{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:03:05Z","timestamp":1790758985660,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Institute for Maternal and Child Health, IRCCS \u201cBurlo Garofolo\u201d, Trieste, Italy","award":["RC41\/08 RC 01\/09 RC 34\/11"],"award-info":[{"award-number":["RC41\/08 RC 01\/09 RC 34\/11"]}]},{"name":"European NoE \u201cEMBIC\u201d within FP6"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jrijournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jri.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T20:31:46Z","timestamp":1474230706000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Alternative functions of the complement protein C1q at embryo implantation site"],"prefix":"10.1016","volume":"119","author":[{"given":"Chiara","family":"Agostinis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tedesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-5776","authenticated-orcid":false,"given":"Roberta","family":"Bulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2016.09.001_bib0005","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.4049\/jimmunol.0903215","article-title":"An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development","volume":"185","author":"Agostinis","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0010","first-page":"271","article-title":"Placental apoptosis in preeclampsia","volume":"96","author":"Allaire","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2016.09.001_bib0015","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jri.2016.09.001_bib0020","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1073\/pnas.82.11.3824","article-title":"The C1q subunit of the first component of complement binds to laminin: a mechanism for the deposition and retention of immune complexes in basement membrane","volume":"82","author":"Bohnsack","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2016.09.001_bib0025","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1073\/pnas.1311968111","article-title":"C1q as a unique player in angiogenesis with therapeutic implication in wound healing","volume":"111","author":"Bossi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2016.09.001_bib0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1042\/bj1590279","article-title":"Circular-dichroism and electron-microscopy studies of human subcomponent C1q before and after limited proteolysis by pepsin","volume":"159","author":"Brodsky-Doyle","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.jri.2016.09.001_bib0035","first-page":"101","article-title":"VE-cadherin is a critical molecule for trophoblast-endothelial cell interaction in decidual spiral arteries","volume":"303","author":"Bulla","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jri.2016.09.001_bib0040","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.molimm.2007.12.025","article-title":"Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium","volume":"45","author":"Bulla","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0045","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1038\/ncomms10346","article-title":"C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation","volume":"7","author":"Bulla","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2016.09.001_bib0050","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/HYPERTENSIONAHA.112.194324","article-title":"Preeclampsia is characterized by placental complement dysregulation","volume":"60","author":"Buurma","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2016.09.001_bib0055","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3109\/14767058.2011.648233","article-title":"Plasma IL-4, IL-8, IL-12, interferon-gamma and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight","volume":"25","author":"Cemgil Arikan","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2016.09.001_bib0060","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4049\/jimmunol.153.4.1430","article-title":"Human T cells express specific binding sites for C1q: role in T cell activation and proliferation","volume":"153","author":"Chen","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0065","doi-asserted-by":"crossref","first-page":"34941","DOI":"10.1074\/jbc.M111.286427","article-title":"Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2016.09.001_bib0070","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1016\/j.molimm.2007.02.014","article-title":"Complement protein C1q induces maturation of human dendritic cells","volume":"44","author":"Csomor","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0075","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jnr.21875","article-title":"C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation","volume":"87","author":"Farber","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jri.2016.09.001_bib0080","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1471-4159.2009.06494.x","article-title":"C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production","volume":"112","author":"Fraser","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jri.2016.09.001_bib0085","doi-asserted-by":"crossref","first-page":"46974","DOI":"10.1074\/jbc.M307764200","article-title":"The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties","volume":"278","author":"Gaboriaud","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2016.09.001_bib0090","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-62703-724-2_26","article-title":"Purification of C1q receptors and functional analysis","volume":"1100","author":"Ghebrehiwet","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jri.2016.09.001_bib0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0090-1229(90)90014-H","article-title":"Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative response","volume":"54","author":"Ghebrehiwet","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jri.2016.09.001_bib0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00052","article-title":"The C1q family of proteins: insights into the emerging non-traditional functions","volume":"3","author":"Ghebrehiwet","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0105","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.4049\/jimmunol.175.7.4715","article-title":"Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins","volume":"175","author":"Groeneveld","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0110","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents","volume":"84","author":"Holtan","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jri.2016.09.001_bib0115","doi-asserted-by":"crossref","first-page":"e5755","DOI":"10.1371\/journal.pone.0005755","article-title":"Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells","volume":"4","author":"Hong","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2016.09.001_bib0120","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1067\/mob.2002.119176","article-title":"Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation","volume":"186","author":"Ishihara","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2016.09.001_bib0125","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2144\/02324st05","article-title":"Evaluation of a homemade SYBR green I reaction mixture for real-time PCR quantification of gene expression","volume":"32","author":"Karsai","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.jri.2016.09.001_bib0130","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.it.2004.08.006","article-title":"C1q and tumor necrosis factor