{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:39:42Z","timestamp":1792427982997,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Proteomics"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jprot.2026.105737","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:16:48Z","timestamp":1791415008000},"page":"105737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated analysis identifies dysregulated secretory proteins and crotonylation profiles associated with immune regulation in IgA nephropathy"],"prefix":"10.1016","volume":"332","author":[{"given":"Jiamin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoshuang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donge","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jprot.2026.105737_bb0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00428-022-03373-w","article-title":"Crohn\u2019s disease may promote inflammation in IgA nephropathy: a case-control study of patients undergoing kidney biopsy","volume":"481","author":"Akiyama","year":"2022","journal-title":"Virchows Arch."},{"key":"10.1016\/j.jprot.2026.105737_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41581-024-00885-3","article-title":"The pathogenesis of IgA nephropathy and implications for treatment","volume":"21","author":"Cheung","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0015","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/ijms21041389","article-title":"Immunological pattern in IgA nephropathy","volume":"21","author":"Esteve Cols","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jprot.2026.105737_bb0020","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI20741","article-title":"Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2\/Mac-1 is critical for host inflammatory response in vivo","volume":"113","author":"Flick","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jprot.2026.105737_bb0025","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ckj\/sfad025","article-title":"Immune abnormalities in IgA nephropathy","volume":"16","author":"Gentile","year":"2023","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.jprot.2026.105737_bb0030","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/qjmed\/hcae034","article-title":"Function and mechanism of lysine crotonylation in health and disease","volume":"117","author":"Hou","year":"2024","journal-title":"QJM"},{"key":"10.1016\/j.jprot.2026.105737_bb0035","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jprot.2026.105737_bb0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jprot.2026.105737_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13072-025-00577-7","article-title":"Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets","volume":"18","author":"Ji","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.jprot.2026.105737_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12014-023-09409-w","article-title":"Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis","volume":"20","author":"Kaga","year":"2023","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.jprot.2026.105737_bb0055","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e26","article-title":"Thapsigargin increases IL-2 production in T cells at nanomolar concentrations","volume":"18","author":"Kim","year":"2018","journal-title":"Immune Netw."},{"key":"10.1016\/j.jprot.2026.105737_bb0060","first-page":"1242","article-title":"Quantitative analysis of protein crotonylation identifies its association with immunoglobulin A nephropathy","volume":"21","author":"Lin","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jprot.2026.105737_bb0065","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/bi025770x","article-title":"Interaction of fibrin(ogen) with fibronectin: further characterization and localization of the fibronectin-binding site","volume":"41","author":"Makogonenko","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jprot.2026.105737_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2402226121","article-title":"Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses","volume":"121","author":"Metwally","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jprot.2026.105737_bb0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000362457","article-title":"Endoplasmic reticulum stress induces epithelial-mesenchymal transition through autophagy via activation of c-Src kinase","volume":"126","author":"Moon","year":"2014","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0080","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0272-6386(97)90457-1","article-title":"Glomerulointerstitial interaction of adhesion molecules in IgA nephropathy and membranoproliferative glomerulonephritis","volume":"29","author":"Ootaka","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jprot.2026.105737_bb0085","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3390\/ijms18122711","article-title":"Fibrinogen as a pleiotropic protein causing human diseases: the mutational burden of A\u03b1, B\u03b2, and \u03b3 chains","volume":"18","author":"Paraboschi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jprot.2026.105737_bb0090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12882-019-1598-1","article-title":"Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli","volume":"20","author":"Paunas","year":"2019","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0095","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2215\/CJN.19171220","article-title":"Genetic basis of type IV collagen disorders of the kidney","volume":"16","author":"Quinlan","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"Suppl. 2","key":"10.1016\/j.jprot.2026.105737_bb0100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nep.14339","article-title":"The pathogenesis of IgAN: where is pathogenic IgA produced?","volume":"29","author":"Reich","year":"2024","journal-title":"Nephrol. (carlt. Vic,)"},{"key":"10.1016\/j.jprot.2026.105737_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.110830","article-title":"A mendelian randomization study investigating the causal relationships between inflammation and immunoglobulin a nephropathy","volume":"85","author":"Ren","year":"2024","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jprot.2026.105737_bb0110","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2215\/CJN.07420716","article-title":"IgA nephropathy","volume":"12","author":"Rodrigues","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0115","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/ndt\/gfaa344","article-title":"High levels of gut-homing immunoglobulin A+ B lymphocytes support the pathogenic role of intestinal mucosal hyperresponsiveness in immunoglobulin a nephropathy patients","volume":"36","author":"Sallustio","year":"2021","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jprot.2026.105737_bb0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.semnephrol.2018.05.013","article-title":"Epidemiology of IgA nephropathy: a global perspective","volume":"38","author":"Schena","year":"2018","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248056","article-title":"B cell and monocyte phenotyping: a quick asset to investigate the immune status in patients with IgA nephropathy","volume":"16","author":"Sendic","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jprot.2026.105737_bb0130","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jprot.2026.105737_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2019.103925","article-title":"A proliferation-inducing ligand (APRIL) induced hyper-production of IgA from tonsillar mononuclear cells in patients with IgA nephropathy","volume":"341","author":"Takahara","year":"2019","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jprot.2026.105737_bb0145","first-page":"389","article-title":"Studies on the intraglomerular distribution of fibronectin in IgA nephropathy--in relation to clinical pictures and prognosis","volume":"32","author":"Urae","year":"1990","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"10.1016\/j.jprot.2026.105737_bb0150","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1007\/s11255-024-03989-8","article-title":"The role of PI3K\/akt signaling pathway in chronic kidney disease","volume":"56","author":"Wang","year":"2024","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0155","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jprot.2026.105737_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002933","article-title":"Dual coordination of post translational modifications in human protein networks","volume":"9","author":"Woodsmith","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jprot.2026.105737_bb0165","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s11255-023-03501-8","article-title":"Glomerular deposition of fibrinogen predicts good prognosis of IgA nephropathy: a single-center cohort study","volume":"55","author":"Yang","year":"2023","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.jprot.2026.105737_bb0170","doi-asserted-by":"crossref","first-page":"44905","DOI":"10.1021\/acsomega.3c06293","article-title":"Qualitative proteome-wide lysine crotonylation profiling reveals protein modification alteration in the leukocyte extravasation pathway in systemic lupus erythematosus","volume":"8","author":"Zeng","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.jprot.2026.105737_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13578-021-00706-1","article-title":"Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy","volume":"11","author":"Zeng","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.jprot.2026.105737_bb0180","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00281-021-00884-7","article-title":"Is IgA nephropathy the same disease in different parts of the world?","volume":"43","author":"Zhang","year":"2021","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jprot.2026.105737_bb0185","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jprot.2026.105737_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.885685","article-title":"Involvement of histone lysine crotonylation in the regulation of nerve-injury-induced neuropathic pain","volume":"13","author":"Zou","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874391926001405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:43:28Z","timestamp":1792424608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874391926001405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":37,"alternative-id":["S1874391926001405"],"URL":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105737","relation":{},"ISSN":["1874-3919"],"issn-type":[{"value":"1874-3919","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated analysis identifies dysregulated secretory proteins and crotonylation profiles associated with immune regulation in IgA nephropathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jprot.2026.105737","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105737"}}