{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:30:11Z","timestamp":1793374211195,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060602"],"award-info":[{"award-number":["82060602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psychiatric Research"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jpsychires.2022.12.005","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:28:16Z","timestamp":1670822896000},"page":"276-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Neurobiochemical biomarkers and other risk factors for post-traumatic acute stress disorder"],"prefix":"10.1016","volume":"157","author":[{"given":"Xiahong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daimin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-319X","authenticated-orcid":false,"given":"Henry","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-6757","authenticated-orcid":false,"given":"Xiuquan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jpsychires.2022.12.005_bib1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00213-021-05785-z","article-title":"Plasma gamma-aminobutyric acid (GABA) levels and posttraumatic stress disorder symptoms in trauma-exposed women: a preliminary report","volume":"238","author":"Arditte Hall","year":"2021","journal-title":"Psychopharmacology(Berl)"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib2","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Association","year":"1994"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2016.11.064","article-title":"Glutamate dysregulation and glutamatergic therapeutics for PTSD: evidence from human studies","volume":"649","author":"Averill","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4306\/pi.2016.13.1.121","article-title":"Increased neutrophil\/lymphocyte ratio in patients with depression is correlated with the severity of depression and cardiovascular risk factors","volume":"13","author":"Aydin Sunbul","year":"2016","journal-title":"Psychiatry Investig"},{"issue":"9","key":"10.1016\/j.jpsychires.2022.12.005_bib5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1037\/bul0000053","article-title":"Sleep and mental disorders: a meta-analysis of polysomnographic research","volume":"142","author":"Baglioni","year":"2016","journal-title":"Psychol. Bull."},{"issue":"3","key":"10.1016\/j.jpsychires.2022.12.005_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/2047487317748506","article-title":"Acute stress disorder and C-reactive protein in patients with acute myocardial infarction","volume":"25","author":"Bielas","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jts.22200","article-title":"Acute stress symptoms in seriously injured patients: precipitating versus cumulative trauma and the contribution of peritraumatic distress","volume":"30","author":"Briere","year":"2017","journal-title":"J. Trauma Stress"},{"issue":"3","key":"10.1016\/j.jpsychires.2022.12.005_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1037\/1040-3590.10.3.215","article-title":"Assessing acute stress disorder: psychometric properties of a structured clinical interview","volume":"10","author":"Bryant","year":"1998","journal-title":"Psychol. Assess."},{"issue":"11","key":"10.1016\/j.jpsychires.2022.12.005_bib9","first-page":"992","article-title":"Resilience characteristics in patients with traumatic fracture and its influence on acute stress disorder","volume":"25","author":"Chen","year":"2016","journal-title":"J Chinese Journal of Behavioral Medicine and Brain Science"},{"issue":"12","key":"10.1016\/j.jpsychires.2022.12.005_bib10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/nn.3266","article-title":"Glucocorticoid receptors recruit the CaMKII\u03b1-BDNF-CREB pathways to mediate memory consolidation","volume":"15","author":"Chen","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/NOR.0000000000000417","article-title":"Posttraumatic stress, depressive emotions, and satisfaction with life after a road traffic accident","volume":"37","author":"Copanitsanou","year":"2018","journal-title":"Orthop. Nurs."},{"issue":"6","key":"10.1016\/j.jpsychires.2022.12.005_bib12","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/eji.200425091","article-title":"The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release","volume":"34","author":"Cowburn","year":"2004","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12888-018-1769-9","article-title":"Prevalence of acute stress disorder among road traffic accident survivors: a meta-analysis","volume":"18","author":"Dai","year":"2018","journal-title":"BMC Psychiatr."},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn.2016.155","article-title":"Stress, glucocorticoids and memory: implications for treating fear-related disorders","volume":"18","author":"de Quervain","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jpsychires.2022.12.005_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pnpbp.2018.10.010","article-title":"The hypothalamic-pituitary-adrenal axis in PTSD: pathophysiology and treatment interventions","volume":"89","author":"Dunlop","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2018.10.012","article-title":"Inflammation as a predictor of disease course in posttraumatic stress disorder and depression: a prospective analysis from the Mind Your Heart Study","volume":"75","author":"Eswarappa","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.jpsychires.2022.12.005_bib17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1570159X15666171123201142","article-title":"Imaging the role of inflammation in mood and anxiety-related disorders","volume":"16","author":"Felger","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.jpsychires.2022.12.005_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000063647","article-title":"Who develops acute stress disorder after accidental injuries?","volume":"71","author":"Fuglsang","year":"2002","journal-title":"Psychother. Psychosom."},{"issue":"9","key":"10.1016\/j.jpsychires.2022.12.005_bib19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/glia.20671","article-title":"Modulation of astrocytic metabolic phenotype by proinflammatory cytokines","volume":"56","author":"Gavillet","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cobeha.2016.09.012","article-title":"Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression","volume":"14","author":"Ghosal","year":"2017","journal-title":"Curr Opin Behav Sci"},{"issue":"5","key":"10.1016\/j.jpsychires.2022.12.005_bib21","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s12035-020-02249-x","article-title":"Impact of COVID-19 in the mental health in elderly: psychological and biological updates","volume":"58","author":"Grolli","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.jpsychires.2022.12.005_bib22","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209510","article-title":"A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks","volume":"16","author":"Karin","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.jpsychires.2022.12.005_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pnpbp.2018.06.008","article-title":"A