{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:28:40Z","timestamp":1790800120660,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jpsychires.2020.12.007","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T09:27:39Z","timestamp":1607074059000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin"],"prefix":"10.1016","volume":"133","author":[{"given":"Rodrigo B.","family":"Mansur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-0248","authenticated-orcid":false,"given":"Francheska","family":"Delgado-Peraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehala","family":"Subramaniapillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Iacobucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Nasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Brietzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Suppes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Raison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fagiolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Rasgon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Nogueras-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-3118","authenticated-orcid":false,"given":"Dimitrios","family":"Kapogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpsychires.2020.12.007_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jad.2018.11.090","article-title":"Double-blind, placebo-controlled trial of pioglitazone for bipolar depression","volume":"245","author":"Aftab","year":"2019","journal-title":"J. Affect. Disord."},{"issue":"12","key":"10.1016\/j.jpsychires.2020.12.007_bib2","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1210\/en.2007-0132","article-title":"Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes","volume":"148","author":"Araujo","year":"2007","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaneurol.2018.4304","article-title":"Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the exenatide-PD trial","volume":"76","author":"Athauda","year":"2019","journal-title":"JAMA Neurol."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.12.007_bib4","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/brain\/awx044","article-title":"Insulin resistance and exendin-4 treatment for multiple system atrophy","volume":"140","author":"Bassil","year":"2017","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.jpsychires.2020.12.007_bib5","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/rheumatology\/kew306","article-title":"Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study","volume":"55","author":"Bissell","year":"2016","journal-title":"Rheumatology"},{"issue":"9","key":"10.1016\/j.jpsychires.2020.12.007_bib6","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1111\/j.1582-4934.2011.01318.x","article-title":"Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis","volume":"15","author":"Bosco","year":"2011","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1192\/bjp.bp.114.152850","article-title":"Insulin resistance and outcome in bipolar disorder","volume":"206","author":"Calkin","year":"2015","journal-title":"Br. J. Psychiatry"},{"issue":"8\u20139","key":"10.1016\/j.jpsychires.2020.12.007_bib8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3109\/00365521.2012.688213","article-title":"Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis","volume":"47","author":"Clemente","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40345-019-0142-3","article-title":"Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives","volume":"7","author":"Coello","year":"2019","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib10","first-page":"1","article-title":"Changes in serum adipokines profile and insulin resistance in patients with rheumatoid arthritis treated with anti-TNF-alpha","author":"Corrado","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/bdi.12200","article-title":"Association of obesity and treated hypertension and diabetes with cognitive ability in bipolar disorder and schizophrenia","volume":"16","author":"Depp","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/npjamd.2016.19","article-title":"Extracellular vesicle-associated abeta mediates trans-neuronal bioenergetic and Ca(2+)-handling deficits in Alzheimer's disease models","volume":"2","author":"Eitan","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"issue":"9","key":"10.1016\/j.jpsychires.2020.12.007_bib14","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/alz.12130","article-title":"Extracellular vesicle biomarkers of Alzheimer\u2019s disease associated with sub-clinical cognitive decline in late middle age","volume":"16","author":"Eren","year":"2020","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib15","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.mcn.2005.12.003","article-title":"Exosomes are released by cultured cortical neurones","volume":"31","author":"Faure","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.jpsychires.2020.12.007_bib16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jalz.2014.06.008","article-title":"Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study","volume":"11","author":"Fiandaca","year":"2015","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S2213-8587(14)70148-2","article-title":"Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review","volume":"3","author":"Geijselaers","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.physbeh.2013.09.001","article-title":"Impaired glucose regulation is associated with poorer performance on the Stroop Task","volume":"122","author":"Gluck","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fnins.2019.00452","article-title":"Neuron-derived exosome proteins may contribute to progression from repetitive mild traumatic brain injuries to chronic traumatic encephalopathy","volume":"13","author":"Goetzl","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12291-012-0292-x","article-title":"Assessment of insulin resistance and metabolic syndrome in drug naive patients of bipolar disorder","volume":"29","author":"Guha","year":"2014","journal-title":"Indian J. Clin. Biochem."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biopsych.2013.11.007","article-title":"Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders","volume":"77","author":"Hajek","year":"2015","journal-title":"Biol. Psychiatr."