{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:07:43Z","timestamp":1759939663852},"reference-count":67,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofpsychiatricresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.jpsychires.2013.06.017","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T20:47:04Z","timestamp":1374180424000},"page":"1343-1348","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder"],"prefix":"10.1016","volume":"47","author":[{"given":"Sheng-Yu","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiou-Lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Hsuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian-Sheng","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Jen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. Hui","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzung Lieh","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Band","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jau-Shyong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2013.06.017_bib1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1176\/ajp.134.11.1227","article-title":"Cyclothymic disorder: validating criteria for inclusion in the bipolar affective group","volume":"134","author":"Akiskal","year":"1977","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0193-953X(05)70093-9","article-title":"The evolving bipolar spectrum. Prototypes I, II, III, and IV","volume":"22","author":"Akiskal","year":"1999","journal-title":"Psychiatric Clinics of North America"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archpsyc.1979.01780060025002","article-title":"Differentiation of primary affective illness from situational, symptomatic, and secondary depressions","volume":"36","author":"Akiskal","year":"1979","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib4","series-title":"Diagnostic and statistical manual of mental disorder-IV-TR","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib5","series-title":"Diagnostic and statistical manual of mental disorder-IV-TR","author":"American Psychiatric Association","year":"2002"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-0327(98)00142-6","article-title":"The emerging epidemiology of hypomania and bipolar II disorder","volume":"50","author":"Angst","year":"1998","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1192\/bjp.bp.106.030957","article-title":"The bipolar spectrum","volume":"190","author":"Angst","year":"2007","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00406-003-0437-2","article-title":"Recurrence of bipolar disorders and major depression. A life-long perspective","volume":"253","author":"Angst","year":"2003","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000067809","article-title":"Serum leptin and cholesterol levels in patients with bipolar disorder","volume":"46","author":"Atmaca","year":"2002","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1020968616616","article-title":"Bipolar disorder","volume":"4","author":"Bauer","year":"2002","journal-title":"Mental Health Services Research"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-0327(99)00038-5","article-title":"Bipolar II depression in late life: prevalence and clinical features in 525 depressed outpatients","volume":"66","author":"Benazzi","year":"2001","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s004060170065","article-title":"Is 4 days the minimum duration of hypomania in bipolar II disorder?","volume":"25","author":"Benazzi","year":"2001","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0327(02)00327-0","article-title":"Refining the evaluation of bipolar II: beyond the strict SCID-CV guidelines for hypomania","volume":"73","author":"Benazzi","year":"2003","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1399-5618.2002.01157.x","article-title":"Volumetric brain imaging findings in mood disorders","volume":"4","author":"Beyer","year":"2002","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.mam.2009.02.001","article-title":"Oxysterols and neurodegenerative diseases","volume":"30","author":"Bjorkhem","year":"2009","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/eat.20541","article-title":"Memantine in the treatment of binge eating disorder: an open-label, prospective trial","volume":"41","author":"Brennan","year":"2008","journal-title":"International Journal of Eating Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib17","series-title":"G-Power: a priori, post hoc, and compromise power analyses for the Macintosh","author":"Buchner","year":"1996"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0749-0690(03)00041-7","article-title":"Late-life mood disorders","volume":"19","author":"Burke","year":"2003","journal-title":"Clinics in Geriatric Medicine"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0327(00)00325-6","article-title":"Seasonal variation of mixed and pure episodes of bipolar disorder","volume":"68","author":"Cassidy","year":"2002","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib20","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/0006-2952(90)90469-2","article-title":"High density lipoprotein is a scavenger of superoxide anions","volume":"40","author":"Chander","year":"1990","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib21","first-page":"189","article-title":"Low cholesterol in erythrocyte membranes and high lipoperoxides in erythrocytes are the potential risk factors for cerebral hemorrhagic stroke in human","volume":"14","author":"Chen","year":"2001","journal-title":"Biomedical and Environmental Sciences"},{"issue":"2","key":"10.1016\/j.jpsychires.2013.06.017_bib69","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11481-011-9337-9","article-title":"Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats","volume":"7","author":"Chen","year":"2012","journal-title":"Journal of Neuroimmune Pharmacology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib22","first-page":"III20","article-title":"Possible mechanisms limiting N-methyl-D-aspartate receptor overactivation and the therapeutic efficacy of N-methyl-D-aspartate antagonists","volume":"21","author":"Choi","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib24","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/386824a0","article-title":"Subgenual prefrontal cortex abnormalities in mood disorders","volume":"386","author":"Drevets","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib25","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A\u00a0diagnostic interview: the schedule for affective disorders and schizophrenia","volume":"35","author":"Endicott","year":"1978","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib26","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1399-5618.2005.00234.x","article-title":"Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians","volume":"7","author":"Fagiolini","year":"2005","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behavior Research Methods"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/WNF.0b013e3180314ae7","article-title":"An open-label, flexible-dose study of memantine in major depressive disorder","volume":"30","author":"Ferguson","year":"2007","journal-title":"Clinical Neuropharmacology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib29","doi-asserted-by":"crossref","first-page":"9N","DOI":"10.1016\/S0002-9149(01)02146-4","article-title":"Epidemiologic evidence for high-density lipoprotein cholesterol as a risk factor for coronary artery disease","volume":"88","author":"Franceschini","year":"2001","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1034\/j.1399-5618.2000.020109.x","article-title":"Cholesterol levels in mood disorders: high or low?","volume":"2","author":"Ghaemi","year":"2000","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A\u00a0rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"British Journal of Social and Clinical Psychology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ehb.2005.04.001","article-title":"A\u00a0new anti-obesity drug treatment: first clinical evidence that, antagonising glutamate-gated Ca2+ ion channels with memantine normalises binge-eating disorders","volume":"3","author":"Hermanussen","year":"2005","journal-title":"Economics and Human