{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:08:07Z","timestamp":1762625287347,"version":"3.37.3"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008793","name":"Universidad Del Rosario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jprot.2024.105323","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T22:56:49Z","timestamp":1727564209000},"page":"105323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Characterizing Leishmania infantum-induced resistance to trivalent stibogluconate (SbIII) through deep proteomics"],"prefix":"10.1016","volume":"309","author":[{"given":"Adriana","family":"Castillo-Casta\u00f1eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz H.","family":"Pati\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan David","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2024.105323_bb0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.idc.2012.03.005","article-title":"Visceral leishmaniasis","volume":"26","author":"van Griensven","year":"2012","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.jprot.2024.105323_bb0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4269\/ajtmh.21-0103","article-title":"Spatial and temporal variability of visceral leishmaniasis in Colombia, 2007 to 2018","volume":"105","author":"Castillo-Casta\u00f1eda","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jprot.2024.105323_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijid.2021.11.029","article-title":"Amplicon-based next-generation sequencing reveals the co-existence of multiple Leishmania species in patients with visceral leishmaniasis","volume":"115","author":"Castillo-Casta\u00f1eda","year":"2022","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jprot.2024.105323_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/HIV.S143929","article-title":"Visceral leishmaniasis and HIV coinfection: current perspectives","volume":"10","author":"Lindoso","year":"2018","journal-title":"HIV"},{"key":"10.1016\/j.jprot.2024.105323_bb0025","doi-asserted-by":"crossref","DOI":"10.35500\/jghs.2020.2.e3","article-title":"Visceral leishmaniasis: a global overview","volume":"2","author":"Wamai","year":"2020","journal-title":"J. Glob. Health Sci."},{"year":"2020","series-title":"Global Leishmaniasis Surveillance, 2017\u20132018, and First Report on 5 Additional Indicators","author":"WHO","key":"10.1016\/j.jprot.2024.105323_bb0030"},{"key":"10.1016\/j.jprot.2024.105323_bb0035","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51243","article-title":"Global genome diversity of the Leishmania donovani complex","volume":"9","author":"Franssen","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.jprot.2024.105323_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006052","article-title":"Drug resistance and treatment failure in leishmaniasis: a 21st century challenge","volume":"11","author":"Ponte-Sucre","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jprot.2024.105323_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182023001129","article-title":"Antimony resistance and gene expression in Leishmania: spotlight on molecular and proteomic aspects","volume":"151","author":"Madusanka","year":"2024","journal-title":"Parasitology"},{"key":"10.1016\/j.jprot.2024.105323_bb0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis","volume":"19","author":"Croft","year":"2006","journal-title":"CMR"},{"key":"10.1016\/j.jprot.2024.105323_bb0055","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00548-17","article-title":"Molecular preadaptation to antimony resistance in Leishmania donovani on the Indian subcontinent","volume":"3","author":"Dumetz","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.jprot.2024.105323_bb0060","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.meegid.2018.04.021","article-title":"Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent","volume":"62","author":"Cuypers","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.jprot.2024.105323_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001514","article-title":"Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background","volume":"6","author":"Decuypere","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"year":"2022","series-title":"Guideline for the Treatment of Leishmaniasis in the Americas","author":"Paho","key":"10.1016\/j.jprot.2024.105323_bb0070"},{"key":"10.1016\/j.jprot.2024.105323_bb0075","doi-asserted-by":"crossref","first-page":"514","DOI":"10.15446\/rsap.v17n4.44663","article-title":"Brote urbano de leishmaniasis visceral en Neiva (Huila), 2012","volume":"17","author":"del Zambrano Hernandez","year":"2015","journal-title":"Rev. Salud P\u00fablica"},{"key":"10.1016\/j.jprot.2024.105323_bb0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ebiom.2018.09.029","article-title":"A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis","volume":"36","author":"Carnielli","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jprot.2024.105323_bb0085","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1128\/AAC.37.9.1842","article-title":"Antileishmanial activity of sodium stibogluconate fractions","volume":"37","author":"Roberts","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0090","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/AAC.27.6.916","article-title":"Biochemical mechanisms of the antileishmanial activity of sodium stibogluconate","volume":"27","author":"Berman","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0095","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1128\/AAC.45.7.2064-2069.2001","article-title":"Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes","volume":"45","author":"Sereno","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0100","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1101\/gr.123430.111","article-title":"Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance","volume":"21","author":"Downing","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.actatropica.2017.10.010","article-title":"Molecular