{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:27:28Z","timestamp":1791444448922,"version":"4.3.3"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017703","name":"Fundaci\u00f3n CeiBA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011749","name":"Pontificia Universidad Cat\u00f3lica del Ecuador","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017639","name":"Ministry of Environment and Sustainable Development","doi-asserted-by":"publisher","award":["008-09 IC-FAU-DNB\/MA"],"award-info":[{"award-number":["008-09 IC-FAU-DNB\/MA"]}],"id":[{"id":"10.13039\/501100017639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jprot.2020.103945","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T12:25:00Z","timestamp":1597926300000},"page":"103945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Venom variation in Bothrops asper lineages from North-Western South America"],"prefix":"10.1016","volume":"229","author":[{"given":"Diana","family":"Mora-Obando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Salazar-Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinia","family":"Pla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Alexander","family":"Guerrero-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ayerbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Lisle","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Calvete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2020.103945_bb0005","series-title":"The Venomous Reptiles of the Western Hemisphere","author":"Campbell","year":"2004"},{"key":"10.1016\/j.jprot.2020.103945_bb0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1463-6409.2011.00511.x","article-title":"Morphology, phylogeny and taxonomy of South American bothropoid pitvipers (Serpentes, Viperidae)","volume":"41","author":"Carrasco","year":"2012","journal-title":"Zool. Scr."},{"key":"10.1016\/j.jprot.2020.103945_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.11646\/zootaxa.4656.1.4","article-title":"A new species of pitviper of the genus Bothrops (Serpentes: Viperidae: Crotalinae) from the Central Andes of South America","volume":"4656","author":"Timms","year":"2019","journal-title":"Zootaxa"},{"key":"10.1016\/j.jprot.2020.103945_bb0020","series-title":"Biology of the Vipers","first-page":"307","article-title":"Ecological and phylogenetic correlates of feeding habits in Neotropical pitvipers of the genus Bothrops","author":"Martins","year":"2002"},{"key":"10.1016\/j.jprot.2020.103945_bb0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.toxicon.2016.05.014","article-title":"Nomenclatural instability in the venomous snakes of the Bothrops complex: implications in toxinology and public health","volume":"119","author":"Carrasco","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0030","series-title":"The Venomous Reptiles of Latin America","author":"Campbell","year":"1989"},{"key":"10.1016\/j.jprot.2020.103945_bb0035","series-title":"The Venomous Reptiles of the Western Hemisphere","first-page":"709","article-title":"Snakebites in Central and South America: epidemiology, clinical features, and clinical management","author":"Warrell","year":"2004"},{"key":"10.1016\/j.jprot.2020.103945_bb0040","first-page":"229","article-title":"Accidente of\u00eddico en Antioquia y Choc\u00f3. Aspectos cl\u00ednicos y epidemiol\u00f3gicos (marzo 1989-febrero 1990)","volume":"17","author":"Otero","year":"1992","journal-title":"Acta Med. Colomb."},{"key":"10.1016\/j.jprot.2020.103945_bb0045","first-page":"1","article-title":"Envenenamientos por mordeduras de serpientes en Am\u00e9rica Latina y el Caribe: Una visi\u00f3n integral de car\u00e1cter regional","volume":"51","author":"Guti\u00e9rrez","year":"2011","journal-title":"Bol. Malariol. Salud Amb."},{"key":"10.1016\/j.jprot.2020.103945_bb0050","series-title":"Clinical Toxinology in Australia, Europe, and Americas","first-page":"51","article-title":"Snakebite envenoming in Latin America and the Caribbean","author":"Guti\u00e9rrez","year":"2018"},{"key":"10.1016\/j.jprot.2020.103945_bb0055","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.toxicon.2009.06.024","article-title":"Natural history of the terciopelo Bothrops asper (Serpentes: Viperidae) in Costa Rica","volume":"54","author":"Sasa","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0060","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0140-6736(18)31224-8","article-title":"Vulnerability to snakebite envenoming: a global mapping of hotspots","volume":"392","author":"Longbottom","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jprot.2020.103945_bb0065","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2307\/2388809","article-title":"Bothrops asper (Viperidae) snakebite and field researchers in middle America","volume":"26","author":"Hardy","year":"1994","journal-title":"Biotropica"},{"key":"10.1016\/j.jprot.2020.103945_bb0070","first-page":"135","article-title":"A note on the geographical distribution of Bothrops asper (Garman, 1883) in Ecuador","volume":"26","author":"Freire","year":"1994","journal-title":"The Snake"},{"key":"10.1016\/j.jprot.2020.103945_bb0075","series-title":"Snake Species of the World: A Taxonomic and Geographic Reference","volume":"Vol. I","author":"McDiarmid","year":"1999"},{"key":"10.1016\/j.jprot.2020.103945_bb0080","first-page":"1","article-title":"Catalogue of batrachians and reptiles of Central America and Mexico","volume":"32","author":"Cope","year":"1887","journal-title":"Bull. U. S. Natl. Museum."