{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:22:45Z","timestamp":1784002965601,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jri.2012.04.005","type":"journal-article","created":{"date-parts":[[2012,6,10]],"date-time":"2012-06-10T10:27:28Z","timestamp":1339324048000},"page":"27-35","source":"Crossref","is-referenced-by-count":7,"title":["Unilateral uterine ischemia\/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5"],"prefix":"10.1016","volume":"95","author":[{"given":"Xiao-Wu","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Jilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Neerhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmet","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry G.","family":"Thaete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2012.04.005_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00024382-200405000-00002","article-title":"The role of the complement system in ischemia-reperfusion injury","volume":"21","author":"Arumugam","year":"2004","journal-title":"Shock"},{"issue":"Suppl. A","key":"10.1016\/j.jri.2012.04.005_bib0010","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.placenta.2006.01.008","article-title":"Comparative placentation and animal models: patterns of trophoblast invasion \u2013 a workshop report","volume":"27","author":"Carter","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2012.04.005_bib0015","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2353\/ajpath.2010.090276","article-title":"Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage","volume":"176","author":"Castellano","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2012.04.005_bib0020","doi-asserted-by":"crossref","first-page":"e8433","DOI":"10.1371\/journal.pone.0008433","article-title":"Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke","volume":"5","author":"Cervera","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2012.04.005_bib0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/mrd.21013","article-title":"Complement 3 deficiency impairs early pregnancy in mice","volume":"76","author":"Chow","year":"2009","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2012.04.005_bib0030","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/path.2893","article-title":"Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss","volume":"225","author":"Cohen","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.jri.2012.04.005_bib0035","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.molimm.2010.01.021","article-title":"Activation of the complement system in normal pregnancy and preeclampsia","volume":"47","author":"Derzsy","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2012.04.005_bib0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/14767058.2010.496880","article-title":"A multicenter, case-control study on risk factors for antepartum stillbirth","volume":"24","author":"Facchinetti","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2012.04.005_bib0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ajog.2004.01.036","article-title":"Intrauterine growth restriction increases morbidity and mortality among premature neonates","volume":"191","author":"Garite","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0050","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1084\/jem.20061022","article-title":"Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction","volume":"203","author":"Girardi","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2012.04.005_bib0055","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm1419","article-title":"Generation of C5a in the absence of C3: a new complement activation pathway","volume":"12","author":"Huber-Lang","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2012.04.005_bib0060","doi-asserted-by":"crossref","first-page":"H701","DOI":"10.1152\/ajpheart.1997.272.2.H701","article-title":"Role of oxygen-derived free radicals in fetal growth retardation induced by ischemia-reperfusion in rats","volume":"272","author":"Ishimoto","year":"1997","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jri.2012.04.005_bib0065","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.molimm.2009.11.022","article-title":"Early complement factors in the local tissue immunocomplex generated during intestinal ischemia\/reperfusion injury","volume":"47","author":"Lee","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2012.04.005_bib0070","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/0002-9378(92)91727-R","article-title":"Association of intrauterine fetal growth retardation and learning deficits at age 9 to 11 years","volume":"167","author":"Low","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0075","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/sj.bjp.0707358","article-title":"Myeloperoxidase: a target for new drug development?","volume":"152","author":"Malle","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jri.2012.04.005_bib0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.placenta.2003.10.010","article-title":"Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies","volume":"25","author":"Mayhew","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2012.04.005_bib0085","doi-asserted-by":"crossref","first-page":"H1215","DOI":"10.1152\/ajpheart.2001.280.3.H1215","article-title":"Role of leukocytes in uterine hypoperfusion and fetal growth retardation induced by ischemia-reperfusion","volume":"280","author":"Miyakoshi","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jri.2012.04.005_bib0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1520-6661(199705\/06)6:3<125::AID-MFM1>3.0.CO;2-N","article-title":"Endothelin-1-induced placental and fetal growth restriction in the rat","volume":"6","author":"Neerhof","year":"1997","journal-title":"J. Maternal-Fetal Med."