{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:15:32Z","timestamp":1791828932051,"version":"4.3.4"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["752614"],"award-info":[{"award-number":["752614"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["703715"],"award-info":[{"award-number":["703715"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["2019_116337"],"award-info":[{"award-number":["2019_116337"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009091","name":"Justus Liebig Universit\u00e4t Gie\u00dfen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jprot.2026.105661","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:44:34Z","timestamp":1776815074000},"page":"105661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The proteomics analysis of mitochondria-enriched fractions reveals alteration of key mitochondrial pathways in breast cancer cell lines"],"prefix":"10.1016","volume":"328","author":[{"given":"Hersson David","family":"V\u00e1zquez-Narv\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Labra-Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"R\u00edos-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Casta\u00f1\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Uribe-Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Le\u00f3n-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"P\u00e9rez-Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Beatriz","family":"\u00c1ngeles-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Luna-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2026.105661_bb0005","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ccr.2013.09.007","article-title":"Origins of metastatic traits","volume":"24","author":"Vanharanta","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0010","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1172\/JCI60534","article-title":"Heterogeneity in breast cancer, J","volume":"121","author":"Polyak","year":"2011","journal-title":"Clin. Invest."},{"key":"10.1016\/j.jprot.2026.105661_bb0015","unstructured":"Ferlay, J.; Ervik, M.; Lam, F.; Laversanne, M.; Colombet, M.; Mery, L.; Pi\u00f1eros, M.; Znaor, A.; Soerjomataram, I.; Bray, F. Global Cancer Observatory: Cancer Today. Lyon, France, International Agency for Research on Cancer. https:\/\/gco.iarc.who.int\/today\/en."},{"key":"10.1016\/j.jprot.2026.105661_bb0020","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0025","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/EBC20190041","article-title":"Metabolism","volume":"64","author":"Judge","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jprot.2026.105661_bb0030","doi-asserted-by":"crossref","first-page":"897","DOI":"10.7150\/ijbs.81609","article-title":"An Overview: The Diversified Role of Mitochondria in Cancer Metabolism","volume":"19","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jprot.2026.105661_bb0035","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1073\/pnas.0306948101","article-title":"Mitochondrial localization of estrogen receptor beta","volume":"101","author":"Yang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2026.105661_bb0040","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbamcr.2005.05.010","article-title":"Differential subcellular distribution of estrogen receptor isoforms: localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines","volume":"1745","author":"Solakidi","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2026.105661_bb0045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10863-017-9704-1","article-title":"Estrogens regulate life and death in mitochondria","volume":"49","author":"Klinge","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.jprot.2026.105661_bb0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0005-2787(70)90014-6","article-title":"A comparative study of RNA synthesis in rat hepatic nuclei and mitochondria under the influence of cortisone","volume":"213","author":"Vander Heiden","year":"1970","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2026.105661_bb0055","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2018.07.014","article-title":"Mitochondria in innate immune signaling","volume":"202","author":"Banoth","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.jprot.2026.105661_bb0060","doi-asserted-by":"crossref","first-page":"e7997","DOI":"10.1073\/pnas.1705768114","article-title":"Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release","volume":"114","author":"Suofu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2026.105661_bb0065","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jprot.2026.105661_bb0070","first-page":"548","article-title":"mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer","volume":"29","author":"Pusapati","year":"2016","journal-title":"Cells"},{"key":"10.1016\/j.jprot.2026.105661_bb0075","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jcb.20985","article-title":"Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors","volume":"99","author":"Belous","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jprot.2026.105661_bb0080","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1073\/pnas.1101507108","article-title":"Identification and characterization of a functional mitochondrial angiotensin system","volume":"108","author":"Abadir","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2026.105661_bb0085","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nn.3053","article-title":"Mitochondrial CB\u2081 receptors regulate neuronal energy metabolism","volume":"15","author":"B\u00e9nard","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jprot.2026.105661_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mito.2016.07.003","article-title":"The rise of mitochondria in medicine","volume":"30","author":"Picard","year":"2016","journal-title":"Mitochondrion"},{"issue":"11","key":"10.1016\/j.jprot.2026.105661_bb0095","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.cmet.2022.10.008","article-title":"Mitochondrial signal transduction","volume":"34","author":"Picard","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2026.105661_bb0100","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.cmet.2021.11.001","article-title":"Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context","volume":"33","author":"Morgenstern","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2026.105661_bb0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jprot.2015.04.018","article-title":"Determination of the protein expression profiles of breast cancer cell lines by quantitative proteomics using iTRAQ labelling and tandem mass spectrometry","volume":"124","author":"Calder\u00f3n-Gonz\u00e1lez","year":"2015","journal-title":"J. Proteome"},{"key":"10.1016\/j.jprot.2026.105661_bb0110","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","article-title":"A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes","volume":"10","author":"Neve","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006146","article-title":"Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery","volume":"4","author":"Kao","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2026.105661_bb0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10549-009-0460-8","article-title":"Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines","volume":"121","author":"Hollestelle","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jprot.2026.105661_bb0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cmet.2016.09.002","article-title":"The