},{"key":"10.1016\/j.jprot.2020.103945_bb0085","first-page":"1","article-title":"An annotated checklist and key of the snakes of Mexico","volume":"187","author":"Smith","year":"1945","journal-title":"Bull. U. S. Natl. Museum."},{"key":"10.1016\/j.jprot.2020.103945_bb0090","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.toxicon.2009.05.031","article-title":"Phenotypic differences in a cryptic predator: factors influencing morphological variation in the terciopelo Bothrops asper (Garman, 1884; Serpentes: Viperidae)","volume":"54","author":"Saldarriaga-C\u00f3rdoba","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0095","first-page":"259","article-title":"Morphological variation in the lancehead pitviper Bothrops asper (Garman) (Serpentes: Viperidae) from Middle America","volume":"50","author":"Sasa","year":"2002","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.jprot.2020.103945_bb0100","first-page":"33","article-title":"Taxonom\u00eda del complejo Bothrops asper (Serpentes: Viperidae) en el sudoeste de Colombia. Revalidaci\u00f3n de la especie Bothrops rhombeatus (Garcia 1896) y descripci\u00f3n de una nueva especie","volume":"10","author":"Folleco-Fern\u00e1ndez","year":"2010","journal-title":"Rev. Noved. Colomb."},{"key":"10.1016\/j.jprot.2020.103945_bb0105","series-title":"Diversification in the Neotropics: Insights from Demographic and Phylogenetic Patterns of Lancehead Pitvipers (Bothrops spp.)","author":"Salazar Valenzuela","year":"2016"},{"key":"10.1016\/j.jprot.2020.103945_bb0110","first-page":"138","article-title":"Bothrops ayerbei Folleco-Fern\u00e1ndez, 2010 and Bothrops rhomboatus Garc\u00eda, 1896 (Serpentes: Viperidae) are an unavailable name and a nomen dubium, respectively","volume":"18","author":"Ram\u00edrez-Chaves","year":"2014","journal-title":"Bol. Cient. Cent. Museos. Museo Hist. Nat."},{"key":"10.1016\/j.jprot.2020.103945_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187969","article-title":"Phylogeography of the central American lancehead Bothrops asper (SERPENTES: VIPERIDAE)","volume":"12","author":"Saldarriaga-C\u00f3rdoba","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2020.103945_bb0120","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1111\/jbi.13661","article-title":"Divergence of tropical pitvipers promoted by independent colonization events of dry montane Andean habitats","volume":"46","author":"Salazar-Valenzuela","year":"2019","journal-title":"J. Biogeogr."},{"key":"10.1016\/j.jprot.2020.103945_bb0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/zsc.12398","article-title":"A complex biogeographic history of diversification in Neotropical lancehead pitvipers (Serpentes, Viperidae)","volume":"49","author":"Hamdan","year":"2020","journal-title":"Zool. Scr."},{"key":"10.1016\/j.jprot.2020.103945_bb0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0040-1951(02)00113-0","article-title":"Geodynamic evolution of southern Costa Rica related to low-angle subduction of the Cocos ridge: constraints from thermochronology","volume":"348","author":"Gr\u00e4fe","year":"2002","journal-title":"Tectonophysics"},{"key":"10.1016\/j.jprot.2020.103945_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600883","article-title":"Formation of the isthmus of Panama","volume":"2","author":"O\u2019Dea","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jprot.2020.103945_bb0140","series-title":"Geomorphology and Volcanology of Costa Rica","author":"Bergoeing","year":"2017"},{"key":"10.1016\/j.jprot.2020.103945_bb0145","series-title":"Biology of the Vipers","first-page":"93","article-title":"Multigene phylogenetic analyses of pitvipers; with comments on the biogeographical history of the group","author":"Parkinson","year":"2002"},{"key":"10.1016\/j.jprot.2020.103945_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602321","article-title":"Comment (1) on \u201cFormation of the isthmus of Panama\u201d by O\u2019Dea et al","volume":"3","author":"Jaramillo","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jprot.2020.103945_bb0155","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602320","article-title":"Comment (2) on \u201cformation of the isthmus of Panama\u201d by O\u2019Dea et al","volume":"3","author":"Molnar","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jprot.2020.103945_bb0160","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1073\/pnas.1423853112","article-title":"Biological evidence supports an early and complex emergence of the isthmus of Panama","volume":"112","author":"Bacon","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2020.103945_bb0165","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1365-2699.2004.01109.x","article-title":"Biological diversification in a complex region: a spatial analysis of faunistic diversity and biogeography of the Andes of Colombia","volume":"31","author":"Kattan","year":"2004","journal-title":"J. Biogeogr."