{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:56:38Z","timestamp":1768830998945,"version":"3.49.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofpsychiatricresearch.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jpsychires.2016.11.011","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T14:48:10Z","timestamp":1480603690000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Suicide attempts and markers of immune response in individuals with serious mental illness"],"prefix":"10.1016","volume":"87","author":[{"given":"Faith","family":"Dickerson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly C.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Adamos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Katsafanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Khushalani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Origoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Schweinfurth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-1545","authenticated-orcid":false,"given":"Cassie","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2016.11.011_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1756-0500-5-140","article-title":"Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine","volume":"5","author":"Arav-Boger","year":"2012","journal-title":"BMC Res. Notes"},{"issue":"12","key":"10.1016\/j.jpsychires.2016.11.011_bib2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/NMD.0b013e3181c29a23","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders","volume":"197","author":"Arling","year":"2009","journal-title":"J.\u00a0Nerv. Ment. Dis."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2014.03.049","article-title":"Astrocytes, microglia\/macrophages, and neurons expressing Toll-like receptor 11 contribute to innate immunity against encephalitic Toxoplasma gondii infection","volume":"269","author":"Atmaca","year":"2014","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/mp.2013.2","article-title":"Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci","volume":"19","author":"Borglum","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jpsychires.2016.11.011_bib5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"Brown","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/acps.12458","article-title":"The role of inflammation in suicidal behaviour","volume":"132","author":"Brundin","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0033291702006943","article-title":"Psychological autopsy studies of suicide: a systematic review","volume":"33","author":"Cavanagh","year":"2003","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib8","series-title":"Web-based Injury Statistics Query and Reporting System (WISQARS)","author":"Centers for Disease Control","year":"2016"},{"issue":"6","key":"10.1016\/j.jpsychires.2016.11.011_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.autrev.2009.11.017","article-title":"Profiling of rheumatoid arthritis associated autoantibodies","volume":"9","author":"Conrad","year":"2010","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.jpsychires.2016.11.011_bib10","doi-asserted-by":"crossref","first-page":"e95510","DOI":"10.1371\/journal.pone.0095510","article-title":"Association between cytomegalovirus antibody levels and cognitive functioning in non-elderly adults","volume":"9","author":"Dickerson","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jpsychires.2016.11.011_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/NMD.0000000000000166","article-title":"Antibodies to Toxoplasma gondii and cognitive functioning in schizophrenia, bipolar disorder, and nonpsychiatric controls","volume":"202","author":"Dickerson","year":"2014","journal-title":"J.\u00a0Nerv. Ment. Dis."},{"issue":"1","key":"10.1016\/j.jpsychires.2016.11.011_bib12","first-page":"134","article-title":"Inflammatory markers in recent onset psychosis and chronic schizophrenia","volume":"42","author":"Dickerson","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib13","article-title":"Antibodies to Toxoplasma gondii in individuals with mania","author":"Dickerson","year":"2013","journal-title":"Bipolar Disord."},{"issue":"11","key":"10.1016\/j.jpsychires.2016.11.011_bib14","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1176\/appi.ajp.162.11.2116","article-title":"Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men","volume":"162","author":"Dumais","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.jpsychires.2016.11.011_bib15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00430-012-0258-x","article-title":"Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection","volume":"201","author":"Ebert","year":"2012","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib16","series-title":"Structured Clinical Interview for DSM-IV Disorders, Non-patient Edition","author":"First","year":"1998"},{"key":"10.1016\/j.jpsychires.2016.11.011_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1192\/bjp.175.2.175","article-title":"Risk factors for suicide independent of DSM-III-R Axis I disorder. Case-control psychological autopsy study in Northern Ireland","volume":"175","author":"Foster","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jpsychires.2016.11.011_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.psyneuen.2015.10.008","article-title":"The role of cytokines in the pathophysiology of suicidal behavior","volume":"63","author":"Gananca","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2016.11.011_bib19","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1038\/srep15066","article-title":"Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation","volume":"5","author":"Gunti","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib20","article-title":"Tobacco use and 12-month suicidality among adults in the United States","author":"Han","year":"2016","journal-title":"Nicotine Tob. Res."