{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:35:28Z","timestamp":1782311728968,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpurol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Urology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jpurol.2016.04.013","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T17:21:12Z","timestamp":1464283272000},"page":"200.e1-200.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biometry of the hypospadic penis after hormone therapy (testosterone and estrogen): A randomized, double-blind controlled trial"],"prefix":"10.1016","volume":"12","author":[{"given":"Kelly Christina de Castro","family":"Paiva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Netto","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Pimenta","family":"Miana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline de Souza","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pl\u00ednio Santos","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Meneguelli","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Maia","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Avarese de Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-4889","authenticated-orcid":false,"suffix":"Jr.","given":"Jos\u00e9","family":"de Bessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-6160","authenticated-orcid":false,"given":"Jos\u00e9 Murillo B.","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpurol.2016.04.013_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpedsurg.2005.11.059","article-title":"Hypospadias: anatomy, etiology, and technique","volume":"41","author":"Baskin","year":"2006","journal-title":"J Pediatr Surg"},{"issue":"6 Pt B","key":"10.1016\/j.jpurol.2016.04.013_bib2","first-page":"971e9","article-title":"Hormone therapy in hypospadias surgery: a systematic review","volume":"9","author":"Netto","year":"2013","journal-title":"J Pediatr Urol"},{"issue":"2","key":"10.1016\/j.jpurol.2016.04.013_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.juro.2013.02.3234","article-title":"Effect of preoperative hormonal stimulation on postoperative complication rates after proximal hypospadias repair: a systematic review","volume":"190","author":"Wright","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib4","doi-asserted-by":"crossref","first-page":"201e3","DOI":"10.1159\/000473517","article-title":"Dihydrotestosterone penile stimulation in hypospadias surgery","volume":"8","author":"Monfort","year":"1982","journal-title":"Eur Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib5","doi-asserted-by":"crossref","first-page":"593e5","DOI":"10.1111\/j.1464-410X.1993.tb16031.x","article-title":"Effect of parenteral testosterone therapy on penile development in boys with hypospadias","volume":"71","author":"Davits","year":"1993","journal-title":"Br J Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib6","doi-asserted-by":"crossref","first-page":"1077e8","DOI":"10.1016\/S0022-5347(17)43507-5","article-title":"The use of parenteral testosterone therapy in genital reconstructive surgery","volume":"138","author":"Gearhart","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib7","doi-asserted-by":"crossref","first-page":"82e4","DOI":"10.1007\/s00383-002-0717-3","article-title":"Use of parenteral testosterone prior to hypospadias surgery","volume":"19","author":"Luo","year":"2003","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpurol.2016.04.013_bib8","doi-asserted-by":"crossref","first-page":"684e8","DOI":"10.1016\/j.juro.2007.09.098","article-title":"The efficacy of dihydrotestosterone transdermal gel before primary hypospadias surgery: a prospective, controlled, randomized study","volume":"179","author":"Kaya","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib9","doi-asserted-by":"crossref","first-page":"97e100","DOI":"10.1016\/j.urology.2009.12.065","article-title":"The effect of intramuscular testosterone enanthate treatment on stretched penile length in prepubertal boys with hypospadias","volume":"76","author":"Ishii","year":"2010","journal-title":"Urology"},{"issue":"6","key":"10.1016\/j.jpurol.2016.04.013_bib10","first-page":"2474e8","article-title":"Structural study of prepuce in hypospadias \u2013 does topical treatment with testosterone produce alterations in prepuce vascularization?","volume":"185","author":"Bastos","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib11","doi-asserted-by":"crossref","first-page":"158e61","DOI":"10.1016\/j.jpurol.2010.05.003","article-title":"Does androgen stimulation prior to hypospadias surgery increase the rate of healing complications? A preliminary report","volume":"7","author":"Gorduza","year":"2011","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib12","doi-asserted-by":"crossref","first-page":"840e3","DOI":"10.1016\/j.jpurol.2014.02.008","article-title":"Survey