},{"key":"10.1016\/j.jprot.2020.103945_bb0170","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/BCJ20160577","article-title":"Venomics: integrative venom proteomics and beyond","volume":"474","author":"Calvete","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.jprot.2020.103945_bb0175","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fevo.2019.00332","article-title":"Snake venom in context: neglected clades and concepts","volume":"7","author":"Jackson","year":"2019","journal-title":"Front. Ecol. Evol."},{"key":"10.1016\/j.jprot.2020.103945_bb0180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/toxins11120711","article-title":"Coevolution of snake venom toxic activities and diet: evidence that ecological generalism favours toxicological diversity","volume":"11","author":"Davies","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.jprot.2020.103945_bb0185","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.jprot.2020.103945_bb0190","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1073\/pnas.1405484111","article-title":"Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms","volume":"111","author":"Casewell","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2020.103945_bb0195","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0041-0101(91)90116-9","article-title":"Snake venom variability: methods of study, results and interpretation","volume":"29","author":"Chippaux","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0200","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/pr800332p","article-title":"Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations","volume":"7","author":"Alape-Gir\u00f3n","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103945_bb0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jprot.2013.11.005","article-title":"Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom","volume":"96","author":"Mora-Obando","year":"2014","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0210","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2164-12-259","article-title":"Profiling the venom gland transcriptomes of costa rican snakes by 454 pyrosequencing","volume":"12","author":"Durban","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0742-8413(86)90069-1","article-title":"Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom","volume":"85","author":"Guti\u00e9rrez","year":"1986","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.jprot.2020.103945_bb0220","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","article-title":"Experimental pathology of local tissue damage induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0225","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.toxicon.2009.01.039","article-title":"Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0230","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.toxicon.2011.11.005","article-title":"Venom of Bothrops asper from Mexico and Costa Rica: intraspecific variation and cross-neutralization by antivenoms","volume":"59","author":"Segura","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxicon.2017.04.002","article-title":"Geographical variability of the venoms of four populations of Bothrops asper from Panama: toxicological analysis and neutralization by a polyvalent antivenom","volume":"132","author":"V\u00e9lez","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0240","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0041-0101(00)00122-7","article-title":"The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms","volume":"39","author":"Saravia","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0245","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0041-0101(03)00171-5","article-title":"Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia","volume":"42","author":"Saldarriaga","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2014.06.008","article-title":"Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica","volume":"88","author":"Laines","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0255","first-page":"25","article-title":"Actividad letal de seis venenos de serpientes de importancia m\u00e9dica en el Ecuador","volume":"37","author":"Ter\u00e1n","year":"2016","journal-title":"Rev. Ecuat. Med. Cienc. Biol."},{"key":"10.1016\/j.jprot.2020.103945_bb0260","series-title":"Cuidado Intensivo y Trauma","first-page":"1143","article-title":"Ofidismo en Colombia. Enfoque, diagn\u00f3stico y tratamiento","author":"Ayerbe","year":"2009"},{"key":"10.1016\/j.jprot.2020.103945_bb0265","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/pr9009518","article-title":"Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches","volume":"9","author":"Guti\u00e9rrez","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103945_bb0270","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.toxicon.2009.12.015","article-title":"Antivenomics and venom phenotyping: a marriage of convenience to address the performance and range of clinical use of antivenoms","volume":"56","author":"Calvete","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0275","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1021\/pr0701714","article-title":"Snake