{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:18:41Z","timestamp":1788351521911,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jprot.2026.105724","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:55:35Z","timestamp":1786690535000},"page":"105724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma proteomic profiling characterizes candidate biomarkers of perimesencephalic non-aneurysmal subarachnoid hemorrhage"],"prefix":"10.1016","volume":"331","author":[{"given":"Chenchen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jprot.2026.105724_bb0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/svn-2023-002546","article-title":"Risk stratification of delayed causative aneurysm detection and long-term outcome in angiographically negative spontaneous subarachnoid haemorrhage","volume":"9","author":"Wang","year":"2024","journal-title":"Stroke Vasc Neurol"},{"issue":"4","key":"10.1016\/j.jprot.2026.105724_bb0010","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1212\/WNL.35.4.493","article-title":"Perimesencephalic hemorrhage: a nonaneurysmal and benign form of subarachnoid hemorrhage","volume":"35","author":"van Gijn","year":"1985","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jprot.2026.105724_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070948","article-title":"Exploration of risk factors for poor prognosis of non-traumatic non-aneurysmal subarachnoid hemorrhage","volume":"12","author":"Yuan","year":"2022","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.jprot.2026.105724_bb0020","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1021\/acs.jproteome.5b00391","article-title":"Measuring serum amyloid a for infection prediction in aneurysmal subarachnoid hemorrhage","volume":"14","author":"Azurmendi","year":"2015","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.jprot.2026.105724_bb0025","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s12028-022-01652-7","article-title":"Leucine-rich alpha-2-glycoprotein 1 is a systemic biomarker of early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage","volume":"38","author":"Savarraj","year":"2023","journal-title":"Neurocrit. Care."},{"key":"10.1016\/j.jprot.2026.105724_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2024.105216","article-title":"Plasma proteomics analysis reveals potential biomarkers for intracranial aneurysm formation and rupture","volume":"303","author":"Wang","year":"2024","journal-title":"J. Proteome"},{"issue":"9","key":"10.1016\/j.jprot.2026.105724_bb0035","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1021\/acs.jproteome.4c00104","article-title":"Deep plasma proteomics with data-independent acquisition: clinical study protocol optimization with a COVID-19 cohort","volume":"23","author":"Ward","year":"2024","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.jprot.2026.105724_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/prca.202000099","article-title":"A comparative study of data-dependent acquisition and data-independent acquisition in proteomics analysis of clinical lung cancer tissues constrained by blood contamination","volume":"16","author":"Su","year":"2022","journal-title":"Proteomics Clin. Appl."},{"issue":"2","key":"10.1016\/j.jprot.2026.105724_bb0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.nic.2021.01.001","article-title":"Subarachnoid hemorrhage of unknown cause: distribution and role of imaging","volume":"31","author":"Larson","year":"2021","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.jprot.2026.105724_bb0050","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/j.wneu.2023.11.115","article-title":"Contribution of deep cerebral venous anomaly to the emergence of nonaneurysmal subarachnoid hemorrhage as opposed to aneurysmal subarachnoid hemorrhage","volume":"182","author":"Kanjilal","year":"2024","journal-title":"World Neurosurg."},{"issue":"6","key":"10.1016\/j.jprot.2026.105724_bb0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2176\/nmc.46.277","article-title":"Perimesencephalic nonaneurysmal subarachnoid hemorrhage caused by physical exertion","volume":"46","author":"Matsuyama","year":"2006","journal-title":"Neurol. Med. Chir. (Tokyo)"},{"key":"10.1016\/j.jprot.2026.105724_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fneur.2022.960702","article-title":"Current status of perimesencephalic non-aneurysmal subarachnoid hemorrhage","volume":"13","author":"Hou","year":"2022","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.jprot.2026.105724_bb0065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2176\/nmc.46.277","article-title":"Perimesencephalic nonaneurysmal subarachnoid hemorrhage caused by physical exertion","volume":"46","author":"Matsuyama","year":"2006","journal-title":"Neurol. Med.-Chir."},{"issue":"7","key":"10.1016\/j.jprot.2026.105724_bb0070","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.mayocp.2021.01.005","article-title":"Diagnosis and treatment of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage","volume":"96","author":"Tawk","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jprot.2026.105724_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.960702","article-title":"Current status of perimesencephalic non-aneurysmal subarachnoid hemorrhage","volume":"13","author":"Hou","year":"2022","journal-title":"Front. Neurol."