epidemiology and in vitro evidence suggest that Leishmania braziliensis strain helps determine antimony response among American tegumenary leishmaniasis patients","volume":"178","author":"Silva","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.jprot.2024.105323_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-45538-9","article-title":"Major changes in chromosomal somy, gene expression and gene dosage driven by SbIII in Leishmania braziliensis and Leishmania panamensis","volume":"9","author":"Patino","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2024.105323_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-019-3603-8","article-title":"Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate","volume":"12","author":"Patino","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jprot.2024.105323_bb0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molbiopara.2013.06.006","article-title":"Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines","volume":"190","author":"Matrangolo","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0125","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/1756-3305-7-406","article-title":"Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and \u2013susceptible Leishmania braziliensis and Leishmania infantum lines","volume":"7","author":"Andrade","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jprot.2024.105323_bb0130","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/nar\/gkn1069","article-title":"Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum","volume":"37","author":"Leprohon","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0135","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpddr.2020.03.003","article-title":"MRPA-independent mechanisms of antimony resistance in Leishmania infantum","volume":"13","author":"Douanne","year":"2020","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.jprot.2024.105323_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081899","article-title":"Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant","volume":"8","author":"Brotherton","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1001973","article-title":"The paradigm of intracellular parasite survival and drug resistance in leishmanial parasite through genome plasticity and epigenetics: perception and future perspective","volume":"13","author":"Kamran","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jprot.2024.105323_bb0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exppara.2009.05.013","article-title":"Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen","volume":"123","author":"El Fadili","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.parint.2014.11.001","article-title":"Functional analysis of iron superoxide dismutase-A in wild-type and antimony-resistant Leishmania braziliensis and Leishmania infantum lines","volume":"64","author":"Tessarollo","year":"2015","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.jprot.2024.105323_bb0160","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1074\/mcp.M600319-MCP200","article-title":"A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death","volume":"6","author":"Vergnes","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2024.105323_bb0165","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2125.2010.03716.x","article-title":"Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani: overexpressed proteins in SAG resistant L. donovani","volume":"70","author":"Kumar","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jprot.2024.105323_bb0170","article-title":"Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum","volume":"15","author":"de Lima","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/proteomes10020010","article-title":"In-depth quantitative proteomics characterization of in vitro selected miltefosine resistance in Leishmania infantum","volume":"10","author":"Saboia-Vahia","year":"2022","journal-title":"Proteomes"},{"key":"10.1016\/j.jprot.2024.105323_bb0180","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1038\/s41467-023-38221-1","article-title":"Translational reprogramming as a driver of antimony-drug resistance in Leishmania","volume":"14","author":"Gutierrez Guarnizo","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2024.105323_bb0185","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00436-010-1852-8","article-title":"Selection and phenotype characterization of potassium antimony tartrate-resistant populations of four New World Leishmania species","volume":"107","author":"Liarte","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0190","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nmeth.2834","article-title":"Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells","volume":"11","author":"Kulak","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2024.105323_bb0195","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jprot.2024.105323_bb0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12575-016-0043-0","article-title":"Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients","volume":"18","author":"Hernandez-Valladares","year":"2016","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.jprot.2024.105323_bb0205","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1074\/mcp.TIR118.000900","article-title":"Online parallel accumulation\u2013serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer","volume":"17","author":"Meier","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2024.105323_bb0210","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry\u2013based proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2024.105323_bb0215","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jprot.2024.105323_bb0220","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/bs.mie.2016.10.002","article-title":"Label-free and standard-free absolute quantitative proteomics using the \u201ctotal protein\u201d and \u201cproteomic ruler\u201d approaches","author":"Wi\u015bniewski","year":"2017"},{"key":"10.1016\/j.jprot.2024.105323_bb0225","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2024.105323_bb0230","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1186\/s12864-022-09058-7","article-title":"Amica: an interactive and user-friendly web-platform for the analysis of proteomics data","volume":"23","author":"Didusch","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jprot.2024.105323_bb0235","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gkad1003","article-title":"VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023","volume":"52","author":"Alvarez-Jarreta","year":"2024","journal-title":"Nucleic Acids Res."