venomics of Bitis species reveals large intragenus venom toxin composition variation: application to taxonomy of congeneric taxa","volume":"6","author":"Calvete","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2020.103945_bb0285","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jms.1242","article-title":"Snake venomics. Strategy and applications","volume":"42","author":"Calvete","year":"2007","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jprot.2020.103945_bb0290","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1586\/14789450.2014.900447","article-title":"Next-generation snake venomics: protein-locus resolution through venom proteome decomplexation","volume":"11","author":"Calvete","year":"2014","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0295","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/pmic.200700777","article-title":"Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures","volume":"8","author":"Fox","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0300","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1586\/14789450.2015.1073590","article-title":"Constructing comprehensive venom proteome reference maps for integrative venomics","volume":"12","author":"Eichberg","year":"2015","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0305","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/14789450.2018.1500904","article-title":"Snake venomics - from low-resolution toxin-pattern recognition to toxin-resolved venom proteomes with absolute quantification","volume":"15","author":"Calvete","year":"2018","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0310","first-page":"23","article-title":"Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms","volume":"28","author":"Lomonte","year":"2017","journal-title":"J. Venom Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jprot.2020.103945_bb0315","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40409-017-0116-9","article-title":"Protein-species quantitative venomics: looking through a crystal ball","volume":"23","author":"Calvete","year":"2017","journal-title":"J. Venom Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jprot.2020.103945_bb0320","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jprot.2020.103945_bb0325","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.toxicon.2008.02.019","article-title":"High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry","volume":"51","author":"Menin","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0330","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1586\/epr.11.61","article-title":"Proteomic tools against the neglected pathology of snake bite envenoming","volume":"8","author":"Calvete","year":"2011","journal-title":"Expert Rev. Proteomics."},{"key":"10.1016\/j.jprot.2020.103945_bb0335","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/toxins5020327","article-title":"ESI-MS\/MS identification of a bradykinin-potentiating peptide from Amazon Bothrops atrox snake venom using a hybrid Qq-oaTOF mass spectrometer","volume":"5","author":"Coutinho-Neto","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.jprot.2020.103945_bb0340","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jprot.2017.06.001","article-title":"Absolute venomics: absolute quantification of intact venom proteins through elemental mass spectrometry","volume":"164","author":"Calder\u00f3n-Celis","year":"2017","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2019.103443","article-title":"Phylovenomics of Daboia russelii across the indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka","volume":"207","author":"Pla","year":"2019","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0350","series-title":"Evolution and Environment in Tropical America","first-page":"21","article-title":"The geologic evolution of the Central American Isthmus","author":"Coates","year":"1996"},{"key":"10.1016\/j.jprot.2020.103945_bb0355","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/jhered\/esp041","article-title":"Genetic diversification, vicariance, and selection in a polytypic frog","volume":"100","author":"Robertson","year":"2009","journal-title":"J. Hered."},{"key":"10.1016\/j.jprot.2020.103945_bb0360","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/jbi.12873","article-title":"Asynchronous diversification of snakes in the North American warm deserts","volume":"44","author":"Myers","year":"2017","journal-title":"J. Biogeogr."