{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:16:09Z","timestamp":1761747369667,"version":"build-2065373602"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"am","delay-in-days":319,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41GM108538","R01 DK071801","R21AG065728","RF1 AG052324","S10RR029531"],"award-info":[{"award-number":["P41GM108538","R01 DK071801","R21AG065728","RF1 AG052324","S10RR029531"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012787","name":"Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jprot.2022.104507","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T12:16:15Z","timestamp":1643890575000},"page":"104507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Isotopic N,N-dimethyl leucine tags for absolute quantification of clusterin and apolipoprotein E in Alzheimer's disease"],"prefix":"10.1016","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-4512","authenticated-orcid":false,"given":"Yuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2875-7243","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-4634","authenticated-orcid":false,"given":"Zihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-3869","authenticated-orcid":false,"given":"Lingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9533","key":"10.1016\/j.jprot.2022.104507_bb0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"issue":"10284","key":"10.1016\/j.jprot.2022.104507_bb0010","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13195-020-00596-4","article-title":"Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer\u2019s disease and PET amyloid-positive patient identification","volume":"12","author":"Barthelemy","year":"2020","journal-title":"Alzheimers Res. Ther."},{"issue":"7691","key":"10.1016\/j.jprot.2022.104507_bb0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High performance plasma amyloid-beta biomarkers for Alzheimer's disease","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0030","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.25334","article-title":"Plasma amyloid as prescreener for the earliest Alzheimer pathological changes","volume":"84","author":"Verberk","year":"2018","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0035","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708763","article-title":"Amyloid blood biomarker detects Alzheimer's disease","volume":"10","author":"Nabers","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41591-020-0762-2","article-title":"Advancing, i. treatment for frontotemporal lobar degeneration, diagnostic value of plasma phosphorylated tau181 in Alzheimer\u2019s disease and frontotemporal lobar degeneration","volume":"26","author":"Thijssen","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0045","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","article-title":"Plasma P-tau181 in Alzheimer\u2019s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia","volume":"26","author":"Janelidze","year":"2020","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.jprot.2022.104507_bb0050","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0055","first-page":"e12081","article-title":"Blood-based biomarkers for Alzheimer's pathology and the diagnostic process for a disease-modifying treatment: projecting the impact on the cost and wait times","volume":"12","author":"Mattke","year":"2020","journal-title":"Alzheimers Dement. (Amst.)"},{"key":"10.1016\/j.jprot.2022.104507_bb0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12014-019-9237-1","article-title":"Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer\u2019s disease","volume":"16","author":"Dey","year":"2019","journal-title":"Clin. Proteomics"},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-020-00384-6","article-title":"Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer\u2019s disease","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/bpa.12392","article-title":"Clusterin levels are increased in Alzheimer\u2019s disease and influence the regional distribution of Abeta","volume":"27","author":"Miners","year":"2017","journal-title":"Brain Pathol."},{"issue":"11","key":"10.1016\/j.jprot.2022.104507_bb0075","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1046\/j.1432-1033.2002.02957.x","article-title":"Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin","volume":"269","author":"Hatters","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"13","key":"10.1016\/j.jprot.2022.104507_bb0080","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1074\/jbc.M115.689539","article-title":"Clusterin binds to abeta1-42 oligomers with high affinity and interferes with peptide aggregation by inhibiting primary and secondary nucleation","volume":"291","author":"Beeg","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.jprot.2022.104507_bb0085","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/glia.21004","article-title":"Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins","volume":"58","author":"Nielsen","year":"2010","journal-title":"Glia"},{"issue":"51","key":"10.1016\/j.jprot.2022.104507_bb0090","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.1021\/bi002189x","article-title":"Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state","volume":"39","author":"Poon","year":"2000","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.jprot.2022.104507_bb0095","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1073\/pnas.76.9.4646","article-title":"Apolipoproteins in human cerebrospinal fluid","volume":"76","author":"Roheim","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.jprot.2022.104507_bb0100","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1073\/pnas.93.9.4229","article-title":"Glycoprotein 