{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:40:49Z","timestamp":1790106049587,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Psychiatry and Behavioral Sciences"},{"DOI":"10.13039\/100015366","name":"McGovern Medical School","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015366","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The University of Texas Health Science Center at Houston (UTHealth)"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008128","name":"Universidade do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jpsychires.2018.02.007","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:24:10Z","timestamp":1518247450000},"page":"71-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats"],"prefix":"10.1016","volume":"100","author":[{"given":"Lutiana Roque","family":"Sim\u00f5es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Sangiogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Hikaru","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline S.","family":"Generoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Julio","family":"Faller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Dominguini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Antunes","family":"Mastella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-0887","authenticated-orcid":false,"given":"Giselli","family":"Scaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayasree Vayalanellore","family":"Giridharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-1976","authenticated-orcid":false,"given":"Monique","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drielly","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricia","family":"Petronilho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Zilli","family":"R\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Dal-Pizzol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra I.","family":"Zugno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Barichello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2018.02.007_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.10.002","article-title":"Animal models of gene-environment interaction in schizophrenia: a dimensional perspective","volume":"136","author":"Ayhan","year":"2016","journal-title":"Prog. Neurobiol."},{"issue":"223","key":"10.1016\/j.jpsychires.2018.02.007_bib3","first-page":"015","article-title":"Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit","volume":"12","author":"Banks","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jpsychires.2018.02.007_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110539.ch5","article-title":"Assays for superoxide dismutase","volume":"32","author":"Bannister","year":"1987","journal-title":"Meth. Biochem. Anal."},{"issue":"8","key":"10.1016\/j.jpsychires.2018.02.007_bib73","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s10096-011-1533-2","article-title":"Circulating concentrations, cerebral output of the CINC-1 and blood-brain barrier disruption in Wistar rats after pneumococcal meningitis induction","volume":"31","author":"Barichello","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib5","first-page":"5","article-title":"Sodium butyrate prevents memory impairment by Re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis","volume":"5","author":"Barichello","year":"2014","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib6","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: a review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"1\u20132","key":"10.1016\/j.jpsychires.2018.02.007_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0920-9964(00)00139-0","article-title":"Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia","volume":"49","author":"Braff","year":"2001","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.jpsychires.2018.02.007_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am. J. Psychiatr."},{"issue":"23","key":"10.1016\/j.jpsychires.2018.02.007_bib10","doi-asserted-by":"crossref","first-page":"7988","DOI":"10.1523\/JNEUROSCI.0777-14.2014","article-title":"Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature","volume":"34","author":"Caccamo","year":"2014","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.jpsychires.2018.02.007_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1176\/appi.ajp.2013.13070943","article-title":"Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring","volume":"171","author":"Canetta","year":"2014","journal-title":"Am. J. Psychiatr."},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4161\/oxim.3.6.13446","article-title":"A rodent model of schizophrenia reveals increase in creatine kinase activity with associated behavior changes","volume":"3","author":"Canever","year":"2010","journal-title":"Oxid. Med. Cell Longev."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.55782\/ane-2011-1868","article-title":"Lipopolysaccharide injected to pregnant mice affects behavior of their offspring in adulthood","volume":"71","author":"Chlodzinska","year":"2011","journal-title":"Acta Neurobiol. Exp."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/mrdd.10005","article-title":"Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm","volume":"8","author":"Dammann","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbr.2004.05.016","article-title":"Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats","volume":"156","author":"de Lima","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.jpsychires.2018.02.007_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archgenpsychiatry.2007.37","article-title":"Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study","volume":"65","author":"Deakin","year":"2008","journal-title":"Arch. Gen. Psychiatr."},{"issue":"217","key":"10.1016\/j.jpsychires.2018.02.007_bib17","first-page":"00217","article-title":"Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions","volume":"7","author":"Dickerson","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","article-title":"Malondialdehyde determination as index of lipid peroxidation","volume":"186","author":"Draper","year":"1990","journal-title":"Methods Enzymol."},{"issue":"8","key":"10.1016\/j.jpsychires.2018.02.007_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrn3978","article-title":"Immune mediators in the brain and peripheral tissues in autism spectrum disorder","volume":"16","author":"Estes","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"6301","key":"10.1016\/j.jpsychires.2018.02.007_bib20","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/ajpregu.00664.2003","article-title":"Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain","volume":"286","author":"Gayle","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.jpsychires.2018.02.007_bib22","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.jpsychires.2012.08.010","article-title":"Evaluation of behavioral and neurochemical changes induced by ketamine in rats: implications as an animal model of mania","volume":"46","author":"Ghedim","year":"2012","journal-title":"J. Psychiatr. Res."