{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:22:22Z","timestamp":1780518142673,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofpsychiatricresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jpsychires.2013.07.004","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T17:17:12Z","timestamp":1375377432000},"page":"1623-1629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes"],"prefix":"10.1016","volume":"47","author":[{"given":"Omer","family":"Zarchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miri","family":"Carmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Attias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Michaelovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Patya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Gothelf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2013.07.004_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/oxfordjournals.schbul.a033320","article-title":"Schizophrenia, sensory gating, and nicotinic receptors","volume":"24","author":"Adler","year":"1998","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0006-3223(86)90244-1","article-title":"Neurophysiological studies of sensory gating in rats: effects of amphetamine, phencyclidine, and haloperidol","volume":"21","author":"Adler","year":"1986","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib3","first-page":"333","article-title":"Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study","volume":"49","author":"Antshel","year":"2010","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biopsych.2005.03.020","article-title":"COMT Val108\/158Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome","volume":"58","author":"Baker","year":"2005","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1086\/428142","article-title":"Functional consequences of PRODH missense mutations","volume":"76","author":"Bender","year":"2005","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib7","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1176\/ajp.155.12.1691","article-title":"Poor P50 suppression among schizophrenia patients and their first-degree biological relatives","volume":"155","author":"Clementz","year":"1998","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib8","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.neuropsychologia.2006.02.006","article-title":"Development of cognitive control and executive functions from 4 to 13 years: evidence from manipulations of memory, inhibition, and task switching","volume":"44","author":"Davidson","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s002130050856","article-title":"Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats","volume":"142","author":"De Bruin","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib10","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1177\/0269881112456610","article-title":"Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val158 Met polymorphism in adults with 22q11 deletion syndrome","volume":"26","author":"de Koning","year":"2012","journal-title":"Journal of Psychopharmacology (Oxf)"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1192\/bjp.bp.111.097139","article-title":"Cognitive development in children with 22q11.2 deletion syndrome","volume":"200","author":"Duijff","year":"2012","journal-title":"The British Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib12","series-title":"User's guide for the structured clinical interview for DSM-IV axis I disorders\u2014research version","author":"First","year":"1996"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib13","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/archpsyc.1996.01830120052009","article-title":"Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects: human recordings, computer simulation, and an animal model","volume":"53","author":"Freedman","year":"1996","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1469-8986.1987.tb00282.x","article-title":"Gating of the auditory evoked potential in children and adults","volume":"24","author":"Freedman","year":"1987","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib15","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1097\/00001756-200009280-00014","article-title":"Maturation of frontal and temporal components of mismatch negativity (MMN) in children","volume":"11","author":"Gomot","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib16","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/nn1572","article-title":"COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome","volume":"8","author":"Gothelf","year":"2005","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ddrr.9","article-title":"Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome","volume":"14","author":"Gothelf","year":"2008","journal-title":"Developmental Disabilities Research Reviews"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib18","first-page":"793","article-title":"l-proline activates glutamate and glycine receptors in cultured rat dorsal horn neurons","volume":"41","author":"Henzi","year":"1992","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib19","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S1388-2457(00)00377-1","article-title":"Associated deficits in mismatch negativity generation and tone matching in schizophrenia","volume":"111","author":"Javitt","year":"2000","journal-title":"Clinical Neurophysiology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib20","doi-asserted-by":"crossref","first-page":"11962","DOI":"10.1073\/pnas.93.21.11962","article-title":"Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia","volume":"93","author":"Javitt","year":"1996","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib21","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","article-title":"Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K- SADS-PL): initial reliability and validity