},{"issue":"12","key":"10.1016\/j.jpsychires.2020.12.007_bib23","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1038\/npp.2014.148","article-title":"Insulin resistance, diabetes mellitus, and brain structure in bipolar disorders","volume":"39","author":"Hajek","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpsychires.2020.12.007_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpsychires.2018.08.012","article-title":"Neuroimaging hippocampal subfields in schizophrenia and bipolar disorder: a systematic review and meta-analysis","volume":"104","author":"Haukvik","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib25","series-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes","year":"2013"},{"issue":"5249","key":"10.1016\/j.jpsychires.2020.12.007_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance","volume":"271","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jpsychires.2020.12.007_bib27","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jalz.2019.05.002","article-title":"Concordance between the assessment of Abeta42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid","volume":"15","author":"Jia","year":"2019","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1096\/fj.14-262048","article-title":"Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease","volume":"29","author":"Kapogiannis","year":"2015","journal-title":"Faseb. J."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.eurpsy.2019.08.012","article-title":"Insulin-signaling abnormalities in drug-naive first-episode schizophrenia: transduction protein analyses in extracellular vesicles of putative neuronal origin","volume":"62","author":"Kapogiannis","year":"2019","journal-title":"Eur. Psychiatr."},{"issue":"11","key":"10.1016\/j.jpsychires.2020.12.007_bib30","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/jamaneurol.2019.2462","article-title":"Association of extracellular vesicle biomarkers with alzheimer disease in the Baltimore longitudinal study of aging","volume":"76","author":"Kapogiannis","year":"2019","journal-title":"JAMA Neurol."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4093\/dmj.2013.37.2.106","article-title":"A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense","volume":"37","author":"Karunakaran","year":"2013","journal-title":"Diabetes Metab. J"},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.neurobiolaging.2012.06.006","article-title":"Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease","volume":"34","author":"Kenna","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.jpsychires.2020.12.007_bib33","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib34","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00032.2015","article-title":"Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans","volume":"96","author":"Kullmann","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib35","first-page":"1","article-title":"Abdominal obesity is associated with impaired cognitive function in euthymic bipolar individuals","author":"Lackner","year":"2015","journal-title":"World J. Biol. Psychiatr."},{"issue":"12","key":"10.1016\/j.jpsychires.2020.12.007_bib36","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2337\/diacare.21.12.2191","article-title":"Correct homeostasis model assessment (HOMA) evaluation uses the computer program","volume":"21","author":"Levy","year":"1998","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/da.22866","article-title":"Structural imaging biomarkers for bipolar disorder: meta-analyses of whole-brain voxel-based morphometry studies","volume":"36","author":"Lu","year":"2019","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jpsychires.2020.12.007_bib38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jad.2016.09.056","article-title":"Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study","volume":"207","author":"Mansur","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/bdi.12826","article-title":"Parsing metabolic heterogeneity in mood disorders: a hypothesis-driven cluster analysis of glucose and insulin abnormalities","volume":"22","author":"Mansur","year":"2019","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpsychires.2015.12.003","article-title":"Adipokines, metabolic dysfunction and illness course in bipolar disorder","volume":"74","author":"Mansur","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib41","doi-asserted-by":"crossref","first-page":"104779","DOI":"10.1016\/j.psyneuen.2020.104779","article-title":"Leptin mediates improvements in cognitive function following treatment with infliximab in adults with bipolar depression","volume":"120","author":"Mansur","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbt.10058","article-title":"Diabetes, oxidative stress, and antioxidants: a review","volume":"17","author":"Maritim","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/bdi.12491","article-title":"Adverse effects of obesity on cognitive functions in individuals at ultra high risk for bipolar disorder: results from the global mood and brain science initiative","volume":"19","author":"McIntyre","year":"2017","journal-title":"Bipolar Disord."},{"issue":"7","key":"10.1016\/j.jpsychires.2020.12.007_bib45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/bdi.12006","article-title":"A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder","volume":"14","author":"McIntyre","year":"2012","journal-title":"Bipolar Disord."},{"issue":"8","key":"10.1016\/j.jpsychires.2020.12.007_bib46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jamapsychiatry.2019.0779","article-title":"Efficacy of adjunctive infliximab vs placebo in the treatment of adults with bipolar I\/II depression: a randomized clinical trial","volume":"76","author":"McIntyre","year":"2019","journal-title":"JAMA Psychiatr."},{"issue":"6","key":"10.1016\/j.jpsychires.2020.12.007_bib47","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/00023210-200822060-00001","article-title":"Insulin, insulin-like growth factors and incretins: neural homeostatic regulators and treatment opportunities","volume":"22","author":"McIntyre","year":"2008","journal-title":"CNS Drugs"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.12.007_bib48","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12716","article-title":"Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro","volume":"88","author":"Mendez-Garcia","year":"2018","journal-title":"Scand. J. Immunol."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib49","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/hbm.23494","article-title":"Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease","volume":"38","author":"Mullins","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib50","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fnins.2017.00278","article-title":"Plasma extracellular vesicles enriched for neuronal origin: a potential window into brain pathologic processes","volume":"11","author":"Mustapic","year":"2017","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib51","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-180578","article-title":"Extracellular vesicle biomarkers track cognitive changes following intranasal insulin in Alzheimer's disease","volume":"69","author":"Mustapic","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib52","article-title":"Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance","author":"Nasca","year":"2020","journal-title":"Mol. Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2251-6581-13-27","article-title":"Executive functions and information processing in patients with type 2 diabetes in comparison to pre-diabetic patients","volume":"13","author":"Nazaribadie","year":"2014","journal-title":"J. Diabetes Metab. Disord."