{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:40:00Z","timestamp":1759034400885,"version":"3.44.0"},"reference-count":119,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.jri.2006.05.006","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T08:33:05Z","timestamp":1162888385000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites"],"prefix":"10.1016","volume":"72","author":[{"given":"Jiri","family":"Mestecky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2006.05.006_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(16)53628-0","article-title":"Sexual transmission of human immunodeficiency virus: virus entry into the male and female genital tract. World Health Organization, Global Programme on Acquired Immune Deficiency Syndrome","volume":"54","author":"Alexander","year":"1990","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2006.05.006_bib2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0167-5699(90)90144-X","article-title":"B-cell activation and HIV-1 infection: deeds and misdeeds","volume":"11","author":"Amadori","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jri.2006.05.006_bib3","series-title":"Mucosal Immunology","first-page":"1647","article-title":"Human male genital tract immunity and experimental models","author":"Anderson","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/infdis\/175.2.265","article-title":"Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: a comparison by site and correlation with clinical information","volume":"175","author":"Artenstein","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/72309","article-title":"Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection","volume":"6","author":"Baba","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/338828","article-title":"Antibody-dependent cell-mediated cytotoxicity in cervical lavage fluids of human immunodeficiency virus type 1-infected women","volume":"185","author":"Battle-Miller","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/infdis\/172.3.691","article-title":"Cervicovaginal overproduction of specific IgG to human immunodeficiency virus (HIV) contrasts with normal or impaired IgA local response in HIV infection","volume":"172","author":"Belec","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-2249.1995.tb02284.x","article-title":"Decreased cervicovaginal production of both IgA1 and IgA2 subclasses in women with AIDS","volume":"101","author":"Belec","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/infdis\/160.3.385","article-title":"Antibodies to human immunodeficiency virus in vaginal secretions of heterosexual women","volume":"160","author":"Belec","year":"1989","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib10","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1128\/iai.65.7.2676-2684.1997","article-title":"Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina","volume":"65","author":"Bergquist","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2006.05.006_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1413","article-title":"Helping the CD8(+) T-cell response","volume":"4","author":"Bevan","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1086\/314556","article-title":"Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand","volume":"179","author":"Beyrer","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib13","unstructured":"Blattner, et al., 2003. Safety and immunogenicity of a Salmonella-vectored HIV vaccine: AVEG 028. AIDS Vaccine 2003. Abstr. 58LB, 62."},{"key":"10.1016\/j.jri.2006.05.006_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nm0197-42","article-title":"Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier","volume":"3","author":"Bomsel","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib15","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1128\/iai.62.9.3957-3961.1994","article-title":"Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination","volume":"62","author":"Bouvet","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2006.05.006_bib16","series-title":"Mucosal Immunology","first-page":"855","article-title":"Mucosal vaccines: an overview","author":"Boyaka","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib17","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1084\/jem.20040874","article-title":"CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract","volume":"200","author":"Brenchley","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-2478(01)00263-2","article-title":"Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers","volume":"79","author":"Broliden","year":"2001","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2006.05.006_bib19","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1089\/08892220152741388","article-title":"HIV-specific IgG in cervicovaginal secretions of exposed HIV-uninfected female sexual partners of HIV-infected men","volume":"17","author":"Buchacz","year":"2001","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.272.5258.104","article-title":"Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity","volume":"272","author":"Burns","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jri.2006.05.006_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ni0304-233","article-title":"HIV vaccine design and the neutralizing antibody problem","volume":"5","author":"Burton","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2249.1997.236-ce1111.x","article-title":"Selective depletion of rectal lamina propria rather than lymphoid aggregate CD4 lymphocytes in HIV infection","volume":"107","author":"Clayton","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0897.1995.tb00948.x","article-title":"Normal uterine cervix: characterization of isolated lymphocyte phenotypes and immunoglobulin secretion","volume":"34","author":"Crowley-Nowick","year":"1995","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1023\/A:1027312223474","article-title":"Rectal immunization for induction of specific antibody in the genital tract of women","volume":"17","author":"Crowley-Nowick","year":"1997","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib25","first-page":"393","article-title":"Menstrual cycle: effects on vaccine-induced antibodies in genital tract secretions","volume":"vol. 1","author":"Crowley-Nowick","year":"1997"},{"key":"10.1016\/j.jri.2006.05.006_bib26","first-page":"144","article-title":"Sexual HIV-1 transmission and mucosal defense mechanisms","volume":"2","author":"Cummins","year":"2000","journal-title":"AIDS Rev."