{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:48:52Z","timestamp":1758386932115,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jpsychires.2011.03.008","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T17:33:28Z","timestamp":1307122408000},"page":"1160-1164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glucocorticoid receptor gene haplotype predicts increased risk of hospital admission for depressive disorders in the Helsinki birth cohort study"],"prefix":"10.1016","volume":"45","author":[{"given":"Jari","family":"Lahti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri","family":"R\u00e4ikk\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu-Katariina","family":"Pesonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rautanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Wahlbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Kere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2011.03.008_bib1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib4","article-title":"Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction","author":"Bet","year":"2008","journal-title":"American Journal of Medical Genetics: Part B Neuropsychiatric Genetics"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.psyneuen.2006.08.001","article-title":"Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression","volume":"31","author":"Brouwer","year":"2006","journal-title":"Psychoneuroendocrinology"},{"issue":"Suppl. 1","key":"10.1016\/j.jpsychires.2011.03.008_bib6","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.psy.0000163456.22154.d2","article-title":"Hypercortisolemia and depression","volume":"67","author":"Gillespie","year":"2005","journal-title":"Psychosomatic Medicine"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/bioinformatics\/btm025","article-title":"SNPassoc: an R package to perform whole genome association studies","volume":"23","author":"Gonzalez","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1176\/appi.ajp.161.3.567","article-title":"Is low dietary intake of omega-3 fatty acids associated with depression?","volume":"161","author":"Hakkarainen","year":"2004","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib9","first-page":"15","article-title":"Accuracy of data on diagnoses, procedures and accidents in the Finnish Hospital Discharge Register","volume":"2","author":"Keskim\u00e4ki","year":"1991","journal-title":"International Journal of Health Services"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib10","first-page":"476","article-title":"Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance","volume":"150B","author":"Kumsta","year":"2009","journal-title":"American Journal of Medical Genetics: Part B Neuropsychiatric Genetics"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib11","article-title":"Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)","author":"Mill","year":"2008","journal-title":"American Journal of Medical Genetics: Part B Neuropsychiatric Genetics"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib12","article-title":"Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts","author":"Muglia","year":"2008","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2009.08.016","article-title":"Glucocorticoid receptor gene and depression in patients with coronary heart disease: the heart and soul study-2009 curt Richter award winner","author":"Otte","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/1359786806066063","article-title":"The glucocorticoid receptor: part of the solution or part of the problem?","volume":"20","author":"Pariante","year":"2006","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1677\/jme.1.02183","article-title":"Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor","volume":"38","author":"Presul","year":"2007","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib16","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1210\/jc.2006-1065","article-title":"Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene","volume":"91","author":"Rautanen","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/gepi.20037","article-title":"Evaluating associations of haplotypes with traits","volume":"27","author":"Schaid","year":"2004","journal-title":"Genetic Epidemiology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000477","article-title":"Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip","volume":"5","author":"Spencer","year":"2009","journal-title":"PLoS Genetics"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/mp.2008.125","article-title":"Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo","volume":"14","author":"Sullivan","year":"2009","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib20","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1677\/jme.1.01822","article-title":"Structure of the glucocorticoid receptor (NR3C1) gene 5\u2032 untranslated region: identification, and tissue distribution of multiple new human exon 1","volume":"35","author":"Turner","year":"2005","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biopsych.2006.02.007","article-title":"Polymorphisms of the glucocorticoid receptor gene and major depression","volume":"59","author":"van Rossum","year":"2006","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/sj.npp.1300898","article-title":"Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression","volume":"31","author":"van West","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib24","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/ajcn\/87.6.1769","article-title":"Body mass index during childhood and adult body composition in men and women aged 56\u201370\u00a0y","volume":"87","author":"Yliharsila","year":"2008","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.jpsychires.2011.03.008_bib25","first-page":"47","article-title":"Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression","volume":"129B","author":"Zubenko","year":"2004","journal-title":"American Journal of Medical Genetics: Part B Neuropsychiatric Genetics"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395611000574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395611000574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:07:02Z","timestamp":1758366422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395611000574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0022395611000574"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2011.03.008","relation":{},"ISSN":["0022-3956"],"issn-type":[{"type":"print","value":"0022-3956"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoid receptor gene haplotype predicts increased risk of hospital admission for depressive disorders in the Helsinki birth cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2011.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}