superfamily: modularity and versatility","volume":"25","author":"Kishore","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fimmu.2015.00317","article-title":"Emerging and novel functions of complement protein C1q","volume":"6","author":"Kouser","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0140","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1097\/HJH.0b013e3282ef8611","article-title":"Induction of C1q expression in glomerular endothelium in a rat model with arterial hypertension and albuminuria","volume":"25","author":"Kreutz","year":"2007","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jri.2016.09.001_bib0145","first-page":"412","article-title":"Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis","volume":"70","author":"Lau","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0150","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fimmu.2014.00312","article-title":"Complement activation and regulation in preeclamptic placenta","volume":"5","author":"Lokki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0155","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.molimm.2003.08.009","article-title":"Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats","volume":"40","author":"Lynch","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fimmu.2015.00053","article-title":"Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human","volume":"6","author":"Madhukaran","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0165","doi-asserted-by":"crossref","first-page":"14847","DOI":"10.1038\/srep14847","article-title":"RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?","volume":"5","author":"Masat","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2016.09.001_bib0170","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2012.03.047","article-title":"Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes","volume":"149","author":"Naito","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jri.2016.09.001_bib0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.imlet.2010.03.012","article-title":"The non-classical functions of the classical complement pathway recognition subcomponent C1q","volume":"131","author":"Nayak","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2016.09.001_bib0180","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/1753425910396252","article-title":"Complement and non-complement activating functions of C1q: a prototypical innate immune molecule","volume":"18","author":"Nayak","year":"2012","journal-title":"Innate Immun."},{"key":"10.1016\/j.jri.2016.09.001_bib0185","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.194.6.781","article-title":"C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells","volume":"194","author":"Ogden","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2016.09.001_bib0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molimm.2014.06.011","article-title":"cC1qR\/CR and gC1qR\/p33: observations in cancer","volume":"61","author":"Peerschke","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0195","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/HYPERTENSIONAHA.115.05484","article-title":"Classical complement pathway activation in the kidneys of women with preeclampsia","volume":"66","author":"Penning","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2016.09.001_bib0200","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.167.7.4033","article-title":"Reconstitution of the complement function in C1q-deficient (C1qa-\/-) mice with wild-type bone marrow cells","volume":"167","author":"Petry","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0205","doi-asserted-by":"crossref","first-page":"248963","DOI":"10.1155\/2014\/248963","article-title":"The first trimester gravid serum regulates procalcitonin expression in human macrophages skewing their phenotype in vitro","volume":"2014","author":"Rami","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.jri.2016.09.001_bib0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.preghy.2014.04.020","article-title":"The six stages of pre-eclampsia","volume":"4","author":"Redman","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.jri.2016.09.001_bib0215","first-page":"21","article-title":"Behaviour of immune complexes and the complement system in normal pregnancy and pre-eclampsia","volume":"7","author":"Schena","year":"1982","journal-title":"J. Clin. Lab. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0220","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0960-9822(98)70133-2","article-title":"The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor","volume":"8","author":"Shapiro","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jri.2016.09.001_bib0225","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1073\/pnas.69.1.65","article-title":"Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq)","volume":"69","author":"Shelton","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2016.09.001_bib0230","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/HYPERTENSIONAHA.111.175919","article-title":"Role of complement component C1q in the onset of preeclampsia in mice","volume":"58","author":"Singh","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2016.09.001_bib0235","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.molimm.2008.09.018","article-title":"Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation","volume":"46","author":"Sjoberg","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2016.09.001_bib0240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/bj2260207","article-title":"Fibronectin binding to complement subcomponent C1q: localization of their respective binding sites","volume":"226","author":"Sorvillo","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.jri.2016.09.001_bib0245","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1242\/jcs.03232","article-title":"EMILIN1 represents a major stromal element determining human trophoblast invasion of the uterine wall","volume":"119","author":"Spessotto","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jri.2016.09.001_bib0250","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jri.2016.09.001_bib0255","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI4106","article-title":"Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor","volume":"103","author":"Wallukat","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jri.2016.09.001_bib0260","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13058-015-0530-2","article-title":"Prognostic stromal gene signatures in breast cancer","volume":"17","author":"Winslow","year":"2015","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.jri.2016.09.001_bib0265","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.4049\/jimmunol.146.10.3356","article-title":"Complement subcomponent C1q stimulates Ig production by human B lymphocytes","volume":"146","author":"Young","year":"1991","journal-title":"J. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037816300845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037816300845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:00:58Z","timestamp":1692507658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037816300845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":53,"alternative-id":["S0165037816300845"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2016.09.001","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative functions of the complement protein C1q at embryo implantation site","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}