{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:29:43Z","timestamp":1770456583380,"version":"3.49.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","award":["2017-0650"],"award-info":[{"award-number":["2017-0650"]}],"id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","award":["IB13-0118"],"award-info":[{"award-number":["IB13-0118"]}],"id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2017-01030"],"award-info":[{"award-number":["2017-01030"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jprot.2020.103647","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T23:29:41Z","timestamp":1580340581000},"page":"103647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["An integrated transcriptomic- and proteomic-based approach to evaluate the human skin sensitization potential of glyphosate and its commercial agrochemical formulations"],"prefix":"10.1016","volume":"217","author":[{"given":"Tim","family":"Lindberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Ivan","family":"de \u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin S.","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-9792","authenticated-orcid":false,"given":"Fredrik","family":"Levander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Chawade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Lindstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2020.103647_bb0005","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S1470-2045(15)70134-8","article-title":"Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate","volume":"16","author":"Guyton","year":"2015","journal-title":"The Lancet. Oncol."},{"key":"10.1016\/j.jprot.2020.103647_bb0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10311-013-0432-4","article-title":"Advances in surfactants for agrochemicals","volume":"12","author":"Castro","year":"2014","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.jprot.2020.103647_bb0015","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0006-291X(80)90547-1","article-title":"The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase","volume":"94","author":"Steinrucken","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jprot.2020.103647_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12940-016-0117-0","article-title":"Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement","volume":"15","author":"Myers","year":"2016","journal-title":"Environ. Health"},{"key":"10.1016\/j.jprot.2020.103647_bb0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/jech-2015-207005","article-title":"Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)","volume":"70","author":"Portier","year":"2016","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.jprot.2020.103647_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.jprot.2020.103647_bb0035","first-page":"4302","article-title":"Conclusion on the peer review of the pesticide risk assessment of the active substance glyphosate","volume":"13","author":"EFSA","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.jprot.2020.103647_bb0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1091581813517906","article-title":"Glyphosate commercial formulation causes cytotoxicity, oxidative effects, and apoptosis on human cells: differences with its active ingredient","volume":"33","author":"Chaufan","year":"2014","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.jprot.2020.103647_bb0045","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.yrtph.2012.05.012","article-title":"Epidemiologic studies of glyphosate and cancer: a review","volume":"63","author":"Mink","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jprot.2020.103647_bb0050","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.tiv.2017.04.001","article-title":"In vitro assessment of skin sensitization, photosensitization and phototoxicity potential of commercial glyphosate-containing formulations","volume":"45","author":"de \u00c1vila","year":"2017","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jprot.2020.103647_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/cod.12847","article-title":"Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens","volume":"77","author":"Bonefeld","year":"2017","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jprot.2020.103647_bb0060","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/cod.13294","article-title":"Evaluation of invitro testing strategies for hazard assessment of the skin sensitization potential of \u201creal-life\u201d mixtures: the case of henna-based hair-colouring products containing p-phenylenediamine","volume":"81","author":"de \u00c1vila","year":"2019","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jprot.2020.103647_bb0065","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00139709-200423030-00003","article-title":"Glyphosate poisoning","volume":"23","author":"Bradberry","year":"2004","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.jprot.2020.103647_bb0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cbpc.2014.06.003","article-title":"Effects of the surfactant polyoxyethylene amine (POEA) on genotoxic, biochemical and physiological parameters of the freshwater teleost Prochilodus lineatus","volume":"165","author":"Navarro","year":"2014","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol."},{"key":"10.1016\/j.jprot.2020.103647_bb0075","first-page":"70","article-title":"Endocrine disruption and cytotoxicity of glyphosate and Roundup in human JAr cells in vitro","volume":"1","author":"Young","year":"2015","journal-title":"Integr. Pharm. Toxicol. Genotoxicol."},{"key":"10.1016\/j.jprot.2020.103647_bb0080","first-page":"1","article-title":"Statement of EFSA on the request for the evaluation of the toxicological assessment of the co-formulant POE-tallowamine","volume":"13","author":"EFSA","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.jprot.2020.103647_bb0085","article-title":"Commission implementing regulation (EU) 2016\/1313 of 1 August 2016 amending Implementation Regulation (EU) No 540\/2011 as regards the conditions of approval of the active substance glyphosate","author":"European Union","year":"2016","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.jprot.2020.103647_bb0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijheh.2016.09.016","article-title":"Glyphosate in German adults - time trend (2001 to 2015) of human exposure to a widely used herbicide","volume":"220","author":"Conrad","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.jprot.2020.103647_bb0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.envres.2018.04.025","article-title":"Glyphosate in Irish adults - a pilot study in 2017","volume":"165","author":"Connolly","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0278-6915(01)00130-2","article-title":"Local lymph node assay - validation, conduct and use in practice","volume":"40","author":"Basketter","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jprot.2020.103647_bb0105","series-title":"Toxicity testing in the 21st Century: A Vision and a Strategy. Committee on Toxicity Testing and Assessment of Environmental Agents; Board on Environmental Studies and Toxicology","author":"NRC","year":"2007"},{"key":"10.1016\/j.jprot.2020.103647_bb0110","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jat.3281","article-title":"Integrated decision strategies for skin sensitization hazard","volume":"36","author":"Strickland","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jprot.2020.103647_bb0115","first-page":"1","volume":"396","year":"2006"},{"key":"10.1016\/j.jprot.2020.103647_bb0120","year":"2017"},{"key":"10.1016\/j.jprot.2020.103647_bb0125","series-title":"EU, Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products, OJ of the European Union","first-page":"342","year":"2009"},{"key":"10.1016\/j.jprot.2020.103647_bb0130","series-title":"Regul. Toxicol. Pharmacol. 