{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:42:44Z","timestamp":1788871364081,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24890202"],"award-info":[{"award-number":["24890202"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25461558"],"award-info":[{"award-number":["25461558"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["40419700"],"award-info":[{"award-number":["40419700"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jrijournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jri.2016.06.007","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T17:21:19Z","timestamp":1466616079000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Diabetic pregnancy activates the innate immune response through TLR5 or TLR1\/2 on neonatal monocyte"],"prefix":"10.1016","volume":"117","author":[{"given":"Sakika","family":"Yanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tokuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sakashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Shintaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-5176","authenticated-orcid":false,"given":"Masayasu","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2016.06.007_bib0005","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0010","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.4049\/jimmunol.178.8.4717","article-title":"Cutting edge: Tlr5-\/- mice are more susceptible to Escherichia coli urinary tract infection","volume":"178","author":"Andersen-Nissen","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1213\/00000539-195301000-00041","article-title":"A proposal for a new method of evaluation of the newborn infant","volume":"32","author":"Apgar","year":"1953","journal-title":"Curr. Res. Anesth. Analg."},{"key":"10.1016\/j.jri.2016.06.007_bib0020","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1210\/jc.2006-0980","article-title":"Modulation of adipokines and cytokines in gestational diabetes and macrosomia","volume":"91","author":"At\u00e8gbo","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2016.06.007_bib0025","doi-asserted-by":"crossref","first-page":"e1513","DOI":"10.1542\/peds.2010-3054","article-title":"Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis","volume":"127","author":"Belderbos","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jri.2016.06.007_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0032-1333412","article-title":"Role of innate immunity in neonatal infection","volume":"30","author":"Cuenca","year":"2013","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.jri.2016.06.007_bib0035","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.imlet.2005.09.005","article-title":"Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci","volume":"102","author":"Draper","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2016.06.007_bib0040","first-page":"857","article-title":"Management of diabetes mellitus complicating pregnancy","volume":"102","author":"Gabbe","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2016.06.007_bib0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/01.ALC.0000167956.28160.5E","article-title":"Maternal alcohol abuse and neonatal infection","volume":"29","author":"Gauthier","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.jri.2016.06.007_bib0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0301-2115(97)00236-4","article-title":"Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia","volume":"78","author":"Ghezzi","year":"1998","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2016.06.007_bib0055","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jri.2016.06.007_bib0060","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.4049\/jimmunol.174.10.6449","article-title":"Role of lipoteichoic acid in the phagocyte response to group B streptococcus","volume":"174","author":"Henneke","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0065","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.4049\/jimmunol.180.9.6149","article-title":"Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis","volume":"180","author":"Henneke","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0070","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jri.2016.06.007_bib0075","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0085","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2567.2004.01923.x","article-title":"Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires toll-like receptor 5-dependent p38 MAP kinase activation","volume":"112","author":"Khan","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.jri.2016.06.007_bib0090","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.immuni.2012.10.014","article-title":"Innate immune function by toll-like receptors: distinct responses in newborns and the elderly","volume":"37","author":"Kollmann","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2016.06.007_bib0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","article-title":"Innate immunity of the newborn: basic mechanisms and clinical correlates","volume":"7","author":"Levy","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00024382-200302000-00008","article-title":"Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis","volume":"19","author":"Liaudet","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.jri.2016.06.007_bib0105","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2016.06.007_bib0110","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.4049\/jimmunol.181.3.2028","article-title":"Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation","volume":"181","author":"Machata","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0115","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1128\/IAI.74.4.1999-2006.2006","article-title":"Neonatal innate immunity to infectious agents","volume":"74","author":"Mar\u00f3di","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2016.06.007_bib0120","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpeds.2013.10.076","article-title":"Infants born to mothers with gestational diabetes mellitus: mild neonatal effects, a long-term threat to global health","volume":"164","author":"Mitanchez","year":"2014","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jri.2016.06.007_bib0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.26248","article-title":"Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice","volume":"58","author":"Mouralidarane","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jri.2016.06.007_bib0130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4149\/gpb_2013075","article-title":"Placental infiltration of inflammatory markers in gestational diabetic women","volume":"33","author":"Mrizak","year":"2014","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.jri.2016.06.007_bib0135","doi-asserted-by":"crossref","first-page":"L1289","DOI":"10.1152\/ajplung.00356.2006","article-title":"Regulation of interleukin-8 via an airway epithelial signaling cascade","volume":"292","author":"Nakanaga","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.jri.2016.06.007_bib0140","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1183\/09031936.06.00050206","article-title":"Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses","volume":"28","author":"Noakes","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jri.2016.06.007_bib0145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpeds.2015.03.035","article-title":"Zymosan induces immune responses comparable with those of adults in monocytes, dendritic cells, and monocyte-derived dendritic cells from cord blood","volume":"167","author":"Nohmi","year":"2015","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jri.2016.06.007_bib0150","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nri3277","article-title":"The impact of differential antiviral immunity in children and adults","volume":"12","author":"Prendergast","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2016.06.007_bib0155","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/glia.22459","article-title":"Microglial activation and expression of immune-related genes in a rat ex vivo nervous system model after infection with Listeria monocytogenes","volume":"61","author":"Remuzgo-Mart\u00ednez","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.jri.2016.06.007_bib0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jri.2016.06.007_bib0165","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jri.2016.06.007_bib0170","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ibd.20296","article-title":"Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine","volume":"14","author":"Subramanian","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jri.2016.06.007_bib0175","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1467-789X.2008.00541.x","article-title":"Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis","volume":"10","author":"Torloni","year":"2009","journal-title":"Obes. Rev."},{"key":"10.1016\/j.jri.2016.06.007_bib0180","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/IAI.72.4.2131-2139.2004","article-title":"Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection","volume":"72","author":"Torres","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jri.2016.06.007_bib0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2393-12-23","article-title":"Gestational diabetes and pregnancy outcomes-a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria","volume":"12","author":"Wendland","year":"2012","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.jri.2016.06.007_bib0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.mce.2015.07.028","article-title":"The impact of maternal obesity during pregnancy on offspring immunity","volume":"418","author":"Wilson","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jri.2016.06.007_bib0195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.2010-3875","article-title":"Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?","volume":"128","author":"Wright","year":"2011","journal-title":"Pediatrics"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781630002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503781630002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T22:51:51Z","timestamp":1536619911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503781630002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":39,"alternative-id":["S016503781630002X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2016.06.007","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetic pregnancy activates the innate immune response through TLR5 or TLR1\/2 on neonatal monocyte","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2016.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}