},{"key":"10.1016\/j.jri.2006.05.006_bib27","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1126\/science.1093137","article-title":"Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission","volume":"303","author":"Derdeyn","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jri.2006.05.006_bib28","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.4049\/jimmunol.165.9.5170","article-title":"Mucosal and plasma IgA from HIV-1-exposed uninfected individuals inhibit HIV-1 transcytosis across human epithelial cells","volume":"165","author":"Devito","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib29","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/00002030-200009080-00006","article-title":"Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate","volume":"14","author":"Devito","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00042560-200208010-00007","article-title":"Cross-clade HIV-1-specific neutralizing IgA in mucosal and systemic compartments of HIV-1-exposed, persistently seronegative subjects","volume":"30","author":"Devito","year":"2002","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.jri.2006.05.006_bib31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/00002030-200006160-00008","article-title":"Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia","volume":"14","author":"Dorrell","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib32","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/00002030-199308000-00010","article-title":"Intestinal antibody responses to oral vaccination in HIV-infected individuals","volume":"7","author":"Eriksson","year":"1993","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00002030-199507000-00005","article-title":"Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals","volume":"9","author":"Eriksson","year":"1995","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000028018","article-title":"Induction and expression of intestinal humoral immunity in HIV-infected individuals: prospects for vaccination against secondary enteric infections","volume":"66","author":"Eriksson","year":"1998","journal-title":"Pathobiology"},{"key":"10.1016\/j.jri.2006.05.006_bib35","first-page":"85","article-title":"Limited secretory-IgA response in cervicovaginal secretions from HIV-1 infected, but not high risk seronegative women: lack of correlation to genital viral shedding","volume":"23","author":"Fiore","year":"2000","journal-title":"New Microbiol."},{"key":"10.1016\/j.jri.2006.05.006_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0165-2478(98)00112-6","article-title":"Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells","volume":"67","author":"Goodrich","year":"1999","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2006.05.006_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/08820139909022724","article-title":"Preferential enhancement of B cell IgA secretion by intestinal epithelial cell-derived cytokines and interleukin-2","volume":"28","author":"Goodrich","year":"1999","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.jri.2006.05.006_bib38","doi-asserted-by":"crossref","first-page":"11708","DOI":"10.1128\/JVI.77.21.11708-11717.2003","article-title":"Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy","volume":"77","author":"Guadalupe","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2006.05.006_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00042560-199707010-00001","article-title":"Quantitation of HIV-1-specific IgG, IgA, and IgM antibodies in human genital tract secretions","volume":"15","author":"Haimovici","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"10.1016\/j.jri.2006.05.006_bib40","unstructured":"He, B., et al., in press. HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving B cell-activating factor of the TNF family and C-type lectin receptors. J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib41","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/aid.1997.13.1179","article-title":"High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160","volume":"13","author":"Hocini","year":"1997","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.20.090501.112049","article-title":"Molecular mechanism of class switch recombination: linkage with somatic hypermutation","volume":"20","author":"Honjo","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib43","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.4049\/jimmunol.174.8.4828","article-title":"Intraepithelial cell neutralization of HIV-1 replication by IgA","volume":"174","author":"Huang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0684.1995.tb00146.x","article-title":"Nonclassical mucosal antibodies predominate in genital secretions of HIV-1 infected chimpanzees","volume":"24","author":"Israel","year":"1995","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.jri.2006.05.006_bib45","first-page":"1035","article-title":"Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeys","volume":"371B","author":"Jackson","year":"1995","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jri.2006.05.006_bib46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/088922200309016","article-title":"False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigens","volume":"16","author":"Jackson","year":"2000","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib47","series-title":"Mucosal Immunology","first-page":"1829","article-title":"Appendix I: collection and processing of human mucosal secretions","author":"Jackson","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/01485019408987799","article-title":"Identification of human seminal plasma components that bind IgG2 variant","volume":"33","author":"Jaiswal","year":"1994","journal-title":"Arch. Androl."