{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:08Z","timestamp":1787065148477,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Carlos III Health Institute through the Ministry of Science, Innovation and Universities","award":["PI10\/01753"],"award-info":[{"award-number":["PI10\/01753"]}]},{"name":"Carlos III Health Institute through the Ministry of Science, Innovation and Universities","award":["PI13\/00918"],"award-info":[{"award-number":["PI13\/00918"]}]},{"name":"Carlos III Health Institute through the Ministry of Science, Innovation and Universities","award":["PI14\/00413"],"award-info":[{"award-number":["PI14\/00413"]}]},{"name":"Carlos III Health Institute through the Ministry of Science, Innovation and Universities","award":["PI15\/00662"],"award-info":[{"award-number":["PI15\/00662"]}]},{"name":"European Regional Development Fund (ERDF)"},{"DOI":"10.13039\/501100006751","name":"CIBERSAM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Catalan Agency for the Management of University and Research Grants","award":["AGAUR, 2017 SGR 1247"],"award-info":[{"award-number":["AGAUR, 2017 SGR 1247"]}]},{"name":"ISCIII-SGEFI\/FEDER","award":["PT13\/0001"],"award-info":[{"award-number":["PT13\/0001"]}]},{"name":"Health Department of the Generalitat de Catalunya","award":["SLT006\/17\/00012"],"award-info":[{"award-number":["SLT006\/17\/00012"]}]},{"name":"Institute of Health Carlos III through the Spanish Ministry of Economy and Competitiveness"},{"name":"Institute of Health Carlos III through the Spanish Ministry of Economy and Competitiveness"},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"crossref","award":["JR14\/00038"],"award-info":[{"award-number":["JR14\/00038"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Economy and Competitiveness"},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"crossref","award":["CP10\/00604"],"award-info":[{"award-number":["CP10\/00604"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Economy and Competitiveness"},{"name":"la Fundaci\u00f3 la Caixa"},{"name":"Institute of Health Carlos III through the Spanish Ministry of Economy and Competitiveness"},{"name":"Spanish Ministry of Economy and Competitiveness (CIBERSAM)"},{"name":"Institute of Health Carlos III through the Spanish Ministry of Economy and Competitiveness"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jpsychires.2018.08.003","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T08:44:48Z","timestamp":1533804288000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder"],"prefix":"10.1016","volume":"104","author":[{"given":"Alex","family":"Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-3990","authenticated-orcid":false,"given":"Javier","family":"Costas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-1886","authenticated-orcid":false,"given":"Javier","family":"Labad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Salvat-Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinto","family":"Segal\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Urretavizcaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Real","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"de Arriba-Arnau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pino","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Barrachina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-6597","authenticated-orcid":false,"given":"Carles","family":"Soriano-Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Carracedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Mench\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2018.08.003_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(09)60240-3","article-title":"Obsessive-compulsive disorder","volume":"374","author":"Abramowitz","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib63","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib2","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/npp.2011.81","article-title":"Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population","volume":"36","author":"Appel","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.psyneuen.2017.01.005","article-title":"Maltreatment and diurnal cortisol regulation: a meta-analysis","volume":"78","author":"Bernard","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib6","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/archgenpsychiatry.2011.152","article-title":"Interaction between FKBP5 and childhood trauma and risk of aggressive behavior","volume":"69","author":"Bevilacqua","year":"2012","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib10","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng1479","article-title":"Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment","volume":"36","author":"Binder","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1176\/appi.ajp.2009.09040576","article-title":"Association of FKBP5 polymorphisms with suicidal events in the treatment of resistant depression in adolescents (TORDIA) study","volume":"167","author":"Brent","year":"2010","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.psyneuen.2017.08.024","article-title":"Interaction between FKBP5 gene and childhood trauma on psychosis, depression and anxiety symptoms in a non-clinical sample","volume":"85","author":"de Castro-Catala","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yhbeh.2011.05.003","article-title":"Negative emotionality, depressive symptoms and cortisol diurnal rhythms: analysis of a community sample of middle-aged males","volume":"60","author":"Doane","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gepi.10252","article-title":"Pedigree disequilibrium tests for multilocus haplotypes","volume":"25","author":"Dudbridge","year":"2003","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib15","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s10654-011-9585-2","article-title":"Reliability of hypothalamic-pituitary-adrenal axis assessment methods for use in population-based studies","author":"Golden","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib17","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/gepi.20299","article-title":"Maximizing association statistics over genetic models","volume":"32","author":"Gonz\u00e1lez","year":"2008","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib64","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The yale-brown obsessive compulsive scale. I. development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.31887\/DCNS.2015.17.3\/ggoodwin","article-title":"The overlap between anxiety, depression, and obsessive-compulsive disorder","volume":"17","author":"Goodwin","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.comppsych.2004.02.010","article-title":"Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders","volume":"45","author":"Gothelf","year":"2004","journal-title":"Compr. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrn3524","article-title":"Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective","volume":"14","author":"Grupe","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000123117","article-title":"Diurnal cortisol levels and cortisol response in youths with obsessive-compulsive disorder","volume":"57","author":"Gustafsson","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S0954579400007045","article-title":"Altered neuroendocrine activity in maltreated children related to symptoms of depression","volume":"8","author":"Hart","year":"1996","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.psyneuen.2008.03.008","article-title":"The link between childhood trauma and depression: insights from HPA axis studies in humans","volume":"33","author":"Heim","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib25","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1177\/0886260512468240","article-title":"Initial validation of the Spanish childhood trauma questionnaire-short form: factor structure, reliability and association with parenting","volume":"28","author":"Hernandez","year":"2013","journal-title":"J. Interpers Violence"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib27","first-page":"47","article-title":"Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals","volume":"83","author":"Huizenga","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopsycho.2013.01.018","article-title":"Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder","volume":"93","author":"Jarcho","year":"2013","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopsych.2005.10.014","article-title":"Cortisol circadian rhythm alterations in psychotic major