{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:02:16Z","timestamp":1781204536374,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpurol.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Urology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jpurol.2022.10.031","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T20:09:16Z","timestamp":1668024556000},"page":"844.e1-844.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The positive predictive value of using fsh and Inhibin-B serum levels to diagnose gonadotropin insufficiency in bilateral cryptorchid boys is high"],"prefix":"10.1016","volume":"18","author":[{"given":"Simone E.","family":"Hildorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Clasen-Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-663X","authenticated-orcid":false,"given":"Magdalena","family":"Fossum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgen","family":"Thorup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jpurol.2022.10.031_bib1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.fertnstert.2004.06.035","article-title":"Etiology of azoospermia in 100 consecutive nonvasectomized men","volume":"82","author":"Fedder","year":"2004","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.jpurol.2022.10.031_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fertnstert.2016.09.015","article-title":"Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility","volume":"107","author":"Olesen","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpurol.2022.10.031_bib3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1651-2227.2006.00159.x","article-title":"Nordic consensus on treatment of undescended testes","volume":"96","author":"Ritz\u00e9n","year":"2007","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpurol.2022.10.031_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jpurol.2016.07.014","article-title":"Corrigendum to \"Management of undescended testes: European association of urology\/European society for paediatric urology guidelines\"","volume":"12","author":"Radmayr","year":"2016","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.juro.2014.05.005","article-title":"American Urological Association. Evaluation and treatment of cryptorchidism: AUA guideline","volume":"192","author":"Kolon","year":"2014","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.jpurol.2022.10.031_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrurol.2015.312","article-title":"Testicular biopsy in prepubertal boys: a worthwhile minor surgical procedure?","volume":"13","author":"Faure","year":"2016","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1464-410X.1991.tb15325.x","article-title":"Histology of testicular biopsies taken at operation for bilateral maldescended testes in relation to fertility in adulthood","volume":"68","author":"Cortes","year":"1991","journal-title":"Br J Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0022-5347(01)64422-7","article-title":"Treatment with a luteinizing hormone-releasing hormone analogue after successful orchiopexy markedly improves the chance of fertility later in life","volume":"158","author":"Hadziselimovic","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/JU.0000000000000615","article-title":"Fertility potential is compromised in 20% to 25% of boys with nonsyndromic cryptorchidism despite orchiopexy within the first year of life","volume":"203","author":"Hildorf","year":"2020","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.jpurol.2022.10.031_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000471937","article-title":"GnRHa treatment of Cryptorchid boys affects genes involved in hormonal control of the HPG Axis and fertility","volume":"11","author":"Hadziselimovic","year":"2017","journal-title":"Sex Dev"},{"issue":"5","key":"10.1016\/j.jpurol.2022.10.031_bib11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-2007-993194","article-title":"Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism","volume":"220","author":"Hadziselimovic","year":"2008","journal-title":"Klin Padiatr"},{"issue":"2","key":"10.1016\/j.jpurol.2022.10.031_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/JU.0000000000001350","article-title":"Fertility potential is impaired in boys with bilateral ascending testes","volume":"205","author":"Hildorf","year":"2021","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.jpurol.2022.10.031_bib13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000497374","article-title":"Sertoli cell number correlates with serum inhibin B in infant cryptorchid boys","volume":"13","author":"Hildorf","year":"2019","journal-title":"Sex Dev"},{"key":"10.1016\/j.jpurol.2022.10.031_bib14","first-page":"2401","article-title":"The influence of orchiopexy on serum inhibin B level: relationship with histology","volume":"172","author":"Irkalata","year":"2004","journal-title":"J Urol"},{"issue":"4 Suppl","key":"10.1016\/j.jpurol.2022.10.031_bib15","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.juro.2012.02.2551","article-title":"Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys","volume":"188","author":"Thorup","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib16","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.juro.2013.01.058","article-title":"The