{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:31:41Z","timestamp":1779222701408,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences (ICES)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012665","name":"ICES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care (MOHLTC)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario (AMOSO)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008093","name":"Schulich School of Medicine and Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012665","name":"ICES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"Western","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpurol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Urology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jpurol.2018.09.021","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T13:47:50Z","timestamp":1539179270000},"page":"41.e1-41.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A retrospective population-based cohort study to evaluate the impact of an older sibling with undescended testis and hypospadias on the known maternal and fetal risk factors for undescended testis and hypospadias in Ontario, Canada, 1997\u20132007"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-647X","authenticated-orcid":false,"given":"S.","family":"Dave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.X.","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Z.","family":"Shariff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpurol.2018.09.021_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ejmg.2014.03.003","article-title":"Review of genetic and environmental factors leading to hypospadias","volume":"57","author":"Shih","year":"2014","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jpurol.2018.09.021_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/j.1939-4640.2003.tb02654.x","article-title":"Cryptorchidism: incidence, risk factors, and potential role of environment; an update","volume":"24","author":"Thonneau","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.jpurol.2018.09.021_bib3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrurol.2017.90","article-title":"Risk factors for cryptorchidism","volume":"14","author":"Gurney","year":"2017","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00431-006-0304-z","article-title":"Risk factors for hypospadias","volume":"166","author":"Brouwers","year":"2007","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpurol.2018.09.021_bib5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.10791","article-title":"Maternal and gestational risk factors for hypospadias","volume":"116","author":"Akre","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jpurol.2018.09.021_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00001648-200203000-00015","article-title":"Maternal, delivery, and perinatal characteristics associated with cryptorchidism: a population-based case-control study among births in Washington State","volume":"13","author":"Biggs","year":"2002","journal-title":"Epidemiol Camb Mass"},{"key":"10.1016\/j.jpurol.2018.09.021_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1464-410X.2012.11745.x","article-title":"Risk factors for different phenotypes of hypospadias: results from a Dutch case-control study","volume":"112","author":"van\u00a0Rooij","year":"2013","journal-title":"BJU Int"},{"key":"10.1016\/j.jpurol.2018.09.021_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jpurol.2010.11.001","article-title":"Risk factors for undescended testis","volume":"8","author":"Brouwers","year":"2012","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00001648-199503000-00007","article-title":"Maternal and neonatal risk factors for cryptorchidism","volume":"6","author":"Berkowitz","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.jpurol.2018.09.021_bib10","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1289\/ehp.7243","article-title":"Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborns","volume":"112","author":"Pierik","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jpurol.2018.09.021_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.juro.2013.09.058","article-title":"Population based nationwide study of hypospadias in Sweden, 1973 to 2009: incidence and risk factors","volume":"191","author":"Nordenvall","year":"2014","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-3016.2007.00809.x","article-title":"The National Birth Defects Prevention Study. Maternal reproductive and demographic characteristics as risk factors for hypospadias","volume":"21","author":"Carmichael","year":"2007","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib13","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0022-5347(05)68992-6","article-title":"Risk factors for cryptorchidism and hypospadias","volume":"161","author":"Weidner","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/pds.3448","article-title":"Maternal medication and herbal use and risk for hypospadias: data from the national birth defects prevention study, 1997\u20132007","volume":"22","author":"Lind","year":"2013","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jpurol.2018.09.021_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/AOG.0000000000000103","article-title":"Maternal hypertension, medication use, and hypospadias in the national birth defects prevention study","volume":"123","author":"Van\u00a0Zutphen","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"8","key":"10.1016\/j.jpurol.2018.09.021_bib16","doi-asserted-by":"crossref","first-page":"e3051","DOI":"10.1371\/journal.pone.0003051","article-title":"Risk factors for congenital cryptorchidism in a prospective birth cohort study","volume":"3","author":"Damgaard","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpurol.2018.09.021_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.fertnstert.2008.09.041","article-title":"Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers","volume":"93","author":"Jensen","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpurol.2018.09.021_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwm317","article-title":"Familial aggregation of hypospadias: a cohort study","volume":"167","author":"Schnack","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/EDE.0b013e3181c15a50","article-title":"Familial coaggregation of cryptorchidism and hypospadias","volume":"21","author":"Schnack","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.jpurol.2018.09.021_bib20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.juro.2012.06.045","article-title":"Accuracy of cryptorchidism diagnoses and corrective surgical treatment registration in the Danish National patient Registry","volume":"188","author":"Jensen","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/humupd\/7.3.282","article-title":"Trends in the incidence of cryptorchidism and hypospadias and methodological limitations of registry-based data","volume":"7","author":"Toppari","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jpurol.2018.09.021_bib22","doi-asserted-by":"crossref","first-page":"e1001885","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.jpurol.2018.09.021_bib23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1701-2163(16)34655-2","article-title":"Severe maternal morbidity in Canada, 2003 to 2007: surveillance using routine hospitalization data and ICD-10CA codes","volume":"32","author":"Joseph","year":"2010","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.jpurol.2018.09.021_bib24","first-page":"96","article-title":"Canadian perinatal surveillance system: validation of perinatal data in the Discharge Abstract database of the Canadian Institute for health information","volume":"29","author":"Joseph","year":"2009","journal-title":"Chron Dis Can"},{"key":"10.1016\/j.jpurol.2018.09.021_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MED.0000000000000063","article-title":"Genetic and environmental origins of hypospadias","volume":"21","author":"Thorup","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.jpurol.2018.09.021_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/bdra.23021","article-title":"Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence","volume":"94","author":"Carmichael","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib27","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.juro.2014.10.113","article-title":"Does intracytoplasmic sperm injection pose an increased risk of genitourinary congenital malformations in offspring compared to in\u00a0vitro fertilization? A systematic review and meta-analysis","volume":"193","author":"Massaro","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-3016.2012.01272.x","article-title":"Nutritional factors and hypospadias risks","volume":"26","author":"Carmichael","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jpurol.2018.09.021_bib29","doi-asserted-by":"crossref","first-page":"e0119006","DOI":"10.1371\/journal.pone.0119006","article-title":"Maternal gestational smoking, diabetes, alcohol drinking, pre-pregnancy obesity and the risk of cryptorchidism: a systematic review and meta-analysis of observational studies","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpurol.2018.09.021_bib30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/bdra.23296","article-title":"Differences in risk factors for second and third degree hypospadias in the national birth defects prevention study","volume":"100","author":"Woud","year":"2014","journal-title":"Birth Defects Res"}],"container-title":["Journal of Pediatric Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513118306041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513118306041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:47:33Z","timestamp":1761486453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477513118306041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1477513118306041"],"URL":"https:\/\/doi.org\/10.1016\/j.jpurol.2018.09.021","relation":{},"ISSN":["1477-5131"],"issn-type":[{"value":"1477-5131","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A retrospective population-based cohort study to evaluate the impact of an older sibling with undescended testis and hypospadias on the known maternal and fetal risk factors for undescended testis and hypospadias in Ontario, Canada, 1997\u20132007","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpurol.2018.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd on behalf of Journal of Pediatric Urology Company.","name":"copyright","label":"Copyright"}]}}