},{"author":"OmicsBox","key":"10.1016\/j.jprot.2024.105323_bb0240"},{"key":"10.1016\/j.jprot.2024.105323_bb0245","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"Gotz","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0250","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0255","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"author":"R Core Team","key":"10.1016\/j.jprot.2024.105323_bb0260"},{"key":"10.1016\/j.jprot.2024.105323_bb0265","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18374-y","article-title":"Resequencing of the Leishmania infantum (strain JPCM5) genome and de novo assembly into 36 contigs","volume":"7","author":"Gonz\u00e1lez-de la Fuente","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2024.105323_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008509","article-title":"In-depth quantitative proteomics uncovers specie-specific metabolic programs in Leishmania (Viannia) species","volume":"14","author":"Pinho","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jprot.2024.105323_bb0275","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3390\/molecules14072317","article-title":"Pentavalent antimonials: new perspectives for old drugs","volume":"14","author":"Fr\u00e9zard","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.jprot.2024.105323_bb0280","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/jac\/dkw096","article-title":"Evidence of a drug-specific impact of experimentally selected paromomycin and miltefosine resistance on parasite fitness in Leishmania infantum","volume":"71","author":"Hendrickx","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155245","article-title":"Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani","volume":"145","author":"Mukherjee","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.jprot.2024.105323_bb0290","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1017\/S0031182011001120","article-title":"Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines","volume":"138","author":"Ouakad","year":"2011","journal-title":"Parasitology"},{"key":"10.1016\/j.jprot.2024.105323_bb0295","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/314896","article-title":"Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani","volume":"180","author":"Lira","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jprot.2024.105323_bb0300","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1111\/febs.14511","article-title":"Characterisation of a putative glutamate 5-kinase from Leishmania donovani","volume":"285","author":"Sienkiewicz","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.jprot.2024.105323_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008042","article-title":"Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania","volume":"15","author":"Inbar","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jprot.2024.105323_bb0310","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fcimb.2019.00100","article-title":"Modulation of host-pathogen communication by extracellular vesicles (EVs) of the protozoan parasite Leishmania","volume":"9","author":"Dong","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jprot.2024.105323_bb0315","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2148-6-61","article-title":"Evolutionary constraints on yeast protein size","volume":"6","author":"Warringer","year":"2006","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.jprot.2024.105323_bb0320","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jprot.2014.07.012","article-title":"Multi-enzyme digestion FASP and the \u2018total protein approach\u2019-based absolute quantification of the Escherichia coli proteome","volume":"109","author":"Wi\u015bniewski","year":"2014","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2024.105323_bb0325","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01393-17","article-title":"Gene expression in Leishmania is regulated predominantly by gene dosage","volume":"8","author":"Iantorno","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.jprot.2024.105323_bb0330","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molbiopara.2007.07.007","article-title":"Post-transcriptional regulation of gene expression in trypanosomes and leishmanias","volume":"156","author":"Clayton","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0335","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.190072","article-title":"Regulation of gene expression in trypanosomatids: living with polycistronic transcription","volume":"9","author":"Clayton","year":"2019","journal-title":"Open Biol."