{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:27:27Z","timestamp":1783416447565,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23390386"],"award-info":[{"award-number":["23390386"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23791818"],"award-info":[{"award-number":["23791818"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24791107"],"award-info":[{"award-number":["24791107"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jri.2014.09.053","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T21:22:24Z","timestamp":1413494544000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content"],"prefix":"10.1016","volume":"107","author":[{"given":"Kumiko","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2014.09.053_bib0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/intimm\/dxm014","article-title":"Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production","volume":"19","author":"Allan","year":"2007","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0010","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0015","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25high regulatory cells in human peripheral blood","volume":"167","author":"Beacher-Allan","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0020","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.1202413","article-title":"Self-specific memory regulatory T cells protect embryos at implantation in mice","volume":"191","author":"Chen","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0215","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/oxfordjournals.humrep.a138703","article-title":"An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases","volume":"9","author":"Clifford","year":"1994","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.imlet.2005.07.002","article-title":"CD4+CD25+ regulatory\/suppressor T cells prevent allogeneic fetus rejection in mice","volume":"102","author":"Darrasse-J\u00e8ze","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2014.09.053_bib0030","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1073\/pnas.0509484103","article-title":"Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development","volume":"103","author":"Gavin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2014.09.053_bib0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1095\/biolreprod.110.088591","article-title":"Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment","volume":"85","author":"Guerin","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0040","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jri.2014.09.053_bib0045","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.ajpath.2012.08.032","article-title":"Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia","volume":"181","author":"Hsu","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2014.09.053_bib0220","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jri.2012.12.001","article-title":"Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content","volume":"97","author":"Inada","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clim.2009.08.009","article-title":"The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage","volume":"133","author":"Jin","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0055","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1073\/pnas.1003909107","article-title":"Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance","volume":"107","author":"Kahn","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2014.09.053_bib0060","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1073\/pnas.0604268104","article-title":"Alloantigen-enhanced accumulation of CCR5+ \u2018effector\u2019 regulatory T cells in the gravid uterus","volume":"104","author":"Kallikourdis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jri.2014.09.053_bib0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1182\/blood-2008-04-150524","article-title":"CD49d provides access to untouched human Foxp3+ Treg free of contaminating effector cells","volume":"113","author":"Kleinewietfeld","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jri.2014.09.053_bib0070","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/humrep\/der301","article-title":"An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss","volume":"26","author":"Lee","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0075","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.fertnstert.2009.11.020","article-title":"Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients","volume":"94","author":"Mei","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2014.09.053_bib0080","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2014.09.053_bib0085","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1095\/biolreprod.108.074658","article-title":"Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice","volume":"80","author":"Robertson","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chom.2011.06.005","article-title":"Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens","volume":"10","author":"Rowe","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jri.2014.09.053_bib0095","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature11462","article-title":"Pregnancy imprints regulatory memory that sustains anergy to fetal antigen","volume":"490","author":"Rowe","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jri.2014.09.053_bib0225","first-page":"710","article-title":"Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-alpha (lL-2R alpha) and IL-2R beta on T cells of human decidua at an early stage of pregnancy","volume":"75","author":"Saito","year":"1992","journal-title":"Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2012.05.031","article-title":"Extrathymic generation of regulatory T cells in placental mammals mitigates maternal\u2013fetal conflict","volume":"150","author":"Samstein","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jri.2014.09.053_bib0115","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.4049\/jimmunol.0901154","article-title":"Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia","volume":"183","author":"Santner-Nanan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases","volume":"10","author":"Sasaki","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2249.2007.03397.x","article-title":"Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia","volume":"149","author":"Sasaki","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0130","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20060468","article-title":"Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells","volume":"203","author":"Seddiki","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2014.09.053_bib0135","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jri.2010.02.006","article-title":"Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice","volume":"85","author":"Shima","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2249.2011.04493.x","article-title":"Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs","volume":"167","author":"Steinborn","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0230","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.4049\/jimmunol.1203488","article-title":"NKG2D blockade inhibits poly(l:C)-triggered fetal loss in wild type but not in IL-1 0-\/- mice","volume":"190","author":"Thaxton","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0235","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.4049\/jimmunol.0904028","article-title":"Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells","volume":"184","author":"Thornton","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0145","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.4049\/jimmunol.180.8.5737","article-title":"Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy","volume":"180","author":"Tilburgs","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jri.2009.05.003","article-title":"Fetal\u2013maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells","volume":"82","author":"Tilburgs","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0155","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI19441","article-title":"Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25\u2212 T cells","volume":"112","author":"Walker","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jri.2014.09.053_bib0160","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/humrep\/deq198","article-title":"The deregulation of regulatory T cells on interleukin-17-producing T helper cells in patients with unexplained early recurrent miscarriage","volume":"25","author":"Wang","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2014.09.053_bib0165","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jri.2011.08.004","article-title":"Dysregulation of macrophage activation by decidual regulatory T cells in unexplained recurrent miscarriage patients","volume":"92","author":"Wang","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0170","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1084\/jem.20120914","article-title":"Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells","volume":"209","author":"Weiss","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2014.09.053_bib0175","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1600-0897.2011.00992.x","article-title":"Low circulating CD4(+) CD25(+) Foxp3(+) T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure","volume":"66","author":"Winger","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2014.09.053_bib0185","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20120822","article-title":"Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo","volume":"209","author":"Yadav","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2014.09.053_bib0190","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2007.03.037","article-title":"Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients","volume":"89","author":"Yang","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2014.09.053_bib0195","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejogrb.2011.12.023","article-title":"Adoptive transfer of CD4+CD25+ regulatory T cells for prevention and treatment of spontaneous abortion","volume":"161","author":"Yin","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2014.09.053_bib0200","doi-asserted-by":"crossref","first-page":"e34547","DOI":"10.1371\/journal.pone.0034547","article-title":"Phenotypic and functional properties of Helios+ regulatory T cells","volume":"7","author":"Zabransky","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jri.2014.09.053_bib0205","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2014.09.053_bib0210","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/eji.200535428","article-title":"Regulatory T cells induce a privileged tolerant microenvironment at the fetal\u2013maternal interface","volume":"36","author":"Zenclussen","year":"2006","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037814001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037814001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:23:16Z","timestamp":1759033396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037814001399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":46,"alternative-id":["S0165037814001399"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2014.09.053","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2014.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}