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.dld.2015.12.008","article-title":"Direct effect of infliximab on intestinal mucosa sustains mucosal healing: exploring new mechanisms of action","volume":"48","author":"Petito","year":"2016","journal-title":"Dig. Liver Dis."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib55","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"Preacher","year":"2008","journal-title":"Behav. Res. Methods"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.12.007_bib56","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s13365-018-0695-4","article-title":"Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer\u2019s disease","volume":"25","author":"Pulliam","year":"2019","journal-title":"J. Neurovirol."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2011.02.004","article-title":"Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications","volume":"233","author":"Reagan","year":"2012","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.jpsychires.2020.12.007_bib59","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/1354750X.2016.1252950","article-title":"Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease","volume":"22","author":"Roman","year":"2017","journal-title":"Biomarkers"},{"issue":"7","key":"10.1016\/j.jpsychires.2020.12.007_bib61","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/070674370304800705","article-title":"Clinical features of bipolar disorder with and without comorbid diabetes mellitus","volume":"48","author":"Ruzickova","year":"2003","journal-title":"Can. J. Psychiatr."},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib62","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s11357-013-9613-0","article-title":"The impact of glucose disorders on cognition and brain volumes in the elderly: the Sydney Memory and Ageing Study","volume":"36","author":"Samaras","year":"2014","journal-title":"Age (Dordr.)"},{"issue":"6","key":"10.1016\/j.jpsychires.2020.12.007_bib63","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/dc12-1017","article-title":"Relationship between markers of insulin resistance, markers of adiposity, HbA1c, and cognitive functions in a middle-aged population-based sample: the MONA LISA study","volume":"36","author":"Sanz","year":"2013","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.jpsychires.2020.12.007_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126804","article-title":"The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?","volume":"10","author":"Sartorius","year":"2015","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.jpsychires.2020.12.007_bib65","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jalz.2016.04.003","article-title":"CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease","volume":"12","author":"Shi","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib66","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1186\/ar3874","article-title":"Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance","volume":"14","author":"Stagakis","year":"2012","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.jpsychires.2020.12.007_bib67","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.jpsychires.2020.12.007_bib68","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jpsychires.2020.12.007_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/683680","article-title":"Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies","volume":"2012","author":"Tran","year":"2012","journal-title":"Exp. Diabetes Res."},{"issue":"1\u20133","key":"10.1016\/j.jpsychires.2020.12.007_bib70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2004.02.055","article-title":"Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus","volume":"490","author":"Trudeau","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.jpsychires.2020.12.007_bib71","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4088\/JCP.14r09635","article-title":"Prevalence and predictors of type 2 diabetes mellitus in people with bipolar disorder: a systematic review and meta-analysis","volume":"76","author":"Vancampfort","year":"2015","journal-title":"J. Clin. Psychiatr."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib72","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/wps.20252","article-title":"Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis","volume":"14","author":"Vancampfort","year":"2015","journal-title":"World Psychiatr."},{"issue":"10","key":"10.1016\/j.jpsychires.2020.12.007_bib73","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.4049\/jimmunol.168.10.5342","article-title":"p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease","volume":"168","author":"Waetzig","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neurobiolaging.2020.09.022","article-title":"Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study","volume":"97","author":"Walker","year":"2020","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.jpsychires.2020.12.007_bib75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1503\/jpn.180002","article-title":"Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis","volume":"44","author":"Wang","year":"2019","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib76","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.schres.2019.01.031","article-title":"Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia","volume":"208","author":"Wijtenburg","year":"2019","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib77","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.schres.2019.01.031","article-title":"Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia","volume":"208","author":"Wijtenburg","year":"2019","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.jpsychires.2020.12.007_bib78","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eurpsy.2011.02.004","article-title":"The effect of overweight\/obesity on cognitive function in euthymic individuals with bipolar disorder","volume":"27","author":"Yim","year":"2012","journal-title":"Eur. Psychiatr."},{"key":"10.1016\/j.jpsychires.2020.12.007_bib79","doi-asserted-by":"crossref","first-page":"656341","DOI":"10.1155\/2014\/656341","article-title":"Duration of type 2 diabetes and very low density lipoprotein levels are associated with cognitive dysfunction in metabolic syndrome","volume":"2014","author":"Yogi-Morren","year":"2014","journal-title":"Cardiovasc. Psychiatr. Neurol."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395620311158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395620311158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:16:58Z","timestamp":1758367018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395620311158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":79,"alternative-id":["S0022395620311158"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.12.007","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2020.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}