{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:17:03Z","timestamp":1765232223018,"version":"3.37.3"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jri.2015.02.009","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T13:36:10Z","timestamp":1428759370000},"page":"117-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Effect of immunization against prostate- and testis-expressed (PATE) proteins on sperm function and fecundity in the rat"],"prefix":"10.1016","volume":"110","author":[{"given":"Angireddy","family":"Rajesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-2267","authenticated-orcid":false,"given":"Suresh","family":"Yenugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2015.02.009_bib0005","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/jcp.21272","article-title":"The multi-PDZ domain protein MUPP1 as a lipid raft-associated scaffolding protein controlling the acrosome reaction in mammalian spermatozoa","volume":"214","author":"Ackermann","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jri.2015.02.009_bib0010","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1073\/pnas.052713699","article-title":"PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach","volume":"99","author":"Bera","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2015.02.009_bib0015","first-page":"1371","article-title":"Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis","volume":"379","author":"Blankenvoorde","year":"1998","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jri.2015.02.009_bib0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1439-0272.2005.00687.x","article-title":"Epididymial defensins and sperm maturation","volume":"37","author":"Chan","year":"2005","journal-title":"Andrologia"},{"key":"10.1016\/j.jri.2015.02.009_bib0025","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1095\/biolreprod.110.084855","article-title":"Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine","volume":"84","author":"Chau","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0030","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/bi00386a008","article-title":"Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat sertoli cells","volume":"26","author":"Collard","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.jri.2015.02.009_bib0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jemt.10312","article-title":"Contribution of epididymal secretory proteins for spermatozoa maturation","volume":"61","author":"Ducheux","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jri.2015.02.009_bib0040","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1530\/REP-08-0471","article-title":"Contraceptive potential of porcine and feline zona pellucida A, B and C subunits in domestic cats","volume":"137","author":"Eade","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2015.02.009_bib0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fertnstert.2007.02.025","article-title":"Immunocontraceptive properties of recombinant sperm protein DE: implications for the development of novel contraceptives","volume":"89","author":"Ellerman","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2015.02.009_bib0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00239-003-2461-2","article-title":"Molecular evolution and phylogeny of elapid snake venom three-finger toxins","volume":"57","author":"Fry","year":"2003","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jri.2015.02.009_bib0055","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1021\/bi00371a003","article-title":"Purification and characterization of a sulfated glycoprotein secreted by sertoli cells","volume":"25","author":"Griswold","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.jri.2015.02.009_bib0060","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/j.1939-4640.2002.tb02295.x","article-title":"Host defense proteins of the male reproductive tract","volume":"23","author":"Hall","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2015.02.009_bib0065","first-page":"62","article-title":"A monoclonal Ab to human SP-10 inhibits in vitro the binding of human sperm to hamster oolemma but not to human Zona pellucida","author":"Hamatani","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0070","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/endo.141.3.7389","article-title":"HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human","volume":"141","author":"Hamil","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2015.02.009_bib0075","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/endo.143.7.8925","article-title":"Cystatin 11: a new member of the cystatin type 2 family","volume":"143","author":"Hamil","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2015.02.009_bib0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1477-7827-1-112","article-title":"LCN6, a novel human epididymal lipocalin","volume":"1","author":"Hamil","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2015.02.009_bib0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1098-2795(199902)52:2<216::AID-MRD13>3.0.CO;2-R","article-title":"Expression of recombinant mouse sperm protein sp56 and assessment of its potential for use as an antigen in an immunocontraceptive vaccine","volume":"52","author":"Hardy","year":"1999","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2015.02.009_bib0090","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1128\/IAI.64.11.4520-4524.1996","article-title":"Antibacterial activity of antileukoprotease","volume":"64","author":"Hiemstra","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2015.02.009_bib0095","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/j.1939-4640.2001.tb02154.x","article-title":"Actin and actin-binding proteins in bovine spermatozoa: potential role in membrane remodeling and intracellular signaling during epididymal maturation and the acrosome reaction","volume":"22","author":"Howes","year":"2001","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2015.02.009_bib0100","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1095\/biolreprod.104.035758","article-title":"Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner","volume":"72","author":"Jalkanen","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1262\/jrd.09-219N","article-title":"Effect of NGF on the motility and acrosome reaction of golden hamster spermatozoa in vitro","volume":"56","author":"Jin","year":"2010","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.jri.2015.02.009_bib0110","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1016\/j.vaccine.2008.04.060","article-title":"Evaluation of the potential of synthetic peptides of 80kDa human sperm antigen (80kDa HSA) for the development of contraceptive vaccine for male","volume":"26","author":"Khobarekar","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2015.02.009_bib0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1095\/biolreprod59.3.527","article-title":"A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice","volume":"59","author":"Lea","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0120","doi-asserted-by":"crossref","first-page":"16928","DOI":"10.1074\/jbc.M801454200","article-title":"PATE gene clusters code for multiple, secreted TFP\/Ly-6\/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity","volume":"283","author":"Levitin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2015.02.009_bib0125","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1056545","article-title":"An antimicrobial peptide gene found in the male reproductive system of rats","volume":"291","author":"Li","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jri.2015.02.009_bib0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0897.2012.01117.x","article-title":"Immunogenicity study of plasmid DNA encoding mouse cysteine-rich secretory protein-1 (mCRISP1) as a contraceptive vaccine","volume":"68","author":"Luo","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.02.009_bib0135","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1095\/biolreprod.102.010108","article-title":"SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa","volume":"68","author":"Mandal","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0140","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/humrep\/des064","article-title":"Involvement of the prostate and testis expression (PATE)-like proteins in sperm\u2013oocyte interaction","volume":"27","author":"Margalit","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0145","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.2164\/jandrol.112.016725","article-title":"Evaluation