{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:09:47Z","timestamp":1785362987654,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007334","name":"Ministry of Health and Family Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jprot.2023.105059","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T10:43:59Z","timestamp":1703501039000},"page":"105059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A comprehensive proteomic profiling of urinary exosomes and the identification of early non-invasive biomarker in patients with coronary artery disease"],"prefix":"10.1016","volume":"293","author":[{"given":"Pratibha","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambuj","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder K.","family":"Dhamija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Baswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Kulandaisamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyavir","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Kishore","family":"Inampudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2023.105059_bb0005","author":"Centers for Disease Control and Preventions (CDC)"},{"issue":"1","key":"10.1016\/j.jprot.2023.105059_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.2009.943","article-title":"Novel and conventional biomarkers for prediction of incident cardiovascular events in the community","volume":"302","author":"Melander","year":"2009","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jprot.2023.105059_bb0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2796.2003.01276.x","article-title":"Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy","volume":"255","author":"Walldius","year":"2004","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jprot.2023.105059_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejphar.2015.06.047","article-title":"Extracellular vesicles as new pharmacological targets to treat atherosclerosis","volume":"763","author":"Yin","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.jprot.2023.105059_bb0025","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrneph.2017.148","article-title":"Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery","volume":"13","author":"Merchant","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jprot.2023.105059_bb0030","series-title":"Urine Exosome Isolation and Characterization. Drug Safety Evaluation: Methods and Protocols","first-page":"413","author":"Street","year":"2017"},{"issue":"6","key":"10.1016\/j.jprot.2023.105059_bb0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcm.2018.10.010","article-title":"The therapeutic and diagnostic role of exosomes in cardiovascular diseases","volume":"29","author":"Zamani","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.jprot.2023.105059_bb0040","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/micmic\/ozad025","article-title":"Different biofluids, small extracellular vesicles or exosomes: structural analysis in atherosclerotic cardiovascular disease using Electron microscopy techniques","volume":"29","author":"Sharma","year":"2023","journal-title":"Microsc. Microanal."},{"issue":"W1","key":"10.1016\/j.jprot.2023.105059_bb0045","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jprot.2023.105059_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.jprot.2023.105059_bb0055","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.jprot.2023.105059_bb0060","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jprot.2023.105059_bb0065","article-title":"Sample preparation and imaging of exosomes by transmission electron microscopy","volume":"131","author":"Jung","year":"2018","journal-title":"JoVE (Journal of Visualized Experiments)."},{"issue":"19","key":"10.1016\/j.jprot.2023.105059_bb0070","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1039\/C5AN00688K","article-title":"Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers","volume":"140","author":"Wu","year":"2015","journal-title":"Analyst."},{"issue":"12","key":"10.1016\/j.jprot.2023.105059_bb0075","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/gerona\/61.12.1262","article-title":"Apolipoprotein A1 is a stronger prognostic marker than are HDL and LDL cholesterol for cardiovascular disease and mortality in elderly men","volume":"61","author":"Florvall","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"D1","key":"10.1016\/j.jprot.2023.105059_bb0080","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.jprot.2023.105059_bb0085","doi-asserted-by":"crossref","first-page":"E1055","DOI":"10.1152\/ajpendo.00075.2019","article-title":"Role of adipokine zinc-\u03b12-glycoprotein in coronary heart disease","volume":"317","author":"Huang","year":"2019","journal-title":"American Journal of Physiology-Endocrinology and Metabolism."},{"issue":"9","key":"10.1016\/j.jprot.2023.105059_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107550","article-title":"Excretion of urinary orosomucoid 1 protein is elevated in patients with chronic heart failure","volume":"9","author":"Hou","year":"2014","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.jprot.2023.105059_bb0095","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20210344","article-title":"Serum biomarker discovery related to pathogenesis in acute coronary syndrome by proteomic approach","volume":"41","author":"Shin","year":"2021","journal-title":"Biosci. Rep."},{"issue":"5733","key":"10.1016\/j.jprot.2023.105059_bb0100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/281677a0","article-title":"Inhibition of platelet aggregation by native and desialised alpha-1 acid glycoprotein","volume":"281","author":"Costello","year":"1979","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.jprot.2023.105059_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-7-45","article-title":"Protein targets of inflammatory serine proteases and cardiovascular disease","volume":"7","author":"Sharony","year":"2010","journal-title":"J. Inflamm."},{"key":"10.1016\/j.jprot.2023.105059_bb0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.redox.2017.01.007","article-title":"Angiogenesis in the atherosclerotic plaque","volume":"12","author":"Camar\u00e9","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.jprot.2023.105059_bb0115","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.matbio.2018.05.010","article-title":"The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis","volume":"71","author":"Gordts","year":"2018","journal-title":"Matrix Biol."