{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:57:10Z","timestamp":1770451030025,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T00:00:00Z","timestamp":1517702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"General Program of the National Nature Science Foundation of China","award":["30972740"],"award-info":[{"award-number":["30972740"]}]},{"name":"General Program of the National Nature Science Foundation of China","award":["81273296"],"award-info":[{"award-number":["81273296"]}]},{"name":"Distinguished Professorship at the Educational Department of Liaoning Province","award":["[2014]187"],"award-info":[{"award-number":["[2014]187"]}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2015020526"],"award-info":[{"award-number":["2015020526"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jri.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T18:22:20Z","timestamp":1518027740000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Physiological low-dose oestrogen promotes the development of experimental autoimmune thyroiditis through the up-regulation of Th1\/Th17 responses"],"prefix":"10.1016","volume":"126","author":[{"given":"Yang","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2018.02.001_bib0005","first-page":"351","article-title":"The effects of female sex steroids on the development of autoimmune thyroiditis in thymectomized and irradiated rats","volume":"54","author":"Ansar Ahmed","year":"1983","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune thyroid disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jri.2018.02.001_bib0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10238-011-0172-3","article-title":"Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis","volume":"12","author":"Aristimu\u00f1o","year":"2012","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jri.2018.02.001_bib0020","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.4049\/jimmunol.168.10.5369","article-title":"Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice","volume":"168","author":"Bao","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0025","doi-asserted-by":"crossref","first-page":"30117","DOI":"10.1074\/jbc.M112.367326","article-title":"p53, a target of estrogen receptor (ER), modulates DNA damage-induced growth suppression in ER-positive breast cancer cells","volume":"287","author":"Berger","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2018.02.001_bib0030","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2174\/15665240113139990065","article-title":"The p53-Estrogen receptor loop in cancer","volume":"13","author":"Berger","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jri.2018.02.001_bib0035","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/toxsci\/51.2.236","article-title":"Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro","volume":"51","author":"Casanova","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jri.2018.02.001_bib0040","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jri.2018.02.001_bib0045","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4161\/mabs.25077","article-title":"The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential","volume":"5","author":"Cl\u00e9menceau","year":"2013","journal-title":"MAbs"},{"key":"10.1016\/j.jri.2018.02.001_bib0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF03401283","article-title":"An overview of the pathogenesis of thyroid autoimmunity","volume":"12","author":"Cogni","year":"2013","journal-title":"Hormones"},{"key":"10.1016\/j.jri.2018.02.001_bib0055","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.4049\/jimmunol.161.7.3365","article-title":"Steroid hormone regulation of cytokine secretion by proteolipid protein-specific CD4\u2009+\u2009T cell clones isolated from multiple sclerosis patients and normal control subjects","volume":"161","author":"Correale","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1586\/1744666X.2014.863149","article-title":"Estrogen's effects in chronic autoimmune\/inflammatory diseases and progression to cancer","volume":"10","author":"Cutolo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0065","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/ard.54.1.6","article-title":"Sex hormones, glucocorticoids and autoimmunity: facts and hypotheses","volume":"54","author":"Da Silva","year":"1995","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jri.2018.02.001_bib0070","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/13697137.2016.1196047","article-title":"Revised global consensus statement on menopausal hormone therapy","volume":"19","author":"De Villiers","year":"2016","journal-title":"Climacteric"},{"key":"10.1016\/j.jri.2018.02.001_bib0075","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jaci.2014.08.012","article-title":"Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of T(H)1\/T(FH) signatures","volume":"135","author":"De Wit","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0080","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0022-4731(89)90421-4","article-title":"The inhibitory effect of hydrocortisone on interferon production by rat spleen cells","volume":"33","author":"Ding","year":"1989","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jri.2018.02.001_bib0085","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1191\/096120398678920352","article-title":"Differential effects of estrogen and prolactin on autoimmune disease in the NZB\/NZW F1 mouse model of systemic lupus erythematosus","volume":"7","author":"Elbourne","year":"1998","journal-title":"Lupus"},{"key":"10.1016\/j.jri.2018.02.001_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVEH.2004.19.1.1","article-title":"Xenoestrogen modulation of the immune system: effects of dichlorodiphenyltrichloroethane (DDT) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"19","author":"Forawi","year":"2004","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.jri.2018.02.001_bib0095","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.4049\/jimmunol.146.12.4362","article-title":"Estrogen regulates the IFN-\u03b3 promoter","volume":"146","author":"Fox","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0100","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1210\/en.2002-0143","article-title":"Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus","volume":"144","author":"Frasor","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2018.02.001_bib0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cyto.2014.11.005","article-title":"Increased IL-21\/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease","volume":"72","author":"Guan","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.jri.2018.02.001_bib0110","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.4049\/jimmunol.0904085","article-title":"p53 represses class switch recombination to IgG2a through its antioxidant function","volume":"184","author":"Guikema","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0115","first-page":"151","article-title":"The effects of estrogen on experimental autoimmune thyroiditis in rats","volume":"20","author":"Guo","year":"2004","journal-title":"Chin. J. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2018.02.001_bib0120","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"T(4), and thyroid antibodies in the United States population (1988\u20131994): national health and nutrition examination survey (NHANES III)","volume":"87","author":"Hollowell","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2018.02.001_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0165-0378(89)90033-8","article-title":"Oestrogen induced suppression of collagen arthritis: IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen mediated therapeutic effect","volume":"15","author":"Jansson","year":"1989","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0896-8411(90)90145-I","article-title":"Estrogen induced suppression of collagen arthritis V: Physiological level of estrogen in DBA\/1 mice is therapeutic on established arthritis, suppresses anti-type II collagen T-cell dependent immunity and stimulates polyclonal B-cell activity","volume":"3","author":"Jansson","year":"1990","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jri.2018.02.001_bib0135","doi-asserted-by":"crossref","first-page":"52797","DOI":"10.18632\/oncotarget.10353","article-title":"Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis","volume":"7","author":"Jin","year":"2016","journal-title":"Oncotarget"},{"issue":"February (4)","key":"10.1016\/j.jri.2018.02.001_bib0140","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S0007114517000344","article-title":"Synergistic attenuation of ovariectomy-induced bone loss by combined use of fish oil and 17\u03b2-oestradiol","volume":"117","author":"Jin","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jri.2018.02.001_bib0145","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1089\/thy.2007.0370","article-title":"Thyroid autoimmunity in schoolchildren in an area with long-standing iodine sufficiency: correlation with gender, pubertal stage, and maternal thyroid autoimmunity","volume":"18","author":"Kaloumenou","year":"2008","journal-title":"Thyroid"},{"key":"10.1016\/j.jri.2018.02.001_bib0150","first-page":"635","article-title":"The immune system is a natural target for estrogen action: opposing effects of estrogen in two prototypical autoimmune diseases","volume":"6","author":"Khan","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0155","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.4049\/jimmunol.1403076","article-title":"Authentic GITR signaling fails to induce tumor regression unless Foxp3+ regulatory T cells are depleted","volume":"195","author":"Kim","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0160","series-title":"Experimental Autoimmune Thyroiditis in the Mouse","first-page":"1","author":"Kong","year":"2007"},{"key":"10.1016\/j.jri.2018.02.001_bib0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogen receptors regulate innate immune cells and signaling pathways","volume":"294","author":"Kovats","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0170","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.4049\/jimmunol.171.11.5820","article-title":"Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis","volume":"171","author":"Latham","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0175","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/imm.12263","article-title":"Oestrogen up-regulates interleukin-21 production by CD4(+) T lymphocytes in patients with systemic lupus erythematosus","volume":"142","author":"Lee","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.jri.2018.02.001_bib0180","first-page":"109","article-title":"Thyroid disorders in women","volume":"106","author":"Li","year":"2015","journal-title":"Minerva Med."},{"key":"10.1016\/j.jri.2018.02.001_bib0185","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.intimp.2006.04.019","article-title":"Effects of estrogen receptor subtype-selective agonists on immune functions in ovariectomized mice","volume":"6","author":"Li","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jri.2018.02.001_bib0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.clim.2007.01.008","article-title":"Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB\/NZW F1 mouse model","volume":"123","author":"Li","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0195","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0897.2009.00784.x","article-title":"Effects of cyclic versus sustained estrogen administration on peripheral immune func\u00actions in ovariectomized mice","volume":"63","author":"Li","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10072-013-1460-3","article-title":"Serum IL-21 levels decrease with glucocorticoid treatment in myasthenia gravis","volume":"35","author":"Li","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jri.2018.02.001_bib0205","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jnr.10409","article-title":"Estrogen inhibition of EAE involves effects on dendritic cell function","volume":"70","author":"Liu","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jri.2018.02.001_bib0210","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/immu.200310027","article-title":"Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor \u03b1 expression in hematopoietic cells","volume":"33","author":"Maret","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1152\/japplphysiol.00254.2015","article-title":"Ventilatory, metabolic, and thermal responses to hypercapnia in female rats: effects of estrous cycle, ovariectomy, and hormonal replacement","volume":"119","author":"Marques","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jri.2018.02.001_bib0220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1677\/joe.0.0620101","article-title":"Progesterone and oestradiol-17beta concentrations in the peripheral plasma during pregnancy in the