{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:37:04Z","timestamp":1763059024248,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jprot.2023.105057","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T17:24:48Z","timestamp":1701451488000},"page":"105057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The erythromycin polyketide compound TMC-154 stimulates ROS generation to exert antibacterial effects against Streptococcus pyogenes"],"prefix":"10.1016","volume":"292","author":[{"given":"Yuan-Feng","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangeri","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Peng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jprot.2023.105057_bb0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.jprot.2023.105057_bb0010","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/S1473-3099(17)30485-1","article-title":"Surveillance for control of antimicrobial resistance","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jprot.2023.105057_bb0015","first-page":"1","article-title":"Group a streptococcal diseases and their global burden","volume":"368","author":"Ralph","year":"2013","journal-title":"Curr. Top. Microbio."},{"issue":"11","key":"10.1016\/j.jprot.2023.105057_bb0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group a streptococcal diseases","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.jprot.2023.105057_bb0025","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3201\/eid2905.221421","article-title":"Emergence of erythromycin-resistant invasive group a streptococcus, West Virginia, USA, 2020-2021","volume":"29","author":"Powell","year":"2023","journal-title":"Emerg. Infect. Dis."},{"issue":"4","key":"10.1016\/j.jprot.2023.105057_bb0030","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1128\/JCM.42.4.1559-1563.2004","article-title":"Detection of multiple macrolideand lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area","volume":"42","author":"Hasenbein","year":"2004","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.jprot.2023.105057_bb0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/cid\/ciz1006","article-title":"Streptococcus pyogenes with reduced susceptibility to \u03b2-lactams: how big an alarm bell?","volume":"71","author":"Hanage","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jprot.2023.105057_bb0040","doi-asserted-by":"crossref","first-page":"1117160","DOI":"10.3389\/fcimb.2023.1117160","article-title":"A review of penicillin binding protein and group a streptococcus with reduced-\u03b2-lactam susceptibility","volume":"13","author":"Yu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"8","key":"10.1016\/j.jprot.2023.105057_bb0045","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jmedchem.6b01243","article-title":"Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria","volume":"60","author":"Dharmaraja","year":"2017","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.jprot.2023.105057_bb0050","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10059-011-0276-3","article-title":"Regulation of reactive oxygen species generation in cell signaling","volume":"32","author":"Bae","year":"2011","journal-title":"Mol. Cell"},{"issue":"6801","key":"10.1016\/j.jprot.2023.105057_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35025109","article-title":"Peroxynitrite reductase activity of bacterial peroxiredoxins","volume":"407","author":"Bryk","year":"2000","journal-title":"Nature."},{"issue":"4","key":"10.1016\/j.jprot.2023.105057_bb0060","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1096\/fj.12-223305","article-title":"Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione","volume":"27","author":"Lu","year":"2013","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.jprot.2023.105057_bb0065","first-page":"203","article-title":"Antibacterial strategies inspired by the oxidative stress and response networks","volume":"57","author":"Kim","year":"2019","journal-title":"J. Microbiol. (Seoul, Korea)"},{"issue":"5","key":"10.1016\/j.jprot.2023.105057_bb0070","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell."},{"issue":"32","key":"10.1016\/j.jprot.2023.105057_bb0075","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1021\/acs.jafc.6b02147","article-title":"iTRAQ-based proteomics revealed the bactericidal mechanism of sodium new houttuyfonate against streptococcus pneumoniae","volume":"64","author":"Yang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jprot.2023.105057_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103666","article-title":"Proteomic investigation into the action mechanism of berberine against streptococcus pyogenes","volume":"215","author":"Du","year":"2020","journal-title":"J. Proteome"},{"issue":"5","key":"10.1016\/j.jprot.2023.105057_bb0085","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.3390\/cimb45050241","article-title":"GC-MS based characterization, antibacterial, antifungal and anti-oncogenic activity of ethyl acetate extract of Aspergillus niger Strain AK-6 isolated from rhizospheric soil","volume":"45","author":"Niazi","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jprot.2023.105057_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113359","article-title":"C12 lactones from the rhizospheric soil-derived fungus Phialocephala sp. YUD18001 associated with Gastrodia elata","volume":"202","author":"Xie","year":"2022","journal-title":"Phytochemistry."},{"issue":"9","key":"10.1016\/j.jprot.2023.105057_bb0095","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1039\/D3OB00005B","article-title":"20-nor-Isopimarane and isopimarane diterpenoids produced by Aspergillus sp. WT03","volume":"21","author":"Tao","year":"2023","journal-title":"Org. Biomol. Chem."},{"issue":"7","key":"10.1016\/j.jprot.2023.105057_bb0100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1039\/b816430b","article-title":"Biosynthesis of polyketides by trans-AT polyketide synthases","volume":"27","author":"Piel","year":"2010","journal-title":"Nat. Prod. Rep."},{"issue":"25","key":"10.1016\/j.jprot.2023.105057_bb0105","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1016\/S0040-4020(99)00408-1","article-title":"Isolation and structure determination of TMC151s: novel polyketide antibiotics from Gliocladium catenulatum Gilman & Abbott TC 1280","volume":"55","author":"Kohno","year":"1999","journal-title":"Tetrahedron."},{"issue":"12","key":"10.1016\/j.jprot.2023.105057_bb0110","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.7164\/antibiotics.52.1114","article-title":"TMC-171A, B, C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282","volume":"52","author":"Kohno","year":"2000","journal-title":"J. Antibiot."