{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:49:30Z","timestamp":1785908970869,"version":"3.56.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011654","name":"Instituto Ant\u00e1rtico Uruguayo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020473","name":"Badan Riset dan Inovasi Nasional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024018","name":"Programme for the Development of Basic Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013395","name":"Sistema Nacional de Investigadores","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006049","name":"University of the Republic Sectoral Commission for Scientific Research","doi-asserted-by":"publisher","award":["24920250100043UD"],"award-info":[{"award-number":["24920250100043UD"]}],"id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jprot.2026.105697","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:30:38Z","timestamp":1781224238000},"page":"105697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Violacein as a multitarget agent in bladder cancer cells"],"prefix":"10.1016","volume":"330","author":[{"given":"Juan F.","family":"Idiarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Canclini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Alem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar X.","family":"Garc\u00eda-Lavi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Castro-Sowinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2026.105697_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11274-021-03120-4","article-title":"Multi-target drug with potential applications: violacein in the spotlight","volume":"37","author":"Dur\u00e1n","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jprot.2026.105697_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fnano.2023.1186386","article-title":"Potential biocide roles of violacein","volume":"5","author":"Rivero Berti","year":"2023","journal-title":"Front. Nanotechnol."},{"key":"10.1016\/j.jprot.2026.105697_bb0015","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s00044-011-9654-9","article-title":"Potential applications of violacein: a microbial pigment","volume":"21","author":"Dur\u00e1n","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jprot.2026.105697_bb0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0300-483X(02)00751-5","article-title":"Violacein and its \u03b2-cyclodextrin complexes induce apoptosis and differentiation in HL60 cells","volume":"186","author":"Melo","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.jprot.2026.105697_bb0025","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.tiv.2006.06.007","article-title":"Cytotoxic activity of violacein in human colon cancer cells","volume":"20","author":"de Carvalho","year":"2006","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jprot.2026.105697_bb0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2010.04.016","article-title":"Growth inhibition and pro-apoptotic activity of violacein in Ehrlich ascites tumor","volume":"186","author":"Bromberg","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jprot.2026.105697_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.etp.2015.10.002","article-title":"Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2","volume":"68","author":"Alshatwi","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jprot.2026.105697_bb0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s11274-020-02893-4","article-title":"Production and antiproliferative effect of violacein, a purple pigment produced by an Antarctic bacterial isolate","volume":"36","author":"Alem","year":"2020","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jprot.2026.105697_bb0045","doi-asserted-by":"crossref","DOI":"10.21608\/jcbr.2021.46268.1079","article-title":"Evaluation of the anticancer effect of violacein, phycocyanin and phycocyanobilin on apoptotic genes expression and glycan profiles in breast cancer cells","volume":"0","author":"Hussein","year":"2021","journal-title":"Int. J. Cancer Biomed. Res."},{"key":"10.1016\/j.jprot.2026.105697_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccmp.2022.100036","article-title":"Chemosensitizer effect of violacein on cisplatin-treated bladder cancer cells","volume":"2","author":"Alem","year":"2022","journal-title":"Clin. Complement. Med. & Pharmacol."},{"key":"10.1016\/j.jprot.2026.105697_bb0055","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jcb.30295","article-title":"Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition","volume":"123","author":"de Souza Oliveira","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jprot.2026.105697_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125409","article-title":"Violacein treatment modulates acute and chronic inflammation through the suppression of cytokine production and induction of regulatory T cells","volume":"10","author":"Verinaud","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2026.105697_bb0065","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1038\/s41598-019-50038-x","article-title":"The bacterial product violacein exerts an immunostimulatory effect via TLR8","volume":"9","author":"Venegas","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2026.105697_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/616432","article-title":"Gastroprotective activity of violacein isolated from Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: investigation of potential mechanisms of action","volume":"2014","author":"Antonisamy","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.jprot.2026.105697_bb0075","article-title":"The natural pigment violacein potentially suppresses the proliferation and stemness of hepatocellular carcinoma cells in vitro","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jprot.2026.105697_bb0080","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1182\/blood-2004-02-0594","article-title":"Molecular mechanism of violacein-mediated human leukemia cell death","volume":"104","author":"Ferreira","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jprot.2026.105697_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045362","article-title":"Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse","volume":"7","author":"Queiroz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2026.105697_bb0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3892\/ol.2022.13252","article-title":"Evaluation of the anti-proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines","volume":"23","author":"Neroni","year":"2022","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jprot.2026.105697_bb0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbrc.2014.10.124","article-title":"Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: potential anti-tumor effect in cancer invasion