{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:04:14Z","timestamp":1780747454176,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.jri.2012.04.001","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T13:34:55Z","timestamp":1335533695000},"page":"183-189","source":"Crossref","is-referenced-by-count":29,"title":["Impaired fetal thymic growth precedes clinical preeclampsia: a case\u2013control study"],"prefix":"10.1016","volume":"94","author":[{"given":"David P.","family":"Eviston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Quinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J.","family":"Benzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph K.","family":"Nanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2012.04.001_bib0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2265.1997.1230939.x","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure","volume":"46","author":"Benediktsson","year":"1997","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.jri.2012.04.001_bib0010","doi-asserted-by":"crossref","first-page":"IX","DOI":"10.3109\/10641950109152635","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.jri.2012.04.001_bib0015","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1542\/peds.26.5.762","article-title":"Regrowth and overgrowth of the thymus after atrophy induced by the oral administration of adrenocorticosteroids to human infants","volume":"26","author":"Caffey","year":"1960","journal-title":"Pediatrics"},{"key":"10.1016\/j.jri.2012.04.001_bib0020","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.mam.2007.04.003","article-title":"11beta-hydroxysteroid dehydrogenase type 2 in pregnancy and preeclampsia","volume":"28","author":"Causevic","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jri.2012.04.001_bib0025","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/uog.3979","article-title":"Diameter of the normal fetal thymus on ultrasound","volume":"29","author":"Cho","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.001_bib0030","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/jmri.22547","article-title":"Comparison of measurements of the transverse diameter and perimeter of the fetal thymus obtained by magnetic resonance and ultrasound imaging","volume":"33","author":"De Leon-Luis","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.jri.2012.04.001_bib0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ajog.2005.05.036","article-title":"Fetal thymic involution: a sonographic marker of the fetal inflammatory response syndrome","volume":"194","author":"Di Naro","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.001_bib0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.jri.2012.04.001_bib0045","doi-asserted-by":"crossref","first-page":"H1467","DOI":"10.1152\/ajpheart.00682.2001","article-title":"Hypoxia in the thymus: role of oxygen tension in thymocyte survival","volume":"282","author":"Hale","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jri.2012.04.001_bib0050","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1210\/jc.87.8.3696","article-title":"The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia","volume":"87","author":"Hardy","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2012.04.001_bib0055","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/BF00187675","article-title":"Sonographic measurement of the thymus in infants","volume":"6","author":"Hasselbalch","year":"1996","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.jri.2012.04.001_bib0060","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0002-9378(70)90335-2","article-title":"Plasma cortisol levels and cortisol binding in normal and pre-eclamptic pregnancies","volume":"108","author":"Kopelman","year":"1970","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.001_bib0065","first-page":"273","article-title":"Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes","volume":"55","author":"Ma","year":"1984","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2012.04.001_bib0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000087912","article-title":"Immunology of preeclampsia","volume":"89","author":"Matthiesen","year":"2005","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.jri.2012.04.001_bib0075","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0039-128X(98)00056-7","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies","volume":"63","author":"Mccalla","year":"1998","journal-title":"Steroids"},{"key":"10.1016\/j.jri.2012.04.001_bib0130","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/uog.8953","article-title":"Smaller fetal thymuses in pre-eclampsia: a prospective cross-sectional study","volume":"37","author":"Mohamed","year":"2011","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.001_bib0085","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/ajcn\/60.2.274","article-title":"In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children","volume":"60","author":"Parent","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jri.2012.04.001_bib0090","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mam.2007.02.006","article-title":"The role of the immune system in preeclampsia","volume":"28","author":"Saito","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jri.2012.04.001_bib0095","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.4049\/jimmunol.0901154","article-title":"Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia","volume":"183","author":"Santner-Nanan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2012.04.001_bib0100","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1210\/jc.86.3.1313","article-title":"Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia","volume":"86","author":"Schoof","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2012.04.001_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2012.04.001_bib0110","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1053\/hupa.2000.16676","article-title":"Acute thymic involution in fetuses and neonates with chorioamnionitis","volume":"31","author":"Toti","year":"2000","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.jri.2012.04.001_bib0115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1530\/ror.0.0020129","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase: barrier to maternal glucocorticoids","volume":"2","author":"Yang","year":"1997","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.jri.2012.04.001_bib0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1469-0705.1997.09030173.x","article-title":"Three-vessel view of the fetal upper mediastinum: an easy means of detecting abnormalities of the ventricular outflow tracts and great arteries during obstetric screening","volume":"9","author":"Yoo","year":"1997","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.001_bib0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/pd.257","article-title":"The development of the fetal thymus: an in utero sonographic evaluation","volume":"22","author":"Zalel","year":"2002","journal-title":"Prenat. Diagn."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037812005554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037812005554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T10:34:26Z","timestamp":1642156466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037812005554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0165037812005554"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2012.04.001","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}