review on inflammatory cytokine-induced alterations of the brain as potential neural biomarkers in post-traumatic stress disorder","volume":"91","author":"Kim","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41398-022-02094-7","article-title":"The role of the immune system in posttraumatic stress disorder","volume":"12","author":"Katrinli","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.jpsychires.2022.12.005_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18041564","article-title":"Different patterns of mental health outcomes among road traffic crash survivors: a prospective cohort study","volume":"18","author":"Kovacevic","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuron.2019.03.017","article-title":"Deconstructing the gestalt: mechanisms of fear, threat, and trauma memory encoding","volume":"102","author":"Maddox","year":"2019","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.jpsychires.2022.12.005_bib27","doi-asserted-by":"crossref","first-page":"T67","DOI":"10.1530\/JOE-15-0121","article-title":"60 years of neuroendocrinology: redefining neuroendocrinology: stress, sex and cognitive and emotional regulation","volume":"226","author":"McEwen","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jpsychires.2022.12.005_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jss.2020.09.023","article-title":"Post-traumatic stress disorder in adult and pediatric trauma populations: a literature review","volume":"259","author":"Meneses","year":"2021","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.jpsychires.2022.12.005_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2015.01.005","article-title":"Diagnostic biomarkers for posttraumatic stress disorder: promising horizons from translational neuroscience research","volume":"78","author":"Michopoulos","year":"2015","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jpsychires.2022.12.005_bib30","series-title":"Crude Death Rate of Urban Residents","author":"National Bureau of Statistics","year":"2021"},{"issue":"1","key":"10.1016\/j.jpsychires.2022.12.005_bib31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12888-018-1910-9","article-title":"Salivary cortisol in post-traumatic stress disorder: a systematic review and meta-analysis","volume":"18","author":"Pan","year":"2018","journal-title":"BMC Psychiatr."},{"issue":"2","key":"10.1016\/j.jpsychires.2022.12.005_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.injury.2016.11.011","article-title":"Psychological distress and physical disability in patients sustaining severe injuries in road traffic crashes: results from a one-year cohort study from three European countries","volume":"48","author":"Papadakaki","year":"2017","journal-title":"Injury"},{"issue":"11","key":"10.1016\/j.jpsychires.2022.12.005_bib33","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S2215-0366(15)00309-0","article-title":"Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression","volume":"2","author":"Passos","year":"2015","journal-title":"Lancet Psychiatr."},{"issue":"16","key":"10.1016\/j.jpsychires.2022.12.005_bib34","first-page":"172","article-title":"Analysis and prevention of related factors of acute stress disorder in patients after traumatic fracture","volume":"27","author":"Qin","year":"2021","journal-title":"Contemporary Med"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577398","article-title":"The neutrophil-to-lymphocyte ratio in Alzheimer's disease: current understanding and potential applications","volume":"349","author":"Sayed","year":"2020","journal-title":"J. Neuroimmunol."},{"issue":"7","key":"10.1016\/j.jpsychires.2022.12.005_bib36","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/2047487318761091","article-title":"Acute stress disorder and C-reactive protein in patients with acute myocardial infarction","volume":"25","author":"Seferovi\u0107","year":"2018","journal-title":"Eur J Prev Cardiol"},{"issue":"25","key":"10.1016\/j.jpsychires.2022.12.005_bib37","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1056\/NEJMra1612499","article-title":"Post-traumatic stress disorder","volume":"376","author":"Shalev","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jpsychires.2022.12.005_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jad.2019.01.037","article-title":"Reduced gamma-amino butyric acid (GABA) and glutamine in the anterior cingulate cortex (ACC) of veterans exposed to trauma","volume":"248","author":"Sheth","year":"2019","journal-title":"J. Affect. Disord."},{"issue":"5","key":"10.1016\/j.jpsychires.2022.12.005_bib39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/10253890.2020.1724949","article-title":"Hair cortisol levels in posttraumatic stress disorder and metabolic syndrome","volume":"23","author":"van den Heuvel","year":"2020","journal-title":"Stress"},{"issue":"6","key":"10.1016\/j.jpsychires.2022.12.005_bib40","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1097\/TA.0000000000001447","article-title":"The course, prediction, and treatment of acute and posttraumatic stress in trauma patients: a systematic review","volume":"82","author":"Visser","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.psyneuen.2017.06.005","article-title":"Cortisol stress response in post-traumatic stress disorder, panic disorder, and major depressive disorder patients","volume":"83","author":"Wichmann","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib42","author":"World Health Organization(WHO)"},{"key":"10.1016\/j.jpsychires.2022.12.005_bib43","author":"World Health Organization (WHO)"},{"issue":"6","key":"10.1016\/j.jpsychires.2022.12.005_bib44","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.burns.2018.02.030","article-title":"Determination of risk factors for burn mortality based on a regional population study in Taiwan","volume":"44","author":"Yen","year":"2018","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.jpsychires.2022.12.005_bib45","first-page":"479","article-title":"Relationship between neutrophil to lymphocyte ratio and post-traumatic stress disorder in early stage after acute trauma","volume":"30","author":"Zhang","year":"2021","journal-title":"Chin. J. Emerg. Med."}],"container-title":["Journal of Psychiatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395622006744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022395622006744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:33:53Z","timestamp":1758368033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022395622006744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":45,"alternative-id":["S0022395622006744"],"URL":"https:\/\/doi.org\/10.1016\/j.jpsychires.2022.12.005","relation":{},"ISSN":["0022-3956"],"issn-type":[{"value":"0022-3956","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurobiochemical biomarkers and other risk factors for post-traumatic acute stress disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Psychiatric Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpsychires.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}