330\/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers","volume":"93","author":"Zlokovic","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2022.104507_bb0105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0110","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.01.056","article-title":"A quarter century of APOE and Alzheimer\u2019s disease: progress to date and the path forward","volume":"101","author":"Belloy","year":"2019","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1073\/pnas.82.1.203","article-title":"Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets","volume":"82","author":"Elshourbagy","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.jprot.2022.104507_bb0120","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.jprot.2022.104507_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034078","article-title":"Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jprot.2022.104507_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.04.028","article-title":"Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer\u2019s disease in the brain in vivo","volume":"32","author":"Darreh-Shori","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.jprot.2022.104507_bb0135","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1074\/mcp.M112.018861","article-title":"Total ApoE and ApoE4 isoform assays in an Alzheimer\u2019s disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides","volume":"11","author":"Simon","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0140","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-014-1266-2","article-title":"Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer\u2019s disease patients and controls","volume":"127","author":"Martinez-Morillo","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jprot.2022.104507_bb0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fnmol.2018.00483","article-title":"A strategy for discovery and verification of candidate biomarkers in cerebrospinal fluid of preclinical Alzheimer\u2019s disease","volume":"11","author":"Zhong","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0150","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1021\/acs.analchem.8b04580","article-title":"HOTMAQ: a multiplexed absolute quantification method for targeted proteomics","volume":"91","author":"Zhong","year":"2019","journal-title":"Anal. Chem."},{"issue":"5\u20136","key":"10.1016\/j.jprot.2022.104507_bb0155","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cbpa.2009.09.014","article-title":"Perspectives of targeted mass spectrometry for protein biomarker verification","volume":"13","author":"Huttenhain","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"6","key":"10.1016\/j.jprot.2022.104507_bb0160","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1021\/pr049893a","article-title":"Large-scale quantitative proteomic study of PUMA-induced apoptosis using two-dimensional liquid chromatography-mass spectrometry coupled with amino acid-coded mass tagging","volume":"3","author":"Gu","year":"2004","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0165","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1074\/mcp.M200025-MCP200","article-title":"Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics","volume":"1","author":"Ong","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"issue":"12","key":"10.1016\/j.jprot.2022.104507_bb0170","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1073\/pnas.0832254100","article-title":"Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS","volume":"100","author":"Gerber","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.jprot.2022.104507_bb0175","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1021\/ac202000v","article-title":"Enhanced sample multiplexing for nitrotyrosine-modified proteins using combined precursor isotopic labeling and isobaric tagging","volume":"84","author":"Robinson","year":"2012","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.jprot.2022.104507_bb0180","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1021\/ac020482s","article-title":"Single peptide-based protein identification in human proteome through MALDI-TOF MS coupled with amino acids coded mass tagging","volume":"75","author":"Pan","year":"2003","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.jprot.2022.104507_bb0185","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1021\/pr9011014","article-title":"Quantitative analysis of mTRAQ-labeled proteome using full MS scans","volume":"9","author":"Kang","year":"2010","journal-title":"J. Proteome Res."},{"issue":"12","key":"10.1016\/j.jprot.2022.104507_bb0190","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1021\/pr500880b","article-title":"Isobaric labeling-based relative quantification in shotgun proteomics","volume":"13","author":"Rauniyar","year":"2014","journal-title":"J. Proteome Res."