},{"key":"10.1016\/j.jprot.2024.105323_bb0340","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijpddr.2018.04.002","article-title":"Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs","volume":"8","author":"Rastrojo","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.jprot.2024.105323_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026660","article-title":"Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin \u2013susceptible \u2013resistant Leishmania donovani","volume":"6","author":"Chawla","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0350","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/sgtp.2.1.15113","article-title":"Evolution of the Ras-like small GTPases and their regulators","volume":"2","author":"Van Dam","year":"2011","journal-title":"Small GTPases"},{"key":"10.1016\/j.jprot.2024.105323_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.636615","article-title":"Unpicking the roles of DNA damage protein kinases in trypanosomatids","volume":"9","author":"Silva","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jprot.2024.105323_bb0360","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.pt.2022.08.009","article-title":"Distinguishing functions of trypanosomatid protein kinases","volume":"38","author":"Cayla","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103847","article-title":"Improvements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications: study of changes in epigenetic marks through the parasite\u2019s metacyclogenesis and life cycle","volume":"225","author":"De Lima","year":"2020","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2024.105323_bb0370","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1186\/s13071-020-04486-4","article-title":"Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines","volume":"13","author":"Andrade","year":"2020","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jprot.2024.105323_bb0375","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pt.2010.06.011","article-title":"Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids","volume":"27","author":"Kramer","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0380","doi-asserted-by":"crossref","first-page":"7520","DOI":"10.1093\/nar\/gkad497","article-title":"A unique mRNA decapping complex in trypanosomes","volume":"51","author":"Kramer","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0385","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.gene.2009.12.009","article-title":"Proteomic analysis reveals the dynamic association of proteins with translated mRNAs in Trypanosoma cruzi","volume":"452","author":"Alves","year":"2010","journal-title":"Gene"},{"key":"10.1016\/j.jprot.2024.105323_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003528","article-title":"Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus","volume":"3","author":"Egea","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0395","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/gb-2013-14-11-r128","article-title":"Polysome profiling reveals translational control of gene expression in the human malaria parasite plasmodium falciparum","volume":"14","author":"Bunnik","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.jprot.2024.105323_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/s40169-017-0160-7","article-title":"Lipidomics and anti-trypanosomatid chemotherapy","volume":"6","author":"Biagiotti","year":"2017","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jprot.2024.105323_bb0405","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-013-3621-y","article-title":"Fatty acid profiles in Leishmania spp. isolates with natural resistance to nitric oxide and trivalent antimony","volume":"113","author":"De Azevedo","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0410","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12688\/wellcomeopenres.15452.1","article-title":"Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites","volume":"4","author":"Pountain","year":"2019","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.jprot.2024.105323_bb0415","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1365-2958.1999.01634.x","article-title":"Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania","volume":"34","author":"Haimeur","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jprot.2024.105323_bb0420","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1096\/fj.15-272757","article-title":"Elevated ergosterol protects Leishmania parasites against antimony-generated stress","volume":"29","author":"Mathur","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.jprot.2024.105323_bb0425","article-title":"Metabolomics to unveil and understand phenotypic diversity between pathogen populations","volume":"4","author":"t\u2019Kindt","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jprot.2024.105323_bb0430","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/AAC.42.2.352","article-title":"Mechanism of amphotericin B resistance in Leishmania donovani promastigotes","volume":"42","author":"Mbongo","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0435","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/microorganisms9040790","article-title":"Drug-induced lipid remodeling in Leishmania parasites","volume":"9","author":"Gutierrez Guarnizo","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jprot.2024.105323_bb0440","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bse0510015","article-title":"Glucose metabolism in Trypanosoma cruzi","volume":"51","author":"Maugeri","year":"2011","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jprot.2024.105323_bb0445","series-title":"Advances in Microbial Physiology","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0065-2911(05)50005-5","article-title":"Energy metabolism and its compartmentation in Trypanosoma brucei","author":"Van Hellemond","year":"2005"},{"key":"10.1016\/j.jprot.2024.105323_bb0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2006.03.017","article-title":"Energy metabolism of trypanosomatids: adaptation to available carbon sources","volume":"149","author":"Bringaud","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0455","series-title":"Oxidative Stress","first-page":"213","article-title":"Reactive oxygen species, glucose metabolism, and lipid metabolism","author":"Yang","year":"2021"},{"key":"10.1016\/j.jprot.2024.105323_bb0460","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.3390\/ijms24054702","article-title":"Fatty