mouse","volume":"62","author":"McCormack","year":"1974","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jri.2018.02.001_bib0225","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaut.2009.03.010","article-title":"Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen","volume":"33","author":"Morris","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jri.2018.02.001_bib0230","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.coph.2013.05.007","article-title":"Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity","volume":"13","author":"Nadkarni","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jri.2018.02.001_bib0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/cimm.1994.1262","article-title":"Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation","volume":"158","author":"Nilsson","year":"1994","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0240","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0090-1229(81)90182-3","article-title":"Effect of castration and sex hormones on experimental autoimmune thyroiditis","volume":"20","author":"Okayasu","year":"1981","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jri.2018.02.001_bib0245","series-title":"International Trends in Immunity","first-page":"24","author":"Pierdominici","year":"2013"},{"key":"10.1016\/j.jri.2018.02.001_bib0250","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molimm.2013.05.226","article-title":"Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: effects on intracellular molecular targets and antioxidant enzymes","volume":"56","author":"Priyanka","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0255","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/thy.2015.0613","article-title":"Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt iodization for 16 years in China: a cross-sectional study in 10 cities","volume":"26","author":"Shan","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.jri.2018.02.001_bib0260","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni759","article-title":"Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance","volume":"3","author":"Shimizu","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0265","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1756-6614-3-11","article-title":"Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state","volume":"3","author":"Staii","year":"2010","journal-title":"Thyroid Res."},{"key":"10.1016\/j.jri.2018.02.001_bib0270","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature13868","article-title":"IgG1 protects against renal disease in a mouse model of cryoglobulinaemia","volume":"517","author":"Strait","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jri.2018.02.001_bib0275","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jri.2018.02.001_bib0280","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/09629350020027609","article-title":"IL-12, IL-6 and IFN-gamma production by lymphocytes of pregnant women with rheumatoid arthritis remission during pregnancy","volume":"9","author":"Tchorzewski","year":"2000","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.jri.2018.02.001_bib0285","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S2213-8587(13)70109-8","article-title":"Hypothyroidism in pregnancy","volume":"1","author":"Teng","year":"2013","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jri.2018.02.001_bib0290","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2010.02414.x","article-title":"Estradiol-dependent perforin expression by human regulatory T-cells","volume":"4","author":"Valor","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jri.2018.02.001_bib0295","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.4049\/jimmunol.174.11.7433","article-title":"Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4\u202f+\u202fCD25+\u202fT Cells","volume":"174","author":"Verginis","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0300","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/cimm.1998.1372","article-title":"Estrogen increases the number of plasma cells and enhances their autoantibody production in nonautoimmune C57BL\/6 mice","volume":"189","author":"Verthelyi","year":"1998","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0305","first-page":"135","article-title":"The role of the spleen in experimental autoimmune thyroiditis","volume":"56","author":"Weetman","year":"1984","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jri.2018.02.001_bib0310","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1038\/ncomms9266","article-title":"GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation","volume":"6","author":"Xiao","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2018.02.001_bib0315","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1507\/endocrj.K10E-063","article-title":"Selenium upregulates CD4(+)CD25(+) regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2(h4) mice","volume":"57","author":"Xue","year":"2010","journal-title":"Endocr. J."},{"key":"10.1016\/j.jri.2018.02.001_bib0320","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mce.2013.05.016","article-title":"Estrogen receptor \u03b1 and \u03b2 in the normal immune system and in lymphoid malignancies","volume":"375","author":"Yakimchuk","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jri.2018.02.001_bib0325","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2016.08.012","article-title":"Prepubertal exposure to an oestrogenic mycotoxin zearalenone induces central precocious puberty in immature female rats through the mechanism of premature activation of hypothalamic kisspeptin-GPR54 signaling","volume":"437","author":"Yang","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jri.2018.02.001_bib0330","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2174\/138920211798120763","article-title":"Hashimoto's thyroiditis: from genes to the disease","volume":"12","author":"Zaletel","year":"2011","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.jri.2018.02.001_bib0335","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1002\/art.25015","article-title":"A novel subpopulation of B-1Cells is enriched with autoreactivity in normal and lupus-prone mice arthritis rheum","volume":"60","author":"Zhong","year":"2009","journal-title":"Arthritis Rheum."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037817302802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037817302802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T22:12:27Z","timestamp":1693519947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037817302802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":67,"alternative-id":["S0165037817302802"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2018.02.001","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological low-dose oestrogen promotes the development of experimental autoimmune thyroiditis through the up-regulation of Th1\/Th17 responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}