{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:51:53Z","timestamp":1772697113596,"version":"3.50.1"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001350","name":"Ministry of Health -Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/OFYIRG\/0020\/2016"],"award-info":[{"award-number":["NMRC\/OFYIRG\/0020\/2016"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jpsychires.2020.03.013","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T06:26:43Z","timestamp":1585376803000},"page":"122-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia"],"prefix":"10.1016","volume":"126","author":[{"given":"New Fei","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordon Xin Jie","family":"Tng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vigneshwaran","family":"Subbaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhailah","family":"Shukor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree Si Xian","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhing-Leet","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Juan","family":"Puang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok-Hong","family":"Kho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Wan En","family":"Siew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen Li","family":"Sin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Wai","family":"Eu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy Chia Ghee","family":"Sng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Medalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ajmg.b.30140","article-title":"Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report","volume":"134B","author":"Abdolmaleky","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib2","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.pcbi.0030017","article-title":"Efficiency and cost of economical brain functional networks","volume":"3","author":"Achard","year":"2007","journal-title":"PLoS Comput. Biol."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1134\/S0026893318050023","article-title":"Methylation of the reelin gene promoter in peripheral blood and its relationship with the cognitive function of schizophrenia patients","volume":"52","author":"Alfimova","year":"2018","journal-title":"Mol. Biol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1523\/JNEUROSCI.2310-14.2015","article-title":"Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change","volume":"35","author":"Anticevic","year":"2015","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tics.2011.11.015","article-title":"Cognition in schizophrenia: core psychological and neural mechanisms","volume":"16","author":"Barch","year":"2012","journal-title":"Trends Cognit. Sci."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib6","series-title":"Methylation matters? Decreased methylation status of genomic DNA in the blood of schizophrenic twins","author":"B\u00f6nsch","year":"2012"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nrn3214","article-title":"The economy of brain network organization","volume":"13","author":"Bullmore","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib8","first-page":"67","article-title":"DNA methylation in psychosis: insights into etiology and treatment","volume":"7","author":"Castellani","year":"2015"},{"issue":"13","key":"10.1016\/j.jpsychires.2020.03.013_bib9","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1093\/nar\/gkf401","article-title":"On the epigenetic regulation of the human reelin promoter","volume":"30","author":"Chen","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib10","series-title":"Statistical Power Analysis for the Behavioral Sciences","first-page":"285","author":"Cohen","year":"1988"},{"issue":"48","key":"10.1016\/j.jpsychires.2020.03.013_bib11","doi-asserted-by":"crossref","first-page":"12083","DOI":"10.1523\/JNEUROSCI.2965-15.2016","article-title":"The segregation and integration of distinct brain networks and their relationship to cognition","volume":"36","author":"Cohen","year":"2016","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib12","first-page":"8","article-title":"Advances and pitfalls in the analysis and interpretation of resting-state FMRI data","volume":"4","author":"Cole","year":"2010","journal-title":"Front. Syst. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2011.02.010","article-title":"Variable global dysconnectivity and individual differences in schizophrenia","volume":"70","author":"Cole","year":"2011","journal-title":"Biol. Psychiatr."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/nbdi.2001.0436","article-title":"Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability","volume":"8","author":"Costa","year":"2001","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"issue":"35","key":"10.1016\/j.jpsychires.2020.03.013_bib16","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1073\/pnas.0505394102","article-title":"Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia","volume":"102","author":"Dong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S0033291717001982","article-title":"Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial","volume":"48","author":"Donohoe","year":"2018","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1086\/686538","article-title":"Cognitive enhancement therapy improves resting-state functional connectivity in early course schizophrenia","volume":"7","author":"Eack","year":"2016","journal-title":"J. Soc. Soc. Work. Res."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/sj.mp.4001371","article-title":"Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis","volume":"8","author":"Eastwood","year":"2003","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1176\/appi.ajp.163.3.540","article-title":"Cellular basis of reduced cortical reelin expression in schizophrenia","volume":"163","author":"Eastwood","year":"2006","journal-title":"Am. J. Psychiatr."},{"issue":"6","key":"10.1016\/j.jpsychires.2020.03.013_bib21","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/mp.2015.35","article-title":"Kraepelin revisited: schizophrenia from degeneration to failed regeneration","volume":"20","author":"Falkai","year":"2015","journal-title":"Mol. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib22","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1038\/s41598-017-04829-9","article-title":"Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia","volume":"7","author":"Fan","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2011.09.022","article-title":"The role of BDNF in the pathophysiology and treatment of schizophrenia","volume":"46","author":"Favalli","year":"2012","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: emerging patterns and implications","volume":"13","author":"Feil","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/mp.2014.117","article-title":"Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications","volume":"20","author":"Fernandes","year":"2014","journal-title":"Mol. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41398-019-0601-8","article-title":"BDNF genetic variants and methylation: effects on cognition in major depressive disorder","volume":"9","author":"Ferrer","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib27","series-title":"Structure Clinical Interview for DSM-IV-TR Axis I Disorders-Non-Patient Edition (SCID-I\/NP, 11\/2002 Revision)","author":"First","year":"2002"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib28","series-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders","author":"First","year":"2002"},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib29","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib30","first-page":"19","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox","year":"2010","journal-title":"Front. Syst. Neurosci."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib31","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1176\/ajp.2007.164.3.450","article-title":"Aberrant \"default mode\" functional connectivity in schizophrenia","volume":"164","author":"Garrity","year":"2007","journal-title":"Am. J. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib33","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pharmthera.2005.01.007","article-title":"The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+\/-) in schizophrenia","volume":"111","author":"Grayson","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"26","key":"10.1016\/j.jpsychires.2020.03.013_bib34","doi-asserted-by":"crossref","first-page":"9341","DOI":"10.1073\/pnas.0503736102","article-title":"Reelin promoter hypermethylation in schizophrenia","volume":"102","author":"Grayson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib35","series-title":"Longitudinal Studies of Cognition and Functional Outcome in Schizophrenia: Implications for MATRICS","author":"Green","year":"2004"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/WCO.0b013e328306f2c5","article-title":"Resting-state functional connectivity in neuropsychiatric disorders","volume":"21","author":"Greicius","year":"2008","journal-title":"Curr. Opin. Neurol."},{"issue":"11","key":"10.1016\/j.jpsychires.2020.03.013_bib37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.57.11.1061","article-title":"Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study","volume":"57","author":"Guidotti","year":"2000","journal-title":"Arch. Gen. Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31887\/DCNS.2014.16.3\/aguidotti","article-title":"DNA methylation and demethylation as targets for antipsychotic therapy","volume":"16","author":"Guidotti","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/schbul\/sbu126","article-title":"Abnormal causal connectivity by structural deficits in first-episode, drug-naive schizophrenia at rest","volume":"41","author":"Guo","year":"2015","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib40","series-title":"Ventral Tegmental Area\/midbrain Functional Connectivity and Response to Antipsychotic Medication in Schizophrenia","author":"Hadley","year":"2014"},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib41","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.4035-04.2005","article-title":"Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia","volume":"25","author":"Hashimoto","year":"2005","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib42","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/npp.2010.52","article-title":"Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity","volume":"35","author":"Haut","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib43","doi-asserted-by":"crossref","DOI":"10.1097\/HRP.0000000000000207","article-title":"The amygdala in schizophrenia and bipolar disorder: a synthesis of structural MRI, diffusion tensor imaging and resting-state functional connectivity findings","author":"Ho","year":"2019","journal-title":"Harv. Rev. Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib44","series-title":"Neurotrophins: Roles in Neuronal Development and Function","author":"Huang","year":"2001"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib45","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neures.2013.08.004","article-title":"DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients","volume":"77","author":"Ikegame","year":"2013","journal-title":"Neurosci. Res."},{"issue":"26","key":"10.1016\/j.jpsychires.2020.03.013_bib46","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.95.26.15718","article-title":"A decrease of reelin expression as a putative vulnerability factor in schizophrenia","volume":"95","author":"Impagnatiello","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7321","key":"10.1016\/j.jpsychires.2020.03.013_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature09552","article-title":"Rethinking schizophrenia","volume":"468","author":"Insel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fncel.2017.00217","article-title":"Differential SLC1A2 promoter methylation in bipolar disorder with or without addiction","volume":"11","author":"Jia","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.9758\/cpn.2012.10.3.125","article-title":"Cognitive remediation in schizophrenia","volume":"10","author":"Kaneko","year":"2012","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative Syndrome Scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"issue":"2\u20133","key":"10.1016\/j.jpsychires.2020.03.013_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.schres.2003.09.011","article-title":"The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery","volume":"68","author":"Keefe","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroimage.2016.11.060","article-title":"Longitudinal functional brain imaging study in early course schizophrenia before and after cognitive enhancement therapy","volume":"151","author":"Keshavan","year":"2017","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib53","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1176\/appi.ajp.2013.13081075","article-title":"Cognitive training in mental disorders: update and future directions","volume":"171","author":"Keshavan","year":"2014","journal-title":"Am. J. Psychiatr."},{"issue":"12","key":"10.1016\/j.jpsychires.2020.03.013_bib54","doi-asserted-by":"crossref","first-page":"10889","DOI":"10.1007\/s11033-012-1986-0","article-title":"DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia","volume":"39","author":"Kordi-Tamandani","year":"2012","journal-title":"Mol. Biol. Rep."},{"issue":"16","key":"10.1016\/j.jpsychires.2020.03.013_bib55","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1017\/S0033291714001020","article-title":"Refining the latent structure of neuropsychological performance in schizophrenia","volume":"44","author":"Lam","year":"2014","journal-title":"Psychol. Med."