{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:26:07Z","timestamp":1791037567869,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.jri.2011.01.006","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T09:38:24Z","timestamp":1298626704000},"page":"219-227","source":"Crossref","is-referenced-by-count":42,"title":["Innate and acquired immunity in the human penile urethra"],"prefix":"10.1016","volume":"88","author":[{"given":"Jeffrey","family":"Pudney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2011.01.006_bib0005","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/978-1-4684-5344-7_56","article-title":"Monoclonal antibodies specific for human and rat intestinal lymphocytes","volume":"216A","author":"Cerf-Bensussan","year":"1987","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jri.2011.01.006_bib0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/3-540-29916-5_8","article-title":"Innate host defense of human vaginal and cervical mucosae","volume":"306","author":"Cole","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jri.2011.01.006_bib0015","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0968-0004(01)02052-7","article-title":"The MUC family: an obituary","volume":"27","author":"Dekker","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jri.2011.01.006_bib0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1189\/jlb.0609382","article-title":"Human defensins and LL-37 in mucosal immunity","volume":"87","author":"Doss","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2011.01.006_bib0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/QAD.0b013e328321b778","article-title":"HIV-1 infection of human penile explant tissue and protection by candidate microbicides","volume":"23","author":"Fischetti","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2011.01.006_bib0030","doi-asserted-by":"crossref","unstructured":"Gipson, I.K., 2005. Human endocervical mucins. In: Ernst Schering Res Found Workshop, pp. 219\u2013244.","DOI":"10.1007\/3-540-27147-3_10"},{"key":"10.1016\/j.jri.2011.01.006_bib0035","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1095\/biolreprod56.4.999","article-title":"Mucin genes expressed by human female reproductive tract epithelia","volume":"56","author":"Gipson","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2011.01.006_bib0040","doi-asserted-by":"crossref","first-page":"15232","DOI":"10.1074\/jbc.272.24.15232","article-title":"Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure","volume":"272","author":"Harada","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2011.01.006_bib0045","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jri.2011.01.006_bib0050","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/IAI.01672-07","article-title":"Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract","volume":"76","author":"Kawana","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2011.01.006_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.146.1.68","article-title":"The molecular configuration and ultrastructural locations of an IgG Fc binding site in human colonic epithelium","volume":"146","author":"Kobayashi","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2011.01.006_bib0060","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.1128\/JVI.01899-08","article-title":"Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus","volume":"83","author":"Lai","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2011.01.006_bib0065","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1073\/pnas.0911748107","article-title":"Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses","volume":"107","author":"Lai","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2011.01.006_bib0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.it.2008.12.003","article-title":"AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense","volume":"30","author":"Lai","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jri.2011.01.006_bib0075","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1128\/JVI.68.3.1624-1632.1994","article-title":"Mucosal model of genital immunization in male rhesus macaques with a recombinant simian immunodeficiency virus p27 antigen","volume":"68","author":"Lehner","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.jri.2011.01.006_bib0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/CMR.19.2.315-337.2006","article-title":"The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides and microbiota","volume":"19","author":"Lievin-Le Moal","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jri.2011.01.006_bib0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00002030-200303070-00008","article-title":"Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men","volume":"17","author":"Lo Caputo","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2011.01.006_bib0090","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/01.aids.0000237364.11123.98","article-title":"Potential HIV-1 target cells in the human penis","volume":"20","author":"McCoombe","year":"2006","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2011.01.006_bib0095","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0006-3495(01)75844-4","article-title":"Diffusion of macromolecules and virus-like particles in human cervical mucus","volume":"81","author":"Olmsted","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.jri.2011.01.006_bib0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1513\/pats.200504-029SR","article-title":"Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease","volume":"2","author":"Owen","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.jri.2011.01.006_bib0105","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1128\/IAI.00766-09","article-title":"C3H male mice with severe combined immunodeficiency cannot clear a urethral infection with a human serovar of chlamydia trachomatis","volume":"77","author":"Pal","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2011.01.006_bib0110","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1073\/pnas.89.5.1924","article-title":"A family of beta 7 integrins on human mucosal lymphocytes","volume":"89","author":"Parker","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2011.01.006_bib0115","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.1128\/IAI.69.11.7178-7181.2001","article-title":"Urethral cytokine and immune responses in chlamydia trachomatis-infected males","volume":"69","author":"Pate","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2011.01.006_bib0120","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1128\/IAI.73.8.4823-4833.2005","article-title":"Distinct defensin profiles in neisseria gonorrhoeae and chlamydia trachomatis urethritis reveal novel epithelial cell\u2013neutrophil interactions","volume":"73","author":"Porter","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2011.01.006_bib0175","first-page":"149","article-title":"Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome","volume":"139","author":"Pudney","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2011.01.006_bib0130","first-page":"155","article-title":"Immunobiology of the human penile urethra","volume":"147","author":"Pudney","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2011.01.006_bib0135","article-title":"Expression of toll-like receptors in genital tract tissues from normal and HIV-infected men","author":"Pudney","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2011.01.006_bib0140","first-page":"1247","article-title":"Gene expression, immunolocalization and secretion of human defensin-5 in human female reproductive tract","volume":"152","author":"Quayle","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2011.01.006_bib0145","first-page":"350","article-title":"Cytotoxic potential of intraepithelial lymphocytes (IELs). Presence of tia-1, the cytolytic granule-associated protein in human IELs in normal and diseased intestine","volume":"143","author":"Russell","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2011.01.006_bib0150","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/humrep\/del164","article-title":"Mucin gene expression in human male urogenital tract epithelia","volume":"21","author":"Russo","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2011.01.006_bib0155","first-page":"362","article-title":"Urethral lymphocyte isolation in non-gonococcal urethritis","volume":"72","author":"Shahmanesh","year":"1996","journal-title":"Genitourin. Med."},{"key":"10.1016\/j.jri.2011.01.006_bib0160","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jcb.21539","article-title":"Molecular signaling in the regulation of mucins","volume":"102","author":"Theodoropoulos","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jri.2011.01.006_bib0165","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1128\/IAI.01339-09","article-title":"Local host response to chlamydial urethral infection in male guinea pigs","volume":"78","author":"Wang","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2011.01.006_bib0170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.286.5437.113","article-title":"Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense","volume":"286","author":"Wilson","year":"1999","journal-title":"Science"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781100012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781100012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T11:43:47Z","timestamp":1685965427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503781100012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S016503781100012X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2011.01.006","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}