{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:10:59Z","timestamp":1790644259679,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771572"],"award-info":[{"award-number":["31771572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071145"],"award-info":[{"award-number":["32071145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20191356"],"award-info":[{"award-number":["BK20191356"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["20KJB180004"],"award-info":[{"award-number":["20KJB180004"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jprot.2022.104556","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:42:48Z","timestamp":1646944968000},"page":"104556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Serum proteome profiling reveals differentially expressed proteins between subjects with metabolically healthy obesity and nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"260","author":[{"given":"Qi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2022.104556_bb0005","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jprot.2022.104556_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jprot.2022.104556_bb0015","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2022.104556_bb0020","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jprot.2022.104556_bb0025","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jprot.2022.104556_bb0030","article-title":"Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis","volume":"359","author":"Ma","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jprot.2022.104556_bb0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ajcn\/4.1.20","article-title":"The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease","volume":"4","author":"Vague","year":"1956","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jprot.2022.104556_bb0040","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/archinte.167.7.642","article-title":"Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity","volume":"167","author":"McLaughlin","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jprot.2022.104556_bb0045","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1210\/jc.2006-0594","article-title":"Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease","volume":"91","author":"Meigs","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jprot.2022.104556_bb0050","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa004","article-title":"Metabolically healthy obesity","volume":"41","author":"Bluher","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jprot.2022.104556_bb0055","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2022.104556_bb0060","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1001\/archinte.168.15.1609","article-title":"Identification and characterization of metabolically benign obesity in humans","volume":"168","author":"Stefan","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jprot.2022.104556_bb0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/eurheartj\/ehs174","article-title":"The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness","volume":"34","author":"Ortega","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jprot.2022.104556_bb0070","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.8505","article-title":"An empirically derived definition of metabolically healthy obesity based on risk of cardiovascular and Total mortality","volume":"4","author":"Zembic","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jprot.2022.104556_bb0075","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S2213-8587(14)70032-4","article-title":"Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome","volume":"2","author":"Yki-Jarvinen","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jprot.2022.104556_bb0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.dld.2014.09.020","article-title":"Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome","volume":"47","author":"Lonardo","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jprot.2022.104556_bb0085","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jprot.2022.104556_bb0090","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2337\/db12-0858","article-title":"Sterol regulatory element-binding factor 2 (SREBF-2) predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism","volume":"62","author":"Musso","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.jprot.2022.104556_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101346","article-title":"Non-alcoholic fatty liver disease in lean and non-obese individuals: current and future challenges","volume":"9","author":"Kuchay","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jprot.2022.104556_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103683","article-title":"Proteomic analysis to identify differentially expressed proteins between subjects with metabolic healthy obesity and non-alcoholic fatty liver disease","volume":"221","author":"Yuan","year":"2020","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2022.104556_bb0105","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.metabol.2015.11.006","article-title":"Adipokines in nonalcoholic fatty liver disease","volume":"65","author":"Polyzos","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jprot.2022.104556_bb0110","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188793","article-title":"Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease","volume":"15","author":"Niu","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.jprot.2022.104556_bb0115","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2022.104556_bb0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cca.2015.04.010","article-title":"Afamin\u2013A pleiotropic glycoprotein involved in various disease states","volume":"446","author":"Dieplinger","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jprot.2022.104556_bb0125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/hep.23271","article-title":"Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease","volume":"51","author":"Bell","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jprot.2022.104556_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235939","article-title":"Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond","volume":"20","author":"Fuior","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jprot.2022.104556_bb0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.thromres.2004.07.017","article-title":"Beta 2 glycoprotein I\u2013function in health and disease","volume":"114","author":"Miyakis","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jprot.2022.104556_bb0140","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1210\/jc.2011-3475","article-title":"Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality","volume":"97","author":"Hamer","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jprot.2022.104556_bb0145","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1177\/2047487315623884","article-title":"Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis","volume":"23","author":"Eckel","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.jprot.2022.104556_bb0150","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ajg.2016.178","article-title":"Metabolically healthy obesity and the development of nonalcoholic fatty liver disease","volume":"111","author":"Chang","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jprot.2022.104556_bb0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11906-020-1027-7","article-title":"Metabolically healthy obesity (MHO)-new research directions for personalised medicine in cardiovascular prevention","volume":"22","author":"Nilsson","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.jprot.2022.104556_bb0160","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1210\/jc.2015-2765","article-title":"Adiponectin levels differentiate metabolically healthy vs unhealthy among obese and nonobese white individuals","volume":"100","author":"Ahl","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jprot.2022.104556_bb0165","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/oby.21482","article-title":"Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: a proteomics study","volume":"24","author":"Doumatey","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jprot.2022.104556_bb0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.molmet.2015.04.002","article-title":"Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes","volume":"4","author":"Berti","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jprot.2022.104556_bb0175","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2337\/dc17-0201","article-title":"Plasma concentrations of Afamin are associated with prevalent and incident type 2 diabetes: a pooled analysis in more than 20,000 individuals","volume":"40","author":"Kollerits","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jprot.2022.104556_bb0180","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCGENETICS.113.000654","article-title":"Plasma concentrations of afamin are associated with the prevalence and development of metabolic syndrome","volume":"7","author":"Kronenberg","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.jprot.2022.104556_bb0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1477-7827-12-88","article-title":"Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome","volume":"12","author":"Seeber","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jprot.2022.104556_bb0190","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.2337\/diabetes.50.12.2779","article-title":"Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1","volume":"50","author":"Jong","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.jprot.2022.104556_bb0195","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5551\/jat.10.79","article-title":"Apolipoprotein H variant modifies plasma triglyceride phenotype in familial hypercholesterolemia: a molecular study in an eight-generation hyperlipidemic family","volume":"10","author":"Takada","year":"2003","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jprot.2022.104556_bb0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.atherosclerosis.2009.09.072","article-title":"APOH is increased in the plasma and liver of type 2 diabetic patients with metabolic syndrome","volume":"209","author":"Castro","year":"2010","journal-title":"Atherosclerosis"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:12:41Z","timestamp":1761739961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391922000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":40,"alternative-id":["S1874391922000793"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104556","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum proteome profiling reveals differentially expressed proteins between subjects with metabolically healthy obesity and nonalcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104556"}}