{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:20:56Z","timestamp":1792815656492,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"am","delay-in-days":307,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23K07915"],"award-info":[{"award-number":["JP 23K07915"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jprot.2025.105412","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T12:03:44Z","timestamp":1740225824000},"page":"105412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Aberrant oxidative modifications of neutrophil myeloperoxidase in anti-neutrophil cytoplasmic antibody-associated vasculitis"],"prefix":"10.1016","volume":"315","author":[{"given":"Masaaki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Shibano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Shibahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Satokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teisuke","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Tsutiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Takakuwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Omoteyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumi","family":"Arito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Suematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seido","family":"Ooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimito","family":"Kawahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manae S.","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2025.105412_bb0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.ajkd.2019.04.031","article-title":"ANCA-associated vasculitis: Core curriculum 2020","volume":"75","author":"Geetha","year":"2020","journal-title":"Am. J. Kidney Dis."},{"issue":"sup1","key":"10.1016\/j.jprot.2025.105412_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00325481.2022.2102368","article-title":"ANCA associated vasculitis (AAV): a review for internists","volume":"135","author":"Yaseen","year":"2023","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.jprot.2025.105412_bb0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-020-0204-y","article-title":"ANCA-associated vasculitis","volume":"6","author":"Kitching","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jprot.2025.105412_bb0020","first-page":"413","article-title":"Pathogenesis of ANCA-associated pulmonary Vasculitis, Semin. Respir","volume":"39","author":"Alba","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jprot.2025.105412_bb0025","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10067-018-4062-x","article-title":"Anti-neutrophil cytoplasmic antibodies and their clinical significance","volume":"37","author":"Suwanchote","year":"2018","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jprot.2025.105412_bb0030","article-title":"Clinical significance of MPO-ANCA in eosinophilic granulomatosis with polyangiitis: experience from a longitudinal Chinese cohort","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0035","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1182\/blood.V96.8.2822","article-title":"Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils","volume":"96","author":"Hess","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jprot.2025.105412_bb0040","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1073\/pnas.87.11.4115","article-title":"Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro","volume":"87","author":"Falk","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2025.105412_bb0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1365-2249.1996.d01-835.x","article-title":"IL-1\u03b2 production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: relevance to systemic vasculitis","volume":"106","author":"Brooks","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0050","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1046\/j.1523-1755.1999.055003852.x","article-title":"Interleukin-8: a pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis","volume":"55","author":"Cockwell","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.jprot.2025.105412_bb0055","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ki.1992.52","article-title":"Anti-myeloperoxidase antibodies stimulate neutrophils to damage human endothelial cells","volume":"41","author":"Ewert","year":"1992","journal-title":"Kidney Int."},{"key":"10.1016\/j.jprot.2025.105412_bb0060","first-page":"335","article-title":"Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells","volume":"141","author":"Savage","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jprot.2025.105412_bb0065","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI0215918","article-title":"Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice","volume":"110","author":"Xiao","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2025.105412_bb0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2025.105412_bb0075","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/BOR.0000000000000452","article-title":"Rheumatoid arthritis and citrullination","volume":"30","author":"Darrah","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jprot.2025.105412_bb0080","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41467-023-36620-y","article-title":"Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis","volume":"14","author":"Curran","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2025.105412_bb0085","doi-asserted-by":"crossref","first-page":"20027","DOI":"10.1074\/jbc.M904549199","article-title":"Reactive oxygen species expose cryptic epitopes associated with autoimmune Goodpasture syndrome","volume":"275","author":"Kalluri","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2025.105412_bb0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.clim.2005.03.005","article-title":"Role of intramolecular epitope spreading in pemphigus vulgaris","volume":"116","author":"Salato","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.imlet.2014.11.001","article-title":"B cell epitope spreading: mechanisms and contribution to autoimmune diseases","volume":"163","author":"Cornaby","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jprot.2025.105412_bb0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clim.2005.07.002","article-title":"Epitope spreading within lupus-associated ribonucleoprotein antigens","volume":"117","author":"Deshmukh","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-3083.2001.00942.x","article-title":"Key sequences involved in the spreading of the systemic autoimmune response to spliceosomal proteins","volume":"54","author":"Monneaux","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2230.2001.00852.x","article-title":"Epitope spreading: protection from pathogens, but propagation of autoimmunity?","volume":"26","author":"Powell","year":"2001","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.jprot.2025.105412_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pmic.201600278","article-title":"SWATH-MS as a tool for biomarker discovery: from basic research to clinical applications","volume":"17","author":"Anjo","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2025.105412_bb0120","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.bbapap.2010.07.001","article-title":"The glycosylation of myeloperoxidase","volume":"1804","author":"Ravnsborg","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2025.105412_bb0125","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.016342","article-title":"Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase","volume":"296","author":"Tjondro","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2025.105412_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised international Chapel Hill consensus conference nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jprot.2025.105412_bb0135","first-page":"768","article-title":"Increased expression of S100 calcium binding protein A8 in GM-CSF-stimulated neutrophils leads to the increased expressions of IL-8 and IL-6","volume":"29","author":"Katano","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jprot.2025.105412_bb0140","first-page":"133","article-title":"Purification of human myeloperoxidase by concanavalin A-sepharose affinity chromatography","volume":"10","author":"Merrill","year":"1980","journal-title":"Prep. Biochem."},{"key":"10.1016\/j.jprot.2025.105412_bb0145","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1038\/s41598-019-40546-1","article-title":"Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging","volume":"9","author":"Yamagata","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2025.105412_bb0150","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/nmeth.2702","article-title":"Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition","volume":"10","author":"Lambert","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2025.105412_bb0155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/glycob\/cwz080","article-title":"GlyGen: computational and informatics resources for Glycoscience","volume":"30","author":"York","year":"2020","journal-title":"Glycobiology"},{"key":"10.1016\/j.jprot.2025.105412_bb0160","doi-asserted-by":"crossref","first-page":"D512","DOI":"10.1093\/nar\/gku1267","article-title":"2014: mutations, PTMs and recalibrations","volume":"43","author":"Hornbeck","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2025.105412_bb0165","doi-asserted-by":"crossref","first-page":"20233","DOI":"10.1074\/jbc.RA119.011098","article-title":"Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation","volume":"294","author":"Reiding","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2025.105412_bb0170","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.redox.2014.05.004","article-title":"Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases","volume":"2","author":"Ryan","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.jprot.2025.105412_bb0175","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ni.3731","article-title":"The multiple pathways to autoimmunity","volume":"18","author":"Theofilopoulos","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jprot.2025.105412_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/imr.13070","article-title":"Role of inhibitory signaling in peripheral B cell tolerance","volume":"307","author":"Getahun","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jprot.2025.105412_bb0185","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/pmic.201200452","article-title":"Protein carbamylation: in vivo modification or in vitro artefact?","volume":"13","author":"Kollipara","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.jprot.2025.105412_bb0190","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391925000399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391925000399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T20:41:24Z","timestamp":1742244084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391925000399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":38,"alternative-id":["S1874391925000399"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2025.105412","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant oxidative modifications of neutrophil myeloperoxidase in anti-neutrophil cytoplasmic antibody-associated vasculitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2025.105412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105412"}}