{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:57:15Z","timestamp":1788476235992,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jri.2012.12.001","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T06:23:57Z","timestamp":1361341437000},"page":"104-111","source":"Crossref","is-referenced-by-count":67,"title":["Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content"],"prefix":"10.1016","volume":"97","author":[{"given":"Kumiko","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2012.12.001_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri2037","article-title":"The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery","volume":"7","author":"Akbar","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0010","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1172\/JCI24685","article-title":"The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs","volume":"115","author":"Allan","year":"2005","journal-title":"Clin. Investig."},{"key":"10.1016\/j.jri.2012.12.001_bib0015","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0020","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.clim.2010.05.002","article-title":"A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure","volume":"136","author":"Arruvito","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0025","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/oxfordjournals.humrep.a138703","article-title":"An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases","volume":"9","author":"Clifford","year":"1994","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0030","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-3083.2009.02308.x","article-title":"How do regulatory T cells work?","volume":"70","author":"Corthay","year":"2009","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.imlet.2005.07.002","article-title":"CD4+CD25+ regulatory\/suppressor T cells prevent allogeneic fetus rejection in mice","volume":"102","author":"Darrasse-J\u00e8ze","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2012.12.001_bib0040","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1095\/biolreprod.110.088591","article-title":"Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment","volume":"85","author":"Guerin","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0045","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jri.2012.12.001_bib0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clim.2009.08.009","article-title":"The CD4+ CD25bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage","volume":"133","author":"Jin","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0055","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1073\/pnas.1003909107","article-title":"Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance","volume":"107","author":"Kahn","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2012.12.001_bib0060","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1073\/pnas.0604268104","article-title":"Alloantigen-enhanced accumulation of CCR5+ \u2018effector\u2019 regulatory T cells in the gravid uterus","volume":"104","author":"Kallikourdis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2012.12.001_bib0065","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/humrep\/der301","article-title":"An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss","volume":"26","author":"Lee","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0070","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.fertnstert.2009.11.020","article-title":"Changes of CD4+ CD25 high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients","volume":"94","author":"Mei","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2012.12.001_bib0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/molehr\/8.2.181","article-title":"Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner","volume":"8","author":"Michimata","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0080","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2012.12.001_bib0085","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1095\/biolreprod.109.081208","article-title":"FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua","volume":"82","author":"Mj\u00f6sberg","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0897.2010.00812.x","article-title":"Accumulation of IL-17-positive cells in decidua of inevitable abortion cases","volume":"64","author":"Nakashima","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0095","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.4049\/jimmunol.176.11.6586","article-title":"CD4+CD25+ Foxp3+ T cells and CD4+CD25\u2212Foxp3+ T cells in aged mice","volume":"176","author":"Nishioka","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0100","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1095\/biolreprod.108.074658","article-title":"Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice","volume":"80","author":"Robertson","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chom.2011.06.005","article-title":"Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens","volume":"10","author":"Rowe","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jri.2012.12.001_bib0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature11462","article-title":"Pregnancy imprints regulatory memory that sustains anergy to fetal antigen","volume":"490","author":"Rowe","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jri.2012.12.001_bib0115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1600-0897.1999.tb00097.x","article-title":"Distribution of Th1, Th2, and Th0 and the Th1\/Th2 cell ratios in human peripheral and endometrial T cells","volume":"42","author":"Saito","year":"1999","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jri.2011.03.003","article-title":"Future directions of studies for recurrent miscarriage associated with immune etiologies","volume":"90","author":"Saito","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0130","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2012.05.031","article-title":"Extrathymic generation of regulatory T cells in placental mammals mitigates maternal\u2013fetal conflict","volume":"150","author":"Samstein","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jri.2012.12.001_bib0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases","volume":"10","author":"Sasaki","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0145","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2249.2007.03397.x","article-title":"Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia","volume":"149","author":"Sasaki","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0150","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of Foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2012.12.001_bib0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jri.2010.06.056","article-title":"Paternal antigen-specific regulatory T cells proliferate in the draining lymph nodes before the implantation and in the uterus after the implantation","volume":"86","author":"Shima","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jri.2010.02.006","article-title":"Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice","volume":"85","author":"Shima","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2249.2011.04493.x","article-title":"Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs","volume":"167","author":"Steinborn","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0170","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/intimm\/10.12.1969","article-title":"Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic\/suppressive state","volume":"10","author":"Takahashi","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0175","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.4049\/jimmunol.180.8.5737","article-title":"Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy","volume":"180","author":"Tilburgs","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0180","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jri.2009.05.003","article-title":"Fetal\u2013maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells","volume":"82","author":"Tilburgs","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0185","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/humrep\/deq198","article-title":"The deregulation of regulatory T cells on interleukin-17-producing T helper cells in patients with unexplained early recurrent miscarriage","volume":"25","author":"Wang","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2012.12.001_bib0190","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jri.2011.08.004","article-title":"Dysregulation of macrophage activation by decidual regulatory T cells in unexplained recurrent miscarriage patients","volume":"92","author":"Wang","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0195","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1600-0897.2011.00992.x","article-title":"Low circulating CD4(+) CD25(+) Foxp3(+) T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure","volume":"66","author":"Winger","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0200","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2007.03.037","article-title":"Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients","volume":"89","author":"Yang","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2012.12.001_bib0205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejogrb.2011.12.023","article-title":"Adoptive transfer of CD4+CD25+ regulatory T cells for prevention and treatment of spontaneous abortion","volume":"161","author":"Yin","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2012.12.001_bib0210","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2012.12.001_bib0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/eji.200535428","article-title":"Regulatory T cells induce a privileged tolerant microenvironment at the fetal\u2013maternal interface","volume":"36","author":"Zenclussen","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jri.2012.12.001_bib0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jri.2007.06.052","article-title":"Fetal alloantigen is responsible for the expansion of the CD4+CD25+ regulatory T cell pool during pregnancy","volume":"75","author":"Zhao","year":"2007","journal-title":"J. Reprod. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781200647X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781200647X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T07:43:31Z","timestamp":1714981411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503781200647X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S016503781200647X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2012.12.001","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}