108","first-page":"104445","article-title":"The 21st Century movement within the area of skin sensitization assessment: from the animal context towards current human-relevant in vitro solutions","author":"de \u00c1vila","year":"2019"},{"key":"10.1016\/j.jprot.2020.103647_bb0135","series-title":"The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins, Part 1: Scientific Evidence, Environment, Health and Safety Publications, Series on Testing and Assessment No. 168. ENV\/JM\/MONO","first-page":"1","volume":"1","author":"OECD","year":"2014"},{"key":"10.1016\/j.jprot.2020.103647_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29662-6","article-title":"An integrative omics approach to unravel toxicity mechanisms of environmental chemicals: effects of a formulated herbicide","volume":"8","author":"Sim\u00f5es","year":"2018","journal-title":"Sci. Rep."},{"issue":"S1","key":"10.1016\/j.jprot.2020.103647_bb0145","first-page":"e170712","article-title":"Advancing human health risk assessment","volume":"17","author":"Lanzoni","year":"2019","journal-title":"EFSA J."},{"key":"10.1016\/j.jprot.2020.103647_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-399","article-title":"A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests","volume":"12","author":"Johansson","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2020.103647_bb0155","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tiv.2016.09.013","article-title":"From genome-wide arrays to tailor-made biomarker readout - Progress towards routine analysis of skin sensitizing chemicals with GARD","volume":"37","author":"Forreryd","year":"2016","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jprot.2020.103647_bb0160","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.tiv.2012.05.019","article-title":"The GARD assay for assessment of chemical skin sensitizers","volume":"27","author":"Johansson","year":"2013","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jprot.2020.103647_bb0165","doi-asserted-by":"crossref","first-page":"539","DOI":"10.14573\/altex.1701101","article-title":"The GARD platform for potency assessment of skin sensitizing chemicals","volume":"34","author":"Zeller","year":"2017","journal-title":"Altex"},{"key":"10.1016\/j.jprot.2020.103647_bb0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tiv.2018.01.021","article-title":"Predicting skin sensitizers with confidence \u2014 using conformal prediction to determine applicability domain of GARD","volume":"48","author":"Forreryd","year":"2018","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jprot.2020.103647_bb0175","first-page":"515","article-title":"Evaluation of the GARD assay in a blind Cosmetics Europe study","volume":"34","author":"Johansson","year":"2017","journal-title":"Altex"},{"key":"10.1016\/j.jprot.2020.103647_bb0180","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.yrtph.2019.01.001","article-title":"The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e-liquids","volume":"103","author":"Stevenson","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jprot.2020.103647_bb0185","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1021\/acs.jproteome.5b01061","article-title":"Targeted proteomics approach for precision plant breeding","volume":"15","author":"Chawade","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0190","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jprot.2020.103647_bb0195","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1074\/mcp.O114.038877","article-title":"DeMix workflow for efficient identification of cofragmented peptides in high resolution data-dependent tandem mass spectrometry","volume":"13","author":"Zhang","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2020.103647_bb0200","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1021\/pr900189c","article-title":"The proteios software environment: an extensible multiuser platform for management and analysis of proteomics data","volume":"8","author":"H\u00e4kkinen","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6277","article-title":"MS-GF+ makes progress towards a universal database search tool for proteomics","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2020.103647_bb0210","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1021\/acs.jproteome.6b00445","article-title":"Tiered human integrated sequence search databases for shotgun proteomics","volume":"15","author":"Deutsch","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0215","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1021\/acs.jproteome.6b00016","article-title":"Dinosaur: a refined open-source peptide MS feature detector","volume":"15","author":"Teleman","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0220","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1074\/mcp.O112.021907","article-title":"An adaptive alignment algorithm for quality-controlled label-free LC-MS","volume":"12","author":"Sandin","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2020.103647_bb0225","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1021\/acs.jproteome.8b00523","article-title":"NormalyzerDE: online tool for improved normalization of omics expression data and high-sensitivity differential expression analysis","volume":"18","author":"Willforss","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0230","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/bioinformatics\/btp362","article-title":"A statistical framework for protein quantitation in bottom-up MS-based proteomics","volume":"25","author":"Karpievitch","year":"2009","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jprot.2020.103647_bb0235","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0240","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics (Oxford, England)"},{"key":"10.1016\/j.jprot.2020.103647_bb0245","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jprot.2020.103647_bb0250","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2016"},{"key":"10.1016\/j.jprot.2020.103647_bb0255","author":"KPA"},{"key":"10.1016\/j.jprot.2020.103647_bb0260","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fgene.2014.00311","article-title":"Epigenetic regulation of cholesterol homeostasis","volume":"5","author":"Meaney","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.jprot.2020.103647_bb0265","doi-asserted-by":"crossref","first-page":"15163","DOI":"10.1073\/pnas.1103623108","article-title":"Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria","volume":"108","author":"Anderson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2020.103647_bb0270","doi-asserted-by":"crossref","first-page":"8055","DOI":"10.1128\/MCB.24.18.8055-8068.2004","article-title":"Sequestosome 1\/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation","volume":"24","author":"Seibenhener","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jprot.2020.103647_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yrtph.2018.03.003","article-title":"International regulatory requirements for skin sensitization testing","volume":"95","author":"Daniel","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jprot.2020.103647_bb0280","first-page":"252","year":"2012","journal-title":"Chem. Mix. Com."