},{"issue":"4","key":"10.1016\/j.jprot.2022.104507_bb0195","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1021\/acs.analchem.9b01974","article-title":"Evaluating combined precursor isotopic labeling and isobaric tagging performance on orbitraps to study the peripheral proteome of Alzheimer\u2019s disease","volume":"92","author":"King","year":"2020","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0200","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s13361-014-1012-y","article-title":"Novel isotopic N,N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach","volume":"26","author":"Greer","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0205","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1474-4422(06)70355-6","article-title":"Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study","volume":"5","author":"Hansson","year":"2006","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.jprot.2022.104507_bb0210","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1021\/ac902778d","article-title":"N,N-dimethyl leucines as novel isobaric tandem mass tags for quantitative proteomics and peptidomics","volume":"82","author":"Xiang","year":"2010","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.jprot.2022.104507_bb0215","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/bfgp\/eln032","article-title":"Proteomics: from hypothesis to quantitative assay on a single platform. Guidelines for developing MRM assays using ion trap mass spectrometers","volume":"7","author":"Han","year":"2008","journal-title":"Brief. Funct. Genomic Proteomic"},{"key":"10.1016\/j.jprot.2022.104507_bb0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1750-1326-7-41","article-title":"Mass spectrometry quantification of clusterin in the human brain","volume":"7","author":"Chen","year":"2012","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.jprot.2022.104507_bb0225","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/pr400802z","article-title":"Cleaved and missed sites for trypsin, lys-C, and lys-N can be predicted with high confidence on the basis of sequence context","volume":"13","author":"Gershon","year":"2014","journal-title":"J. Proteome Res."},{"issue":"15","key":"10.1016\/j.jprot.2022.104507_bb0230","doi-asserted-by":"crossref","first-page":"7636","DOI":"10.1021\/acs.analchem.5b00866","article-title":"Insight into trypsin miscleavage: comparison of kinetic constants of problematic peptide sequences","volume":"87","author":"Slechtova","year":"2015","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.jprot.2022.104507_bb0235","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/pr401060x","article-title":"Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms","volume":"13","author":"Martinez-Morillo","year":"2014","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0240","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11011-018-0325-0","article-title":"Association between clusterin concentration and dementia: a systematic review and meta-analysis","volume":"34","author":"Yang","year":"2019","journal-title":"Metab. Brain Dis."},{"issue":"10","key":"10.1016\/j.jprot.2022.104507_bb0245","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1021\/pr100646w","article-title":"Depletion of abundant plasma proteins and limitations of plasma proteomics","volume":"9","author":"Tu","year":"2010","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.jprot.2022.104507_bb0250","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1038\/s41467-018-07454-w","article-title":"Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry","volume":"9","author":"Searle","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0255","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1021\/ac901801b","article-title":"Deconvolution of mixture spectra from ion-trap data-independent-acquisition tandem mass spectrometry","volume":"82","author":"Bern","year":"2010","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.jprot.2022.104507_bb0260","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.010587","article-title":"PEAKS DB: de novo sequencing assisted database search for sensitive and accurate peptide identification","volume":"11","author":"Zhang","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2022.104507_bb0265","doi-asserted-by":"crossref","first-page":"100879","DOI":"10.1016\/j.yfrne.2020.100879","article-title":"Sex and gender differences in cognitive and brain reserve: implications for Alzheimer\u2019s disease in women","volume":"60","author":"Subramaniapillai","year":"2021","journal-title":"Front. Neuroendocrinol."},{"issue":"3","key":"10.1016\/j.jprot.2022.104507_bb0270","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3233\/JAD-200203","article-title":"Simple and fast assay for apolipoprotein E phenotyping and glycotyping: discovering isoform-specific glycosylation in plasma and cerebrospinal fluid","volume":"76","author":"Hu","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.jprot.2022.104507_bb0275","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12035-012-8237-1","article-title":"The role of clusterin in Alzheimer\u2019s disease: pathways, pathogenesis, and therapy","volume":"45","author":"Yu","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jprot.2022.104507_bb0280","doi-asserted-by":"crossref","first-page":"100081","DOI":"10.1016\/j.mcpro.2021.100081","article-title":"In-depth site-specific analysis of N-glycoproteome in human cerebrospinal fluid and glycosylation landscape changes in Alzheimer\u2019s disease","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"issue":"6","key":"10.1016\/j.jprot.2022.104507_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer\u2019s disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"issue":"D1","key":"10.1016\/j.jprot.2022.104507_bb0290","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922000306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922000306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:12:27Z","timestamp":1761739947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391922000306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":58,"alternative-id":["S1874391922000306"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104507","relation":{},"ISSN":["1874-3919"],"issn-type":[{"type":"print","value":"1874-3919"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isotopic N,N-dimethyl leucine tags for absolute quantification of clusterin and apolipoprotein E in Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104507"}}