Assembly Pathway of Mitochondrial Respiratory Chain Complex I","volume":"25","author":"Guerrero-Castillo","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2026.105661_bb0130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-4939-3040-1_6","article-title":"Scalable Isolation of Mammalian Mitochondria for Nucleic Acid and Nucleoid Analysis","volume":"1351","author":"Lee","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0135","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/nprot.2009.151","article-title":"Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells","volume":"4","author":"Wieckowski","year":"2009","journal-title":"Nat. Protoc. B"},{"key":"10.1016\/j.jprot.2026.105661_bb0140","article-title":"One-dimensional SDS gel electrophoresis of proteins","volume":"Chapter 10","author":"Gallagher","year":"2012","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0145","first-page":"35","article-title":"Gradient SDS polyacrylamide gel electrophoresis of proteins","volume":"32","author":"Walker","year":"1994","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0150","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1021\/jasms.0c00134","article-title":"Quantitative Proteomic Analysis of MARC-145 Cells Infected with a Mexican Porcine Reproductive and Respiratory Syndrome Virus Strain Using a Label-Free Based DIA approach","volume":"31","author":"Rios-Castro","year":"2020","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jprot.2026.105661_bb0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nmeth.2767","article-title":"Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics","volume":"11","author":"Distler","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2026.105661_bb0160","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nprot.2016.042","article-title":"Label-free quantification in ion mobility-enhanced data-independent acquisition proteomics","volume":"11","author":"Distler","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jprot.2026.105661_bb0165","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2026.105661_bb0170","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2026.105661_bb0175","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.4161\/cc.10.15.16585","article-title":"Cancer cells metabolically \u201cfertilize\u201d the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors","volume":"10","author":"Martinez-Outschoorn","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jprot.2026.105661_bb0180","doi-asserted-by":"crossref","first-page":"30472","DOI":"10.18632\/oncotarget.5401","article-title":"High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant","volume":"6","author":"Farnie","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jprot.2026.105661_bb0185","doi-asserted-by":"crossref","first-page":"30453","DOI":"10.18632\/oncotarget.5852","article-title":"Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: understanding WNT\/FGF-driven anabolic signaling","volume":"6","author":"Lamb","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jprot.2026.105661_bb0190","series-title":"Detection of mitochondrial mass, damage, and reactive oxygen species by flow cytometry","author":"Puleston","year":"2015"},{"key":"10.1016\/j.jprot.2026.105661_bb0195","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.jprot.2026.105661_bb0200","doi-asserted-by":"crossref","unstructured":"Perez-Riverol, Y., Bandla, C., Kundu, D. J., Kamatchinathan, S., Bai, J., Hewapathirana, S., John, N. S., Prakash, A., Walzer, M., Wang, S., Vizca\u00edno, J. A. The PRIDE database at 20 years: 2025 update. Nucleic Acids Res. 53(2025) D1, D543-D553. doi:10.1093\/nar\/gkae1011.","DOI":"10.1093\/nar\/gkae1011"},{"key":"10.1016\/j.jprot.2026.105661_bb0205","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac1040","article-title":"The ProteomeXchange Consortium at 10 years: 2023 update","volume":"51","author":"Deutsch","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"2016","key":"10.1016\/j.jprot.2026.105661_bb0210","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/mcp.O115.050229","article-title":"PRIDE Inspector Toolsuite: moving towards a universal visualization tool for proteomics data standard formats and quality assessment of ProteomeXchange datasets","volume":"15","author":"Perez-Riverol","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jprot.2026.105661_bb0215","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/onc.2015.86","article-title":"Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein","volume":"35","author":"Teng","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.jprot.2026.105661_bb0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ceca.2014.12.007","article-title":"A crosstalk between Na+ channels, Na+\/K+ pump and mitochondrial Na+ transporters controls glucose-dependent cytosolic and mitochondrial Na+ signals","volume":"57","author":"Nita","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jprot.2026.105661_bb0225","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2018.06.010","article-title":"LRRK2 and mitochondria: Recent advances and current views","volume":"1702","author":"Singh","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.jprot.2026.105661_bb0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12964-024-01997-w","article-title":"Loss of LRRK2 activity induces cytoskeleton defects and oxidative stress during porcine oocyte maturation","volume":"23","author":"Wei","year":"2025","journal-title":"Cell Commun.Signal."},{"key":"10.1016\/j.jprot.2026.105661_bb0235","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jprot.2026.105661_bb0240","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1158\/1055-9965.EPI-13-0472","article-title":"Parkinson's disease genes do not segregate with breast cancer genes' loci","volume":"22","author":"Kravitz","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jprot.2026.105661_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102860","article-title":"LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity","volume":"66","author":"Zhang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0250","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jprot.2026.105661_bb0255","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jprot.2026.105661_bb0260","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jprot.2026.105661_bb0265","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1242\/jcs.02745","article-title":"The axonal transport of mitochondria","volume":"118","author":"Hollenbeck","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jprot.2026.105661_bb0270","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jprot.2026.105661_bb0275","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s42003-022-03377-x","article-title":"The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes","volume":"5","author":"Huo","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0280","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1038\/s41467-019-11327-1","article-title":"Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis","volume":"10","author":"Chung","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2026.105661_bb0285","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrm2959","article-title":"Mitochondrial