},{"issue":"584","key":"10.1016\/j.jprot.2023.105059_bb0120","doi-asserted-by":"crossref","first-page":"eabe1433","DOI":"10.1126\/scitranslmed.abe1433","article-title":"Prosaposin mediates inflammation in atherosclerosis","volume":"13","author":"van Leent","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.jprot.2023.105059_bb0125","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCRESAHA.108.172882","article-title":"Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I\u2013mediated apoptosis","volume":"104","author":"Li","year":"2009","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.jprot.2023.105059_bb0130","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/039463201202500409","article-title":"Attenuated expression and gelsolin in association with induction of Aquaporin-1 and nitric oxide synthase in dysfunctional hearts of aging mice exposed to endotoxin","volume":"25","author":"Madonna","year":"2012","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.jprot.2023.105059_bb0135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.imlet.2013.09.025","article-title":"Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (\u2212\/\u2212) mice","volume":"156","author":"Li","year":"2013","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jprot.2023.105059_bb0140","first-page":"58","article-title":"Kininogen supports inflammation and bacterial spreading during Streptococccus pyogenes Sepsis","author":"K\u00f6hler","year":"2020","journal-title":"EBioMedicine."},{"issue":"5","key":"10.1016\/j.jprot.2023.105059_bb0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/ATVBAHA.109.184549","article-title":"Kallikrein\u2013kinin system in neovascularization","volume":"29","author":"Bader","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jprot.2023.105059_bb0150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fphys.2014.00379","article-title":"Red blood cell, hemoglobin and heme in the progression of atherosclerosis","volume":"5","author":"Jeney","year":"2014","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.jprot.2023.105059_bb0155","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002779","article-title":"Disequilibrium of blood coagulation and fibrinolytic system in patients with coronary artery ectasia","volume":"95","author":"Wu","year":"2016","journal-title":"Medicine."},{"issue":"2","key":"10.1016\/j.jprot.2023.105059_bb0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41422-019-0260-6","article-title":"Transferrin plays a central role in coagulation balance by interacting with clotting factors","volume":"30","author":"Tang","year":"2020","journal-title":"Cell Res."},{"issue":"9","key":"10.1016\/j.jprot.2023.105059_bb0165","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015480","article-title":"Iron metabolism contributes to prognosis in coronary artery disease: prognostic value of the soluble transferrin receptor within the AtheroGene study","volume":"9","author":"Weidmann","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.jprot.2023.105059_bb0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1091\/mbc.e08-08-0876","article-title":"Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly","volume":"20","author":"Schaeffer","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.jprot.2023.105059_bb0175","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gft345","article-title":"Determination of uromodulin in human urine: influence of storage and processing","volume":"29","author":"Youhanna","year":"2014","journal-title":"Nephrology Dialysis Transplantation."},{"issue":"1","key":"10.1016\/j.jprot.2023.105059_bb0180","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1038\/s41598-020-60619-w","article-title":"Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet-a neglected source for uEVs","volume":"10","author":"Musante","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jprot.2023.105059_bb0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/MNH.0000000000000522","article-title":"Uromodulin in mineral metabolism","volume":"28","author":"Wolf","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"3","key":"10.1016\/j.jprot.2023.105059_bb0190","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/cvr\/cvaa081","article-title":"Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling","volume":"117","author":"Alesutan","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.jprot.2023.105059_bb0195","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1681\/ASN.2016111162","article-title":"Serum uromodulin and mortality risk in patients undergoing coronary angiography","volume":"28","author":"Delgado","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jprot.2023.105059_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.01.030","article-title":"Serum uromodulin and risk for cardiovascular morbidity and mortality in the community-based KORA F4 study","volume":"297","author":"Then","year":"2020","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.jprot.2023.105059_bb0205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2019.01.003","article-title":"Identification of six cardiovascular risk biomarkers in the young population: a promising tool for early prevention","volume":"282","author":"Mart\u00ednez","year":"2019","journal-title":"Atherosclerosis."},{"issue":"14","key":"10.1016\/j.jprot.2023.105059_bb0210","first-page":"1537","article-title":"Prediction of coronary artery disease using urinary proteomics","volume":"30","author":"Wei","year":"2023","journal-title":"medRxiv"},{"issue":"2","key":"10.1016\/j.jprot.2023.105059_bb0215","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1074\/mcp.M700394-MCP200","article-title":"Urinary proteomic biomarkers in coronary artery disease","volume":"7","author":"Zimmerli","year":"2008","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391923002488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391923002488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:17:09Z","timestamp":1761740229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391923002488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":43,"alternative-id":["S1874391923002488"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2023.105059","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive proteomic profiling of urinary exosomes and the identification of early non-invasive biomarker in patients with coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2023.105059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105059"}}