{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:59:53Z","timestamp":1761487193195,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpurol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Urology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jpurol.2020.10.015","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T12:53:00Z","timestamp":1602766380000},"page":"48.e1-48.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spermatogenesis in pre-pubertal boys with Leydig cell neoplasms suggests paracrine stimulation by testosterone"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-1007","authenticated-orcid":false,"given":"Daniel T.","family":"Keefe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Blais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-1824","authenticated-orcid":false,"given":"Mandy","family":"Rickard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagam","family":"Yehia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Chami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-9462","authenticated-orcid":false,"given":"Armando J.","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpurol.2020.10.015_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0094-0143(05)70201-9","article-title":"Classification and pathology of testicular germ cell and sex cord-stromal tumors","volume":"26","author":"Cheville","year":"1999","journal-title":"Urol Clin"},{"key":"10.1016\/j.jpurol.2020.10.015_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0094-0143(21)00458-4","article-title":"Gonadal stromal tumors, gonadoblastoma, epidermoid cysts, and secondary tumors of the testis in children","volume":"20","author":"Cortez","year":"1993","journal-title":"Urol Clin"},{"key":"10.1016\/j.jpurol.2020.10.015_bib3","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1097\/01.ju.0000060121.33899.4b","article-title":"Is post-chemotherapy resection of seminomatous elements associated with higher acute morbidity?","volume":"169","author":"Mosharafa","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2020.10.015_bib4","first-page":"494","article-title":"The diagnosis of Leydig cell tumors in childhood","volume":"132","author":"Urban","year":"1978","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpurol.2020.10.015_bib5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/rmb2.12046","article-title":"Leydig cell tumor of the testis, presenting with azoospermia","volume":"16","author":"Hibi","year":"2017","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.jpurol.2020.10.015_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.fertnstert.2007.07.1308","article-title":"Testicular sperm extraction in a single cancerous testicle in patients with azoospermia: a case report","volume":"90","author":"Descombe","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpurol.2020.10.015_bib7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.juro.2011.10.021","article-title":"Histological examination of solitary contralateral descended testis in congenital absence of testis","volume":"187","author":"Kraft","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2020.10.015_bib8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0090-4295(00)00636-1","article-title":"Focal lobular spermatogenesis and pubertal acceleration associated with ipsilateral Leydig cell hyperplasia","volume":"56","author":"Leung","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.jpurol.2020.10.015_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1080\/15513815.2016.1214198","article-title":"Paraffine effects of Leydig cell nodular hyperplasia, two case reports: a neglected phenomenon","volume":"35","author":"Shinnick","year":"2016","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1016\/j.jpurol.2020.10.015_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.urology.2019.09.016","article-title":"Testis-sparing surgery for pediatric Leydig cell tumors: evidence of favorable outcomes irrespective of surgical margins","volume":"134","author":"Zu\u2019bi","year":"2019","journal-title":"Urology"},{"key":"10.1016\/j.jpurol.2020.10.015_bib11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0188-0128(99)00058-5","article-title":"Follicle-stimulating hormone ligand and receptor mutations, and gonadal dysfunction","volume":"30","author":"Levallet","year":"1999","journal-title":"Arch Med Res"},{"key":"10.1016\/j.jpurol.2020.10.015_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4161\/spmg.1.2.16956","article-title":"Testosterone signaling and the regulation of spermatogenesis","volume":"1","author":"Walker","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.jpurol.2020.10.015_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/rep.1.00358","article-title":"FSH and testosterone signaling in Sertoli cells","volume":"130","author":"Walker","year":"2005","journal-title":"Reprod Camb Engl"},{"key":"10.1016\/j.jpurol.2020.10.015_bib14","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/humrep\/dez083","article-title":"Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study","volume":"34","author":"Pozza","year":"2019","journal-title":"Hum Reprod Oxf Engl"},{"key":"10.1016\/j.jpurol.2020.10.015_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12610-016-0041-8","article-title":"Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report","volume":"26","author":"Prasivoravong","year":"2016","journal-title":"Basic Clin Androl"},{"key":"10.1016\/j.jpurol.2020.10.015_bib16","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.aav2914","article-title":"Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring","volume":"363","author":"Fayomi","year":"2019","journal-title":"Science"}],"container-title":["Journal of Pediatric Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513120305726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513120305726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:49:41Z","timestamp":1761486581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477513120305726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1477513120305726"],"URL":"https:\/\/doi.org\/10.1016\/j.jpurol.2020.10.015","relation":{},"ISSN":["1477-5131"],"issn-type":[{"type":"print","value":"1477-5131"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spermatogenesis in pre-pubertal boys with Leydig cell neoplasms suggests paracrine stimulation by testosterone","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpurol.2020.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}