relation between adult dark spermatogonia and other parameters of fertility potential in cryptorchid testes","volume":"190","author":"Thorup","year":"2013","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.jpurol.2022.10.031_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jpedsurg.2015.08.059","article-title":"The Sertoli cell hormones inhibin-B and anti Mullerian hormone have different patterns of secretion in prepubertal cryptorchid boys","volume":"51","author":"Cortes","year":"2016","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpurol.2022.10.031_bib18","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0022-5347(01)67029-0","article-title":"Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants","volume":"154","author":"Cortes","year":"1995","journal-title":"J Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fendo.2018.00286","article-title":"The expression of markers for intratubular germ cell neoplasia in normal infantile testes","volume":"9","author":"Kvist","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.jpurol.2022.10.031_bib20","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.fertnstert.2016.09.002","article-title":"Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis","volume":"106","author":"Masliukaite","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpurol.2022.10.031_bib21","first-page":"675","article-title":"Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men","volume":"83","author":"Andersson","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jpurol.2022.10.031_bib23","first-page":"38","article-title":"Hormonal therapy for the subfertility of cryptorchidism","volume":"55","author":"Huff","year":"2001","journal-title":"Horm Res"},{"issue":"3","key":"10.1016\/j.jpurol.2022.10.031_bib24","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/01.ju.0000153562.07287.77","article-title":"Neoadjuvant gonadotropin-releasing hormone therapy before surgery may improve the fertility index in undescended testes: a prospective randomized trial","volume":"173","author":"Schwentner","year":"2005","journal-title":"J Urol"},{"issue":"6","key":"10.1016\/j.jpurol.2022.10.031_bib25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.urology.2008.10.078","article-title":"Neoadjuvant gonadotropin-releasing hormone therapy before surgery and effect on fertility index in unilateral undescended testes: a prospective randomized trial","volume":"73","author":"Jallouli","year":"2009","journal-title":"Urology"},{"issue":"5","key":"10.1016\/j.jpurol.2022.10.031_bib26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jpurol.2005.11.007","article-title":"Effects of hormonal treatment on the contralateral descended testis in unilateral cryptorchidism","volume":"2","author":"Zivkovic","year":"2006","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.jpurol.2022.10.031_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4651218","article-title":"Gonadotropin-releasing hormone agonist corrects defective Mini-puberty in boys with cryptorchidism: a prospective randomized study","author":"Vincel","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jpurol.2022.10.031_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fendo.2018.00299","article-title":"Selecting infants with cryptorchidism and high risk of infertility for optional adjuvant hormonal therapy and cryopreservation of germ cells: experience from a pilot study","volume":"9","author":"Thorup","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jpurol.2022.10.031_bib29","doi-asserted-by":"crossref","DOI":"10.1097\/JU.0000000000002085.04","article-title":"Low serum inhibin B\/Follicle-Stimulating hormones and anti-M\u00fcllerian hormone\/follicle-stimulating hormones ratios as markers of decreased germ cells in infants with bilateral cryptorchidism","author":"Kato","year":"2021","journal-title":"J Urol"},{"issue":"4","key":"10.1016\/j.jpurol.2022.10.031_bib30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jpedsurg.2016.08.006","article-title":"The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism","volume":"52","author":"Osterballe","year":"2017","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpurol.2022.10.031_bib31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3109\/00365599.2010.549091","article-title":"The challenge of early surgery for cryptorchidism","volume":"45","author":"Thorup","year":"2011","journal-title":"Scand J Urol Nephrol"}],"container-title":["Journal of Pediatric Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513122004739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477513122004739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:53:23Z","timestamp":1761486803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477513122004739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S1477513122004739"],"URL":"https:\/\/doi.org\/10.1016\/j.jpurol.2022.10.031","relation":{},"ISSN":["1477-5131"],"issn-type":[{"value":"1477-5131","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The positive predictive value of using fsh and Inhibin-B serum levels to diagnose gonadotropin insufficiency in bilateral cryptorchid boys is high","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpurol.2022.10.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}