data","volume":"36","author":"Kaufman","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib23","doi-asserted-by":"crossref","first-page":"e1000252","DOI":"10.1371\/journal.pgen.1000252","article-title":"Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function","volume":"4","author":"Kempf","year":"2008","journal-title":"PLoS Genetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib24","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biopsych.2006.11.030","article-title":"Effect of catechol O-methyltransferase Val158Met polymorphism on the P50 gating endophenotype in schizophrenia","volume":"62","author":"Lu","year":"2007","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib25","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/sj.npp.1301556","article-title":"Differential effects of acute serotonin and dopamine depletion on prepulse inhibition and P50 suppression measures of sensorimotor and sensory gating in humans","volume":"33","author":"Mann","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijpsycho.2003.08.004","article-title":"The development of P50 suppression in the auditory event-related potential","volume":"51","author":"Marshall","year":"2004","journal-title":"International Journal of Psychophysiology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-2350-13-122","article-title":"Genotype-phenotype correlation in 22q11.2 deletion syndrome","volume":"13","author":"Michaelovsky","year":"2012","journal-title":"BMC Medical Genetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-8760(01)00166-0","article-title":"What has MMN revealed about the auditory system in schizophrenia?","volume":"42","author":"Michie","year":"2001","journal-title":"International Journal of Psychophysiology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/cercor\/bhh155","article-title":"The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generators","volume":"15","author":"Molholm","year":"2005","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00422-002-0372-8","article-title":"Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus: its relationship to sensory gating in schizophrenia","volume":"88","author":"Moxon","year":"2003","journal-title":"Biological Cybernetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0001-6918(78)90006-9","article-title":"Early selective-attention effect on evoked potential reinterpreted","volume":"42","author":"N\u00e4\u00e4t\u00e4nen","year":"1978","journal-title":"Acta Psychologica"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clinph.2003.04.001","article-title":"The mismatch negativity (MMN): towards the optimal paradigm","volume":"115","author":"N\u00e4\u00e4t\u00e4nen","year":"2004","journal-title":"Clinical Neurophysiology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0006-3223(89)90215-1","article-title":"Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval","volume":"25","author":"Nagamoto","year":"1989","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib34","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/nn1562","article-title":"Transcriptional and behavioral interaction between 22q11. 2 orthologs modulates schizophrenia-related phenotypes in mice","volume":"8","author":"Paterlini","year":"2005","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/hmg\/ddl443","article-title":"Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome","volume":"16","author":"Raux","year":"2007","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archpsyc.59.8.686","article-title":"Mismatch negativity in chronic schizophrenia and first-episode schizophrenia","volume":"59","author":"Salisbury","year":"2002","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00003446-200006000-00008","article-title":"Maturation of mismatch negativity in school-age children","volume":"21","author":"Shafer","year":"2000","journal-title":"Ear and Hearing"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib38","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1176\/appi.ajp.162.6.1090","article-title":"Lower prepulse inhibition in children with the 22q11 deletion syndrome","volume":"162","author":"Sobin","year":"2005","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib39","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/humu.20330","article-title":"MLPA: a rapid, reliable, and sensitive method for detection and analysis of abnormalities of 22q","volume":"27","author":"Vorstman","year":"2006","journal-title":"Human Mutation"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib40","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/npp.2008.132","article-title":"Proline affects brain function in 22q11DS children with the low activity COMT158 allele","volume":"34","author":"Vorstman","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0920-9964(94)90067-1","article-title":"Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings","volume":"12","author":"Waldo","year":"1994","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib42","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00726-008-0111-0","article-title":"PRODH variants and risk for schizophrenia","volume":"35","author":"Willis","year":"2008","journal-title":"Amino Acids"},{"key":"10.1016\/j.jpsychires.2013.07.004_bib43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpeds.2010.07.056","article-title":"A\u00a0comparative study of hearing loss in two microdeletion syndromes: Velocardiofacial (22q11. 2 deletion) and Williams (7q11. 23 deletion) syndromes","volume":"158","author":"Zarchi","year":"2011","journal-title":"The Journal of Pediatrics"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395613002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395613002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T06:50:27Z","timestamp":1539499827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395613002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0022395613002161"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2013.07.004","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2013.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}