{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:40:28Z","timestamp":1793720428110,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpurol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Urology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jpurol.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T18:53:47Z","timestamp":1549911227000},"page":"240.e1-240.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pathological changes in ureterovesical and ureteropelvic junction obstruction explained by fetal ureter histology"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-5795","authenticated-orcid":false,"given":"R.","family":"Babu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vittalraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpurol.2019.02.001_bib1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1046\/j.1464-410x.2000.00645.x","article-title":"Antenatal hydronephrosis: changing concepts in diagnosis and subsequent management","volume":"85","author":"Shokeir","year":"2000","journal-title":"BJU Int"},{"key":"10.1016\/j.jpurol.2019.02.001_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.juro.2007.03.054","article-title":"Myocyte apoptosis in primary obstructive megaureters: the role of decreased vascular and neural supply","volume":"178","author":"Payabvash","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0022-5347(17)49272-X","article-title":"In\u00a0vitro studies on human primary obstructed megaureters","volume":"133","author":"Hertle","year":"1985","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib4","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0022-5347(17)36944-6","article-title":"A quantitative histological analysis of the dilated ureter of childhood","volume":"148","author":"Lee","year":"1992","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0090-4295(98)00013-2","article-title":"A quantitative histologic analysis of collagen subtypes: the primary obstructed and refluxing megaureter of childhood","volume":"51","author":"Lee","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.jpurol.2019.02.001_bib6","first-page":"32","article-title":"Acetylcholinesterase activities in association with congenital malformation of the terminal ureter in infants and children","volume":"41","author":"Hofmann","year":"1986","journal-title":"Z Kinderchir"},{"key":"10.1016\/j.jpurol.2019.02.001_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/nau.22310","article-title":"Pacemakers in the upper urinary tract","volume":"32","author":"Di Benedetto","year":"2013","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.jpurol.2019.02.001_bib8","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1097\/01.ju.0000097401.03293.f0","article-title":"Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction","volume":"170","author":"Solari","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib9","first-page":"128","article-title":"Distribution of Cajal like cells and innervation in intrinsic ureteropelvic junction obstruction","volume":"83","author":"Kuvel","year":"2011","journal-title":"Arch Ital Di Urol Androl Organo Uff [Di] Soc Ital Di Ecogr Urol e Nefrol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib10","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/j.jpedsurg.2009.07.061","article-title":"The expression of Cajal cells at the obstruction site of congenital pelviureteric junction obstruction and quantitative image analysis","volume":"44","author":"Yang","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpurol.2019.02.001_bib11","first-page":"105","article-title":"Changes in structure, interstitial cajal-like cells and apoptosis of smooth muscle cells in congenital ureteropelvic junction obstruction","volume":"24","author":"Mehrazma","year":"2014","journal-title":"Iran J Pediatr"},{"key":"10.1016\/j.jpurol.2019.02.001_bib12","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jpurol.2013.02.003","article-title":"Altered expression of interstitial cells of Cajal in primary obstructive megaureter","volume":"9","author":"Kart","year":"2013","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib13","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.jpedsurg.2005.06.025","article-title":"Structural changes of smooth muscle in congenital ureteropelvic junction obstruction","volume":"40","author":"Hosgor","year":"2005","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpurol.2019.02.001_bib14","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.juro.2006.03.041","article-title":"Smooth muscle cell apoptosis and defective neural development in congenital ureteropelvic junction obstruction","volume":"176","author":"Kajbafzadeh","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0090-4295(98)00215-5","article-title":"Collagen studies for pediatric ureteropelvic junction obstruction","volume":"52","author":"Yoon","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.jpurol.2019.02.001_bib16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/01.ju.0000157003.04760.c3","article-title":"Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery","volume":"173","author":"Kim","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/S0022-5347(01)64910-3","article-title":"Structural changes of collagen components and diminution of nerves in congenital ureteropelvic junction obstruction","volume":"157","author":"Murakumo","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-5347(17)58324-X","article-title":"Ureteral structure and ultrastructure. Part III. The congenitally dilated ureter (megaureter)","volume":"117","author":"Hanna","year":"1977","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib19","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0022-5347(05)67759-2","article-title":"Collagen-to-smooth muscle ratio helps prediction of prognosis after pyeloplasty","volume":"163","author":"Kim","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib20","first-page":"7","article-title":"C-kit positive interstitial cells of Cajal network in primary obstructive megaureter","volume":"59","author":"Arena","year":"2007","journal-title":"Minerva Pediatr"},{"key":"10.1016\/j.jpurol.2019.02.001_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1464-410X.1978.tb02790.x","article-title":"Functional obstruction of the ureter and renal pelvis. A histological and electron microscopic study","volume":"50","author":"Gosling","year":"1978","journal-title":"Br J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib22","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.urology.2009.02.062","article-title":"Decreased interstitial cells of Cajal-like cells, possible cause of congenital refluxing megaureters: histopathologic differences in refluxing and obstructive megaureters","volume":"74","author":"Kang","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.jpurol.2019.02.001_bib23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1046\/j.1464-410X.1997.00486.x","article-title":"Segmental up-regulation of transforming growth factor-beta in the pathogenesis of primary megaureter. An immunocytochemical study","volume":"80","author":"Nicotina","year":"1997","journal-title":"Br J Urol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib24","first-page":"15","article-title":"Development of the fetal ureter: a fetal metric and histological study","volume":"14","author":"Martis","year":"2018","journal-title":"Mal J Med Heal Sci"},{"key":"10.1016\/j.jpurol.2019.02.001_bib25","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/dev.022442","article-title":"Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4","volume":"135","author":"Caubit","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.jpurol.2019.02.001_bib26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00467-017-3629-0","article-title":"The molecular biology of pelvi-ureteric junction obstruction","volume":"33","author":"Jackson","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib27","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI4401","article-title":"Angiotensin induces the urinary peristaltic machinery during the perinatal period","volume":"102","author":"Miyazaki","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpurol.2019.02.001_bib28","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1089\/end.2006.20.590","article-title":"Serial microscopic changes in cell proliferation and apoptosis in obstructed ureter of rat","volume":"20","author":"Kim","year":"2006","journal-title":"J Endourol"},{"key":"10.1016\/j.jpurol.2019.02.001_bib29","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/sj.ki.5002589","article-title":"Down the tube of obstructive nephropathies: the importance of tissue interactions during ureter development","volume":"72","author":"Airik","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.jpurol.2019.02.001_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0022-5347(17)38354-4","article-title":"Obstruction and recanalization of the ureter during embryonic development","volume":"145","author":"Alcaraz","year":"1991","journal-title":"J Urol"}],"container-title":["Journal of Pediatric Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513119300397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513119300397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:45:05Z","timestamp":1761486305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477513119300397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1477513119300397"],"URL":"https:\/\/doi.org\/10.1016\/j.jpurol.2019.02.001","relation":{},"ISSN":["1477-5131"],"issn-type":[{"value":"1477-5131","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathological changes in ureterovesical and ureteropelvic junction obstruction explained by fetal ureter histology","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpurol.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}