},{"issue":"1","key":"10.1016\/j.jpsychires.2016.11.011_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1079\/AHR2005100","article-title":"Biology and epidemiology of Toxoplasma gondii in man and animals","volume":"6","author":"Hill","year":"2005","journal-title":"Anim. Health Res. Rev."},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00281-015-0483-7","article-title":"CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection","volume":"37","author":"Hwang","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"10","key":"10.1016\/j.jpsychires.2016.11.011_bib23","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1128\/IAI.00217-16","article-title":"Toxoplasma gondii infection in mice impairs long-term fear memory consolidation through dysfunction of the cortex and amygdala","volume":"84","author":"Ihara","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000346085","article-title":"Inflammation in suicidality: implications for novel treatment options","volume":"28","author":"Janelidze","year":"2013","journal-title":"Mod. Trends Pharmacopsychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00004583-199005000-00021","article-title":"Acute psychosis in a patient with Epstein-Barr virus infection","volume":"29","author":"Jarvis","year":"1990","journal-title":"J.\u00a0Am. Acad. Child. Adolesc. Psychiatry"},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2016.11.011_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.schres.2014.05.019","article-title":"Childhood Epstein-Barr Virus infection and subsequent risk of psychotic experiences in adolescence: a population-based prospective serological study","volume":"158","author":"Khandaker","year":"2014","journal-title":"Schizophr. Res."},{"issue":"Pt 3","key":"10.1016\/j.jpsychires.2016.11.011_bib27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S003118200006368X","article-title":"Naturally occurring immunoglobulin M antibodies: enhancement of phagocytic and microbicidal activities of human neutrophils against Toxoplasma gondii","volume":"104","author":"Konishi","year":"1992","journal-title":"Parasitology"},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2016.11.011_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.schres.2015.05.005","article-title":"Cytokines in schizophrenia: methodological issues","volume":"166","author":"Koola","year":"2015","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2466\/12.19.PR0.107.6.713-714","article-title":"Predicting European suicide rates with physiological indices","volume":"107","author":"Lester","year":"2010","journal-title":"Psychol. Rep."},{"issue":"7","key":"10.1016\/j.jpsychires.2016.11.011_bib30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/NMD.0b013e318221416e","article-title":"Toxoplasma gondii seropositivity and suicide rates in women","volume":"199","author":"Ling","year":"2011","journal-title":"J.\u00a0Nerv. Ment. Dis."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.drugalcdep.2016.01.004","article-title":"Heavy tobacco dependence in suicide attempters making recurrent and medically serious attempts","volume":"160","author":"Lopez-Castroman","year":"2016","journal-title":"Drug Alcohol Depend."},{"issue":"4","key":"10.1016\/j.jpsychires.2016.11.011_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaut.2007.07.007","article-title":"Homeostatic roles of naturally occurring antibodies: an overview","volume":"29","author":"Lutz","year":"2007","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2015.08.005","article-title":"Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells","volume":"306","author":"Martin","year":"2015","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.jpsychires.2016.11.011_bib34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/ajmg.b.32247","article-title":"Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study","volume":"165B","author":"Mullins","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"2","key":"10.1016\/j.jpsychires.2016.11.011_bib35","first-page":"378","article-title":"Naturally occurring human antibodies to the F(ab')2 portion of IgG","volume":"42","author":"Nasu","year":"1980","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.jpsychires.2016.11.011_bib36","first-page":"76","article-title":"Serum antibodies to the major proteins found in cow's milk of Iranian patients with Type 1 diabetes mellitus","volume":"17","author":"Neyestani","year":"2004","journal-title":"Diabetes Nutr. Metab."},{"issue":"10","key":"10.1016\/j.jpsychires.2016.11.011_bib37","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/archgenpsychiatry.2011.113","article-title":"Absolute risk of suicide after first hospital contact in mental disorder","volume":"68","author":"Nordentoft","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.jpsychires.2016.11.011_bib38","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0006-8993(91)90019-R","article-title":"Cytomegalovirus infection of the developing brain alters catecholamine and indoleamine metabolism","volume":"559","author":"O'Kusky","year":"1991","journal-title":"Brain Res."