},{"issue":"9","key":"10.1016\/j.jprot.2023.105057_bb0115","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7164\/antibiotics.52.815","article-title":"Structure elucidation of roselipins, inhibitors of diacylglycerol acyltransferase produced by Gliocladium roseum KF-1040","volume":"52","author":"Tabata","year":"1999","journal-title":"J. Antibiot."},{"issue":"12","key":"10.1016\/j.jprot.2023.105057_bb0120","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1021\/acs.jproteome.7b00352","article-title":"Detergent-insoluble proteome analysis revealed aberrantly aggregated proteins in human preeclampsia placentas","volume":"16","author":"Zhang","year":"2017","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.jprot.2023.105057_bb0125","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1086\/381972","article-title":"Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of gram-positive bacterial infections","volume":"38","author":"Pankey","year":"2004","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"10.1016\/j.jprot.2023.105057_bb0130","first-page":"Dc13","article-title":"In vitro fractional inhibitory concentration (FIC) study of cefixime and azithromycin fixed dose combination (FDC) against respiratory clinical isolates","volume":"9","author":"Patil","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"issue":"8","key":"10.1016\/j.jprot.2023.105057_bb0135","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.bjp.0707432","article-title":"Novel approaches to developing new antibiotics for bacterial infections","volume":"152","author":"Coates","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.jprot.2023.105057_bb0140","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/1751-7915.14268","article-title":"Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections","volume":"16","author":"Douglas","year":"2023","journal-title":"Microb. Biotechnol."},{"issue":"2","key":"10.1016\/j.jprot.2023.105057_bb0145","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04843-22","article-title":"Efficacy of zidovudine-amikacin combination therapy in vitro and in a rat tissue cage infection model against amikacin-resistant, multidrug-resistant Enterobacteriales","volume":"11","author":"Gong","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"10","key":"10.1016\/j.jprot.2023.105057_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103753","article-title":"Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance","volume":"28","author":"Peng","year":"2023","journal-title":"Drug Discov. Today"},{"issue":"3","key":"10.1016\/j.jprot.2023.105057_bb0155","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1039\/b604193k","article-title":"Heme and virulence: how bacterial pathogens regulate, transport and utilize heme","volume":"24","author":"Wilks","year":"2007","journal-title":"Nat. Prod. Rep."},{"issue":"2","key":"10.1016\/j.jprot.2023.105057_bb0160","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2958.2009.06650.x","article-title":"The mntH gene encodes the major Mn2+ transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein","volume":"72","author":"Hohle","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jprot.2023.105057_bb0165","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jprot.2018.11.021","article-title":"Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae","volume":"194","author":"Yang","year":"2019","journal-title":"J. Proteome"},{"issue":"5","key":"10.1016\/j.jprot.2023.105057_bb0170","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211939120","article-title":"The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin","volume":"120","author":"Macdonald","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jprot.2023.105057_bb0175","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1128\/IAI.71.3.1042-1055.2003","article-title":"Identification and characterization of a Streptococcus pyogenes operon involved in binding of hemoproteins and acquisition of iron","volume":"71","author":"Bates","year":"2003","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.jprot.2023.105057_bb0180","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1128\/IAI.71.10.5962-5969.2003","article-title":"Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes","volume":"71","author":"Lei","year":"2003","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.jprot.2023.105057_bb0185","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1128\/IAI.70.8.4494-4500.2002","article-title":"Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes","volume":"70","author":"Lei","year":"2002","journal-title":"Infect. Immun."},{"issue":"34","key":"10.1016\/j.jprot.2023.105057_bb0190","doi-asserted-by":"crossref","first-page":"12891","DOI":"10.1073\/pnas.0605440103","article-title":"The housekeeping dipeptide permease is the Escherichia coli heme transporter and functions with two optional peptide binding proteins","volume":"103","author":"L\u00e9toff\u00e9","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jprot.2023.105057_bb0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/157489109789318514","article-title":"Iron metabolism: a promising target for antibacterial strategies","volume":"4","author":"Ballouche","year":"2009","journal-title":"Rec. Pat. Antiinfect. Drug Discov."},{"issue":"11","key":"10.1016\/j.jprot.2023.105057_bb0200","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1021\/acs.jmedchem.7b00554","article-title":"Bacterial iron uptake pathways: gates for the import of bactericide compounds","volume":"60","author":"Schalk","year":"2017","journal-title":"J. Med. Chem."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391923002464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391923002464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:24:38Z","timestamp":1716488678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391923002464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":40,"alternative-id":["S1874391923002464"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2023.105057","relation":{},"ISSN":["1874-3919"],"issn-type":[{"type":"print","value":"1874-3919"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The erythromycin polyketide compound TMC-154 stimulates ROS generation to exert antibacterial effects against Streptococcus pyogenes","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2023.105057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105057"}}