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib56","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2217\/epi.12.31","article-title":"The epigenetic lorax: gene-environment interactions in human health","volume":"4","author":"Latham","year":"2012","journal-title":"Epigenomics"},{"issue":"12","key":"10.1016\/j.jpsychires.2020.03.013_bib57","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0006-3223(02)01316-1","article-title":"Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations","volume":"51","author":"Lawrie","year":"2002","journal-title":"Biol. Psychiatr."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.03.013_bib58","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbagrm.2008.01.001","article-title":"The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene","volume":"1779","author":"Levenson","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib59","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/mp.2012.38","article-title":"Epigenetic regulation of BDNF expression according to antidepressant response","volume":"18","author":"Lopez","year":"2013","journal-title":"Mol. Psychiatr."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib60","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/epi.24362","article-title":"Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies","volume":"8","author":"Lowe","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-45106-5_9","article-title":"BDNF and synaptic plasticity, cognitive function, and dysfunction","volume":"220","author":"Lu","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"issue":"11","key":"10.1016\/j.jpsychires.2020.03.013_bib62","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/s41380-017-0008-y","article-title":"Meta-analysis of epigenome-wide association studies of cognitive abilities","volume":"23","author":"Marioni","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib63","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/npjscilearn.2016.14","article-title":"Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?","volume":"1","author":"Marshall","year":"2016","journal-title":"Npj Sci. Learn."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib64","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11065-009-9097-y","article-title":"Cognitive remediation in schizophrenia","volume":"19","author":"Medalia","year":"2009","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib65","series-title":"Cognitive Remediation for Psychological Disorders: Therapist Guide","author":"Medalia","year":"2017"},{"issue":"6","key":"10.1016\/j.jpsychires.2020.03.013_bib66","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1096\/fj.11-202069","article-title":"Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset","volume":"26","author":"Melas","year":"2012","journal-title":"Faseb. J."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1471-4159.2005.03040.x","article-title":"Histone deacetylase inhibitors decrease reelin promoter methylation in vitro","volume":"93","author":"Mitchell","year":"2005","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2011.181","article-title":"From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment","volume":"37","author":"Moghaddam","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpsychires.2016.12.020","article-title":"Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia","volume":"88","author":"Nabil Fikri","year":"2017","journal-title":"J. Psychiatr. Res."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib70","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1073\/pnas.0409648102","article-title":"DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures","volume":"102","author":"Noh","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0925-4927(99)00050-5","article-title":"Brain perfusion and neuropsychological changes in schizophrenic patients after cognitive rehabilitation","volume":"98","author":"Penades","year":"2000","journal-title":"Psychiatr. Res."},{"issue":"10","key":"10.1016\/j.jpsychires.2020.03.013_bib72","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biopsych.2013.01.017","article-title":"Brain effects of cognitive remediation therapy in schizophrenia: a structural and functional neuroimaging study","volume":"73","author":"Penad\u00e9s","year":"2013","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.140","article-title":"Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene","volume":"3","author":"Perroud","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib74","series-title":"Brain-computer-interface-based Intervention Re-normalizes Brain Functional Network Topology in Children with Attention Deficit\/hyperactivity Disorder","author":"Qian","year":"2018"},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib75","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.nlm.2005.11.001","article-title":"Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice","volume":"85","author":"Qiu","year":"2006","journal-title":"Neurobiol. Learn. Mem."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib76","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1001\/jamapsychiatry.2015.0276","article-title":"Functional and neuroanatomic specificity of episodic memory dysfunction in schizophrenia: a functional magnetic resonance imaging study of the relational and item-specific encoding task","volume":"72","author":"Ragland","year":"2015","journal-title":"JAMA Psychiatr."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib77","first-page":"355","article-title":"Increases in intrinsic thalamocortical connectivity and overall cognition following cognitive remediation in chronic schizophrenia","volume":"2","author":"Ramsay","year":"2017","journal-title":"Biol. Psychiatr. Cogn. Neurosci. Neuroimag."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.conb.2005.03.017","article-title":"Directing the mind's eye: prefrontal, inferior and medial temporal mechanisms for visual working memory","volume":"15","author":"Ranganath","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.03.013_bib79","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib80","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1101\/lm.2153511","article-title":"Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density","volume":"18","author":"Rogers","year":"2011","journal-title":"Learn. Mem."