},{"key":"10.1016\/j.jprot.2020.103647_bb0285","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau6753","article-title":"\u201cInactive\u201d ingredients in oral medications","volume":"11","author":"Reker","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jprot.2020.103647_bb0290","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00204-018-2341-6","article-title":"Skin sensitization testing needs and data uses by US regulatory and research agencies","volume":"93","author":"Strickland","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.jprot.2020.103647_bb0295","first-page":"320","article-title":"Animal experiments scrutinised: systematic reviews demonstrate poor human clinical and toxicological utility","volume":"24","author":"Knight","year":"2007","journal-title":"Altex"},{"key":"10.1016\/j.jprot.2020.103647_bb0300","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1194\/jlr.M056986","article-title":"The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally","volume":"56","author":"Luu","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0305","doi-asserted-by":"crossref","DOI":"10.1007\/s11882-015-0548-7","article-title":"Regulation of adaptive immunity in health and disease by cholesterol metabolism","volume":"15","author":"Fessler","year":"2015","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jprot.2020.103647_bb0310","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cmet.2011.04.001","article-title":"Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a","volume":"13","author":"Im","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2020.103647_bb0315","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1016\/j.celrep.2017.05.093","article-title":"Lanosterol modulates TLR4-mediated innate immune responses in macrophages","volume":"19","author":"Araldi","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jprot.2020.103647_bb0320","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw."},{"key":"10.1016\/j.jprot.2020.103647_bb0325","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fimmu.2014.00343","article-title":"Pattern recognition receptors and DNA repair: starting to put a jigsaw puzzle together","volume":"5","author":"Kutikhin","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jprot.2020.103647_bb0330","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00705-016-3130-2","article-title":"Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections","volume":"162","author":"Li","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jprot.2020.103647_bb0335","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1189\/jlb.0412214","article-title":"Regulation of inflammation by interleukin-4: a review of alternatives","volume":"92","author":"Luzina","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jprot.2020.103647_bb0340","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2012\/597514","article-title":"Anti-inflammatory properties of Sirtuin 6 in human umbilical vein endothelial cells","volume":"2012","author":"Lappas","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jprot.2020.103647_bb0345","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1002\/1873-3468.12711","article-title":"mTORC1 and mTORC2 as regulators of cell metabolism in immunity","volume":"591","author":"Linke","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jprot.2020.103647_bb0350","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2020.103647_bb0355","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13046-016-0461-5","article-title":"Sirtuins in metabolism, DNA repair and cancer","volume":"35","author":"Mei","year":"2016","journal-title":"J. Exper. Clin. Cancer Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0360","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The role of sirtuins in antioxidant and redox signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jprot.2020.103647_bb0365","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.yexcr.2017.09.028","article-title":"Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation","volume":"360","author":"Singh","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jprot.2020.103647_bb0370","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/cmi.2018.2","article-title":"Autophagy in dendritic cells","volume":"15","author":"Ghislat","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jprot.2020.103647_bb0375","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.jaci.2017.03.021","article-title":"Autophagy: Nobel prize 2016 and allergy and asthma research","volume":"140","author":"Renz","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jprot.2020.103647_bb0380","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2020.103647_bb0385","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","article-title":"Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice","volume":"131","author":"Komatsu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2020.103647_bb0390","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.freeradbiomed.2014.09.008","article-title":"Oxidative stress-dependent activation of the eIF2alpha-ATF4 unfolded protein response branch by skin sensitizer 1-fluoro-2,4-dinitrobenzene modulates dendritic-like cell maturation and inflammatory status in a biphasic manner","volume":"77","author":"Luis","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jprot.2020.103647_bb0395","article-title":"N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2020.103647_bb0400","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ntt.2012.03.005","article-title":"Glyphosate induced cell death through apoptotic and autophagic mechanisms","volume":"34","author":"Gui","year":"2012","journal-title":"Neurotoxicol. Teratol."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391920300154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391920300154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:03:49Z","timestamp":1761739429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391920300154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":80,"alternative-id":["S1874391920300154"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2020.103647","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An integrated transcriptomic- and proteomic-based approach to evaluate the human skin sensitization potential of glyphosate and its commercial agrochemical formulations","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2020.103647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103647"}}