},{"issue":"1\u20132","key":"10.1016\/j.jpsychires.2018.02.007_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-5728(03)00095-X","article-title":"Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat","volume":"138","author":"Gilmore","year":"2003","journal-title":"J. Neuroimmunol."},{"issue":"1\u20132","key":"10.1016\/j.jpsychires.2018.02.007_bib24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2004.10.008","article-title":"Maternal poly I: C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat","volume":"159","author":"Gilmore","year":"2005","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ajog.2012.01.008","article-title":"Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration","volume":"206","author":"Girard","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nn.2764","article-title":"MHCI negatively regulates synapse density during the establishment of cortical connections","volume":"14","author":"Glynn","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib27","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1128\/AAC.01014-06","article-title":"Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis","volume":"51","author":"Grandgirard","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.jpsychires.2018.02.007_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00588242","article-title":"Mechanisms of blood-brain barrier breakdown","volume":"33","author":"Greenwood","year":"1991","journal-title":"Neuroradiology"},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib29","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.22620","article-title":"Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults","volume":"71","author":"Hagberg","year":"2012","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.jpsychires.2018.02.007_bib30","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/dneu.22043","article-title":"Prenatal and postnatal animal models of immune activation: relevance to a range of neurodevelopmental disorders","volume":"72","author":"Harvey","year":"2012","journal-title":"Dev Neurobiol"},{"issue":"2","key":"10.1016\/j.jpsychires.2018.02.007_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/GRF.0b013e3182510b7b","article-title":"Prevention of maternal and congenital cytomegalovirus infection","volume":"55","author":"Johnson","year":"2012","journal-title":"Clin. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pneurobio.2006.11.008","article-title":"Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy?","volume":"80","author":"Klein","year":"2006","journal-title":"Prog. Neurobiol."},{"issue":"5\u20136","key":"10.1016\/j.jpsychires.2018.02.007_bib33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000446405","article-title":"True effects or Bias? MMP-2 and MMP-9 serum concentrations after acute stroke","volume":"42","author":"Kreisel","year":"2016","journal-title":"Cerebrovasc. Dis."},{"issue":"6","key":"10.1016\/j.jpsychires.2018.02.007_bib34","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00001756-199504190-00011","article-title":"Ketamine activates psychosis and alters limbic blood flow in schizophrenia","volume":"6","author":"Lahti","year":"1995","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.jpsychires.2018.02.007_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-3223(99)00257-7","article-title":"Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT","volume":"47","author":"Laruelle","year":"2000","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/schbul\/sbm039","article-title":"Injections of NGF into neonatal frontal cortex decrease social interaction as adults: a rat model of schizophrenia","volume":"34","author":"Lazar","year":"2008","journal-title":"Schizophr. Bull."},{"issue":"2\u20133","key":"10.1016\/j.jpsychires.2018.02.007_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0165-0173(01)00101-1","article-title":"Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis","volume":"36","author":"Leppert","year":"2001","journal-title":"Brain Res. Rev."},{"issue":"7","key":"10.1016\/j.jpsychires.2018.02.007_bib74","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.pnpbp.2011.06.003","article-title":"Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine","volume":"35","author":"Levin","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.1998.tb08316.x","article-title":"Cytokines and fever. Mechanisms and sites of action","volume":"856","author":"Luheshi","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"9","key":"10.1016\/j.jpsychires.2018.02.007_bib41","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0883073809338066","article-title":"Fetal inflammatory response and brain injury in the preterm newborn","volume":"24","author":"Malaeb","year":"2009","journal-title":"J. Child Neurol."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","article-title":"Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems","volume":"75","author":"Meyer","year":"2014","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pnpbp.2012.03.010","article-title":"Prenatal inflammation and neurodevelopment in schizophrenia: a review of human studies","volume":"42","author":"Miller","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.jpsychires.2018.02.007_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051028","article-title":"NGF and its receptors in the regulation of inflammatory response","volume":"18","author":"Minnone","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jpsychires.2018.02.007_bib45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neuint.2009.07.006","article-title":"Understanding the molecular mechanism of blood-brain barrier damage in an experimental model of Japanese encephalitis: correlation with minocycline administration as a therapeutic agent","volume":"55","author":"Mishra","year":"2009","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.jpsychires.2018.02.007_bib46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1440-1819.2009.01945.x","article-title":"Cytokines and schizophrenia: microglia hypothesis of schizophrenia","volume":"63","author":"Monji","year":"2009","journal-title":"Psychiatr. Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.jpsychires.2018.02.007_bib47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pharmthera.2010.07.004","article-title":"Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism","volume":"128","author":"Neill","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxlet.2007.08.002","article-title":"Maternally-administered lipopolysaccharide (LPS) increases tumor necrosis factor alpha in fetal liver and fetal brain: its suppression by low-dose LPS pretreatment","volume":"176","author":"Ning","year":"2008","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib49","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbi.2012.01.015","article-title":"Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response","volume":"26","author":"Oskvig","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.jpsychires.2018.02.007_bib50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.jpsychires.2018.02.007_bib51","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1006\/bbrc.2000.3881","article-title":"Estimation of gelatinase content in rat brain: effect of focal ischemia","volume":"278","author":"Planas","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib52","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000368554","article-title":"Effects of subcutaneous LPS injection on gestational length and intrauterine and neonatal mortality in mice","volume":"22","author":"Pujol Lopez","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jpsychires.2018.02.007_bib53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pharmthera.2015.01.001","article-title":"The poly(I: C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery","volume":"149","author":"Reisinger","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pnpbp.2017.10.009","article-title":"The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia","volume":"81","author":"Reus","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2018.02.007_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuroscience.2017.04.016","article-title":"Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life","volume":"353","author":"Reus","year":"2017","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.jpsychires.2018.02.007_bib56","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3892\/or.2017.5391","article-title":"Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells","volume":"37","author":"Roomi","year":"2017","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.jpsychires.2018.02.007_bib57","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.2217\/14622416.9.11.1589","article-title":"BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia","volume":"9","author":"Rybakowski","year":"2008","journal-title":"Pharmacogenomics"},{"issue":"6263","key":"10.1016\/j.jpsychires.2018.02.007_bib58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1126\/science.aab3897","article-title":"Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders","volume":"350","author":"Sahin","year":"2015","journal-title":"Science"},{"issue":"7589","key":"10.1016\/j.jpsychires.2018.02.007_bib59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jpsychires.2018.02.007_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0072-9752(09)96001-8","article-title":"Pathogenesis and pathophysiology of bacterial CNS infections","volume":"96","author":"Sellner","year":"2010","journal-title":"Handb. Clin. Neurol."},{"issue":"4","key":"10.1016\/j.jpsychires.2018.02.007_bib61","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3892\/mmr.2017.6275","article-title":"Dynamics of MMP9, MMP2 and TIMP1 in a rat model of brain injury combined with traumatic heterotopic ossification","volume":"15","author":"Shi","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.jpsychires.2018.02.007_bib62","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cppeds.2015.06.008","article-title":"Association between prenatal exposure to maternal infection and offspring mood disorders: a review of the literature","volume":"45","author":"Simanek","year":"2015","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"issue":"12","key":"10.1016\/j.jpsychires.2018.02.007_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1371\/journal.pone.0051518","article-title":"HIV-1 Nef breaches placental barrier in rat model","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1996.13.1","article-title":"Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat","volume":"13","author":"Smith","year":"1996","journal-title":"J. Neurotrauma"},{"issue":"7","key":"10.1016\/j.jpsychires.2018.02.007_bib64","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/mp.2011.171","article-title":"Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology","volume":"17","author":"Stone","year":"2012","journal-title":"Mol. Psychiatr."},{"issue":"5","key":"10.1016\/j.jpsychires.2018.02.007_bib65","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.jpsychires.2018.02.007_bib66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1101\/lm.34600","article-title":"Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat","volume":"7","author":"Vianna","year":"2000","journal-title":"Learn. Mem."},{"issue":"12","key":"10.1016\/j.jpsychires.2018.02.007_bib67","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nrn988","article-title":"Role of neurotrophins in central synapse formation and stabilization","volume":"3","author":"Vicario-Abejon","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib68","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.brainres.2009.02.022","article-title":"Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide","volume":"10","author":"Wang","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib69","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbi.2014.06.202","article-title":"Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring","volume":"42","author":"Xia","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.jpsychires.2018.02.007_bib70","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/mmr.2016.5974","article-title":"Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib71","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbi.2014.01.017","article-title":"Neonatal intrahippocampal injection of lipopolysaccharide induces deficits in social behavior and prepulse inhibition and microglial activation in rats: implication for a new schizophrenia animal model","volume":"38","author":"Zhu","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jpsychires.2018.02.007_bib72","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2013.05.059","article-title":"Effect of maternal deprivation on acetylcholinesterase activity and behavioral changes on the ketamine-induced animal model of schizophrenia","volume":"248","author":"Zugno","year":"2013","journal-title":"Neuroscience"}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395617311822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395617311822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T03:28:16Z","timestamp":1719804496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395617311822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":75,"alternative-id":["S0022395617311822"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2018.02.007","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2018.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}