{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:14:36Z","timestamp":1784826876773,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jpsychires.2020.03.003","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T13:12:39Z","timestamp":1583932359000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features"],"prefix":"10.1016","volume":"125","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.H.","family":"Verwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Lucassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Huitinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick F.","family":"Swaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2020.03.003_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0447.2007.01076.x","article-title":"Hospital\u2010treated psychosis and suicide in a rural community (1877\u20132005). Part 2: genetic founder effects","volume":"116","author":"Andersen","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.03.003_bib2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2174\/1381612822666151214105314","article-title":"Bipolar disorder: the role of the kynurenine and melatonergic pathways","volume":"22","author":"Anderson","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.003_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/jamapsychiatry.2013.3469","article-title":"Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder","volume":"71","author":"Baker","year":"2014","journal-title":"JAMA psychiatry"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbi.2015.10.003","article-title":"Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex","volume":"52","author":"Bollinger","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.003_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.genm.2009.07.004","article-title":"Gender differences in psychotic bipolar mania","volume":"6","author":"Br\u00e4unig","year":"2009","journal-title":"Gend. Med."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib7","series-title":"Practical Nonparametric Statistics","author":"Conover","year":"1980"},{"issue":"7","key":"10.1016\/j.jpsychires.2020.03.003_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/sj.npp.1301275","article-title":"Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment","volume":"32","author":"Cz\u00e9h","year":"2007","journal-title":"Neuropsychopharmacology : Off. Publ.Am. Coll. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1399-5618.2011.00896.x","article-title":"A population-based morphometric MRI study in patients with first-episode psychotic bipolar disorder: comparison with geographically matched healthy controls and major depressive disorder subjects","volume":"13","author":"de Azevedo-Marques Perico","year":"2011","journal-title":"Bipolar Disord."},{"issue":"2\u20133","key":"10.1016\/j.jpsychires.2020.03.003_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.schres.2014.10.055","article-title":"Innate immune response is differentially dysregulated between bipolar disease and schizophrenia","volume":"161","author":"de Baumont","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib11","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jad.2017.06.048","article-title":"Gender differences in the association between physical activity and cognitive function in individuals with bipolar disorder","volume":"221","author":"Fellendorf","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/neu.20179","article-title":"Seasonal plasticity of brain aromatase mRNA expression in glia: divergence across sex and vocal phenotypes","volume":"65","author":"Forlano","year":"2005","journal-title":"J. Neurobiol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/neu.20178","article-title":"Steroid regulation of brain aromatase expression in glia: female preoptic and vocal motor nuclei","volume":"65","author":"Forlano","year":"2005","journal-title":"J. Neurobiol."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.003_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2008.05.009","article-title":"Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia","volume":"439","author":"Fuke","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12991-016-0101-7","article-title":"Psychotic spectrum symptoms across the lifespan are related to lifetime suicidality among 147 patients with bipolar I or major depressive disorder","volume":"15","author":"Gesi","year":"2016","journal-title":"Ann. Gen. Psychiatr."},{"issue":"1\u20132","key":"10.1016\/j.jpsychires.2020.03.003_bib16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jad.2011.03.042","article-title":"A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder","volume":"133","author":"Gittins","year":"2011","journal-title":"J. Affect. Disord."},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2020.03.003_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2012.04.041","article-title":"Suicidal behavior in bipolar disorder: epidemiology, characteristics and major risk factors","volume":"143","author":"Gonda","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib18","series-title":"Manic-depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin","year":"2007"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ajmg.b.30133","article-title":"Family history influences age of onset in bipolar I disorder in females but not in males","volume":"133b","author":"Grigoroiu-Serbanescu","year":"2005","journal-title":"Am. J. Med. Genet. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics"},{"issue":"10","key":"10.1016\/j.jpsychires.2020.03.003_bib20","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/j.celrep.2018.08.001","article-title":"Transcriptional and translational differences of microglia from male and female brains","volume":"24","author":"Guneykaya","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jad.2015.10.002","article-title":"Seasonal pattern of manic episode admissions among bipolar I disorder patients is associated with male gender and presence of psychotic features","volume":"190","author":"Hochman","year":"2016","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.003_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1503\/jpn.140183","article-title":"Monocyte and microglial activation in patients with mood-stabilized bipolar disorder","volume":"40","author":"Jakobsson","year":"2015","journal-title":"J. Psychiatr. Neurosci. : JPN"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib23","first-page":"1","article-title":"Structural brain changes in first episode mania with and without psychosis: data from the systematic treatment optimization program for early mania (STOP-EM)","author":"Keramatian","year":"2016","journal-title":"World J. Biol. Psychiatr. : Off. J.World Fed.Soc.Biol.Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.003_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1017\/neu.2016.56","article-title":"Glial cells as key elements in the pathophysiology and treatment of bipolar disorder","volume":"29","author":"Keshavarz","year":"2017","journal-title":"Acta Neuropsychiatr."