{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:07:53Z","timestamp":1790626073368,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["R01 MH077047"],"award-info":[{"award-number":["R01 MH077047"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["K23 MH064460"],"award-info":[{"award-number":["K23 MH064460"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","award":["K23 MH085919"],"award-info":[{"award-number":["K23 MH085919"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journalofpsychiatricresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jpsychires.2014.11.013","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T14:03:25Z","timestamp":1417269805000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder"],"prefix":"10.1016","volume":"61","author":[{"given":"Min-Hyeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki D.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Hallmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Chul","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2014.11.013_bib2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history method using diagnostic criteria. Reliability and validity","volume":"34","author":"Andreasen","year":"1977","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib3","doi-asserted-by":"crossref","first-page":"1001 e3","DOI":"10.1016\/j.jaac.2011.07.005","article-title":"Course of subthreshold bipolar disorder in youth: diagnostic progression from bipolar disorder not otherwise specified","volume":"50","author":"Axelson","year":"2011","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-244X-8-48","article-title":"Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Tr\u00f8ndelag Health Study (HUNT)","volume":"8","author":"Baekken","year":"2008","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J\u00a0Pers Soc Psychol"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib6","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jad.2013.08.016","article-title":"Family environment of bipolar families: a UK study","volume":"152\u2013154","author":"Barron","year":"2014","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib7","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.psyneuen.2008.12.018","article-title":"Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor","volume":"34","author":"Bazak","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jad.2007.08.011","article-title":"Family environment patterns in families with bipolar children","volume":"107","author":"Belardinelli","year":"2008","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2005.09.022","article-title":"BDNF Val66Met\u00a0allele is associated with reduced hippocampal volume in healthy subjects","volume":"59","author":"Bueller","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.neuroscience.2012.10.073","article-title":"Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor","volume":"239","author":"Carbone","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ajmg.c.20011","article-title":"Studies of offspring of parents with bipolar disorder","volume":"123C","author":"Chang","year":"2003","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1399-5618.2001.030205.x","article-title":"Family environment of children and adolescents with bipolar parents","volume":"3","author":"Chang","year":"2001","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1129663","article-title":"Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.psyneuen.2011.04.010","article-title":"BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults","volume":"36","author":"Colzato","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jad.2009.07.017","article-title":"Is subclinical anxiety an endophenotype for bipolar I patients? A study from a Costa Rican sample","volume":"122","author":"Contreras","year":"2010","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2005.12.085","article-title":"Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes","volume":"398","author":"Cunha","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib17","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jpsychires.2009.04.002","article-title":"Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients","volume":"43","author":"de Oliveira","year":"2009","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00004583-199903000-00015","article-title":"Influence of parental concordance for psychiatric disorders on psychopathology in offspring","volume":"38","author":"Dierker","year":"1999","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jad.2013.04.021","article-title":"Childhood anxiety: an early predictor of mood disorders in offspring of bipolar parents","volume":"150","author":"Duffy","year":"2013","journal-title":"J\u00a0Affect Disord"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.jpsychires.2014.11.013_bib20","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.mp.4001016","article-title":"Synaptic plasticity and mood disorders","volume":"7","author":"Duman","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib21","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jpsychires.2009.03.008","article-title":"Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains","volume":"43","author":"Dunham","year":"2009","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/da.20378","article-title":"Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders","volume":"25","author":"Enoch","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib24","series-title":"Structured clinical interview for DSM-IV axis I disorders \u2013 Patient edition (SCID-I\/P, version 2.0)","author":"First","year":"1996"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/archpsyc.64.4.410","article-title":"Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression","volume":"64","author":"Frodl","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000182892","article-title":"Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits","volume":"58","author":"Frustaci","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/mp.2008.143","article-title":"Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety","volume":"14","author":"Gatt","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib28","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1176\/appi.ajp.161.9.1698","article-title":"Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype","volume":"161","author":"Geller","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00004583-200104000-00014","article-title":"Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections","volume":"40","author":"Geller","year":"2001","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.biopsych.2006.08.025","article-title":"Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia","volume":"61","author":"Gratacos","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1192\/bjp.bp.105.009969","article-title":"Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK","volume":"188","author":"Green","year":"2006","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib32","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/sj.npp.1301383","article-title":"Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits","volume":"32","author":"H\u00fcnnerkopf","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib33","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib34","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1093\/emboj\/20.21.5887","article-title":"Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses","volume":"20","author":"Hartmann","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.biopsych.2005.06.010","article-title":"Psychopathology in the offspring of parents with bipolar disorder: a controlled study","volume":"58","author":"Henin","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib36","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/j.1460-2075.1990.tb07423.x","article-title":"Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain","volume":"9","author":"Hofer","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1037\/0022-006X.65.4.599","article-title":"Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures","volume":"65","author":"Holmbeck","year":"1997","journal-title":"J\u00a0Consult Clin Psychol"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000074636","article-title":"Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior","volume":"48","author":"Hong","year":"2003","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib39","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/sj.npp.1300703","article-title":"BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects","volume":"30","author":"Jiang","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.biopsych.2005.10.026","article-title":"Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children","volume":"59","author":"Kaufman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000162356","article-title":"Brain-derived neurotrophic factor Val\/Met polymorphism and bipolar disorder. Association of the Met\u00a0allele with suicidal behavior of bipolar patients","volume":"58","author":"Kim","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.biopsych.2006.11.020","article-title":"Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders","volume":"62","author":"Kim","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/016128401750158768","article-title":"Moderating and mediating effects in causal models","volume":"22","author":"Kim","year":"2001","journal-title":"Issues Ment Health