},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2016.11.011_bib39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2011.08.006","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with schizophrenia","volume":"133","author":"Okusaga","year":"2011","journal-title":"Schizophr. Res."},{"issue":"8","key":"10.1016\/j.jpsychires.2016.11.011_bib40","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1176\/appi.ajp.161.8.1433","article-title":"Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder","volume":"161","author":"Oquendo","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jpsychires.2016.11.011_bib41","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2466\/pr0.1962.10.3.799","article-title":"The brief psychiatric rating scale","volume":"10","author":"Overall","year":"1962","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.jpsychires.2016.11.011_bib42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpsychires.2014.01.021","article-title":"Toll-like receptors in the depressed and suicide brain","volume":"53","author":"Pandey","year":"2014","journal-title":"J.\u00a0Psychiatr. Res."},{"issue":"11","key":"10.1016\/j.jpsychires.2016.11.011_bib43","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archgenpsychiatry.2012.668","article-title":"Toxoplasma gondii infection and self-directed violence in mothers","volume":"69","author":"Pedersen","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.jpsychires.2016.11.011_bib44","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","article-title":"The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults","volume":"168","author":"Posner","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jpsychires.2016.11.011_bib45","doi-asserted-by":"crossref","first-page":"939780","DOI":"10.1155\/2015\/939780","article-title":"Cytomegalovirus antibody elevation in bipolar disorder: relation to elevated mood states","volume":"2015","author":"Prossin","year":"2015","journal-title":"Neural Plast."},{"issue":"3","key":"10.1016\/j.jpsychires.2016.11.011_bib46","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","article-title":"The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity","volume":"20","author":"Randolph","year":"1998","journal-title":"J.\u00a0Clin. Exp. Neuropsychol."},{"issue":"11","key":"10.1016\/j.jpsychires.2016.11.011_bib47","first-page":"929","article-title":"The past and present role of the Sabin-Feldman dye test in the serodiagnosis of toxoplasmosis","volume":"77","author":"Reiter-Owona","year":"1999","journal-title":"Bull. World Health Organ"},{"issue":"9","key":"10.1016\/j.jpsychires.2016.11.011_bib48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/BF01964270","article-title":"Onset of ocular complications in congenital toxoplasmosis associated with immunoglobulin M antibodies to Toxoplasma gondii","volume":"9","author":"Sibalic","year":"1990","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jpsychires.2016.11.011_bib49","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/rmv.475","article-title":"Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models","volume":"15","author":"Tsutsui","year":"2005","journal-title":"Rev. Med. Virol."},{"issue":"2","key":"10.1016\/j.jpsychires.2016.11.011_bib50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/CVI.00356-12","article-title":"Comparison of four commercially available avidity tests for Toxoplasma gondii-specific IgG antibodies","volume":"20","author":"Villard","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"issue":"9","key":"10.1016\/j.jpsychires.2016.11.011_bib51","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1128\/JVI.03177-15","article-title":"Viral persistence induces antibody inflation without altering antibody avidity","volume":"90","author":"Welten","year":"2016","journal-title":"J.\u00a0Virol."},{"issue":"5","key":"10.1016\/j.jpsychires.2016.11.011_bib52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00365548.2012.737017","article-title":"Neuropsychiatric symptoms are common in immunocompetent adult patients with Toxoplasma gondii acute lymphadenitis","volume":"45","author":"Wong","year":"2013","journal-title":"Scand. J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jpsychires.2016.11.011_bib53","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mp.2008.5","article-title":"Are some cases of psychosis caused by microbial agents? A review of the evidence","volume":"13","author":"Yolken","year":"2008","journal-title":"Mol. Psychiatry"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395616302783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395616302783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T03:52:30Z","timestamp":1536205950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395616302783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":53,"alternative-id":["S0022395616302783"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2016.11.011","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suicide attempts and markers of immune response in individuals with serious mental illness","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2016.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}