},{"issue":"7203","key":"10.1016\/j.jprot.2026.105724_bb0080","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jprot.2026.105724_bb0085","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1089\/089771501316919139","article-title":"Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury","volume":"18","author":"Stahel","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jprot.2026.105724_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocn.2025.111837","article-title":"Comparative analysis of matrix metalloproteinases and growth factors in aneurysmal and perimesencephalic subarachnoid hemorrhage: evidence for an aneurysm-driven molecular response","volume":"145","author":"Nagybanyai-Nagy","year":"2026","journal-title":"J. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.jprot.2026.105724_bb0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s13105-015-0389-9","article-title":"Orosomucoid, an acute response protein with multiple modulating activities","volume":"71","author":"Luo","year":"2015","journal-title":"J. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.jprot.2026.105724_bb0100","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<257::AID-PATH756>3.0.CO;2-U","article-title":"Cytokines and the hepatic acute phase response","volume":"181","author":"Moshage","year":"1997","journal-title":"J. Pathol."},{"issue":"11","key":"10.1016\/j.jprot.2026.105724_bb0105","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.0b013e3181f2b37f","article-title":"Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling","volume":"75","author":"Barr","year":"2010","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jprot.2026.105724_bb0110","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/STROKEAHA.116.013374","article-title":"Orosomucoid, carotid plaque, and incidence of stroke","volume":"47","author":"Berntsson","year":"2016","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jprot.2026.105724_bb0115","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1002\/jcp.28653","article-title":"Role of acute-phase protein ORM in a mice model of ischemic stroke","volume":"234","author":"Wan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jprot.2026.105724_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107422","article-title":"Orosomucoid 2 is an endogenous regulator of neuronal mitochondrial biogenesis and promotes functional recovery post-stroke","volume":"209","author":"Jing","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"20","key":"10.1016\/j.jprot.2026.105724_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015267","article-title":"Acute phase protein orosomucoid (alpha-1-acid glycoprotein) predicts delayed cerebral ischemia and 3-month unfavorable outcome after aneurysmal subarachnoid hemorrhage","volume":"24","author":"Zavori","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.jprot.2026.105724_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316922","article-title":"The haptoglobin response after aneurysmal subarachnoid haemorrhage","volume":"24","author":"Bandyopadhyay","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 1(Suppl 1)","key":"10.1016\/j.jprot.2026.105724_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/ijlh.13954","article-title":"Diagnosis and treatment of thrombotic microangiopathy","volume":"44","author":"Thompson","year":"2022","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.jprot.2026.105724_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.961534","article-title":"Haptoglobin treatment contributes to regulating nitric oxide signal and reduces oxidative stress in the penis: a preventive treatment for priapism in sickle cell disease","volume":"13","author":"Pereira","year":"2022","journal-title":"Front. Physiol."},{"issue":"35","key":"10.1016\/j.jprot.2026.105724_bb0145","doi-asserted-by":"crossref","first-page":"26825","DOI":"10.1074\/jbc.M110.147058","article-title":"Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells","volume":"285","author":"Habrukowich","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.jprot.2026.105724_bb0150","doi-asserted-by":"crossref","first-page":"20053","DOI":"10.1074\/jbc.274.29.20053","article-title":"Identification of sequences required for inhibition of oncogene-mediated transformation by pp32","volume":"274","author":"Brody","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.jprot.2026.105724_bb0155","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/sj.onc.1204294","article-title":"Tumor suppression and potentiation by manipulation of pp32 expression","volume":"20","author":"Bai","year":"2001","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.jprot.2026.105724_bb0160","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/sj.cdd.4401825","article-title":"Tumor suppressor pp32 represses cell growth through inhibition of transcription by blocking acetylation and phosphorylation of histone H3 and initiating its proapoptotic activity","volume":"13","author":"Fan","year":"2006","journal-title":"Cell Death Differ."},{"issue":"18","key":"10.1016\/j.jprot.2026.105724_bb0165","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1038\/emboj.2013.187","article-title":"PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7","volume":"32","author":"Martin","year":"2013","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.jprot.2026.105724_bb0170","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1074\/jbc.M805801200","article-title":"PHAPI\/pp32 suppresses tumorigenesis by stimulating apoptosis","volume":"284","author":"Pan","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:43:51Z","timestamp":1788349431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391926001272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"alternative-id":["S1874391926001272"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105724","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma proteomic profiling characterizes candidate biomarkers of perimesencephalic non-aneurysmal subarachnoid hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105724"}}