{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:06:32Z","timestamp":1775480792480,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jrijournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jri.2015.08.006","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T10:48:06Z","timestamp":1440845286000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Patients with idiopathic recurrent miscarriage show higher levels of DR+ activated T-cells that are less responsive to mitogens"],"prefix":"10.1016","volume":"112","author":[{"given":"R.J.","family":"Kuon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schaumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Goeggl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Strowitzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Opelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2015.08.006_bib0005","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1046\/j.1537-2995.2001.41121524.x","article-title":"Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for noninvasive prenatal diagnosis","volume":"41","author":"Ariga","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.jri.2015.08.006_bib0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0897.2012.01118.x","article-title":"Immune etiology of recurrent pregnancy loss and its diagnosis","volume":"67","author":"Beaman","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0015","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1073\/pnas.93.2.705","article-title":"Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum","volume":"93","author":"Bianchi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jri.2015.08.006_bib0020","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/01.gco.0000194112.86051.26","article-title":"Recurrent miscarriage: pathophysiology and outcome","volume":"17","author":"Carrington","year":"2005","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2015.08.006_bib0025","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/molehr\/8.7.667","article-title":"Expression of the interleukin-2 receptor alpha (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies","volume":"8","author":"Chao","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2015.08.006_bib0030","doi-asserted-by":"crossref","first-page":"e29805","DOI":"10.1371\/journal.pone.0029805","article-title":"Class II MHC self-antigen presentation in human B and T lymphocytes","volume":"7","author":"Costantino","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2015.08.006_bib0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/bmj.38498.669595.8F","article-title":"Selective chromosome analysis in couples with two or more miscarriages: case-control study","volume":"331","author":"Franssen","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.jri.2015.08.006_bib0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.fertnstert.2007.02.012","article-title":"Intracellular cytokine expression of peripheral blood natural killer cell subsets in women with recurrent spontaneous abortions and implantation failures","volume":"89","author":"Fukui","year":"2008","journal-title":"Fert. Ster."},{"key":"10.1016\/j.jri.2015.08.006_bib0045","first-page":"201","article-title":"Expression patterns of HLA-DR+ or HLA-DR- on CD4+\/CD25++\/CD127low regulatory T cells in patients with allergy","volume":"20","author":"Geraldes","year":"2010","journal-title":"J. Invest. Allergol. Clin. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0050","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2015.08.006_bib0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/den011","article-title":"Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage","volume":"23","author":"Hiby","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2015.08.006_bib0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MOP.0000000000000087","article-title":"Maternal-fetal cellular trafficking: clinical implications and consequences","volume":"26","author":"Jeanty","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.jri.2015.08.006_bib0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clim.2009.08.009","article-title":"The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage","volume":"133","author":"Jin","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0070","doi-asserted-by":"crossref","first-page":"e19658","DOI":"10.1371\/journal.pone.0019658","article-title":"Pregnancy and the risk of autoimmune disease","volume":"6","author":"Khashan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2015.08.006_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-0897.2010.00821.x","article-title":"Regulatory T cells and their role in pregnancy","volume":"63","author":"Leber","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-0897.2012.01116.x","article-title":"Th17 and regulatory T cells in women with recurrent pregnancy loss","volume":"67","author":"Lee","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0085","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jri.2007.07.005","article-title":"Butyrylcholinesterase activity and lymphocyte subpopulations in peripheral blood of Kuwaiti women experiencing recurrent spontaneous abortion","volume":"77","author":"Mahmoud","year":"2008","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1389200024605082","article-title":"Neopterin as a marker for immune system activation","volume":"3","author":"Murr","year":"2002","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jri.2015.08.006_bib0095","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1600-0897.2012.01115.x","article-title":"The balance of the immune system between T Cells and NK Cells in miscarriage","volume":"67","author":"Nakashima","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0100","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri3084","article-title":"Towards a systems understanding of MHC class I and MHC class II antigen presentation","volume":"11","author":"Neefjes","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0301-2115(99)00126-8","article-title":"Hysteroscopic metroplasty for septate uterus and repetitive abortions: reproductive outcome","volume":"88","author":"Porcu","year":"2000","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2015.08.006_bib0110","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0897.2008.00591.x","article-title":"Immunophenotype of peripheral T lymphocytes, NK cells and expression of CD69 activation marker in patients with recurrent spontaneous abortions, during the mid-luteal phase","volume":"60","author":"Prado-Drayer","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0115","first-page":"65","article-title":"Immunopathophysiologic characteristics of early pregnancy in women with recurrent miscarriage","volume":"51","author":"Radysh","year":"2005","journal-title":"Fiziol. Zh"},{"key":"10.1016\/j.jri.2015.08.006_bib0120","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/AOG.0b013e31817e8acc","article-title":"Inherited thrombophilia and pregnancy complications revisited","volume":"112","author":"Rodger","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2015.08.006_bib0125","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1440-1711.2002.01055.x","article-title":"Interleukin-dependent modulation of HLA-DR expression on CD4and CD8 activated T cells","volume":"80","author":"Salgado","year":"2002","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jri.2015.08.006_bib0130","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1600-065X.1982.tb00437.x","article-title":"HLA-DR antigens: structure, separation of subpopulations, gene cloning and function","volume":"66","author":"Shackelford","year":"1982","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jri.2015.08.006_bib0135","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/humrep\/der164","article-title":"Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review","volume":"26","author":"Tang","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2015.08.006_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jri.2009.12.006","article-title":"Recurrent miscarriage: current concepts in diagnosis and treatment","volume":"85","author":"Toth","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0145","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2015.08.006_bib0150","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/eji.201242852","article-title":"T-cell exhaustion due to persistent antigen: quantity not quality?","volume":"42","author":"Zuniga","year":"2012","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037815300139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037815300139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T20:25:54Z","timestamp":1567110354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037815300139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":30,"alternative-id":["S0165037815300139"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2015.08.006","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients with idiopathic recurrent miscarriage show higher levels of DR+ activated T-cells that are less responsive to mitogens","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2015.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}