},{"key":"10.1016\/j.jprot.2020.103945_bb0365","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0305-0491(92)90129-F","article-title":"Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops asper","volume":"102","author":"Lomonte","year":"1992","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.jprot.2020.103945_bb0370","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.toxicon.2009.06.011","article-title":"Studies on the venom proteome of Bothrops asper: perspectives and applications","volume":"54","author":"Alape-Gir\u00f3n","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0375","first-page":"341","article-title":"Estudio comparativo de venenos de ejemplares reci\u00e9n nacidos y adultos de Bothrops asper","volume":"28","author":"Guti\u00e9rrez","year":"1980","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.jprot.2020.103945_bb0380","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0041-0101(92)90055-A","article-title":"Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo)","volume":"30","author":"Chaves","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0385","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2307\/1383163","article-title":"Optimal foraging and risk of predation: effects on behavior and social structure in ungulates","volume":"80","author":"Kie","year":"1999","journal-title":"J. Mammal."},{"key":"10.1016\/j.jprot.2020.103945_bb0390","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/physzool.69.3.30164211","article-title":"Ontogenetic limits on locomotor performance","volume":"69","author":"Carrier","year":"1996","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.jprot.2020.103945_bb0395","first-page":"200","article-title":"Relationship of venom ontogeny and Diet in Bothrops","volume":"55","author":"Andrade","year":"1999","journal-title":"Herpetologica"},{"key":"10.1016\/j.jprot.2020.103945_bb0400","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.toxicon.2006.01.007","article-title":"Venom of the Brown Treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity","volume":"47","author":"Mackessy","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0405","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2307\/1445927","article-title":"Venom ontogeny in the Pacific rattlesnakes Crotalus viridis helleri and C. v. oreganus","volume":"1988","author":"Mackessy","year":"1988","journal-title":"Copeia"},{"key":"10.1016\/j.jprot.2020.103945_bb0410","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/toxins10040135","article-title":"Phenotypic variation in mojave rattlesnake (Crotalus scutulatus) venom is driven by four toxin families","volume":"10","author":"Strickland","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.jprot.2020.103945_bb0415","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/molbev\/msz125","article-title":"Many options, few solutions: over 60 million years snakes converged on a few optimal venom formulations","volume":"36","author":"Barua","year":"2019","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jprot.2020.103945_bb0420","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2016.09.008","article-title":"Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses","volume":"122","author":"Lomonte","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0425","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jprot.2017.08.016","article-title":"The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms","volume":"172","author":"Ainsworth","year":"2018","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0430","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jprot.2019.03.014","article-title":"New insights into the phylogeographic distribution of the 3FTx\/PLA 2 venom dichotomy across genus Micrurus in South America","volume":"200","author":"Sanz","year":"2019","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0435","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1111\/mec.14051","article-title":"Genetic architecture and balancing selection: the life and death of differentiated variants","volume":"26","author":"Llaurens","year":"2017","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.jprot.2020.103945_bb0440","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s13059-017-1365-1","article-title":"Balancing selection and trans-specific polymorphisms","volume":"18","author":"Wang","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.jprot.2020.103945_bb0445","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1130\/0016-7606(2000)112<1091:UHOTCA>2.0.CO;2","article-title":"Uplift history of the Central and Northern Andes: a review","volume":"112","author":"Gregory-wodzicki","year":"2000","journal-title":"Geol. Soc. Am. Bull."},{"key":"10.1016\/j.jprot.2020.103945_bb0450","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1130\/0091-7613(1996)024<0687:TLMPIS>2.3.CO;2","article-title":"The late Miocene Panama isthmian strait","volume":"24","author":"Collins","year":"1996","journal-title":"Geology"},{"key":"10.1016\/j.jprot.2020.103945_bb0455","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jprot.2009.07.013","article-title":"Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Per\u00fa and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism","volume":"73","author":"N\u00fa\u00f1ez","year":"2009","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0460","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jprot.2011.01.003","article-title":"Snake population venomics and antivenomics of Bothrops atrox: paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management","volume":"74","author":"Calvete","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jprot.2020.103945_bb0465","series-title":"The Amphibians and Reptiles of Costa Rica: A Herpetofauna between Two Continents, between Two