},{"key":"10.1016\/j.jri.2006.05.006_bib49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000231778","article-title":"Immunoglobulins in human cervico-vaginal secretions","volume":"53","author":"Jalanti","year":"1977","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib50","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/infdis\/158.5.983","article-title":"Class-specific antibody response to pneumococcal capsular polysaccharides in men infected with human immunodeficiency virus type 1","volume":"158","author":"Janoff","year":"1988","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib51","doi-asserted-by":"crossref","first-page":"9069","DOI":"10.1128\/JVI.72.11.9069-9078.1998","article-title":"Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS","volume":"72","author":"Joag","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2006.05.006_bib52","series-title":"Mucosal Immunology","first-page":"211","article-title":"Immunoglobulin transport and the polymeric immunoglobulin receptor","author":"Kaetzel","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/01485019108987645","article-title":"Identification of IgG and Fc-binding proteins in human seminal plasma and sperm","volume":"27","author":"Kamada","year":"1991","journal-title":"Arch. Androl."},{"key":"10.1016\/j.jri.2006.05.006_bib54","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1128\/IAI.66.12.5630-5635.1998","article-title":"Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: evidence for compartmentalization within the common mucosal immune system in humans","volume":"66","author":"Kantele","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2006.05.006_bib55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00002030-199901140-00004","article-title":"HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers","volume":"13","author":"Kaul","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1566524033479852","article-title":"The role of mucosal immunity in prevention of HIV transmission","volume":"3","author":"Kozlowski","year":"2003","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib57","first-page":"56","article-title":"Secretory immune system of the female reproductive tract: I. Immunoglobulin and secretory component-containing cells","volume":"71","author":"Kutteh","year":"1988","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2006.05.006_bib58","series-title":"Reproductive Immunology","first-page":"151","article-title":"Production of immunoglobulin A by the cervix of the human female genital tract","author":"Kutteh","year":"1993"},{"key":"10.1016\/j.jri.2006.05.006_bib59","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1046\/j.1365-2249.1996.36742.x","article-title":"Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation","volume":"104","author":"Kutteh","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-0378(01)00109-7","article-title":"Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccine","volume":"52","author":"Kutteh","year":"2001","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib61","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1016\/S0264-410X(01)00051-2","article-title":"A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects","volume":"19","author":"Lambert","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2006.05.006_bib62","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S0264-410X(03)00204-4","article-title":"Innate and adaptive mucosal immunity in protection against HIV infection","volume":"21","author":"Lehner","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2006.05.006_bib63","series-title":"Mucosal Immunology","first-page":"1179","article-title":"Mucosal infection and immune responses to simian immunodeficiency virus","author":"Lehner","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib64","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1016\/j.vaccine.2005.07.009","article-title":"European Union and EDCTP strategy in the global context: recommendations for preventive HIV\/AIDS vaccines research","volume":"23","author":"Lehner","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2006.05.006_bib65","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00002030-199406000-00009","article-title":"Immune response following oral administration of cholera toxin B subunit to HIV-1-infected UK and Kenyan subjects","volume":"8","author":"Lewis","year":"1994","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00002030-200303070-00008","article-title":"Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men","volume":"17","author":"Lo Caputo","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2006.05.006_bib67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/clim.2000.4910","article-title":"Predominate HIV1-specific IgG activity in various mucosal compartments of HIV1-infected individuals","volume":"97","author":"L\u00fc","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib68","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1126\/science.288.5474.2222","article-title":"A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria","volume":"288","author":"Macpherson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jri.2006.05.006_bib69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/72318","article-title":"Protection of macaques against vaginal transmission of a pathogenic HIV-1\/SIV chimeric virus by passive infusion of neutralizing antibodies","volume":"6","author":"Mascola","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib70","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/nm1197-1250","article-title":"HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals","volume":"3","author":"Mazzoli","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib71","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1086\/314934","article-title":"Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons","volume":"180","author":"Mazzoli","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib72","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00916814","article-title":"Regulation of IgA synthesis and immune response by T cells and