{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:02:10Z","timestamp":1783101730638,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jprot.2024.105124","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:38:30Z","timestamp":1707917910000},"page":"105124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Untargeted metabolomics of buffalo urine reveals hydracyrlic acid, 3-bromo-1-propanol and benzyl serine as potential estrus biomarkers"],"prefix":"10.1016","volume":"296","author":[{"given":"Pooja","family":"Doshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetana","family":"Bhalaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Patidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrutlal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Raval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2024.105124_bb0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.foodchem.2009.10.053","article-title":"Buffalo vs. cow milk fat globules: size distribution, zeta-potential, compositions in total fatty acids and in polar lipids from the milk fat globule membrane","volume":"120","author":"M\u00e9nard","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.jprot.2024.105124_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.theriogenology.2016.04.031","article-title":"New approaches in buffalo artificial insemination programs with special reference to India","volume":"86","author":"Singh","year":"2016","journal-title":"Theriogenology."},{"key":"10.1016\/j.jprot.2024.105124_bb0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.anireprosci.2010.08.022","article-title":"Reproductive cycles of buffalo","volume":"124","author":"Perera","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0020","first-page":"12","article-title":"Comparative studies on different herbal medicines for induction of estrus in anoestrus buffalo heifers","volume":"2","author":"Chaudhiry","year":"2018","journal-title":"Turkish J. Vet. Res. Tjvr."},{"key":"10.1016\/j.jprot.2024.105124_bb0025","series-title":"International Veterinary Information service, Ithaca NY (www.ivis.org)","first-page":"12","author":"Purohit","year":"2018"},{"key":"10.1016\/j.jprot.2024.105124_bb0030","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.3168\/jds.2022-22209","article-title":"Serum metabolomics assessment of etiological processes predisposing ketosis in water buffalo during early lactation","volume":"106","author":"Fiore","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0035","series-title":"Proc. Intl. Soc. Mag. Reson. Med","first-page":"1584","article-title":"Urinary 1 H NMR-based metabolomics can distinguish sub-fertility Buffalo bulls","author":"Kumar","year":"2015"},{"key":"10.1016\/j.jprot.2024.105124_bb0040","doi-asserted-by":"crossref","first-page":"106115","DOI":"10.1016\/j.jsbmb.2022.106115","article-title":"Targeted metabolomics analysis of bile acids and cell biology studies reveal the critical role of glycodeoxycholic acid in buffalo follicular atresia","volume":"221","author":"Wei","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jprot.2024.105124_bb0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.anireprosci.2007.04.014","article-title":"Identification of putative pheromones in bovine (Bos taurus) faeces in relation to estrus detection","volume":"103","author":"Sankar","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1023\/A:1006495404407","article-title":"Chemical characterization of bovine urine with special reference to Oestrus","volume":"24","author":"Ramesh Kumar","year":"2000","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.jprot.2024.105124_bb0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.rvsc.2010.12.005","article-title":"Identification of urinary sex pheromones in female buffaloes and their influence on bull reproductive behaviour","volume":"91","author":"Rajanarayanan","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0060","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00216-011-5098-9","article-title":"GC\/MS-based metabolomic approach to validate the role of urinary sarcosine and target biomarkers for human prostate cancer by microwave-assisted derivatization","volume":"401","author":"Wu","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jprot.2024.105124_bb0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-61737-985-7_11","article-title":"Gas chromatography-mass spectrometry (GC-MS)-based metabolomics","author":"Garcia","year":"2011","journal-title":"Metab. Profilin. Meth. Protoc."},{"key":"10.1016\/j.jprot.2024.105124_bb0070","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jprot.2024.105124_bb0075","doi-asserted-by":"crossref","first-page":"D640","DOI":"10.1093\/nar\/gkad1045","article-title":"MetaboLights: open data repository for metabolomics","volume":"52","author":"Yurekten","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105124_bb0080","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2024.105124_bb0085","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105124_bb0090","first-page":"1","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou Feunang","year":"2016","journal-title":"J. Chemother."},{"key":"10.1016\/j.jprot.2024.105124_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.domaniend.2019.106392","article-title":"Detection of estrous biomarkers in the body exudates of Kangayam cattle (Bos indicus) from interplay of hormones and behavioral expressions","volume":"72","author":"Ramachandran","year":"2020","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.jprot.2024.105124_bb0100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0168-1591(93)90117-8","article-title":"Behavioral responses of bulls kept under artificial breeding conditions to compounds presented for olfaction, taste or with topical nasal application","volume":"37","author":"Presicce","year":"1993","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0105","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3168\/jds.2020-19024","article-title":"The potential of volatile organic compound analysis in cervicovaginal mucus to predict estrus and ovulation in estrus-synchronized heifers","volume":"104","author":"Pluta","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-4320(94)90003-5","article-title":"Blood acetaldehyde fluctuates markedly during bovine estrous cycle","volume":"35","author":"Klemm","year":"1994","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0115","first-page":"124","article-title":"Archunan, p-cresol and oleic acid as reliable biomarkers of estrus: evidence from synchronized Murrah buffaloes, Iran","volume":"18","author":"Muniasamy","year":"2017","journal-title":"J. Vet. Res."