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.schres.2010.01.001","article-title":"Resting-state functional network correlates of psychotic symptoms in schizophrenia","volume":"117","author":"Rotarska-Jagiela","year":"2010","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuron.2013.02.011","article-title":"Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver","volume":"78","author":"Schobel","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib83","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jneumeth.2011.04.010","article-title":"Default network correlations analyzed on native surfaces","volume":"198","author":"Seibert","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib84","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neubiorev.2015.12.007","article-title":"Cognition and resting-state functional connectivity in schizophrenia","volume":"61","author":"Sheffield","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.jpsychires.2020.03.013_bib85","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jamapsychiatry.2017.0669","article-title":"Transdiagnostic associations between functional brain network integrity and cognition","volume":"74","author":"Sheffield","year":"2017","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib86","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuropsychologia.2015.05.006","article-title":"Fronto-parietal and cingulo-opercular network integrity and cognition in health and schizophrenia","volume":"73","author":"Sheffield","year":"2015","journal-title":"Neuropsychologia"},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib87","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/schbul\/sbv148","article-title":"Evidence for accelerated decline of functional brain network efficiency in schizophrenia","volume":"42","author":"Sheffield","year":"2016","journal-title":"Schizophr. Bull."},{"issue":"10","key":"10.1016\/j.jpsychires.2020.03.013_bib88","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/cercor\/bhn256","article-title":"The resting brain: unconstrained yet reliable","volume":"19","author":"Shehzad","year":"2009","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.jpsychires.2020.03.013_bib89","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuroimage.2014.05.057","article-title":"Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains","volume":"99","author":"Subramaniam","year":"2014","journal-title":"Neuroimage"},{"issue":"6282","key":"10.1016\/j.jpsychires.2020.03.013_bib90","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.aad8127","article-title":"Task-free MRI predicts individual differences in brain activity during task performance","volume":"352","author":"Tavor","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib91","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biopsych.2007.07.003","article-title":"Methylation status of the reelin promoter region in the brain of schizophrenic patients","volume":"63","author":"Tochigi","year":"2008","journal-title":"Biol. Psychiatr."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.03.013_bib92","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrn2774","article-title":"Abnormal neural oscillations and synchrony in schizophrenia","volume":"11","author":"Uhlhaas","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib93","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/schbul\/sbt077","article-title":"Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction","volume":"40","author":"Unschuld","year":"2014","journal-title":"Schizophr. Bull."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.03.013_bib94","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.euroneuro.2010.03.008","article-title":"Exploring the brain network: a review on resting-state fMRI functional connectivity","volume":"20","author":"van den Heuvel","year":"2010","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"23","key":"10.1016\/j.jpsychires.2020.03.013_bib95","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1523\/JNEUROSCI.1443-09.2009","article-title":"Efficiency of functional brain networks and intellectual performance","volume":"29","author":"van den Heuvel","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.03.013_bib96","doi-asserted-by":"crossref","DOI":"10.1186\/s13072-018-0225-x","article-title":"Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs","volume":"11","author":"van Dongen","year":"2018","journal-title":"Epigenet. Chromatin"},{"issue":"6","key":"10.1016\/j.jpsychires.2020.03.013_bib97","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sj.mp.4001308","article-title":"Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia","volume":"8","author":"Weickert","year":"2003","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib98","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect."},{"key":"10.1016\/j.jpsychires.2020.03.013_bib99","series-title":"WRAT-3 : Wide Range Achievement Test Administration Manual","author":"Wilkinson","year":"1993"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.03.013_bib100","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1212\/01.wnl.0000341782.71418.6c","article-title":"Educational attainment and cognitive decline in old age","volume":"72","author":"Wilson","year":"2009","journal-title":"Neurology"},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2020.03.013_bib101","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.schres.2011.03.010","article-title":"Functional resting-state networks are differentially affected in schizophrenia","volume":"130","author":"Woodward","year":"2011","journal-title":"Schizophr. Res."},{"issue":"1\u20132","key":"10.1016\/j.jpsychires.2020.03.013_bib102","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0920-9964(98)00076-0","article-title":"What are we changing with neurocognitive rehabilitation? Illustrations from two single cases of changes in neuropsychological performance and brain systems as measured by SPECT","volume":"34","author":"Wykes","year":"1998","journal-title":"Schizophr. Res."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.03.013_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025423","article-title":"Altered topological properties of functional network connectivity in schizophrenia during resting state: a small-world brain network study","volume":"6","author":"Yu","year":"2011","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.jpsychires.2020.03.013_bib104","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neulet.2007.02.081","article-title":"Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI","volume":"417","author":"Zhou","year":"2007","journal-title":"Neurosci. Lett."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395619310817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395619310817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:16:19Z","timestamp":1758366979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395619310817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":104,"alternative-id":["S0022395619310817"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.03.013","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}