depression","volume":"60","author":"Keller","year":"2006","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition","volume":"22","author":"Keller","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.psyneuen.2018.04.008","article-title":"Hypothalamic-pituitary-adrenal axis activity in the comorbidity between obsessive-compulsive disorder and major depression","volume":"93","author":"Labad","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jad.2010.02.113","article-title":"Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort","volume":"125","author":"Lavebratt","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpsychires.2016.03.009","article-title":"In search of the HPA axis activity in unipolar depression patients with childhood trauma: combined cortisol awakening response and dexamethasone suppression test","volume":"78","author":"Lu","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00406-015-0612-2","article-title":"The role of hypothalamus\u2013pituitary\u2013adrenal genes and childhood trauma in borderline personality disorder","volume":"266","author":"Mart\u00edn-Blanco","year":"2016","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib35","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/jc.2008-2054","article-title":"Combined receptor antagonist stimulation of the hypothalamic-pituitary- adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men","volume":"94","author":"Mattsson","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/gbb.12026","article-title":"Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression","volume":"12","author":"Menke","year":"2013","journal-title":"Gene Brain Behav."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib37","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/psyp.12354","article-title":"Hunting genes, hunting endophenotypes","volume":"51","author":"Miller","year":"2014","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.psyneuen.2012.09.013","article-title":"Transformation techniques for cross-sectional and longitudinal endocrine data: application to salivary cortisol concentrations","volume":"38","author":"Miller","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib39","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/da.22158","article-title":"Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders","volume":"30","author":"Minelli","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2013.00021","article-title":"Perceived stress in obsessive-compulsive disorder is related with obsessive but not compulsive symptoms","volume":"4","author":"Morgado","year":"2013","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib41","first-page":"139","article-title":"Adaptaci\u00f3n espa\u00f1ola del General Health Questionnaire (GHQ) de D.P. Goldberg","volume":"42","author":"Mu\u00f1oz","year":"1979","journal-title":"Arch. Neurobiol. (Madr)."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib43","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/npp.2009.236","article-title":"Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide","volume":"35","author":"Roy","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpsychires.2011.09.009","article-title":"Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior","volume":"46","author":"Roy","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.psyneuen.2016.11.007","article-title":"Hypothalamic-pituitary-adrenal axis activity and cognition in major depression: the role of remission status","volume":"76","author":"Salvat-Pujol","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/mp.2013.129","article-title":"HPA axis genetic variation, cortisol and psychosis in major depression","volume":"19","author":"Schatzberg","year":"2014","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib47","doi-asserted-by":"crossref","first-page":"e855","DOI":"10.4088\/JCP.15m10146","article-title":"Cortisol and brain-derived neurotrophic factor levels prior to treatment in children with obsessive-compulsive disorder","volume":"77","author":"\u015eim\u015fek","year":"2016","journal-title":"J. Clin. Psychiatr."},{"issue":"Suppl 2","key":"10.1016\/j.jpsychires.2018.08.003_bib65","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib48","series-title":"Manual for the State-trait Anxiety Inventory (Form Y), Manual for the Statetrait Anxiety Inventory STAI","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jad.2014.04.002","article-title":"FKBP5 polymorphism is associated with major depression but not with bipolar disorder","volume":"164","author":"Szczepankiewicz","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib50","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jad.2015.10.051","article-title":"Comorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions: results from a large multicentre clinical sample","volume":"190","author":"Torres","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ajmg.b.32593","article-title":"Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD","volume":"177","author":"Van der Auwera","year":"2018","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1210\/jc.2002-020354","article-title":"Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability","volume":"88","author":"Vermeer","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib52","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jad.2017.08.066","article-title":"Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: a systematic review and meta-analysis","volume":"225","author":"Wang","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib53","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.psyneuen.2016.04.001","article-title":"FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: results from the national Health and resilience in veterans study","volume":"69","author":"Watkins","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib54","series-title":"Anatomical Therapeutic Chemical (ATC) Classification System","author":"WHO (World Health Organization) Collaboration Centre for Drug Statistics Methodology","year":"2017"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib55","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1074\/jbc.M407498200","article-title":"FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells","volume":"280","author":"Wochnik","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib56","series-title":"Annals of the New York Academy of Sciences","first-page":"19","article-title":"Glucocorticoids: mood, memory, and mechanisms","author":"Wolkowitz","year":"2009"},{"key":"10.1016\/j.jpsychires.2018.08.003_bib57","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2174\/1570159X1304150831150507","article-title":"The effects of psychological stress on depression","volume":"13","author":"Yang","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2018.03.037","article-title":"The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans","author":"Young","year":"2018","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/gbb.12104","article-title":"Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism","volume":"13","author":"Zannas","year":"2014","journal-title":"Gene Brain Behav."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib60","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1167\/iovs.07-1279","article-title":"FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor \u03b2 and glucocorticoid responsiveness","volume":"49","author":"Zhang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/appi.ajp.2011.10111577","article-title":"Interaction of FKBP5 gene variants and adverse life events in prediction depression onset: results from a 10-year prospective community study","volume":"168","author":"Zimmermann","year":"2011","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.jpsychires.2018.08.003_bib62","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/ajmg.b.30709","article-title":"Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene","volume":"147","author":"Zobel","year":"2008","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395618305697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395618305697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:10:58Z","timestamp":1758366658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395618305697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":65,"alternative-id":["S0022395618305697"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2018.08.003","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2018.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}