of testicular sperm CRISP2 as a potential target for contraception","volume":"33","author":"Munoz","year":"2012","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2015.02.009_bib0150","doi-asserted-by":"crossref","first-page":"e30552","DOI":"10.1371\/journal.pone.0030552","article-title":"Elucidation of the involvement of p14, a sperm protein during maturation, capacitation and acrosome reaction of caprine spermatozoa","volume":"7","author":"Nandi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jri.2015.02.009_bib0155","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/mrd.20783","article-title":"Immunocontraceptive effect of Izumo and enhancement by combination vaccination","volume":"75","author":"Naz","year":"2008","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2015.02.009_bib0160","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0897.2011.01000.x","article-title":"Antisperm contraceptive vaccines: where we are and where we are going?","volume":"66","author":"Naz","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.02.009_bib0165","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1095\/biolreprod67.2.674","article-title":"Human sperm-specific peptide vaccine that causes long-term reversible contraception","volume":"67","author":"Naz","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0170","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1095\/biolreprod59.5.1095","article-title":"Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice","volume":"59","author":"Naz","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0175","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0264-410X(97)00105-9","article-title":"Colinear synthesis of an antigen-specific B-cell epitope with a \u2018promiscuous\u2019 tetanus toxin T-cell epitope: a synthetic peptide immunocontraceptive","volume":"15","author":"O\u2019Hern","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2015.02.009_bib0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-0378(93)90051-I","article-title":"Inhibition of fertility in female mice by immunization with a B-cell epitope, the synthetic sperm peptide, P10G","volume":"25","author":"O\u2019Rand","year":"1993","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.02.009_bib0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mce.2005.12.039","article-title":"Eppin: an effective target for male contraception","volume":"250","author":"O\u2019Rand","year":"2006","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jri.2015.02.009_bib0190","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1530\/jrf.0.0830169","article-title":"Effects of seminal vesicle fluid components on sperm motility in the house mouse","volume":"83","author":"Peitz","year":"1988","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.jri.2015.02.009_bib0195","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1095\/biolreprod35.3.608","article-title":"Effects of seminal vesicle removal on fertility and uterine sperm motility in the house mouse","volume":"35","author":"Peitz","year":"1986","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0200","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.2174\/1381612033454630","article-title":"Structure\u2013function relationships in the interaction between the urokinase-type plasminogen activator and its receptor","volume":"9","author":"Ploug","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jri.2015.02.009_bib0205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-5793(94)00674-1","article-title":"Structure\u2013function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins","volume":"349","author":"Ploug","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jri.2015.02.009_bib0210","doi-asserted-by":"crossref","first-page":"841615","DOI":"10.1155\/2014\/841615","article-title":"Calcium influx and male fertility in the context of the sperm proteome: an update","volume":"2014","author":"Rahman","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jri.2015.02.009_bib0215","doi-asserted-by":"crossref","first-page":"e32633","DOI":"10.1371\/journal.pone.0032633","article-title":"Genomic organization, tissue distribution and functional characterization of the rat Pate gene cluster","volume":"7","author":"Rajesh","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jri.2015.02.009_bib0220","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1095\/biolreprod55.4.813","article-title":"Purification and characterization of the active precursor of a human sperm motility inhibitor secreted by the seminal vesicles: identity with semenogelin","volume":"55","author":"Robert","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0225","first-page":"3441","article-title":"Redistribution of a rat sperm epididymal glycoprotein after in vitro and in vivo capacitation","volume":"31","author":"Rochweger","year":"1992","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2015.02.009_bib0230","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/rep.1.00576","article-title":"The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein","volume":"129","author":"Soler-Garcia","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2015.02.009_bib0235","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1128\/IAI.68.5.2748-2755.2000","article-title":"Bactericidal activity of mammalian cathelicidin-derived peptides","volume":"68","author":"Travis","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2015.02.009_bib0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1477-7827-9-128","article-title":"Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors","volume":"9","author":"Turunen","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2015.02.009_bib0245","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/aji.12272","article-title":"Antisperm antibodies: invaluable tools toward the identification of sperm proteins involved in fertilization","volume":"72","author":"Vazquez-Levin","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.02.009_bib0250","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0897.2007.00571.x","article-title":"Investigation of recombinant mouse sperm protein izumo as a potential immunocontraceptive antigen","volume":"59","author":"Wang","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.02.009_bib0255","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/mrd.21027","article-title":"Immunocontraceptive potential of the Ig-like domain of Izumo","volume":"76","author":"Wang","year":"2009","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2015.02.009_bib0260","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/en.2003-1698","article-title":"The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin","volume":"145","author":"Yenugu","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2015.02.009_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-4-1","article-title":"Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)","volume":"4","author":"Yenugu","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2015.02.009_bib0270","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humrep\/dep356","article-title":"The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa","volume":"25","author":"Zhang","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0275","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1095\/biolreprod.105.041889","article-title":"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme\/alpha-lactalbumin family","volume":"73","author":"Zhang","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2015.02.009_bib0280","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb1127","article-title":"An epididymis-specific beta-defensin is important for the initiation of sperm maturation","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat. Cell. Biol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037815000522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037815000522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T10:20:18Z","timestamp":1717842018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037815000522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":56,"alternative-id":["S0165037815000522"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2015.02.009","relation":{},"ISSN":["0165-0378"],"issn-type":[{"type":"print","value":"0165-0378"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of immunization against prostate- and testis-expressed (PATE) proteins on sperm function and fecundity in the rat","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2015.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}