hyopneumoniae and Mycoplasma flocculare differential domains from orthologous surface proteins induce distinct cellular immune responses in mice","volume":"190","author":"Leal","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jprot.2016.12.002","article-title":"Secretomes of Mycoplasma hyopneumoniae and Mycoplasma flocculare reveal differences associated to pathogenesis","volume":"154","author":"Paes","year":"2017","journal-title":"J. Proteome"},{"issue":"11","key":"10.1016\/j.jprot.2018.08.018_bb0110","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2460\/ajvr.1972.33.11.2249","article-title":"Pathogenesis of mycoplasmal pneumonia in swine","volume":"33","author":"Livingston","year":"1972","journal-title":"Am. J. Vet. Res."},{"issue":"1","key":"10.1016\/j.jprot.2018.08.018_bb0115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jcpa.2005.06.009","article-title":"Expression of inflammatory cytokines in pigs experimentally infected with Mycoplasma hyopneumoniae","volume":"134","author":"Choi","year":"2006","journal-title":"J. Comp. Pathol."},{"issue":"1\u20132","key":"10.1016\/j.jprot.2018.08.018_bb0120","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.vetmic.2012.07.025","article-title":"Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates","volume":"161","author":"Woolley","year":"2012","journal-title":"Vet. Microbiol."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00480169.2011.579553","article-title":"Inflammatory responses to Mycoplasma hyopneumoniae in murine alveolar macrophage cell lines","volume":"59","author":"Damte","year":"2011","journal-title":"N. Z. Vet. J."},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0130","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1292\/jvms.70.1065","article-title":"Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae","volume":"70","author":"Muneta","year":"2008","journal-title":"J. Vet. Med. Sci."},{"issue":"9","key":"10.1016\/j.jprot.2018.08.018_bb0135","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1089\/jir.2006.26.637","article-title":"IL-18 expression in pigs following infection with Mycoplasma hyopneumoniae","volume":"26","author":"Muneta","year":"2006","journal-title":"J. Interf. Cytokine Res."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0140","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jcpa.2003.12.008","article-title":"Immunohistochemical labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniae","volume":"130","author":"Rodr\u00edguez","year":"2004","journal-title":"J. Comp. Pathol."},{"issue":"6","key":"10.1016\/j.jprot.2018.08.018_bb0145","first-page":"337","article-title":"Some recommendations concerning primary isolation of Mycoplasma suipneumoniae and Mycoplasma flocculare a survey","volume":"27","author":"Friis","year":"1975","journal-title":"Nord. Vet. Med."},{"issue":"2","key":"10.1016\/j.jprot.2018.08.018_bb0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0166-0934(02)00236-7","article-title":"Establishment and characterization of two new pig cell lines for use in virological diagnostic laboratories","volume":"107","author":"Ferrari","year":"2003","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jprot.2018.08.018_bb0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2180-14-27","article-title":"Global secretome characterization of A549 human alveolar epithelial carcinoma cells during Mycoplasma pneumoniae infection","volume":"14","author":"Li","year":"2014","journal-title":"BMC Microbiol."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0160","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/nar\/gkw004","article-title":"Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances","volume":"44","author":"Chen","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0165","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/pmic.201500187","article-title":"Rescuing discarded spectra: Full comprehensive analysis of a minimal proteome","volume":"16","author":"Lluch-Senar","year":"2016","journal-title":"Proteomics"},{"issue":"20","key":"10.1016\/j.jprot.2018.08.018_bb0170","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal. Chem."},{"issue":"17","key":"10.1016\/j.jprot.2018.08.018_bb0175","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem."},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0180","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/pmic.200700965","article-title":"Proteomic analysis of exoproteins expressed by enterotoxigenic Staphylococcus aureus strains","volume":"8","author":"Pocsfalvi","year":"2008","journal-title":"Proteomics"},{"issue":"9","key":"10.1016\/j.jprot.2018.08.018_bb0185","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/pr060161n","article-title":"Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae","volume":"5","author":"Zybailov","year":"2006","journal-title":"J. Proteome Res."