{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:02:36Z","timestamp":1786993356182,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["134106"],"award-info":[{"award-number":["134106"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SW 320030-130237"],"award-info":[{"award-number":["SW 320030-130237"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jpsychires.2017.10.010","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T09:30:14Z","timestamp":1508146214000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-7265","authenticated-orcid":false,"given":"Edna","family":"Gr\u00fcnblatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Marinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Geissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz K.","family":"Wojdacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Romanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Walitza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2017.10.010_bib1","doi-asserted-by":"crossref","first-page":"e443","DOI":"10.1038\/tp.2014.88","article-title":"DNA methylation profiles within the serotonin transporter gene moderate the association of 5-HTTLPR and cortisol stress reactivity","volume":"4","author":"Alexander","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib2","series-title":"Diagnostic and Statistical Manual of Mental Disorders, fifth ed. (DSM-5)","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.janxdis.2011.03.002","article-title":"Serotonin transporter gene polymorphism implicates reduced orbito-frontal cortex in obsessive-compulsive disorder","volume":"25","author":"Atmaca","year":"2011","journal-title":"J. Anxiety Disord."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.pnpbp.2005.04.019","article-title":"A pilot genetic study of the continuum between compulsivity and impulsivity in females: the serotonin transporter promoter polymorphism","volume":"29","author":"Baca-Garcia","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib5","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.mp.4000550","article-title":"Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder","volume":"4","author":"Bengel","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.mp.4000257","article-title":"Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene","volume":"2","author":"Billett","year":"1997","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib8","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/ajmg.b.30699","article-title":"Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review","volume":"147B","author":"Bloch","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S1461145701002516","article-title":"Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder","volume":"4","author":"Camarena","year":"2001","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1089\/gtmb.2014.0319","article-title":"Genetic polymorphism of the serotonin transporter gene, SLC6A4 rs16965628, is associated with obsessive compulsive disorder","volume":"19","author":"Cengiz","year":"2015","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2004.03.065","article-title":"Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans","volume":"363","author":"Chabane","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jad.2005.12.011","article-title":"Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder","volume":"91","author":"Denys","year":"2006","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/sj.tpj.6500090","article-title":"Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response","volume":"2","author":"Di Bella","year":"2002","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biopsych.2006.09.030","article-title":"Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder","volume":"61","author":"Dickel","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib15","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1017\/S146114571400039X","article-title":"Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response","volume":"17","author":"Domschke","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5498\/wjp.v2.i1.13","article-title":"Childhood stressful events, HPA axis and anxiety disorders","volume":"2","author":"Faravelli","year":"2012","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0924-977X(00)00071-7","article-title":"Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways","volume":"10","author":"Frisch","year":"2000","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.comppsych.2004.02.010","article-title":"Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders","volume":"45","author":"Gothelf","year":"2004","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/sj.mp.4001970","article-title":"Rare plus common SERT variants in obsessive-compulsive disorder","volume":"12","author":"Grados","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3233\/JAD-2009-0996","article-title":"Gene expression as peripheral biomarkers for sporadic Alzheimer's disease","volume":"16","author":"Gr\u00fcnblatt","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neurobiolaging.2004.06.001","article-title":"Oxidative stress related markers in the \"VITA\" and the centenarian projects","volume":"26","author":"Gr\u00fcnblatt","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib23","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1080\/15592294.2015.1100786","article-title":"Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes","volume":"10","author":"Hannon","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib24","first-page":"1","article-title":"Increased fronto-striatal reward prediction errors moderate decision making in obsessive-compulsive disorder","author":"Hauser","year":"2017","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12991-017-0126-6","article-title":"A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients","volume":"16","author":"Honda","year":"2017","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1086\/503850","article-title":"Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder","volume":"78","author":"Hu","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib27","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.euroneuro.2017.07.005","article-title":"Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: neural correlates and tissue specificity","volume":"27","author":"Ismaylova","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"33 Suppl. l","key":"10.1016\/j.jpsychires.2017.10.010_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib29","series-title":"Factor Analysis of Childhood Onset Obsessive-compulsive Disorder: Symptom Dimensions and Association Analysis with the Serotonin Transporter Gene","first-page":"50","author":"Kenezloi","year":"2010"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000088860","article-title":"Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism","volume":"52","author":"Kim","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S1461145700002054","article-title":"Obsessive-compulsive disorder and the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population","volume":"3","author":"Kinnear","year":"2000","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.pnpbp.2006.12.024","article-title":"Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder","volume":"31","author":"Lin","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib33","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1755-5949.2011.00274.x","article-title":"An association analysis between 5-HTTLPR polymorphism and obsessive-compulsive disorder, Tourette syndrome in a Chinese Han population","volume":"17","author":"Liu","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00737-015-0526-z","article-title":"Is serotonin transporter polymorphism (5-HTTLPR) allele status a predictor for obsessive-compulsive disorder? A meta-analysis","volume":"18","author":"Mak","year":"2015","journal-title":"Arch. Womens Ment. Health"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S1138741600004066","article-title":"Cognitive performance and morning levels of salivary cortisol and alpha-amylase in children reporting high vs. low daily stress perception","volume":"11","author":"Maldonado","year":"2008","journal-title":"Span. J. Psychol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.mp.4001952","article-title":"Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance","volume":"12","author":"Martin","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/jamapsychiatry.2013.3","article-title":"Population-based, multigenerational family clustering study of obsessive-compulsive disorder","volume":"70","author":"Mataix-Cols","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.jpsychires.2017.10.010_bib38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/mp.2014.43","article-title":"Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS","volume":"20","author":"Mattheisen","year":"2014","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pnpbp.2016.01.012","article-title":"The need for inclusion of