{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:20:52Z","timestamp":1793064052194,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2020XM01"],"award-info":[{"award-number":["2020XM01"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170523"],"award-info":[{"award-number":["82170523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["1331KFC"],"award-info":[{"award-number":["1331KFC"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jprot.2022.104667","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T20:23:18Z","timestamp":1656879798000},"page":"104667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Global profiling of protein lysine malonylation in mouse cardiac hypertrophy"],"prefix":"10.1016","volume":"266","author":[{"given":"Li-Fei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2022.104667_bb0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/j.2040-4603.2016.tb00669.x","article-title":"Pathophysiology of heart failure","volume":"6","author":"Tanai","year":"2015","journal-title":"Comprehens. Physiol."},{"key":"10.1016\/j.jprot.2022.104667_bb0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jprot.2022.104667_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jprot.2022.104667_bb0020","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/157340311799960618","article-title":"Transcription factors in heart: promising therapeutic targets in cardiac hypertrophy","volume":"7","author":"Kohli","year":"2011","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.jprot.2022.104667_bb0025","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s10741-020-09959-3","article-title":"The role and molecular mechanism of epigenetics in cardiac hypertrophy","volume":"26","author":"Lei","year":"2021","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.jprot.2022.104667_bb0030","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1111\/jcmm.14330","article-title":"The role of post-translational modifications in cardiac hypertrophy","volume":"23","author":"Yan","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jprot.2022.104667_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jprot.2022.104667_bb0040","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2174\/1386207320666170314102647","article-title":"Prediction of lysine malonylation sites based on pseudo amino acid","volume":"20","author":"Xiang","year":"2017","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jprot.2022.104667_bb0045","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/jcc.25353","article-title":"Predicting lysine-malonylation sites of proteins using sequence and predicted structural features","volume":"39","author":"Taherzadeh","year":"2018","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jprot.2022.104667_bb0050","doi-asserted-by":"crossref","unstructured":"Modis LK, O'Neill LA, Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, et al. Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation. Cell metabolism. 2018;28:866\u201380.e15.","DOI":"10.1016\/j.cmet.2018.07.019"},{"key":"10.1016\/j.jprot.2022.104667_bb0055","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41467-018-08187-6","article-title":"Malonylation of GAPDH is an inflammatory signal in macrophages","volume":"10","author":"Galv\u00e1n-Pe\u00f1a","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2022.104667_bb0060","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science."},{"key":"10.1016\/j.jprot.2022.104667_bb0065","first-page":"311","article-title":"Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology","volume":"53","author":"Makosa","year":"2018","journal-title":"Cartilage."},{"key":"10.1016\/j.jprot.2022.104667_bb0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molcel.2015.05.022","article-title":"SIRT5 regulates both cytosolic and mitochondrial protein malonylation with glycolysis as a major target","volume":"59","author":"Nishida","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jprot.2022.104667_bb0075","doi-asserted-by":"crossref","DOI":"10.1177\/1947603521993209","article-title":"Sirt5 deficiency causes posttranslational protein malonylation and dysregulated cellular metabolism in chondrocytes under obesity conditions","volume":"13","author":"Zhu","year":"2021","journal-title":"Cartilage"},{"key":"10.1016\/j.jprot.2022.104667_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ebiom.2018.09.037","article-title":"SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in Ob\/Ob mice","volume":"36","author":"Du","year":"2018","journal-title":"EBioMedicine."},{"key":"10.1016\/j.jprot.2022.104667_bb0085","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1042\/BCJ20180617","article-title":"Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism","volume":"476","author":"Karwi","year":"2019","journal-title":"Biochem. J."},{"key":"10.1016\/j.jprot.2022.104667_bb0090","doi-asserted-by":"crossref","unstructured":"Bowman CE, Rodriguez S, Selen Alpergin ES, Acoba MG, Zhao L, Hartung T, et al. The mammalian malonyl-CoA synthetase ACSF3 is required for mitochondrial protein malonylation and metabolic efficiency. Cell Chem. Biol. 2017;24:673\u201384.e4.","DOI":"10.1016\/j.chembiol.2017.04.009"},{"key":"10.1016\/j.jprot.2022.104667_bb0095","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1074\/mcp.M115.048850","article-title":"Proteomic and biochemical studies of lysine malonylation suggest its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid axidation","volume":"14","author":"Colak","year":"2015","journal-title":"Mol. Cell. Proteomics\u202f: MCP."},{"key":"10.1016\/j.jprot.2022.104667_bb0100","doi-asserted-by":"crossref","first-page":"14598","DOI":"10.1074\/jbc.M111.220525","article-title":"Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection","volume":"286","author":"el Azzouzi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2022.104667_bb0105","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/ATVBAHA.112.249706","article-title":"Interleukin-12p35 deletion promotes CD4 T-cell\u2013dependent aacrophage differentiation and enhances angiotensin II\u2013induced cardiac fibrosis","volume":"32","author":"Li","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jprot.2022.104667_bb0110","article-title":"Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2022.104667_bb0115","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2022.104667_bb0120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jjcc.2021.03.004","article-title":"Current trends and future perspectives for heart failure treatment leveraging cGMP modifiers and the practical effector PKG","volume":"78","author":"Nakamura","year":"2021","journal-title":"J. Cardiol."},{"key":"10.1016\/j.jprot.2022.104667_bb0125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2014.12.018","article-title":"IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice","volume":"80","author":"Ku","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jprot.2022.104667_bb0130","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10545-014-9684-9","article-title":"Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism","volume":"37","author":"Pougovkina","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jprot.2022.104667_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/prca.201900103","article-title":"Identification of malonylation, succinylation, and glutarylation in serum proteins of acute myocardial infarction patients","volume":"14","author":"Zhou","year":"2020","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.jprot.2022.104667_bb0140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jacbts.2019.02.003","article-title":"Malonyl CoA decarboxylase inhibition improves cardiac function post-myocardial infarction","volume":"4","author":"Wang","year":"2019","journal-title":"JACC Basic Translat. Sci."},{"key":"10.1016\/j.jprot.2022.104667_bb0145","first-page":"139","article-title":"Malonyl CoA: a promising target for the treatment of cardiac disease","volume":"66","author":"Makosa","year":"2014","journal-title":"Cartilage."},{"key":"10.1016\/j.jprot.2022.104667_bb0150","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.120.049438","article-title":"Short-chain enoyl-CoA hydratase mediates histone crotonylation and contributes to cardiac homeostasis","volume":"143","author":"Tang","year":"2021","journal-title":"Circulation."},{"key":"10.1016\/j.jprot.2022.104667_bb0155","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1073\/pnas.1519858113","article-title":"Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function","volume":"113","author":"Sadhukhan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jprot.2022.104667_bb0160","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.15252\/embj.201591271","article-title":"Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions","volume":"34","author":"Weinert","year":"2015","journal-title":"EMBO J."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922001919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391922001919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:03:05Z","timestamp":1778828585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391922001919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":32,"alternative-id":["S1874391922001919"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104667","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global profiling of protein lysine malonylation in mouse cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2022.104667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104667"}}