Nurs"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.mp.4001471","article-title":"Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium","volume":"9","author":"Knable","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib45","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biopsych.2004.06.017","article-title":"No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study","volume":"56","author":"Kunugi","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib46","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.npp.1300382","article-title":"BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits","volume":"29","author":"Lang","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/070674379704200609","article-title":"Children of parents with bipolar disorder: a metaanalysis of risk for mental disorders","volume":"42","author":"Lapalme","year":"1997","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neulet.2009.09.044","article-title":"State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study","volume":"466","author":"Lin","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1192\/bjp.bp.105.010587","article-title":"Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study","volume":"189","author":"M\u00fcller","year":"2006","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib50","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00004583-199704000-00019","article-title":"The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity","volume":"36","author":"March","year":"1997","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.2001.tb03469.x","article-title":"From molecules to mind. Stress, individual differences, and the social environment","volume":"935","author":"McEwen","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib52","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/da.21891","article-title":"The anxiety spectrum and the reflex physiology of defense: from circumscribed fear to broad distress","volume":"29","author":"McTeague","year":"2012","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib53","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.psychres.2008.08.005","article-title":"The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans","volume":"179","author":"Montag","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib54","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1017\/S0033291709005509","article-title":"The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression","volume":"39","author":"Montag","year":"2009","journal-title":"Psychol Med"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(02)01292-2","article-title":"Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder","volume":"337","author":"Nakata","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2005.11.067","article-title":"The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology","volume":"397","author":"Nemoto","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib57","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/342288","article-title":"The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study","volume":"71","author":"Neves-Pereira","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib58","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1752-0606.2009.00175.x","article-title":"FACES IV and the Circumplex Model: validation study","volume":"37","author":"Olson","year":"2011","journal-title":"J\u00a0Marital Fam Ther"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jad.2008.08.006","article-title":"Chronic stress and stressful life events in the offspring of parents with bipolar disorder","volume":"114","author":"Ostiguy","year":"2009","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib60","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1017\/S0033291711000523","article-title":"Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels","volume":"41","author":"Ostiguy","year":"2011","journal-title":"Psychol Med"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ajmg.b.30056","article-title":"Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study","volume":"129B","author":"Oswald","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib62","first-page":"979","article-title":"Children's depression rating scale-revised (September 1984)","volume":"21","author":"Poznanski","year":"1985","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/mp.2011.121","article-title":"BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity","volume":"17","author":"Rakofsky","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0893-133X(02)00286-5","article-title":"Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock","volume":"27","author":"Rasmusson","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib65","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1399-5618.2005.00270.x","article-title":"Family environment in families with versus families without parental bipolar disorder: a preliminary comparison study","volume":"7","author":"Romero","year":"2005","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib66","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.biopsych.2008.11.028","article-title":"Lasting epigenetic influence of early-life adversity on the BDNF gene","volume":"65","author":"Roth","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib67","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/scnp.2003.50014","article-title":"Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders","volume":"8","author":"Russo-Neustadt","year":"2003","journal-title":"Semin Clin Neuropsychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib68","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.pnpbp.2005.04.018","article-title":"No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder","volume":"29","author":"Shimizu","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib69","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jad.2007.01.004","article-title":"Psychopathology in children of bipolar parents","volume":"102","author":"Singh","year":"2007","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib70","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/15622970410029936","article-title":"Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder","volume":"5","author":"Skibinska","year":"2004","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib71","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.mp.4001058","article-title":"Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor","volume":"7","author":"Sklar","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib72","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.1181886","article-title":"A\u00a0genetic variant BDNF polymorphism alters extinction learning in both mouse and human","volume":"327","author":"Soliman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib73","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.mp.4001685","article-title":"Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample","volume":"10","author":"Strauss","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnint.2013.00055","article-title":"Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis","volume":"7","author":"Suliman","year":"2013","journal-title":"Front Integr Neurosci"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib75","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jpsychires.2006.01.004","article-title":"No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults","volume":"41","author":"Surtees","year":"2007","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib76","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neulet.2008.01.001","article-title":"Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China","volume":"433","author":"Tang","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib77","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1022837911156","article-title":"Defense style and family environment","volume":"28","author":"Thienemann","year":"1998","journal-title":"Child Psychiatry Hum Dev"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib78","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.schres.2006.06.029","article-title":"No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits","volume":"87","author":"Tochigi","year":"2006","journal-title":"Schizophr Res"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib79","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/da.20452","article-title":"Screening capacity of the Multidimensional Anxiety Scale for Children (MASC) for DSM-IV anxiety disorders","volume":"25","author":"van Gastel","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib80","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1399-5618.2008.00603.x","article-title":"Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene","volume":"10","author":"Vincze","year":"2008","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib81","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.npp.1301394","article-title":"A\u00a0large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder","volume":"32","author":"Wendland","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib82","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A\u00a0rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jpsychires.2014.11.013_bib83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ajmg.b.30332","article-title":"Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence","volume":"141B","author":"Zhang","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395614003367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395614003367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T23:20:04Z","timestamp":1566084004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395614003367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":82,"alternative-id":["S0022395614003367"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2014.11.013","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2014.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}