{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:01:08Z","timestamp":1786993268387,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.jpsychires.2009.09.006","type":"journal-article","created":{"date-parts":[[2009,10,9]],"date-time":"2009-10-09T06:22:52Z","timestamp":1255069372000},"page":"278-285","source":"Crossref","is-referenced-by-count":35,"title":["Bipolar disorder comorbid with alcoholism: A 1H magnetic resonance spectroscopy study"],"prefix":"10.1016","volume":"44","author":[{"given":"Fabiano G.","family":"Nery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Hsuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Serap Monkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beny","family":"Lafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair C.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2009.09.006_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10673220490910844","article-title":"Neurobiologic processes in drug reward and addiction","volume":"12","author":"Adinoff","year":"2004","journal-title":"Harvard Review of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1176\/appi.ajp.160.10.1892","article-title":"Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects","volume":"160","author":"Adinoff","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/1522-2594(200008)44:2<185::AID-MRM4>3.0.CO;2-V","article-title":"Comparison of the quantification of human short echo time (1)H spectroscopy at 1.5 and 4.0T","volume":"44","author":"Bartha","year":"2000","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/brain\/awl303","article-title":"Manifestations of early brain recovery associated with abstinence from alcoholism","volume":"130","author":"Bartsch","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib5","first-page":"1926","article-title":"Sequential MR imaging and proton MR spectroscopy in patients who underwent recent detoxification for chronic alcoholism:correlation with clinical and neuropsychological data","volume":"22","author":"Bendszus","year":"2001","journal-title":"AJNR American Journal of Neuroradiology"},{"issue":"61","key":"10.1016\/j.jpsychires.2009.09.006_bib6","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.biopsych.2006.08.048","article-title":"Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects","volume":"15","author":"Bhagwagar","year":"2007","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neuroimage.2005.02.012","article-title":"Neural substrates of faulty decision-making in abstinent marijuana users","volume":"26","author":"Bolla","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0006-3223(02)01744-4","article-title":"Decreased N-acetylaspartate in children with familial bipolar disorder","volume":"53","author":"Chang","year":"2003","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","article-title":"Brain metabolic alterations in medication-free patients with bipolar disorder","volume":"61","author":"Dager","year":"2004","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/mrm.1910150212","article-title":"Improved quantification of in vivo 1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into the spectral fitting","volume":"15","author":"de Graaf","year":"1990","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib11","series-title":"Neuropsychiatry","first-page":"328","article-title":"Executive functions and frontal systems","author":"D\u2019Esposito","year":"2003"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib12","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1097\/01.ALC.0000148112.92525.AC","article-title":"Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study","volume":"28","author":"Durazzo","year":"2004","journal-title":"Alcoholism Clinical and Experimental Research"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib13","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.biopsych.2005.05.038","article-title":"Monitoring the effects of chronic alcohol consumption and abstinence on brain metabolism: a longitudinal proton magnetic resonance spectroscopy study","volume":"58","author":"Ende","year":"2005","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0301-0082(90)90013-7","article-title":"Metabolism and role of glutamate in mammalian brain","volume":"35","author":"Erecinska","year":"1990","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib15","series-title":"Structured clinical interview for DSM-IV axis disorders","author":"First","year":"1995"},{"issue":"Suppl. 1","key":"10.1016\/j.jpsychires.2009.09.006_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1399-5618.2007.00454.x","article-title":"Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study","volume":"9","author":"Frey","year":"2007","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1399-5618.2006.00370.x","article-title":"Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations","volume":"8","author":"Frye","year":"2006","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib18","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1176\/appi.ajp.160.5.883","article-title":"Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder","volume":"160","author":"Frye","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib19","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1038\/sj.npp.1301387","article-title":"Increased anterior cingulate\/medial prefrontal cortical glutamate and creatine in bipolar depression","volume":"32","author":"Frye","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0006-3223(01)01321-X","article-title":"Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine","volume":"15","author":"Goff","year":"2002","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib21","series-title":"ECDEU assessment manual for psychopharmacology","first-page":"179","article-title":"Hamilton psychiatric rating scale for depression","author":"Hamilton","year":"1976"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib22","first-page":"5","article-title":"Classification of alcohol use disorders","volume":"27","author":"Hasin","year":"2003","journal-title":"Alcohol Research and Health"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib23","series-title":"MRI anatomy: a new angle on the brain","author":"Jackson","year":"1996"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib24","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1176\/appi.ajp.162.8.1403","article-title":"The neural basis of addiction: a pathology of motivation and choice","volume":"162","author":"Kalivas","year":"2004","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib25","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1523\/JNEUROSCI.1198-07.2007","article-title":"Excitatory synaptic transmission persists independently of the glutamate\u2013glutamine cycle","volume":"27","author":"Kam","year":"2007","journal-title":"Journal of