Seas","author":"Savage","year":"2002"},{"key":"10.1016\/j.jprot.2020.103945_bb0470","first-page":"71","article-title":"Sea-level changes during the tertiary","volume":"22","author":"Vail","year":"1979","journal-title":"Oceanus"},{"key":"10.1016\/j.jprot.2020.103945_bb0475","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0040-1951(75)90144-4","article-title":"Recent crustal movements in Costa Rica disclosed by relevelling surveys","volume":"29","author":"Miyamura","year":"1975","journal-title":"Tectonophysics"},{"key":"10.1016\/j.jprot.2020.103945_bb0480","doi-asserted-by":"crossref","first-page":"714","DOI":"10.4269\/ajtmh.18-0826","article-title":"Case report: hemothorax in envenomation by the Viperid Snake Bothrops asper","volume":"100","author":"Pinto","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jprot.2020.103945_bb0485","first-page":"59","article-title":"Neutralizaci\u00f3n de las actividades t\u00f3xicas y enzim\u00e1ticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica","volume":"35","author":"Rojas","year":"1987","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.jprot.2020.103945_bb0490","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/0041-0101(96)00016-5","article-title":"Short communication biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis)","volume":"34","author":"Kuch","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0495","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.trstmh.2006.01.006","article-title":"Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without \u03b2-propiolactone, in the treatment of Bothrops asper bites in Colombia","volume":"100","author":"Otero","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jprot.2020.103945_bb0500","first-page":"5","article-title":"Caracter\u00edsticas bioqu\u00edmicas y capacidad neutralizante de cuatro antivenenos polivalentes frente a los efectos farmacol\u00f3gicos y enzim\u00e1ticos del veneno de Bothrops asper y Porthidium nasutum de Antioquia y Choc\u00f3","volume":"15","author":"Otero","year":"2002","journal-title":"Iatreia"},{"key":"10.1016\/j.jprot.2020.103945_bb0505","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0041-0101(81)90007-6","article-title":"Neutralizaci\u00f3n de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente","volume":"19","author":"Guti\u00e9rrez","year":"1981","journal-title":"Toxicon"},{"key":"10.1016\/j.jprot.2020.103945_bb0510","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.zool.2011.10.001","article-title":"Food resources influence spatial ecology, habitat selection, and foraging behavior in an ambush-hunting snake (Viperidae: Bothrops asper): an experimental study","volume":"115","author":"Wasko","year":"2012","journal-title":"Zoology"},{"key":"10.1016\/j.jprot.2020.103945_bb0515","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.0021-8790.2004.00831.x","article-title":"Ontogenetic changes in metabolism may determine diet shifts for a sit-and-wait predator","volume":"73","author":"Jackson","year":"2004","journal-title":"J. Anim. Ecol."},{"key":"10.1016\/j.jprot.2020.103945_bb0520","series-title":"Evolutionary Game Theory, Natural Selection, and Darwinian Dynamics","author":"Vincent","year":"2005"},{"key":"10.1016\/j.jprot.2020.103945_bb0525","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00442-017-4056-4","article-title":"Combined effects of predator cues and competition define habitat choice and food consumption of amphipod mesograzers","volume":"186","author":"Beermann","year":"2018","journal-title":"Oecologia"},{"key":"10.1016\/j.jprot.2020.103945_bb0530","series-title":"Herpetology","author":"Pough","year":"2016"},{"key":"10.1016\/j.jprot.2020.103945_bb0535","doi-asserted-by":"crossref","first-page":"20182735","DOI":"10.1098\/rspb.2018.2735","article-title":"When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species","volume":"286","author":"Zancolli","year":"2019","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.jprot.2020.103945_bb0540","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.epsl.2007.02.039","article-title":"The role of climate during high plateau formation. Insights from numerical experiments","volume":"257","author":"Garcia-Castellanos","year":"2007","journal-title":"Earth Planet. Sci. Lett."},{"key":"10.1016\/j.jprot.2020.103945_bb0545","series-title":"Costa Rican Ecosystems","first-page":"30","article-title":"Geology, tectonics, and geomorphology of Costa Rica: a natural history approach","author":"Alvarado","year":"2017"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391920303134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391920303134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:07:10Z","timestamp":1761739630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391920303134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":108,"alternative-id":["S1874391920303134"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2020.103945","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venom variation in Bothrops asper lineages from North-Western South America","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2020.103945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103945"}}