interleukins","volume":"9","author":"McGhee","year":"1989","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib73","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.20041196","article-title":"Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract","volume":"200","author":"Mehandru","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib74","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nm0202-150","article-title":"Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells","volume":"8","author":"Meng","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib75","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00915547","article-title":"The common mucosal immune system and current strategies for induction of immune responses in external secretions","volume":"7","author":"Mestecky","year":"1987","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib76","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1574-695X.2000.tb01449.x","article-title":"Induction of mucosal immune responses in the human genital tract","volume":"27","author":"Mestecky","year":"2000","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.jri.2006.05.006_bib77","series-title":"Microbial Pathogens and the Intestinal Epithelial Cell","first-page":"95","article-title":"Intestinal immunoglobulin A: role in host defense.","author":"Mestecky","year":"2003"},{"key":"10.1016\/j.jri.2006.05.006_bib78","series-title":"Fundamental Immunology","first-page":"965","article-title":"The mucosal immune system","author":"Mestecky","year":"2003"},{"key":"10.1016\/j.jri.2006.05.006_bib79","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1089\/aid.2004.20.972","article-title":"Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals","volume":"20","author":"Mestecky","year":"2004","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib80","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0897.2005.00267.x","article-title":"Immunologic uniqueness of the genital tract: challenge for vaccine development","volume":"53","author":"Mestecky","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib81","series-title":"Mucosal Immunology","first-page":"153","article-title":"Mucosal immunoglobulins","author":"Mestecky","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib82","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.4049\/jimmunol.175.6.4127","article-title":"Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity","volume":"175","author":"Moldoveanu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib83","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1086\/425582","article-title":"Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA loads","volume":"190","author":"Nag","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib84","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.coi.2004.05.004","article-title":"CD8+ T-cell memory: only the good ones last","volume":"16","author":"Northrop","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib85","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000028006","article-title":"Interpreting data on lymphocyte subsets in the blood of HIV patients\u2014organ distribution, proliferation and migration kinetics are critical factors","volume":"66","author":"Pabst","year":"1998","journal-title":"Pathobiology"},{"key":"10.1016\/j.jri.2006.05.006_bib86","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2249.1991.tb08145.x","article-title":"Antibody responses in HIV infection","volume":"84","author":"Pinching","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib87","first-page":"155","article-title":"Immunobiology of the human penile urethra","volume":"147","author":"Pudney","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2006.05.006_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/ni1302","article-title":"Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells","author":"Qiao","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib89","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-1759(97)00003-3","article-title":"Comparative analysis of methods for collection and measurement of immunoglobulins in cervical and vaginal secretions of women","volume":"202","author":"Quesnel","year":"1997","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jri.2006.05.006_bib90","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1089\/088922299310070","article-title":"Comparison of the distribution of IgG and IgA antibodies in serum and various mucosal fluids of HIV type 1-infected subjects","volume":"15","author":"Raux","year":"1999","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib91","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1128\/IAI.66.7.3390-3396.1998","article-title":"Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans","volume":"66","author":"Rudin","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2006.05.006_bib92","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S1286-4579(02)01585-X","article-title":"Humoral immune responses to microbial infections in the genital tract","volume":"4","author":"Russell","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jri.2006.05.006_bib93","series-title":"Mucosal Immunology","first-page":"267","article-title":"Biological activities of IgA","author":"Russell","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib94","series-title":"Mucosal Immunology","first-page":"1693","article-title":"Mucosal immunology of sexually transmitted diseases","author":"Russell","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib95","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1073\/pnas.0503463102","article-title":"Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors","volume":"102","author":"Sankaran","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2006.05.006_bib96","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.4049\/jimmunol.169.7.4008","article-title":"Mucosal plasma cell repertoire during HIV-1 infection","volume":"169","author":"Scamurra","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib97","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/gut.50.5.608","article-title":"Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaques","volume":"50","author":"Schafer","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jri.2006.05.006_bib98","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/gut.37.4.524","article-title":"Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood","volume":"37","author":"Schneider","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.jri.2006.05.006_bib99","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000028009","article-title":"Secretory