Biology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/01.ALC.0000117832.62901.61","article-title":"Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence","volume":"28","author":"Huang","year":"2004","journal-title":"Alcoholism Clinical and Experimental Research"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-0327(02)00324-5","article-title":"The comparative clinical phenotype and long term longitudinal episode course of bipolar I and II: a clinical spectrum or distinct disorders?","volume":"73","author":"Judd","year":"2003","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib37","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1001\/archpsyc.62.12.1322","article-title":"Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study","volume":"62","author":"Judd","year":"2005","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/WNF.0b013e318184fae2","article-title":"Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: a pilot evaluation","volume":"32","author":"Keck","year":"2009","journal-title":"Clinical Neuropharmacology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1399-5618.2010.00803.x","article-title":"Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder","volume":"12","author":"Koukopoulos","year":"2010","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2011.09.040","article-title":"The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial","volume":"136","author":"Koukopoulos","year":"2012","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00004583-200503000-00006","article-title":"Treatment guidelines for children and adolescents with bipolar disorder","volume":"44","author":"Kowatch","year":"2005","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib42","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1212\/WNL.57.8.1447","article-title":"Cholesterol and neuropathologic markers of AD: a population-based autopsy study","volume":"57","author":"Launer","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0447.1997.tb09622.x","article-title":"Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers","volume":"95","author":"Maes","year":"1997","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib44","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1176\/ajp.140.7.920","article-title":"Is serum cholesterol a biological marker for major depressive disorder?","volume":"140","author":"Oxenkrug","year":"1983","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jad.2004.04.010","article-title":"Aberration of cholesterol level in first-onset bipolar I patients","volume":"83","author":"Pae","year":"2004","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib46","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1176\/ajp.156.7.1094","article-title":"Awareness of illness and subjective experience of cognitive complaints in patients with bipolar I and bipolar II disorder","volume":"156","author":"Pallanti","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1212\/01.WNL.0000070182.02537.84","article-title":"Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology","volume":"61","author":"Pappolla","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000075792","article-title":"Reconstituted high-density lipoprotein exhibits neuroprotection in two rat models of stroke","volume":"17","author":"Paterno","year":"2004","journal-title":"Cerebrovascular Diseases"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00726-010-0659-3","article-title":"Memantine reduces consumption of highly palatable food in a rat model of binge eating","volume":"40","author":"Popik","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2011.03.026","article-title":"Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model","volume":"182","author":"Quan","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib51","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0028-3908(02)00055-2","article-title":"Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats","volume":"42","author":"Rogoz","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib52","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1001\/jama.285.21.2729","article-title":"High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study","volume":"285","author":"Sacco","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jad.2006.05.030","article-title":"Platelet serotonin and serum lipids in psychotic mania","volume":"97","author":"Sagud","year":"2007","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib54","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.psychres.2008.06.048","article-title":"Lipid levels in female patients with affective disorders","volume":"168","author":"Sagud","year":"2009","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib55","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2165\/11634390-000000000-00000","article-title":"The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence","volume":"26","author":"Sani","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1055\/s-2007-984391","article-title":"Memantine-associated reversal of clozapine-induced weight gain","volume":"40","author":"Schaefer","year":"2007","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib57","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1385\/MN:25:2:191","article-title":"Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders?","volume":"25","author":"Schiffer","year":"2002","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib58","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0006-3223(00)00982-3","article-title":"Neuroimaging in bipolar disorder: what have we learned?","volume":"48","author":"Stoll","year":"2000","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1192\/apt.8.3.189","article-title":"Glutamate and psychiatric disorders","volume":"8","author":"Tsapakis","year":"2002","journal-title":"Advances in Psychiatric Treatment"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib60","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0010-440X(97)90088-2","article-title":"Differential features between bipolar I and bipolar II disorder","volume":"38","author":"Vieta","year":"1997","journal-title":"Comprehensive Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1399-5618.2007.00561.x","article-title":"Bipolar II disorder: arguments for and against a distinct diagnostic entity","volume":"10","author":"Vieta","year":"2008","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib62","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1161\/01.STR.31.8.1882","article-title":"HDL-Cholesterol, total cholesterol, and the risk of stroke in middle-aged British men","volume":"31","author":"Wannamethee","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib63","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/npp.2009.64","article-title":"Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation","volume":"34","author":"Wu","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl.\u00a05","key":"10.1016\/j.jpsychires.2013.06.017_bib64","first-page":"40","article-title":"Atypical antipsychotics in bipolar depression: potential mechanisms of action","volume":"66","author":"Yatham","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib65","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A\u00a0rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib66","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A\u00a0randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1176\/appi.ajp.163.1.153","article-title":"A\u00a0double-blind, placebo-controlled study of memantine in the treatment of major depression","volume":"163","author":"Zarate","year":"2006","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.06.017_bib68","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2307\/2531734","article-title":"Models for longitudinal data: a generalized estimating equation approach","volume":"44","author":"Zeger","year":"1988","journal-title":"Biometrics"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395613002008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395613002008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T08:48:32Z","timestamp":1688374112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395613002008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0022395613002008"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2013.06.017","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2013.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}