},{"issue":"16","key":"10.1016\/j.jprot.2018.08.018_bb0190","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.jprot.2018.08.018_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jprot.2018.08.018_bb0200","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1088\/0967-3334\/36\/9\/1889","article-title":"A novel curve fitting method for AV optimisation of biventricular pacemakers","volume":"36","author":"Dehbi","year":"2015","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.jprot.2018.08.018_bb0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jprot.2017.04.009","article-title":"Comparative proteomics of hydatid fluids from two Echinococcus multilocularis isolates","volume":"162","author":"Monteiro","year":"2017","journal-title":"J. Proteome"},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0210","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"issue":"5","key":"10.1016\/j.jprot.2018.08.018_bb0215","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jmb.2004.03.016","article-title":"A combined transmembrane topology and signal peptide prediction method","volume":"338","author":"K\u00e4ll","year":"2004","journal-title":"J. Mol. Biol."},{"issue":"Web Server","key":"10.1016\/j.jprot.2018.08.018_bb0220","doi-asserted-by":"crossref","first-page":"W375","DOI":"10.1093\/nar\/gkh378","article-title":"PrediSi: prediction of signal peptides and their cleavage positions","volume":"32","author":"Hiller","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0225","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"Bendtsen","year":"2004","journal-title":"Protein Eng. Des. Sel."},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001450","article-title":"Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation","volume":"10","author":"Kalra","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0235","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jprot.2018.08.018_bb0240","doi-asserted-by":"crossref","first-page":"8.13.1","DOI":"10.1002\/0471250953.bi0813s47","article-title":"Biological network exploration with Cytoscape 3","volume":"47","author":"Su","year":"2014","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.jprot.2018.08.018_bb0245","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/1471-2105-12-436","article-title":"clusterMaker: a multi-algorithm clustering plugin for Cytoscape","volume":"12","author":"Morris","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jprot.2018.08.018_bb0250","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jprot.2018.08.018_bb0255","first-page":"11","article-title":"A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis","volume":"30","author":"Ferreira","year":"2007","journal-title":"Genet. Mol. Biol."},{"issue":"9","key":"10.1016\/j.jprot.2018.08.018_bb0260","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1128\/CVI.00140-13","article-title":"Recombinant secreted antigens from Mycoplasma hyopneumoniae delivered as a cocktail vaccine enhance the immune response of mice","volume":"20","author":"Galli","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"issue":"2\u20133","key":"10.1016\/j.jprot.2018.08.018_bb0265","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jcpa.2016.01.007","article-title":"Relationship between Expression of Interleukin-5 and Interleukin-13 by Epithelial Cells and Bronchiolar changes in Pigs Infected with Mycoplasma hyopneumoniae","volume":"154","author":"Rodr\u00edguez","year":"2016","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0270","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semcdb.2017.06.030","article-title":"Proteomic approaches to decipher cancer cell secretome","volume":"78","author":"Brandi","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0275","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1096\/fj.02-0352rev","article-title":"Reappraisal of serum starvation, the restriction point, G0, and G1 phase arrest points","volume":"17","author":"Cooper","year":"2003","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.jprot.2018.08.018_bb0280","first-page":"435","article-title":"Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells","volume":"32","author":"Shin","year":"2008","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0285","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/pr050375p","article-title":"Secretory protein enrichment and analysis: an optimized approach applied on cancer cell lines using 2D LC-MS\/MS","volume":"5","author":"Mbeunkui","year":"2006","journal-title":"J. Proteome Res."},{"issue":"11","key":"10.1016\/j.jprot.2018.08.018_bb0290","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/pmic.200601024","article-title":"Toward a better analysis of secreted proteins: the example of the myeloid cells secretome","volume":"7","author":"Chevallet","year":"2007","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0295","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1021\/pr8008572","article-title":"Pathway-based biomarker search by high-throughput proteomics profiling of secretomes","volume":"8","author":"Lawlor","year":"2009","journal-title":"J. Proteome Res."},{"issue":"11","key":"10.1016\/j.jprot.2018.08.018_bb0300","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1074\/mcp.M600465-MCP200","article-title":"Proteomics analysis of conditioned media from three breast cancer cell lines: a mine for biomarkers and therapeutic targets","volume":"6","author":"Kulasingam","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0305","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1021\/pr900411g","article-title":"Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer","volume":"8","author":"Gunawardana","year":"2009","journal-title":"J. Proteome Res."