protein import: from proteomics to functional mechanisms","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0290","doi-asserted-by":"crossref","first-page":"27199","DOI":"10.18632\/oncotarget.4508","article-title":"The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jprot.2026.105661_bb0295","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1126863","article-title":"p53 regulates mitochondrial respiration","volume":"312","author":"Matoba","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jprot.2026.105661_bb0300","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/gad.1756509","article-title":"Tumor suppressors and cell metabolism: a recipe for cancer growth","volume":"23","author":"Jones","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.jprot.2026.105661_bb0305","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/2211-5463.13398","article-title":"Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells","volume":"12","author":"Uchenunu","year":"2022","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.jprot.2026.105661_bb0310","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.humpath.2017.12.029","article-title":"High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma","volume":"77","author":"Liu","year":"2018","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.jprot.2026.105661_bb0315","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.3390\/cimb45100536","article-title":"Validation of a Novel Cuproptosis-Related Prognostic Gene Marker and Differential Expression Associated with Lung Adenocarcinoma","volume":"45","author":"Liu","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0320","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/3804","article-title":"SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome","volume":"20","author":"Zhu","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jprot.2026.105661_bb0325","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.cell.2012.11.053","article-title":"MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation","volume":"151","author":"Mick","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0330","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.7150\/jca.94142","article-title":"Mendelian randomization combined with multi-omics explores the relationship between heart failure and cancer","volume":"15","author":"Sun","year":"2024","journal-title":"J. Cancer"},{"key":"10.1016\/j.jprot.2026.105661_bb0335","doi-asserted-by":"crossref","first-page":"7462","DOI":"10.1074\/jbc.M309232200","article-title":"Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1","volume":"279","author":"Williams","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2026.105661_bb0340","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/onc.2010.193","article-title":"Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression","volume":"29","author":"Chen","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jprot.2026.105661_bb0345","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.18632\/aging.205892","article-title":"A novel mitochondrial metabolism-related gene signature for predicting the prognosis of oesophageal squamous cell carcinoma","volume":"16","author":"Lin","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jprot.2026.105661_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109209","article-title":"Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion","volume":"35","author":"Mah-Som","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jprot.2026.105661_bb0355","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2026.105661_bb0360","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.omto.2021.09.002","article-title":"Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq","volume":"23","author":"Vishnubalaji","year":"2021","journal-title":"Mol. Ther. Oncolytics."},{"key":"10.1016\/j.jprot.2026.105661_bb0365","doi-asserted-by":"crossref","first-page":"145697","DOI":"10.1016\/j.gene.2021.145697","article-title":"Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes","volume":"790","author":"Oviya","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.jprot.2026.105661_bb0370","doi-asserted-by":"crossref","first-page":"10658","DOI":"10.1038\/s41598-022-14724-7","article-title":"Expression and prognosis analysis of mitochondrial ribosomal protein family in breast cancer","volume":"12","author":"Lin","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2026.105661_bb0375","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/hmg\/ddz093","article-title":"MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy","volume":"28","author":"Bugiardini","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jprot.2026.105661_bb0380","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s12276-022-00894-x","article-title":"Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids","volume":"54","author":"Lee","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jprot.2026.105661_bb0385","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2026.105661_bb0390","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.freeradbiomed.2017.04.018","article-title":"PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway","volume":"108","author":"Hocsak","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jprot.2026.105661_bb0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007065","article-title":"PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance","volume":"14","author":"Wen","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jprot.2026.105661_bb0400","doi-asserted-by":"crossref","first-page":"13161","DOI":"10.1093\/nar\/gku1089","article-title":"Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function","volume":"42","author":"Szczesny","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2026.105661_bb0405","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.4161\/cc.22777","article-title":"Mitochondria \u201cfuel\u201d breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells","volume":"11","author":"Sotgia","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jprot.2026.105661_bb0410","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jfma.2016.08.007","article-title":"High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer","volume":"116","author":"Lin","year":"2017","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.jprot.2026.105661_bb0415","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17463","article-title":"Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability","volume":"5","author":"Kang","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jprot.2026.105661_bb0420","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1002\/1873-3468.12450","article-title":"TIM29 is a subunit of the human carrier translocase required for protein transport","volume":"590","author":"Callegari","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jprot.2026.105661_bb0425","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial proteins: from biogenesis to functional networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0430","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s13277-015-3878-0","article-title":"Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer","volume":"37","author":"Gao","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0435","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/cge.12855","article-title":"Mitochondrial epileptic encephalopathy, 3-methylglutaconic aciduria and variable complex V deficiency associated with TIMM50 mutations","volume":"91","author":"Shahrour","year":"2017","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jprot.2026.105661_bb0440","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2026.105661_bb0445","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1023\/A:1027391831382","article-title":"Contribution of the phosphorylable complex I in the growth phase-dependent respiration of C6 glioma cells in vitro","volume":"35","author":"Pasdois","year":"2003","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.jprot.2026.105661_bb0450","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ymthe.2021.08.032","article-title":"Downregulation of a mitochondrial micropeptide, MPM, promotes hepatoma metastasis by enhancing mitochondrial complex I activity","volume":"30","author":"Xiao","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jprot.2026.105661_bb0455","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbrc.2003.11.136","article-title":"Cancer metabolism: facts, fantasy, and fiction","volume":"313","author":"Zu","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jprot.2026.105661_bb0460","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1074\/jbc.RA118.006727","article-title":"Mitochondrial localization, import, and mitochondrial function of the androgen receptor","volume":"294","author":"Bajpai","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2026.105661_bb0465","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0005-2787(70)90014-6","article-title":"A comparative study of RNA synthesis in rat hepatic nuclei and mitochondria under the influence of cortisone","volume":"213","author":"Yu","year":"1970","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2026.105661_bb0470","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1021\/acschemneuro.7b00516","article-title":"Intracellular GPCRs Play Key Roles in Synaptic Plasticity","volume":"9","author":"Jong","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jprot.2026.105661_bb0475","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.devcel.2014.03.012","article-title":"Cyclin B1\/Cdk1 coordinates mitochondrial respiration for cell-cycle G2\/M progression","volume":"29","author":"Wang","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0480","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jprot.2026.105661_bb0485","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.neo.7900213","article-title":"Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1","volume":"3","author":"Pathan","year":"2001","journal-title":"Neoplasia"},{"key":"10.1016\/j.jprot.2026.105661_bb0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012341","article-title":"Cyclin B1\/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response","volume":"5","author":"Nantajit","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2026.105661_bb0495","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S1097-2765(02)00524-5","article-title":"Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery","volume":"9","author":"Konishi","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jprot.2026.105661_bb0500","doi-asserted-by":"crossref","DOI":"10.1126\/science.1261253","article-title":"Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase","volume":"346","author":"Harbauer","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jprot.2026.105661_bb0505","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/jmcb\/mjs062","article-title":"CyclinB1\/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress","volume":"5","author":"Candas","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.jprot.2026.105661_bb0510","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.jprot.2026.105661_bb0515","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of cancer metabolism","volume":"2","author":"DeBerardinis","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jprot.2026.105661_bb0520","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.630109","article-title":"A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets","volume":"12","author":"Kaur","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.jprot.2026.105661_bb0525","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jimd.12410","article-title":"3-Hydroxyisobutyrate dehydrogenase (HIBADH) deficiency-A novel disorder of valine metabolism","volume":"44","author":"Meyer","year":"2021","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jprot.2026.105661_bb0530","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13036-024-00449-w","article-title":"Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation","volume":"18","author":"Daga","year":"2024","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.jprot.2026.105661_bb0535","article-title":"Cancer Metastasis Prediction and Genomic Biomarker Identification through Machine Learning and eXplainable Artificial Intelligence in Breast Cancer Research","volume":"13","author":"Yagin","year":"2023","journal-title":"Diagnostics. (Basel)"},{"key":"10.1016\/j.jprot.2026.105661_bb0540","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.freeradbiomed.2011.11.033","article-title":"Aldehyde dehydrogenases and cell proliferation","volume":"52","author":"Muzio","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jprot.2026.105661_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110320","article-title":"Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions","volume":"38","author":"Westbrook","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jprot.2026.105661_bb0550","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/carcin\/bgx022","article-title":"Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers","volume":"38","author":"Ding","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jprot.2026.105661_bb0555","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jprot.2016.03.022","article-title":"Identification of proteins that are differentially expressed in brains with Alzheimer\u2019s disease using iTRAQ labeling and tandem mass spectrometry","volume":"139","author":"Minjarez","year":"2016","journal-title":"J. Proteome"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926000643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926000643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:21:13Z","timestamp":1783149673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391926000643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":111,"alternative-id":["S1874391926000643"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105661","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The proteomics analysis of mitochondria-enriched fractions reveals alteration of key mitochondrial pathways in breast cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105661"}}