{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:26:50Z","timestamp":1771907210569,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jprot.2024.105199","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:57:44Z","timestamp":1715943464000},"page":"105199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease"],"prefix":"10.1016","volume":"302","author":[{"given":"Nicolas","family":"Pierre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2n Anh","family":"Huynh-Thu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Baiwir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Vieujean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Bequet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Reenaers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Van Kemseke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Sal\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Massot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilien","family":"Fl\u00e9ron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Mazzucchelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"Trzpiot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauthier","family":"Eppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"De Pauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Alice","family":"Meuwis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2024.105199_bb0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jprot.2024.105199_bb0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR guideline for diagnostic assessment in IBD part 1: initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jprot.2024.105199_bb0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","article-title":"The natural history of adult Crohn\u2019s disease in population-based cohorts","volume":"105","author":"Peyrin-Biroulet","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jprot.2024.105199_bb0020","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/apt.16536","article-title":"Review article: distinctions between ileal and colonic Crohn\u2019s disease: from physiology to pathology","volume":"54","author":"Pierre","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jprot.2024.105199_bb0025","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/gutjnl-2016-312673","article-title":"Recent advances in clinical practice: a systematic review of isolated colonic Crohn\u2019s disease: the third IBD?","volume":"66","author":"Subramanian","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jprot.2024.105199_bb0030","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(15)00465-1","article-title":"Inherited determinants of Crohn\u2019s disease and ulcerative colitis phenotypes: a genetic association study","volume":"387","author":"Cleynen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jprot.2024.105199_bb0035","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/gut.52.4.552","article-title":"Early development of stricturing or penetrating pattern in Crohn\u2019s disease is influenced by disease location, number of flares, and smoking but not by NOD2\/CARD15 genotype","volume":"52","author":"Louis","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jprot.2024.105199_bb0040","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.49.6.777","article-title":"Behaviour of Crohn\u2019s disease according to the Vienna classification: changing pattern over the course of the disease","volume":"49","author":"Louis","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jprot.2024.105199_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphar.2022.100097","article-title":"Ileal and colonic Crohn\u2019s disease: does location makes a difference in therapy efficacy?","volume":"3","author":"Atreya","year":"2022","journal-title":"Curr Res Pharmacol drug Discov"},{"key":"10.1016\/j.jprot.2024.105199_bb0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ibd.20312","article-title":"Crohn\u2019s disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn\u2019s disease activity index and endoscopic findings","volume":"14","author":"Sipponen","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jprot.2024.105199_bb0055","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1365-2036.2008.03835.x","article-title":"Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn\u2019s disease and histological findings","volume":"28","author":"Sipponen","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jprot.2024.105199_bb0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.5114\/aoms.2014.43672","article-title":"Is faecal calprotectin equally useful in all Crohn\u2019s disease locations? A prospective, comparative study","volume":"11","author":"Stawczyk-Eder","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jprot.2024.105199_bb0065","first-page":"201","article-title":"Fecal calprotectin correlates with active colonic inflammatory bowel disease but not with small intestinal Crohn\u2019s disease activity. JGH open an open access","volume":"2","author":"Zittan","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jprot.2024.105199_bb0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/00365520500217118","article-title":"Clinically active Crohn\u2019s disease in the presence of a low C-reactive protein","volume":"41","author":"Florin","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jprot.2024.105199_bb0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/01.MIB.0000173271.18319.53","article-title":"Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease","volume":"11","author":"Solem","year":"2005","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jprot.2024.105199_bb0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5009\/gnl13424","article-title":"Usefulness of C-reactive protein as a disease activity marker in Crohn\u2019s disease according to the location of disease","volume":"9","author":"Yang","year":"2015","journal-title":"Gut Liver"},{"key":"10.1016\/j.jprot.2024.105199_bb0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ibd\/izab311","article-title":"Meta-analysis of IBD gut samples gene expression identifies specific markers of Ileal and colonic diseases","volume":"28","author":"Perez","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jprot.2024.105199_bb0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ecco-jcc\/jjz130","article-title":"Proteomics highlights common and distinct pathophysiological processes associated with Ileal and colonic ulcers in Crohn\u2019s disease","volume":"14","author":"Pierre","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jprot.2024.105199_bb0095","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/ibd\/izab012","article-title":"Metabolic alteration in plasma and biopsies from patients with IBD","volume":"27","author":"Santoru","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jprot.2024.105199_bb0100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ecco-jcc\/jjy146","article-title":"T-cell composition in Ileal and colonic creeping fat - separating Ileal from colonic Crohn\u2019s disease","volume":"13","author":"Kredel","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jprot.2024.105199_bb0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/ibd\/izab123","article-title":"Serum Analyte profiles associated with Crohn\u2019s disease and disease location","volume":"28","author":"Boucher","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jprot.2024.105199_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2020-322100","article-title":"Discovery of biomarker candidates associated with the risk of short-term and mid\/long-term relapse after infliximab withdrawal in Crohn\u2019s patients: a proteomics-based study","volume":"70","author":"Pierre","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jprot.2024.105199_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jprot.2024.105199_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jprot.2024.105199_bb0125","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3109\/00365521.2015.1008035","article-title":"Impact of disease location on fecal calprotectin levels in Crohn\u2019s disease","volume":"50","author":"Gecse","year":"2015","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jprot.2024.105199_bb0130","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0966-842X(96)10057-3","article-title":"The indigenous gastrointestinal microflora","volume":"4","author":"Berg","year":"1996","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jprot.2024.105199_bb0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cytogfr.2014.07.011","article-title":"G-CSF: from granulopoietic stimulant to bone marrow stem cell mobilizing agent","volume":"25","author":"Bendall","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jprot.2024.105199_bb0140","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jprot.2024.105199_bb0145","first-page":"1218","article-title":"Relationships between disease activity and serum and fecal biomarkers in patients with Crohn\u2019s disease","volume":"6","author":"Jones","year":"2008","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"10.1016\/j.jprot.2024.105199_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4049\/jimmunol.1000832","article-title":"Cutting edge: FcR-like 6 is an MHC class II receptor","volume":"185","author":"Schreeder","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jprot.2024.105199_bb0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-immunol-031210-101352","article-title":"Signaling by myeloid C-type lectin receptors in immunity and homeostasis","volume":"30","author":"Sancho","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jprot.2024.105199_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.575175","article-title":"Roles for the FCRL6 Immunoreceptor in tumor immunology","volume":"11","author":"Davis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jprot.2024.105199_bb0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gutjnl-2022-327321","article-title":"Distinct blood protein profiles associated with the risk of short-term and mid\/long-term clinical relapse in patients with Crohn\u2019s disease stopping infliximab: when the remission state hides different types of residual disease activity","volume":"72","author":"Pierre","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.jprot.2024.105199_bb0170","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nri3406","article-title":"Lymphotoxin signalling in immune homeostasis and the control of microorganisms","volume":"13","author":"Upadhyay","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jprot.2024.105199_bb0175","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nmeth.2015","article-title":"Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions","volume":"9","author":"Picotti","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2024.105199_bb0180","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1074\/mcp.M113.036095","article-title":"Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach","volume":"13","author":"Carr","year":"2014","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924001313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924001313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T06:05:53Z","timestamp":1726380353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391924001313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":36,"alternative-id":["S1874391924001313"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105199","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum proteome signatures associated with ileal and colonic ulcers in Crohn's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105199"}}