sex and age of onset variables in genetic association studies of obsessive-compulsive disorder: Overview","volume":"67","author":"Mattina","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj.mp.4000391","article-title":"Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder","volume":"3","author":"McDougle","year":"1998","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1601-1848.2003.0042.x","article-title":"Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder","volume":"3","author":"Meira-Lima","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib42","doi-asserted-by":"crossref","first-page":"e52501","DOI":"10.1371\/journal.pone.0052501","article-title":"Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation","volume":"8","author":"Migheli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib43","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fpsyt.2013.00021","article-title":"Perceived stress in obsessive-compulsive disorder is related with obsessive but not compulsive symptoms","volume":"4","author":"Morgado","year":"2013","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12888-016-0822-9","article-title":"Obsessive-compulsive and posttraumatic stress symptoms among civilian survivors of war","volume":"16","author":"Morina","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/mds.25460","article-title":"Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder","volume":"28","author":"Moya","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib47","doi-asserted-by":"crossref","first-page":"20120435","DOI":"10.1098\/rstb.2012.0435","article-title":"Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity","volume":"368","author":"Murphy","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib48","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn.3778","article-title":"Beyond genotype: serotonin transporter epigenetic modification predicts human brain function","volume":"17","author":"Nikolova","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fpsyt.2016.00035","article-title":"DNA methylation at the neonatal state and at the time of diagnosis: preliminary support for an association with the estrogen receptor 1, gamma-aminobutyric acid B receptor 1, and myelin oligodendrocyte glycoprotein in female adolescent patients with OCD","volume":"7","author":"Nissen","year":"2016","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2049-9256-2-1","article-title":"Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism","volume":"2","author":"Nyffeler","year":"2014","journal-title":"J. Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpsychires.2014.02.002","article-title":"The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression","volume":"53","author":"Okada","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib52","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1017\/S0033291712002784","article-title":"Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins","volume":"43","author":"Ouellet-Morin","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib53","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrn3746","article-title":"Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective","volume":"15","author":"Pauls","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neubiorev.2016.08.021","article-title":"SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: a systematic review of literature","volume":"71","author":"Provenzi","year":"2016","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib55","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S1516-44462009000300021","article-title":"Obsessive-compulsive disorder and 5-HTTLPR","volume":"31","author":"Rocha","year":"2009","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib58","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.pnpbp.2007.12.005","article-title":"Association study between obsessive-compulsive disorder and serotonergic candidate genes","volume":"32","author":"Saiz","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.b.32278","article-title":"DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain","volume":"168B","author":"Smith","year":"2015","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib60","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1101\/gr.180273.114","article-title":"Methylomic trajectories across human fetal brain development","volume":"25","author":"Spiers","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib61","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/mp.2012.85","article-title":"Genome-wide association study of obsessive-compulsive disorder","volume":"18","author":"Stewart","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib62","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jgg.2012.10.002","article-title":"Epigenetic regulation of serotonin transporter in psychiatric disorders","volume":"40","author":"Sugawara","year":"2013","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib63","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/mp.2012.76","article-title":"Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib64","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ajmg.b.32407","article-title":"Disorder-specific genetic factors in obsessive-compulsive disorder: a comprehensive meta-analysis","volume":"171B","author":"Taylor","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib65","first-page":"690","article-title":"Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population","volume":"132","author":"Tibrewal","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib66","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/13854046.2016.1162329","article-title":"Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder","volume":"30","author":"T\u00fckel","year":"2016","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib67","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1375\/twin.8.5.450","article-title":"Twin studies on obsessive-compulsive disorder: a review","volume":"8","author":"van Grootheest","year":"2005","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib68","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib69","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fpsyt.2012.00055","article-title":"Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter","volume":"3","author":"Vijayendran","year":"2012","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib70","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/mp.2009.100","article-title":"Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study","volume":"16","author":"Voyiaziakis","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib71","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2014.07.038","article-title":"Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder","volume":"580","author":"Walitza","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib72","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00702-004-0134-y","article-title":"Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway","volume":"111","author":"Walitza","year":"2004","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib73","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.npp.1301394","article-title":"A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder","volume":"32","author":"Wendland","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib74","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.mp.4001789","article-title":"Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531","volume":"11","author":"Wendland","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2017.10.010_bib75","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/hmg\/ddm343","article-title":"A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder","volume":"17","author":"Wendland","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib76","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Wittchen","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib77","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/00043764-200112000-00003","article-title":"Salivary cortisol levels and work-related stress among emergency department nurses","volume":"43","author":"Yang","year":"2001","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.jpsychires.2017.10.010_bib78","doi-asserted-by":"crossref","first-page":"31333","DOI":"10.1038\/srep31333","article-title":"Genome-wide DNA methylation analysis in obsessive-compulsive disorder patients","volume":"6","author":"Yue","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395617303187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395617303187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:10:39Z","timestamp":1758366639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395617303187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":78,"alternative-id":["S0022395617303187"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2017.10.010","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2017.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}