and metastasis","volume":"455","author":"Platt","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jprot.2026.105697_bb0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejca.2012.05.005","article-title":"A review on CXCR4\/CXCL12 axis in oncology: no place to hide","volume":"49","author":"Domanska","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jprot.2026.105697_bb0105","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/mmr.2015.3525","article-title":"Violacein induces p44\/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration","volume":"12","author":"Mehta","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jprot.2026.105697_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106000","article-title":"Violacein switches off low molecular weight tyrosine phosphatase and rewires mitochondria in colorectal cancer cells","volume":"127","author":"Faria","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jprot.2026.105697_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of Cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2026.105697_bb0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jprot.2026.105697_bb0125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ijc.2910110327","article-title":"Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen","volume":"11","author":"Buben\u00edk","year":"1973","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jprot.2026.105697_bb0130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jprot.2026.105697_bb0135","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jprot.2026.105697_bb0140","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jprot.2026.105697_bb0145","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1038\/s41598-025-88307-7","article-title":"Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage","volume":"15","author":"Alem","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jprot.2026.105697_bb0150","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/elps.201100335","article-title":"Bleach gel: a simple agarose gel for analyzing RNA quality","volume":"33","author":"Aranda","year":"2012","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jprot.2026.105697_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/jme.0.0290023","article-title":"Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems","volume":"29","author":"Bustin","year":"2002","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.jprot.2026.105697_bb0160","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/B:BILE.0000019559.84305.47","article-title":"Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations","volume":"26","author":"Pfaffl","year":"2004","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jprot.2026.105697_bb0165","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.jprot.2026.105697_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.872223","article-title":"Characterization of anti-Cancer activities of violacein: actions on tumor cells and the tumor microenvironment","volume":"12","author":"Dahlem","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jprot.2026.105697_bb0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BA20070115","article-title":"Violacein: properties and biological activities","volume":"48","author":"Dur\u00e1n","year":"2007","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.jprot.2026.105697_bb0180","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jprot.2026.105697_bb0185","article-title":"Intercellular adhesion molecule-1 (ICAM-1): from molecular functions to clinical applications in cancer investigation, Biochimica et Biophysica acta (BBA) - reviews on","volume":"1879","author":"Qian","year":"2024","journal-title":"Cancer"},{"key":"10.1016\/j.jprot.2026.105697_bb0190","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s13577-024-01053-2","article-title":"The mechanism of the contribution of ICAM-1 to epithelial-mesenchymal transition (EMT) in bladder cancer","volume":"37","author":"Zarzycka","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jprot.2026.105697_bb0195","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.advenzreg.2010.09.005","article-title":"The mechanism of contribution of integrin linked kinase (ILK) to epithelial-mesenchymal transition (EMT)","volume":"51","author":"Gil","year":"2011","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.jprot.2026.105697_bb0200","doi-asserted-by":"crossref","first-page":"15185","DOI":"10.1007\/s13277-016-5354-x","article-title":"Integrin-linked kinase regulates cadherin switch in bladder cancer","volume":"37","author":"Gil","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jprot.2026.105697_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1327478","article-title":"Desmoglein-2 as a cancer modulator: friend or foe?","volume":"13","author":"Myo Min","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jprot.2026.105697_bb0210","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12885-024-12229-2","article-title":"Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer","volume":"24","author":"Han","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jprot.2026.105697_bb0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40709-020-00130-5","article-title":"Cell adhesion molecules\u2019 altered profile in benign and malignant salivary gland tumors. The paradigm of beta4-integrin, desmoglein-2, ICAM-1 and CD44s","volume":"27","author":"Andreadis","year":"2020","journal-title":"J. Biol. Res. (Thessalon)"},{"key":"10.1016\/j.jprot.2026.105697_bb0220","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.eururo.2009.10.029","article-title":"The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder Cancer progression","volume":"57","author":"Catto","year":"2010","journal-title":"Eur. Urol."