{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:46:46Z","timestamp":1775688406445,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofpsychiatricresearch.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jpsychires.2015.07.011","type":"journal-article","created":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T00:42:46Z","timestamp":1437180166000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression"],"prefix":"10.1016","volume":"69","author":[{"given":"Xiaoyun","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zezhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haozhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengmei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daihui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chowdhury M.I.","family":"Golam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiru","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2015.07.011_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.schres.2009.04.019","article-title":"Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder","volume":"112","author":"Barley","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-0327(00)00189-0","article-title":"Subsyndromal depression in adolescents after a brief psychotherapy trial: course and outcome","volume":"63","author":"Brent","year":"2001","journal-title":"J.\u00a0Affect Disord."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/YPG.0b013e32833a21e3","article-title":"Strategies to identify genes for complex disorders: a focus on bipolar disorder and chromosome 16p","volume":"21","author":"Byerley","year":"2011","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jpsychires.2009.12.012","article-title":"Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women","volume":"44","author":"Costas","year":"2010","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2006.10.010","article-title":"Subsyndromal depression: an impact on quality of life?","volume":"100","author":"da Silva Lima","year":"2007","journal-title":"J.\u00a0Affect Disord."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.08.044","article-title":"Signaling pathways underlying the rapid antidepressant actions of ketamine","volume":"62","author":"Duman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1399-0004.1993.tb03892.x","article-title":"Suggestion of linkage between manic-depressive illness and the enzyme phosphoglycolate phosphatase (PGP) on chromosome 16p","volume":"44","author":"Eiberg","year":"1993","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib8","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nature08928","article-title":"Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling","volume":"464","author":"Fazzari","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/archpsyc.62.1.66","article-title":"Subthreshold depression in adolescence and mental health outcomes in adulthood","volume":"62","author":"Fergusson","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.neuron.2014.01.027","article-title":"The genetics of major depression","volume":"81","author":"Flint","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00127-004-0745-5","article-title":"Subsyndromal depression: prevalence, use of health services and quality of life in an Australian population","volume":"39","author":"Goldney","year":"2004","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.metabol.2005.01.006","article-title":"Genetics and genomics of depression","volume":"54","author":"Hamet","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.pbio.1000001","article-title":"Tissue-specific genetic control of splicing: implications for the study of complex traits","volume":"6","author":"Heinzen","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib15","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","article-title":"The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists","volume":"8","author":"Huang da","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib16","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.neuroimage.2010.02.065","article-title":"Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression","volume":"53","author":"Inkster","year":"2010","journal-title":"Neuroimage"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.jpsychires.2015.07.011_bib17","first-page":"18","article-title":"Subsyndromal symptomatic depression: a new mood disorder?","volume":"55","author":"Judd","year":"1994","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jcla.10091","article-title":"Quantification of chemotherapeutic target gene mRNA expression in human breast cancer biopsies: comparison of real-time reverse transcription-PCR vs. relative quantification reverse transcription-PCR utilizing DNA sequencer analysis of PCR products","volume":"17","author":"Juhasz","year":"2003","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-0327(97)00056-6","article-title":"Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey","volume":"45","author":"Kessler","year":"1997","journal-title":"J.\u00a0Affect Disord."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib20","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biopsych.2005.08.024","article-title":"The genetics of depression: a review","volume":"60","author":"Levinson","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib22","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib24","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1220845","article-title":"A\u00a0critical period for social experience-dependent oligodendrocyte maturation and myelination","volume":"337","author":"Makinodan","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jad.2010.09.015","article-title":"A\u00a0tune in \u201ca minor\u201d can \u201cb major\u201d: a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults","volume":"129","author":"Meeks","year":"2011","journal-title":"J.\u00a0Affect Disord."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib26","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/NMD.0b013e31818ec823","article-title":"Suicidal ideation and suicide attempts among middle-aged and older patients with schizophrenia spectrum disorders and concurrent subsyndromal depression","volume":"196","author":"Montross","year":"2008","journal-title":"J.\u00a0Nerv. Ment. Dis."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib27","doi-asserted-by":"crossref","first-page":"e1000888","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1001\/archpsyc.1996.01830100026004","article-title":"Subthreshold psychiatric symptoms in a primary care group practice","volume":"53","author":"Olfson","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib29","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/sj.mp.4001704","article-title":"Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism","volume":"10","author":"Philippi","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1017\/S0033291712002309","article-title":"Subsyndromal depression in the United States: prevalence, course, and risk for incident psychiatric outcomes","volume":"43","author":"Pietrzak","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm.2315","article-title":"Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors","volume":"17","author":"Pitcher","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0165-0327(97)00196-1","article-title":"Minor depressive disorder and subsyndromal depressive symptoms: functional impairment and response to treatment","volume":"48","author":"Rapaport","year":"1998","journal-title":"J.\u00a0Affect Disord."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1532-5415.1999.tb01605.x","article-title":"Minor and subsyndromal depression: functional disability worth treating","volume":"47","author":"Rollman","year":"1999","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1254\/jphs.12057FP","article-title":"Neuregulin-1 exerts protective effects against neurotoxicities induced by C-terminal fragments of APP via ErbB4 receptor","volume":"119","author":"Ryu","year":"2012","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib35","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.0710373105","article-title":"Alteration of BACE1-dependent NRG1\/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice","volume":"105","author":"Savonenko","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib36","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1176\/ajp.151.12.1777","article-title":"Subthreshold depression and depressive disorder: clinical characteristics of general medical and mental health specialty outpatients","volume":"151","author":"Sherbourne","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.psc.2009.10.004","article-title":"The genetics of major depression: moving beyond the monoamine hypothesis","volume":"33","author":"Shyn","year":"2010","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1017\/S1461145706007322","article-title":"Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?","volume":"10","author":"Sokolov","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2013.03.005","article-title":"Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects","volume":"246","author":"Strauss","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jpsychires.2015.07.011_bib40","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-9-531","article-title":"Combining gene expression, demographic and clinical data in modeling disease: a case study of bipolar disorder and schizophrenia","volume":"9","author":"Struyf","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.eurpsy.2009.12.016","article-title":"Genetics of HPA-axis, depression and suicidality","volume":"25","author":"Wasserman","year":"2010","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.jpsychires.2015.07.011_bib42","doi-asserted-by":"crossref","first-page":"e31283","DOI":"10.1371\/journal.pone.0031283","article-title":"Blood-based gene expression profiles models for classification of subsyndromal symptomatic depression and major depressive disorder","volume":"7","author":"Yi","year":"2012","journal-title":"PLoS One"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395615002046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395615002046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T21:29:27Z","timestamp":1537478967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395615002046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":42,"alternative-id":["S0022395615002046"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2015.07.011","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2015.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}