},{"key":"10.1016\/j.jri.2012.04.005_bib0095","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1080\/j.1600-0412.1998.770705.x","article-title":"Clinical and pathologic correlates of stillbirths in a single institution","volume":"77","author":"Ogunyemi","year":"1998","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.jri.2012.04.005_bib0100","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0029-7844(95)00400-9","article-title":"Do growth-retarded premature infants have different rates of perinatal morbidity and mortality than appropriately grown premature infants?","volume":"87","author":"Piper","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0090-6980(96)00020-2","article-title":"Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method","volume":"51","author":"Qu","year":"1996","journal-title":"Prostaglandins"},{"key":"10.1016\/j.jri.2012.04.005_bib0110","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2008.07.008","article-title":"The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro","volume":"29","author":"Rampersad","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2012.04.005_bib0115","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1182\/blood-2008-12-194258","article-title":"Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury","volume":"113","author":"Redecha","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jri.2012.04.005_bib0120","first-page":"49","article-title":"Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations","volume":"136","author":"Remick","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2012.04.005_bib0125","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0002-9378(95)91325-4","article-title":"Intrauterine growth restriction in infants of less than thirty-two weeks\u2019 gestation: associated placental pathologic features","volume":"173","author":"Salafia","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0130","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1191\/0961203303lu397oa","article-title":"Activation of complement mediates antiphospholipid antibody-induced pregnancy loss","volume":"12","author":"Salmon","year":"2003","journal-title":"Lupus"},{"key":"10.1016\/j.jri.2012.04.005_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2006.10.879","article-title":"Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies","volume":"196","author":"Shamonki","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0140","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0022-3476(05)80965-5","article-title":"Growth and neurodevelopmental outcome of very low birth weight infants with intrauterine growth retardation: Comparison with control subjects matched by birth weight and gestational age","volume":"123","author":"Sung","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jri.2012.04.005_bib0145","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1523\/JNEUROSCI.5249-09.2010","article-title":"Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic\u2013ischemic brain injury","volume":"30","author":"Ten","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jri.2012.04.005_bib0150","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.placenta.2004.06.003","article-title":"Endothelin and the regulation of uteroplacental perfusion in nitric oxide synthase inhibition-induced fetal growth restriction","volume":"26","author":"Thaete","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2012.04.005_bib0155","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ajog.2005.11.019","article-title":"Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia\/reperfusion-induced fetal growth restriction in the rat","volume":"194","author":"Thaete","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0160","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9378(97)80014-2","article-title":"Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat","volume":"176","author":"Thaete","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2012.04.005_bib0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1071-5576(03)00005-4","article-title":"Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat","volume":"10","author":"Thaete","year":"2003","journal-title":"J. Soc. Gynecol. Investig."},{"key":"10.1016\/j.jri.2012.04.005_bib0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/SHK.0b013e318188b3cc","article-title":"Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs","volume":"31","author":"Xu","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.jri.2012.04.005_bib0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0897.2008.00605.x","article-title":"LPS-induced murine abortions require C5 but not C3, and are prevented by upregulating expression of the CD200 tolerance signaling molecule","volume":"60","author":"Yu","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.04.005_bib0180","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2007.03.152","article-title":"C5aR-mediated myocardial ischemia\/reperfusion injury","volume":"357","author":"Zhang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jri.2012.04.005_bib0185","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2353\/ajpath.2008.080103","article-title":"Gene silencing of complement C5a receptor using siRNA for preventing ischemia\/reperfusion injury","volume":"173","author":"Zheng","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2012.04.005_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2009.07.005","article-title":"Complement and immune defense: from innate immunity to human diseases","volume":"126","author":"Zipfel","year":"2009","journal-title":"Immunol. Lett."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037812005803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037812005803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T17:37:31Z","timestamp":1561829851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037812005803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0165037812005803"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2012.04.005","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}