acid composition and metabolism in Leishmania parasite species: potential biomarkers or drug targets for leishmaniasis?","volume":"24","author":"Leroux","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.jprot.2024.105323_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2006.02.008","article-title":"Leishmania amazonensis: metabolic adaptations induced by resistance to an ABC transporter blocker","volume":"114","author":"Machuca","year":"2006","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137976","article-title":"Dissecting Leishmania infantum energy metabolism - a systems perspective","volume":"10","author":"Subramanian","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0475","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11306-022-01880-0","article-title":"Trypanosoma brucei: metabolomics for analysis of cellular metabolism and drug discovery","volume":"18","author":"Fall","year":"2022","journal-title":"Metabolomics"},{"key":"10.1016\/j.jprot.2024.105323_bb0480","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1128\/AAC.02813-15","article-title":"The LABCG2 transporter from the protozoan parasite Leishmania is involved in antimony resistance","volume":"60","author":"Perea","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0485","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1128\/AAC.00211-13","article-title":"A new ABC half-transporter in Leishmania major is involved in resistance to antimony","volume":"57","author":"Manzano","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jprot.2024.105323_bb0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079042","article-title":"Identification of ABC transporter genes of fusarium graminearum with roles in azole tolerance and\/or virulence","volume":"8","author":"Abou Ammar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2024.105323_bb0495","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s00253-013-5425-5","article-title":"ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility","volume":"98","author":"Ren","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jprot.2024.105323_bb0500","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/cells10051063","article-title":"Metabolite biomarkers of Leishmania antimony resistance","volume":"10","author":"Gutierrez Guarnizo","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jprot.2024.105323_bb0505","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jb\/mvad082","article-title":"Access and utilization of host-derived iron by Leishmania parasites","volume":"175","author":"Goto","year":"2024","journal-title":"J. Biochem."},{"key":"10.1016\/j.jprot.2024.105323_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2020.107964","article-title":"Assessing the composition of the plasma membrane of Leishmania (Leishmania) infantum and L. (L.) amazonensis using label-free proteomics","volume":"218","author":"Oliveira","year":"2020","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0515","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.molbiopara.2009.05.005","article-title":"The role of ATP-binding cassette (ABC) proteins in protozoan parasites","volume":"167","author":"Sauvage","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jprot.2024.105323_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgar.2019.01.023","article-title":"Drug resistance in protozoan parasites: an incessant wrestle for survival","volume":"18","author":"Pramanik","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.jprot.2024.105323_bb0525","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0924-8579(03)00210-3","article-title":"ABC transporters and drug resistance in parasitic protozoa","volume":"22","author":"Klokouzas","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jprot.2024.105323_bb0530","doi-asserted-by":"crossref","first-page":"11547","DOI":"10.1074\/jbc.M116.774067","article-title":"Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis","volume":"292","author":"Agrawal","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2024.105323_bb0535","series-title":"International Review of Cytology","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0074-7696(06)55005-3","article-title":"Growth and division of peroxisomes","author":"Schrader","year":"2006"},{"key":"10.1016\/j.jprot.2024.105323_bb0540","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev-biochem-081111-125123","article-title":"Peroxisome formation and maintenance are dependent on the endoplasmic reticulum","volume":"82","author":"Tabak","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jprot.2024.105323_bb0545","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.703603","article-title":"A small molecule inhibitor of Pex3\u2013Pex19 interaction disrupts glycosome biogenesis and causes lethality in Trypanosoma brucei","volume":"9","author":"Banerjee","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jprot.2024.105323_bb0550","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.737159","article-title":"Novel trypanocidal inhibitors that block glycosome biogenesis by targeting PEX3\u2013PEX19 interaction","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924002550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391924002550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T23:11:55Z","timestamp":1729811515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391924002550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":110,"alternative-id":["S1874391924002550"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105323","relation":{},"ISSN":["1874-3919"],"issn-type":[{"type":"print","value":"1874-3919"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing Leishmania infantum-induced resistance to trivalent stibogluconate (SbIII) through deep proteomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2024.105323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105323"}}