immunity in HIV infection","volume":"66","author":"Schneider","year":"1998","journal-title":"Pathobiology"},{"key":"10.1016\/j.jri.2006.05.006_bib100","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.3016902","article-title":"Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus","volume":"233","author":"Schnittman","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jri.2006.05.006_bib101","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/j.1939-4640.1993.tb00379.x","article-title":"Soluble Fc\u03b3RIII (CD16) and immunoglobulin G levels in seminal plasma of men with immunological infertility","volume":"14","author":"Sedor","year":"1993","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2006.05.006_bib102","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrmicro729","article-title":"Inhibiting sexual transmission of HIV-1 infection","volume":"1","author":"Shattock","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jri.2006.05.006_bib103","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI115621","article-title":"Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation","volume":"89","author":"Shirai","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jri.2006.05.006_bib104","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1086\/338830","article-title":"Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure","volume":"185","author":"Skurnick","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib105","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1128\/JVI.72.8.6646-6656.1998","article-title":"Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes","volume":"72","author":"Smit-McBride","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2006.05.006_bib106","series-title":"Mucosal Immunology","first-page":"1199","article-title":"Immunobiology of mucosal HIV-1 infection","author":"Smith","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib107","series-title":"Mucosal Immunology","first-page":"583","article-title":"IgA B cell development.","author":"Strober","year":"2005"},{"key":"10.1016\/j.jri.2006.05.006_bib108","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-3083.1985.tb01435.x","article-title":"Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis","volume":"21","author":"Svanborg Eden","year":"1985","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib109","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1128\/jvi.67.11.6447-6452.1993","article-title":"Productive infection of a cervical epithelial cell line with human immunodeficiency virus: implications for sexual transmission","volume":"67","author":"Tan","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2006.05.006_bib110","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4049\/jimmunol.143.6.1937","article-title":"Soluble antigens of IgG receptor Fc\u03b3RIII in human seminal plasma","volume":"143","author":"Thaler","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2006.05.006_bib111","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0002-9440(10)64560-9","article-title":"Differential effects of simian immunodeficiency virus infection on immune inductive and effector sites in the rectal mucosa of rhesus macaques","volume":"157","author":"Vajdy","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2006.05.006_bib112","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1126\/science.280.5362.427","article-title":"Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection","volume":"280","author":"Veazey","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jri.2006.05.006_bib113","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20041464","article-title":"Getting to the guts of HIV pathogenesis","volume":"200","author":"Veazey","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib114","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1086\/368386","article-title":"Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection","volume":"187","author":"Veazey","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2006.05.006_bib115","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nm833","article-title":"Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120","volume":"9","author":"Veazey","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2006.05.006_bib116","series-title":"AIDS","first-page":"147","article-title":"Transmission of HIV","author":"Vermund","year":"1997"},{"key":"10.1016\/j.jri.2006.05.006_bib117","first-page":"65","article-title":"A comparison of HIV-1 antibody classes, titers, and specificities in paired semen and blood samples from HIV-1 seropositive men","volume":"5","author":"Wolff","year":"1992","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.jri.2006.05.006_bib118","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/088922202320886334","article-title":"Detection of mucosal antibodies in HIV type 1-infected individuals","volume":"18","author":"Wright","year":"2002","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jri.2006.05.006_bib119","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1086\/382088","article-title":"Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein","volume":"189","author":"Wright","year":"2004","journal-title":"J. Infect. Dis."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503780600074X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503780600074X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:20:49Z","timestamp":1759033249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503780600074X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":119,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S016503780600074X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2006.05.006","relation":{},"ISSN":["0165-0378"],"issn-type":[{"type":"print","value":"0165-0378"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2006.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}