of pediatric urologists on the preoperative use of testosterone in the surgical correction of hypospadias","volume":"10","author":"Malik","year":"2014","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib13","doi-asserted-by":"crossref","first-page":"221e3","DOI":"10.1053\/jpsu.2003.50047","article-title":"Testosterone therapy in microphallic hypospadias: topical or parenteral?","volume":"38","author":"Chalapathi","year":"2003","journal-title":"J Pediatr Surg"},{"issue":"4","key":"10.1016\/j.jpurol.2016.04.013_bib15","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0022-5347(05)68333-4","article-title":"Preoperative treatment with human chorionic gonadotropin in infancy decreases the severity of proximal hypospadias and chordee","volume":"162","author":"Koff","year":"1999","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.jpurol.2016.04.013_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000282182","article-title":"Use of testosterone ointment before hypospadias repair","volume":"47","author":"Sakakibara","year":"1991","journal-title":"Urol Int"},{"issue":"2","key":"10.1016\/j.jpurol.2016.04.013_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/01485010601166862","article-title":"Expression of estrogen and androgen receptors in children with hypospadias: preliminary report","volume":"53","author":"Celayir","year":"2007","journal-title":"Arch Androl"},{"issue":"3","key":"10.1016\/j.jpurol.2016.04.013_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-5122(99)00079-1","article-title":"Oestrogens and wound healing","volume":"34","author":"Calvin","year":"2000","journal-title":"Maturitas"},{"key":"10.1016\/j.jpurol.2016.04.013_bib19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jaad.2004.08.039","article-title":"Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin","volume":"53","author":"Hall","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/13697130701456630","article-title":"Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens","volume":"10","author":"Gilliver","year":"2007","journal-title":"Climateric"},{"issue":"4","key":"10.1016\/j.jpurol.2016.04.013_bib21","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0002-9440(10)65217-0","article-title":"Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response","volume":"155","author":"Ashcroft","year":"1999","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jpurol.2016.04.013_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1590\/S0021-75572007000600008","article-title":"Penile anthropometry in Brazilian children and adolescents","volume":"83","author":"Gabrich","year":"2007","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.jpurol.2016.04.013_bib23","doi-asserted-by":"crossref","first-page":"57e9","DOI":"10.1007\/s00383-008-2278-6","article-title":"Comparison of topicalversus parenteral testosterone in children with microphallichypospadias","volume":"25","author":"Nerli","year":"2009","journal-title":"Pediatr Surg Int"},{"issue":"6","key":"10.1016\/j.jpurol.2016.04.013_bib24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.0022-202X.2005.23736.x","article-title":"Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in\u00a0vivo","volume":"124","author":"Son","year":"2005","journal-title":"Invest Dermatol"},{"key":"10.1016\/j.jpurol.2016.04.013_bib25","doi-asserted-by":"crossref","first-page":"143e6","DOI":"10.1016\/j.jpurol.2014.12.014","article-title":"The effect of parenteral testosterone administration prior to hypospadias surgery: a prospective, randomized and controlled study","volume":"11","author":"Asgari","year":"2015","journal-title":"J Pediatr Urol"},{"issue":"3","key":"10.1016\/j.jpurol.2016.04.013_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0022-5347(17)45730-2","article-title":"Gonadotropin and testosterone response in prepubertal boys with hypospadias","volume":"135","author":"Shima","year":"1986","journal-title":"J Urol"}],"container-title":["Journal of Pediatric Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513116300389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513116300389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:42:00Z","timestamp":1761486120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477513116300389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1477513116300389"],"URL":"https:\/\/doi.org\/10.1016\/j.jpurol.2016.04.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726449010.793522969","asserted-by":"object"}]},"ISSN":["1477-5131"],"issn-type":[{"value":"1477-5131","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biometry of the hypospadic penis after hormone therapy (testosterone and estrogen): A randomized, double-blind controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpurol.2016.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}