},{"key":"10.1016\/j.jprot.2024.105124_bb0120","series-title":"Multi-and Megavariate Data Anal. Part II Adv. Appl. Method Extensions","author":"Eriksson","year":"2006"},{"key":"10.1016\/j.jprot.2024.105124_bb0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C4MB00414K","article-title":"PLS\/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters","volume":"11","author":"Triba","year":"2015","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.jprot.2024.105124_bb0130","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11306-012-0482-9","article-title":"Translational biomarker discovery in clinical metabolomics: an introductory tutorial","volume":"9","author":"Xia","year":"2013","journal-title":"Metabolomics."},{"key":"10.1016\/j.jprot.2024.105124_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fvets.2021.678388","article-title":"GC\/MS and LC\/MS based serum Metabolomic analysis of dairy cows with ovarian inactivity","volume":"8","author":"Bai","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0140","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3390\/metabo11120842","article-title":"Integrated metabolomics and proteomics dynamics of serum samples reveals dietary zeolite clinoptilolite supplementation restores energy balance in high yielding dairy cows","volume":"11","author":"Maity","year":"2021","journal-title":"Metabolites."},{"key":"10.1016\/j.jprot.2024.105124_bb0145","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3168\/jds.2020-18883","article-title":"Differential gene expression in dairy cows under negative energy balance and ketosis: a systematic review and meta-analysis","volume":"104","author":"Soares","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jprot.2024.105124_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.867909","article-title":"Comparative proteome profiling of saliva between estrus and non-estrus stages by employing label-free quantitation (LFQ) and tandem mass tag (TMT)-LC-MS\/MS analysis: an approach for estrus biomarker identification in Bubalus bubalis","volume":"13","author":"Singh","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.jprot.2024.105124_bb0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.106.059899","article-title":"Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo","volume":"77","author":"Johnson","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jprot.2024.105124_bb0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humupd\/dmg009","article-title":"Effects of in-vivo and in-vitro environments on the metabolism of the cumulus--oocyte complex and its influence on oocyte developmental capacity","volume":"9","author":"Sutton","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jprot.2024.105124_bb0165","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3390\/ani12101300","article-title":"Heat stress induces shifts in the rumen bacteria and metabolome of buffalo","volume":"12","author":"Wang","year":"2022","journal-title":"Animals."},{"key":"10.1016\/j.jprot.2024.105124_bb0170","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/mrd.20607","article-title":"Amino acids in oviduct and uterine fluid and blood plasma during the estrous cycle in the bovine","volume":"74","author":"Hugentobler","year":"2007","journal-title":"Mol. Reprod. Dev. Inc. Gamete Res."},{"key":"10.1016\/j.jprot.2024.105124_bb0175","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1095\/biolreprod28.1.235","article-title":"Development of preimplantation embryos of the golden hamster in a defined culture medium","volume":"28","author":"Bavister","year":"1983","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jprot.2024.105124_bb0180","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jez.1402530211","article-title":"Glycine protects preimplantation mouse conceptuses from a detrimental effect on development of the inorganic ions in oviductal fluid","volume":"253","author":"Van Winkle","year":"1990","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.jprot.2024.105124_bb0185","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1095\/biolreprod48.4.833","article-title":"Glycine and alanine supplementation of culture medium enhances development of in vitro matured and fertilized cattle embryos","volume":"48","author":"Moore","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jprot.2024.105124_bb0190","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0093-691X(84)90385-6","article-title":"Free amino acids and protein concentrations in reproductive tract fluids of the mare","volume":"21","author":"Engle","year":"1984","journal-title":"Theriogenology."},{"key":"10.1016\/j.jprot.2024.105124_bb0195","first-page":"35","article-title":"Metabolism of the preimplantation mammalian embryo","volume":"13","author":"Leese","year":"1991","journal-title":"Oxf. Rev. Reprod. Biol."},{"key":"10.1016\/j.jprot.2024.105124_bb0200","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/jrf.0.0830585","article-title":"Measurement of the metabolism of energy substrates in individual bovine blastocysts","volume":"83","author":"Rieger","year":"1988","journal-title":"Reproduction."},{"key":"10.1016\/j.jprot.2024.105124_bb0205","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1095\/biolreprod61.3.731","article-title":"Temporal and differential effects of amino acids on bovine embryo development in culture","volume":"61","author":"Steeves","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jprot.2024.105124_bb0210","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1530\/rep.0.1240311","article-title":"The cooperative action of angiotensin II with subluteolytic administration of PGF2\u03b1 in inducing luteolysis and oestrus in the cow","volume":"124","author":"Hayashi","year":"2002","journal-title":"Reproduction."},{"key":"10.1016\/j.jprot.2024.105124_bb0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1017\/S1751731114000482","article-title":"Endocrine and metabolic mechanisms linking postpartum glucose with early embryonic and foetal development in dairy cows","volume":"8","author":"Lucy","year":"2014","journal-title":"Animal."},{"key":"10.1016\/j.jprot.2024.105124_bb0220","doi-asserted-by":"crossref","first-page":"2100457","DOI":"10.1002\/mnfr.202100457","article-title":"Resveratrol improves follicular development of PCOS rats by regulating the glycolytic pathway","volume":"65","author":"Liang","year":"2021","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924000563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924000563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T20:33:12Z","timestamp":1732048392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391924000563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"alternative-id":["S1874391924000563"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105124","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Untargeted metabolomics of buffalo urine reveals hydracyrlic acid, 3-bromo-1-propanol and benzyl serine as potential estrus biomarkers","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105124"}}