},{"issue":"12","key":"10.1016\/j.jpsychires.2020.03.003_bib25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jamapsychiatry.2014.1582","article-title":"Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder","volume":"71","author":"Konopaske","year":"2014","journal-title":"JAMA psychiatry"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pnpbp.2018.05.011","article-title":"Attentional engagement increases inferior frontal gyrus activity and mutes limbic activity in pediatric bipolar disorder: meta-analyses of fMRI studies","volume":"91","author":"Lee","year":"2018","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12974-016-0672-x","article-title":"Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages","volume":"13","author":"Lehmann","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-018-1197-2","article-title":"Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms","volume":"15","author":"Lesh","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib29","article-title":"Abnormal brain activation during emotion processing of euthymic bipolar patients taking different mood stabilizers","author":"Li","year":"2018","journal-title":"Brain imaging and behavior"},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.003_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jad.2011.04.055","article-title":"Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity","volume":"133","author":"Nivoli","year":"2011","journal-title":"J. Affect. Disord."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.003_bib31","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/mp.2016.130","article-title":"Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity","volume":"22","author":"Pantazatos","year":"2017","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.003_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/138920007780362545","article-title":"Pharmacological targeting of Ido-mediated tolerance for treating autoimmune disease","volume":"8","author":"Penberthy","year":"2007","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jad.2018.08.054","article-title":"Association between completed suicide and bipolar disorder: a systematic review of the literature","volume":"242","author":"Plans","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.psyneuen.2018.01.024","article-title":"The relationship between inflammatory state and quantity of affective episodes in bipolar disorder","volume":"90","author":"Queissner","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.003_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0006-3223(01)01080-0","article-title":"Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder","volume":"49","author":"Rajkowska","year":"2001","journal-title":"Biol. Psychiatr."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.03.003_bib36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.euroneuro.2015.04.023","article-title":"CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment","volume":"25","author":"Rolstad","year":"2015","journal-title":"Eur. Neuropsychopharmacol : J. Eur.Coll.Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2018.01385","article-title":"Prediction of violence, suicide behaviors and suicide ideation in a sample of institutionalized offenders with Schizophrenia and other psychosis","volume":"9","author":"SanSegundo","year":"2018","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bdi.12271","article-title":"International Society for Bipolar Disorders Task Force on Suicide: meta\u2010analyses and meta\u2010regression of correlates of suicide attempts and suicide deaths in bipolar disorder","volume":"17","author":"Schaffer","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2018.01.017","article-title":"Opposite molecular signatures of depression in men and women","author":"Seney","year":"2018","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41398-019-0490-x","article-title":"Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated","volume":"9","author":"Sneeboer","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib41","series-title":"Anterior Cingulate Cortex Glutamatergic Metabolites and Mood Stabilizers in Euthymic Bipolar I Disorder Patients: A Proton Magnetic Resonance Spectroscopy Study. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging","author":"Soeiro-de-Souza","year":"2018"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.003_bib42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.jpsychires.2020.03.003_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4088\/JCP.v63n0602","article-title":"Risk factors for completed suicide in bipolar disorder","volume":"63","author":"Tsai","year":"2002","journal-title":"J. Clin. Psychiatr."},{"issue":"7","key":"10.1016\/j.jpsychires.2020.03.003_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.03.003_bib45","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2008.38","article-title":"Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances","volume":"13","author":"Wang","year":"2008","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib46","doi-asserted-by":"crossref","first-page":"10717","DOI":"10.1038\/ncomms10717","article-title":"Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders","volume":"7","author":"Werling","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.003_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu015","article-title":"Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders","volume":"18","author":"Wesseling","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpsychires.2020.03.003_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00197","article-title":"Sex differences in psychiatric disease: a focus on the glutamate system","volume":"11","author":"Wickens","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.jpsychires.2020.03.003_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077318","article-title":"Gender differences in neuropsychological performance across psychotic disorders\u2013a multi-centre population based case-control study","volume":"8","author":"Zanelli","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jpsychires.2020.03.003_bib50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpsychires.2019.11.002","article-title":"Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide","volume":"121","author":"Zhang","year":"2020","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.003_bib51","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbrc.2018.03.226","article-title":"TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395619312580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395619312580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:14:17Z","timestamp":1758366857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395619312580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":51,"alternative-id":["S0022395619312580"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.03.003","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}