},{"key":"10.1016\/j.jprot.2026.105697_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/biom11040503","article-title":"Syndecan-4 as a pathogenesis factor and therapeutic target in Cancer","volume":"11","author":"Onyeisi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jprot.2026.105697_bb0230","doi-asserted-by":"crossref","first-page":"C1345","DOI":"10.1152\/ajpcell.00152.2022","article-title":"Role of syndecan-4 in breast cancer pathophysiology","volume":"323","author":"Onyeisi","year":"2022","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.jprot.2026.105697_bb0235","doi-asserted-by":"crossref","first-page":"13826","DOI":"10.1002\/jcb.28656","article-title":"Heparan sulfate proteoglycans as trastuzumab targets in anoikis-resistant endothelial cells","volume":"120","author":"Onyeisi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jprot.2026.105697_bb0240","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.bbagen.2012.07.013","article-title":"Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid","volume":"1820","author":"Dedes","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jprot.2026.105697_bb0245","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s10637-012-9875-x","article-title":"Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab","volume":"31","author":"Gialeli","year":"2013","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.jprot.2026.105697_bb0250","article-title":"The basic characteristics of the pentraxin family and their functions in tumor progression","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jprot.2026.105697_bb0255","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1007\/s10238-023-01137-7","article-title":"Role of long pentraxin PTX3 in cancer","volume":"23","author":"Li","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jprot.2026.105697_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16223754","article-title":"Prognostic value of Pentraxin3 protein expression in human malignancies: a systematic review and Meta-analysis","volume":"16","author":"Jung","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jprot.2026.105697_bb0265","first-page":"649","article-title":"Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways","volume":"28","author":"Hu","year":"2014","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.jprot.2026.105697_bb0270","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.it.2004.06.004","article-title":"uPA and uPAR in fibrinolysis, immunity and pathology","volume":"25","author":"Mondino","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jprot.2026.105697_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12061167","article-title":"Urokinase-type plasminogen activator receptor (uPAR) in inflammation and disease: a unique inflammatory pathway activator","volume":"12","author":"Hamada","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jprot.2026.105697_bb0280","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.juro.2008.08.123","article-title":"Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression","volume":"181","author":"Chen","year":"2009","journal-title":"J. Urol."},{"key":"10.1016\/j.jprot.2026.105697_bb0285","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2174\/1381612033454612","article-title":"Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA\/uPAR interaction and their effects in vitro and in vivo","volume":"9","author":"Reuning","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jprot.2026.105697_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/cells14151131","article-title":"Prosaposin: a multifaceted protein orchestrating biological processes and diseases","volume":"14","author":"Li","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.jprot.2026.105697_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117551","article-title":"Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms","volume":"180","author":"Yan","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jprot.2026.105697_bb0300","doi-asserted-by":"crossref","first-page":"12115","DOI":"10.1073\/pnas.0903120106","article-title":"Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and tsp-1","volume":"106","author":"Kang","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jprot.2026.105697_bb0305","doi-asserted-by":"crossref","first-page":"329ra34","DOI":"10.1126\/scitranslmed.aad5653","article-title":"Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jprot.2026.105697_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107199","article-title":"TNFAIP2 as an emerging therapeutic target in cancer therapy and its underlying mechanisms","volume":"204","author":"Fu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jprot.2026.105697_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071267","article-title":"Anti-proliferative effects of lidocaine as an autophagy inducer in bladder cancer via intravesical instillation: in vitro and xenograft mouse model experiments","volume":"16","author":"Yoo","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jprot.2026.105697_bb0320","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jprot.2026.105697_bb0325","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/15548627.2022.2080382","article-title":"Protective effect of the tunneling nanotube-TNFAIP2\/M-sec system on podocyte autophagy in diabetic nephropathy","volume":"19","author":"Barutta","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jprot.2026.105697_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157971","article-title":"Secretome and tunneling nanotubes: a multilevel network for long range intercellular communication between endothelial cells and distant cells","volume":"22","author":"Charreau","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jprot.2026.105697_bb0335","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/s41374-019-0285-y","article-title":"TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells","volume":"99","author":"Niwa","year":"2019","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jprot.2026.105697_bb0340","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1111\/jcmm.13822","article-title":"The roles of <scp>TNFAIP<\/scp> 2 in cancers and infectious diseases","volume":"22","author":"Jia","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jprot.2026.105697_bb0345","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.3390\/cancers13246330","article-title":"RalGPS2 interacts with Akt and PDK1 promoting tunneling nanotubes formation in bladder cancer and kidney cells microenvironment","volume":"13","author":"D\u2019Aloia","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jprot.2026.105697_bb0350","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cca.2015.05.016","article-title":"Annexin A4 and cancer","volume":"447","author":"Wei","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jprot.2026.105697_bb0355","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3892\/ol.2015.3498","article-title":"Role of annexin A6 in cancer","volume":"10","author":"Qi","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jprot.2026.105697_bb0360","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cca.2014.01.031","article-title":"Annexin A11 in disease","volume":"431","author":"Wang","year":"2014","journal-title":"Clin. Chim. Acta"}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:26:12Z","timestamp":1785907572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391926001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":72,"alternative-id":["S1874391926001004"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105697","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Violacein as a multitarget agent in bladder cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105697"}}