Neurosciences"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib26","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1038\/sj.mp.4001021","article-title":"Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments","volume":"7","author":"Krystal","year":"2002","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib27","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/WNR.0b013e3282ef7625","article-title":"Alteration of brain metabolites in young alcoholics without structural changes","volume":"18","author":"Lee","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1098\/rstb.1999.0471","article-title":"Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging","volume":"354","author":"Magistretti","year":"1999","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00213-003-1440-z","article-title":"Acute mania is accompanied by elevated glutamate\/glutamine levels within the left dorsolateral prefrontal cortex","volume":"168","author":"Michael","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.eurpsy.2007.07.006","article-title":"Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder","volume":"22","author":"Molina","year":"2007","journal-title":"European Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib31","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1530-0277.2002.tb02681.x","article-title":"Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy","volume":"26","author":"Parks","year":"2002","journal-title":"Alcoholism Clinical and Experimental Research"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib32","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1176\/appi.ajp.161.10.1776","article-title":"Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism","volume":"161","author":"Petrakis","year":"2004","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib33","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1530-0277.1992.tb00702.x","article-title":"Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study","volume":"16","author":"Pfefferbaum","year":"1992","journal-title":"Alcoholism Clinical and Experimental Research"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib34","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mrm.1910250110","article-title":"Localized 1H NMR spectra of glutamate in the human brain","volume":"25","author":"Rothman","year":"1992","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1176\/appi.ajp.159.4.663","article-title":"Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors","volume":"159","author":"Sanacora","year":"2002","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib37","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1176\/appi.ajp.162.11.2109","article-title":"Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients","volume":"162","author":"Sassi","year":"2005","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1099-1492(200002)13:1<28::AID-NBM606>3.0.CO;2-L","article-title":"On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain","volume":"13","author":"Schirmer","year":"2000","journal-title":"NMR in Biomedicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/sj.npp.1301575","article-title":"Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder","volume":"33","author":"Schloesser","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib40","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.neuroimage.2003.11.014","article-title":"Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3T","volume":"21","author":"Schubert","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib41","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1001\/archpsyc.1996.01830030020005","article-title":"An 8-year follow-up of 450 sons of alcoholic and control subjects","volume":"53","author":"Schuckit","year":"1996","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib42","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1001\/archpsyc.65.7.826","article-title":"Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior","volume":"65","author":"Schumann","year":"2008","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/mrm.10332","article-title":"Parameterized evaluation of macromolecules and lipids in proton MR spectroscopy of brain diseases","volume":"49","author":"Seeger","year":"2003","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00004850-200303000-00002","article-title":"Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients","volume":"18","author":"Silverstone","year":"2003","journal-title":"International Clinical Psychopharmacology"},{"issue":"Suppl. 1","key":"10.1016\/j.jpsychires.2009.09.006_bib45","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S1461145703003390","article-title":"Contributions from brain imaging to the elucidation of pathophysiology of bipolar disorder","volume":"6","author":"Soares","year":"2003","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/070674370204700402","article-title":"In vivo magnetic resonance spectroscopy and its application to neuropsychiatric disorders","volume":"47","author":"Stanley","year":"2002","journal-title":"Canadian Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/mrm.1910340105","article-title":"The use of a priori knowledge to quantify short echo in vivo 1H MR spectra","volume":"34","author":"Stanley","year":"1995","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0006-3223(00)00949-5","article-title":"Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings \u2013 part I","volume":"48","author":"Stanley","year":"2000","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib50","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00213-005-2267-6","article-title":"Neurocircuitry in alcoholism: a substrate of disruption and repair","volume":"180","author":"Sullivan","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib51","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4088\/JCP.v66n0609","article-title":"Does recovery from substance use disorder matter in patients with bipolar disorder?","volume":"66","author":"Weiss","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib52","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0006-3223(99)00183-3","article-title":"Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder","volume":"47","author":"Winsberg","year":"2000","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2009.09.006_bib53","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensibility","volume":"133","author":"Young","year":"1978","journal-title":"British Journal of Psychiatry"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395609002064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395609002064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T20:33:15Z","timestamp":1710621195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395609002064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0022395609002064"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2009.09.006","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}