},{"issue":"8","key":"10.1016\/j.jprot.2018.08.018_bb0310","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1021\/pr8003216","article-title":"Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers","volume":"7","author":"Sardana","year":"2008","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0315","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<400::AID-IJC11>3.0.CO;2-U","article-title":"Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death","volume":"80","author":"Hasan","year":"1999","journal-title":"Int. J. Cancer"},{"issue":"10","key":"10.1016\/j.jprot.2018.08.018_bb0320","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1021\/pr060287k","article-title":"Improved mass spectrometric proteomic profiling of the secretome of rat vascular endothelial cells","volume":"5","author":"Pellitteri-Hahn","year":"2006","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.jprot.2018.08.018_bb0325","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/bp060121o","article-title":"Proteomic analysis for the assessment of different lots of fetal bovine serum as a raw material for cell culture. Part IV. Application of proteomics to the manufacture of biological drugs","volume":"22","author":"Zheng","year":"2006","journal-title":"Biotechnol. Prog."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010136","article-title":"Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria","volume":"5","author":"Anand","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036138","article-title":"Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0340","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1128\/iai.62.12.5312-5318.1994","article-title":"Ciliostasis and loss of cilia induced by Mycoplasma hyopneumoniae in porcine tracheal organ cultures","volume":"62","author":"Debey","year":"1994","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.jprot.2018.08.018_bb0345","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Kono","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0350","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","article-title":"Immunogenic cell death in cancer therapy","volume":"31","author":"Kroemer","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0355","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jprot.2018.08.018_bb0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11259-010-9447-5","article-title":"Mycoplasma hyopneumoniae induces pro-inflammatory cytokine and nitric oxide production through NF\u03baB and MAPK pathways in RAW264.7 cells","volume":"35","author":"Hwang","year":"2011","journal-title":"Vet. Res. Commun."},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0365","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/pmic.200701029","article-title":"Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles","volume":"8","author":"Peterson","year":"2008","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.jprot.2018.08.018_bb0370","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2217\/bmm-2017-0182","article-title":"Endothelial cell-derived microvesicles: potential mediators and biomarkers of pathologic processes","volume":"12","author":"V\u00edtkov\u00e1","year":"2018","journal-title":"Biomark. Med"},{"issue":"12","key":"10.1016\/j.jprot.2018.08.018_bb0375","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbadis.2008.06.005","article-title":"Extracellular, circulating proteasomes and ubiquitin - incidence and relevance","volume":"1782","author":"Sixt","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"60","key":"10.1016\/j.jprot.2018.08.018_bb0380","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.18632\/oncotarget.22230","article-title":"Proteomic analysis of affinity-purified extracellular proteasomes reveals exclusively 20S complexes","volume":"8","author":"Kulichkova","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jprot.2018.08.018_bb0385","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fcimb.2018.00054","article-title":"Extracellular Actin Is a Receptor for","volume":"8","author":"Raymond","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jprot.2018.08.018_bb0390","series-title":"22nd Congress of the International Organization for Mycoplasmology, Portsmouth, New Hampshire, USA","first-page":"32","article-title":"Insights into the Pathogenic Arsenal of Mycoplasma hyopneumoniae","author":"Djordjevic","year":"2018"},{"issue":"S1","key":"10.1016\/j.jprot.2018.08.018_bb0395","first-page":"110","article-title":"Update on Mycoplasma hyopneumoniae infections in pigs: Knowledge gaps for improved disease control","volume":"65","author":"Maes","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"issue":"3","key":"10.1016\/j.jprot.2018.08.018_bb0400","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/BF03547746","article-title":"A selective medium for Mycoplasma suipneumoniae","volume":"12","author":"Friis","year":"1971","journal-title":"Acta Vet. Scand."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918303324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391918303324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:59:07Z","timestamp":1761739147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391918303324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":80,"alternative-id":["S1874391918303324"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2018.08.018","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential secretome profiling of a swine tracheal cell line infected with mycoplasmas of the swine respiratory tract","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2018.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}